• 디지털융복합연구
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• 제20권5호
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• pp.119-128
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• 2022

오늘날 중국의료기관에 종사하는 구성원의 업무량은 여전히 증가하고 있으며 이에 따라 초과근무도 증가하고 있다. 초과근무의 빈도는 조직신뢰와 직접적인 관계가 있다. 기존의 연구는 대부분 초과근무를 하나의 변수로 보고 연구해 왔다. 이를 기반으로 본 연구는 초과근무를 자발적 및 비자발적 초과근무로 구분하였다. 중국의료기관에 존재하는 초과근무 현상이 구성원의 조직신뢰에 어떤 영향력을 미치는지에 대해 연구할 필요가 있다. 또한, 개인성취가 초과근무와 조직신뢰 사이에서 매개변수로서의 매개효과를 탐구했다. 본 연구의 분석결과를 통해 구성원의 자발적 초과근무와 비자발적 초과근무는 모두 조직신뢰에 긍정적인 영향을 미치는 결과를 보여주었다. 또한, 본 연구의 결과는 개인성취가 초과근무(자발적/비자발적)와 조직신뢰 사이에서 매개효과가 있음을 보여준다. 전반적으로 본 연구는 의료진의 초과근무(자발적/비자발적)가 조직신뢰에 미치는 영향을 탐색하는 데 중점을 두고 구성원의 조직신뢰를 높이려는 방안을 제시하였다.

• 항공우주의학회지
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• 제30권2호
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• pp.75-79
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• 2020

This study focuses on the comparative and quantitative analysis of the epidemiologic trends and aspects of severe fever with thrombocytopenia syndrome (SFTS) outbreaks between Korea and Japan from 2013 to 2017. The following factors were analyzed; cumulative incidence rate (CIR), cases-fatality rate (CFR), and the epidemic aspects, including cases related to gender, male-to-female morbidity ratio (MFMR), age, seasonal, and geographical distributions. We observed 607 SFTS cases with CIR in Korea during the period 2013 to 2017 were as 0.24 per 100,000 populations and with a 127 fatal-cases (F.C.s), corresponding to a CFR of 20.9%, respectively. During the same period in Japan, 319 SFTS cases with a CIR of 0.05 and with 60 F.C.s to a CFR of 18.8% observed. When compared, the CIR of SFTS in Korea was significantly higher than in Japan (P<0.01), but there were no significant differences levels of the CFR and MFMR between Korea and Japan. Also, a higher incidence of SFTS was observed in people aged over 50-years or elders in Korea and those of 60-years or elders in Japan (P<0.01). The seasonal distribution of SFTS outbreak cases showed that the incidence in summer through autumn in Korea (92.4% of total cases) was higher than in Japan (65.2%), while the outbreaks of SFTS in spring was much higher in Japan (31.0%) than in Korea (7.4%), (P<0.01). The regional distribution revealed no significant difference between the eastern area (44.8%) and the western area (46.8%) of the Korean peninsula except Jeju-island (8.4%). However, in Japan, the incidence only occurred in Chubu-Kinki-Chugoku (30.3%), Shikoku (25.7%), Kyushu (42.6%) and Okinawa (0.3%), which are the western and southern areas of Japan. These differences in SFTS occurrence may reflect the influences of vector/hosts, climate, and geographical and cultural characteristics between the two countries.

• Communications for Statistical Applications and Methods
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• 제29권5호
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• pp.499-512
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• 2022

Intervention measures have been implemented worldwide to reduce the spread of the COVID-19 outbreak. The COVID-19 outbreak has occured in several waves of infection, so this paper is divided into three groups, namely those countries who have passed the pandemic period, those countries who are still experiencing a single-wave pandemic, and those countries who are experiencing a multi-wave pandemic. The purpose of this study is to develop a multi-wave Richards model with several changepoint detection methods so as to obtain more accurate prediction results, especially for the multi-wave case. We investigated epidemiological trends in different countries from January 2020 to October 2021 to determine the temporal changes during the epidemic with respect to the intervention strategy used. In this article, we adjust the daily cumulative epidemiological data for COVID-19 using the logistic growth model and the multi-wave Richards curve development model. The changepoint detection methods used include the interpolation method, the Pruned Exact Linear Time (PELT) method, and the Binary Segmentation (BS) method. The results of the analysis using 9 countries show that the Richards model development can be used to analyze multi-wave data using changepoint detection so that the initial data used for prediction on the last wave can be determined precisely. The changepoint used is the coincident changepoint generated by the PELT and BS methods. The interpolation method is only used to find out how many pandemic waves have occurred in given a country. Several waves have been identified and can better describe the data. Our results can find the peak of the pandemic and when it will end in each country, both for a single-wave pandemic and a multi-wave pandemic.

• 한국ITS학회 논문지
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• 제21권4호
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• pp.78-95
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• 2022

아프리카 돼지열병, 구제역 등 가축전염병 유행과 관련된 기존의 연구 결과에서 가축전염병 확산의 주요 원인으로 축산 관련 차량 통행을 지목하는 경우가 많다. 이에 본 연구는 경기도 내 축산시설의 차량 방문이력 데이터와 화물차량의 디지털 운행기록계 데이터를 결합하여 각 읍면동의 주중 축산 화물차량 OD 통행량을 구한 후, 이에 기반한 가축전염병 확산 예측모형을 개발하였다. 모형은 2015년 1~2월 당시 주차별 구제역 발병기록을 이용하여 훈련되었으며, 긍정적 시나리오 기준으로 검증용 감염 표본 13개의 감염을 모두 예측해내는 데에 성공했다.

• Clinical and Experimental Pediatrics
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• 제65권5호
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• pp.230-238
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• 2022

Myocarditis was previously attributed to an epidemic viral infection. Additional harmful reagents, in addition to viruses, play a role in its etiology. Coronavirus disease 2019 (COVID-19) vaccine-induced myocarditis has recently been described, drawing attention to vaccine-induced myocarditis in children and adolescents. Its pathology is based on a series of complex immune responses, including initial innate immune responses in response to viral entry, adaptive immune responses leading to the development of antigen-specific antibodies, and autoimmune responses to cellular injury caused by cardiomyocyte rupture that releases antigens. Chronic inflammation and fibrosis in the myocardium eventually result in cardiac failure. Recent advancements in molecular biology have remarkably increased our understanding of myocarditis. In particular, microRNAs (miRNAs) are a hot topic in terms of the role of new biomarkers and the pathophysiology of myocarditis. Myocarditis has been linked with microRNA-221/222 (miR-221/222), miR-155, miR-10a^*, and miR-590. Despite the lack of clinical trials of miRNA intervention in myocarditis yet, multiple clinical trials of miRNAs in other cardiac diseases have been aggressively conducted to help pave the way for future research, which is bolstered by the success of recently U.S. Food and Drug Administration-approved small-RNA medications. This review presents basic information and recent research that focuses on myocarditis and related miRNAs as a potential novel biomarker and the therapeutics.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제25권5호
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• pp.422-431
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• 2022

Purpose: At the beginning of the Coronavirus disease (COVID-19) epidemic, physicians paid close attention to children with chronic diseases to prevent transmission or a severe course of infection. We aimed to measure the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody levels in children with chronic gastrointestinal and liver diseases to analyze the risk factors for infection and its interaction with their primary disease. Methods: This cross-sectional study analyzed SARS-CoV-2 antibody levels in patients with gastrointestinal and liver diseases (n=141) and in healthy children (n=48) between January and February 2021. Results: During the pandemic, 10 patients (7%) and 1 child (2%) had confirmed COVID-19 infection (p=0.2). The SARS-CoV-2 antibody test was positive in 36 patients (25.5%) and 11 children (22.9%) (p=0.7). SARS-CoV-2 antibody positivity was found in 20.4%, 26.6%, 33.3%, and 33.3% of patients with chronic liver diseases, chronic gastrointestinal tract diseases, cystic fibrosis, and liver transplantation recipients, respectively (p>0.05, patients vs. healthy children). Risk factors for SARS-CoV-2 antibody positivity were COVID-19-related symptoms (47.2% vs. 14.2%, p=0.00004) and close contact with SARS-CoV-2 polymerase chain reaction-positive patients (69.4% vs. 9%, p<0.00001). The use, number, and type of immunosuppressants and primary diagnosis were not associated with SARS-CoV-2 antibody positivity. The frequency of disease activation/flare was not significant in patients with (8.3%) or without (14.2%) antibody positivity (p=0.35). Conclusion: SARS-CoV-2 antibodies in children with chronic gastrointestinal and liver diseases are similar to that in healthy children. Close follow-up is important to understand the long-term effects of past COVID-19 infection in these children.

• Journal of Information Processing Systems
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• 제18권3호
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• pp.359-373
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• 2022

The new crown pneumonia (COVID-19) has become a global epidemic. The disease has spread to most countries and poses a challenge to the healthcare system. Contact tracing technology is an effective way for public health to deal with diseases. Many experts have studied traditional contact tracing and developed digital contact tracking. In order to better understand the field of contact tracking, it is necessary to analyze the development of contact tracking in the field of computer science by bibliometrics. The purpose of this research is to use literature statistics and topic analysis to characterize the research literature of contact tracking in the field of computer science, to gain an in-depth understanding of the literature development status of contact tracking and the trend of hot topics over the past decade. In order to achieve the aforementioned goals, we conducted a bibliometric study in this paper. The study uses data collected from the Scopus database. Which contains more than 10,000 articles, including more than 2,000 in the field of computer science. For popular trends, we use VOSviewer for visual analysis. The number of contact tracking documents published annually in the computer field is increasing. At present, there are 200 to 300 papers published in the field of computer science each year, and the number of uncited papers is relatively small. Through the visual analysis of the paper, we found that the hot topic of contact tracking has changed from the past "mathematical model," "biological model," and "algorithm" to the current "digital contact tracking," "privacy," and "mobile application" and other topics. Contact tracking is currently a hot research topic. By selecting the most cited papers, we can display high-quality literature in contact tracking and characterize the development trend of the entire field through topic analysis. This is useful for students and researchers new to field of contact tracking ai well as for presenting our results to other subjects. Especially when comprehensive research cannot be conducted due to time constraints or lack of precise research questions, our research analysis can provide value for it.

• 한국미생물학회:학술대회논문집
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• 한국미생물학회 2000년도 추계학술발표대회
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• pp.78-82
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• 2000

The AIDS epidemic continues unabated in many part of the world. After near two decades, no vaccine is available to combat the spread of this deadly disease. Much of the HIV -1 vaccine effort during the past decade has focused on the viral envelope glycoprotein, largely because it is the only protein that can elicit neutralizing antibodies (Nabs). Eliciting broadly cross-reactive Nabs has been a primary goal. The intrinsic genetic diversity of the viral envelope, however, has been one of the major impediments in vaccine development. We have recently completed a comprehensive study examining whether it is possible to elicit broadly acting Nabs by immunizing monkeys with mixtures of envelope proteins from multiple HIV -1 isolates. We compared the humoral immune responses elicited by vaccination with either single or multiple envelope proteins and evaluated the importance of humoral and non-humoral immune response in protection against a challenge virus with a homologous or heterologous envelope protein. Our results show that (1) Nab is the correlate of sterilizing immunity, (2) Nabs against primary HIV -1 isolates can be elicited by the live vector-prime/protein boost approach, and (3) polyvalent envelope vaccines elicit broader Nab response than monovalent vaccines. Nonetheless, our findings clearly indicate that the increased breadth of Nab response is by and large limited to strains included in the vaccine mixture and does not extend to heterologous non-vaccine strains. Our study strongly demonstrates how difficult it may be to elicit broadly reactive Nabs using envelope proteins and sadly predicts a similar fate for many of the vaccine candidates currently being evaluated in clinical trials. We have started to evaluate other vaccine candidates (e.g. genetically modified envelope proteins) that might elicit broadly reactive Nabs. We are also exploring other vaccine strategies to elicit potent cytotoxic T lymphocyte responses. Preliminary results from some of these experiments will be discussed.

• 한국간호교육학회지
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• 제28권4호
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• pp.444-455
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• 2022

Purpose: This study explored the meaning of the social perceptions of nurses in online news articles during the coronavirus disease 2019 (COVID-19) pandemic. Methods: A total of 339 nurse-related articles published in Korean online newspapers from January 1 to December 31, 2020, were extracted by entering various combinations of OR and AND with the four words "Corona," "COVID," "Nursing," and "Nurse" as search keywords using BIGKinds, a news database provided by the Korea Press Foundation. The collected data were analyzed with a keyword network analysis and topic modeling using NetMiner 4. Results: The top keywords extracted from the nurse-related news articles were, in the following order, "metropolitan area," "protective clothing," "government," "task," and "admission." Four topics representing keywords were identified: "encouragement for dedicated nurses," "poor work environment," "front-line nurses working with obligation during the COVID-19 pandemic," and "nurses' efforts to prevent the spread of COVID-19." Conclusion: The media's attention to the dedication of nurses, the shortage of nursing resources, and the need for government support is encouraging in that it forms the public opinion necessary to lead to substantial improvements in treating nurses. The nursing community should actively promote policy proposals to improve treatment toward nurses by utilizing the net function of the media and proactively seek and apply strategies to improve the image of nurses working in various fields.

• 한국물환경학회지
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• 제39권1호
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• pp.102-110
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• 2023

Wastewater Based Epidemiology (WBE) provides useful information not only on the use of illegal drugs in the community, but also on the presence of hygiene and health products and infectious pathogens in sewage facilities. As a consequence of the SARS-CoV-19 virus epidemic in 2019, monitoring the status of the infection is of utmost importance. SARS-CoV-19 was also detected in sewage, and the number and trend of infections in the community suggest that the application of the WBE system would be useful and appropriate. This study introduces a pre-treatment concentration method including viruses in sewage samples. A total of seven methods which were subdivided into methods for adsorption-extraction, ultra-filtration, PEG precipitation, and ultra-centrifugation, and the results for analyzing the recovery rates were included. Meanwhile, it is necessary to pay attention to rapid detection technologies which analyze infectious pathogens at the site of sewage facilities. These can include ELISA, FTIR, SERS, and biosensor based on the detection principle, and the characteristics, advantages, and disadvantages of each were summarized herein. If rapid detection technologies and accurate quantitative analyses are further developed, the use of sewage mechanics in response to pandemic viruses is expected to expand further.