• Title/Summary/Keyword: Enzyme/metal bicatalysis

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Lipase/Ruthenium-Catalyzed Dynamic Kinetic Resolution of β-Hydroxyalkylferrocene Derivatives

  • Lee, Han-Ki;Ahn, Yang-Soo
    • Bulletin of the Korean Chemical Society
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    • v.25 no.10
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    • pp.1471-1473
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    • 2004
  • An efficient dynamic kinetic resolution of racemic ${\beta}$-hydroxyalkylferrocene and 1,1'-bis( ${\beta}$-hydroxyalkyl)-ferrocene derivatives was achieved using lipase/ruthenium-catalyzed transesterification in the presence of an acyl donor. The racemic ${\beta}$-hydroxyalkylferrocene derivatives were successfully transformed to the corresponding chiral acetates of high optical purities in high yields.