• 광물과 암석
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• 제33권4호
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• pp.391-405
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• 2020

본 연구에서는 안동댐 퇴적물의 일반항목과 중금속의 용출 특성에 대해 조사하였다. 용출 실험은 카드뮴, 구리, 납, 크롬, 아연, 수은, 비소, 철, 망간 등 중금속 9개 및 pH, 총인, 총질소등 일반 3개 항목에 대해 혐기성과 호기성 조건에서 60일간 실험을 수행하였다. 총질소와 총인은 호기성 조건에 비해 혐기성 조건의 용출이 높게 나타났으며, 일부 시료에서 높은 농도가 검출되었다. 대부분의 중금속의 용출율은 아주 낮았으며, 퇴적물에서 함유량이 높은 비소와 카드뮴도 최대 용출량이 각각 0.028 mg/L, 0.003 mg/L로 낮은 값을 나타낸다. 5단계 연속추출연구에서는 쉽게 용출될 수 있는 이온교환형태나 흡착한 형태의 분율이 전체 함유량의 10% 미만으로 낮게 나타났다. 대부분의 중금속은 왕수에 용해되는 잔류(residual)형태로 존재하고 있으며, 특히 독성이 높고 오염도가 높은 비소와 카드뮴의 경우 잔류형태로 존재하는 비율이 각각 80%와 95%로 오염도에 비해 짧은 시간에 용출되어 유해성을 일으킬 가능성은 낮은 것으로 판단된다.

• 한국융합학회논문지
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• 제9권8호
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• pp.365-377
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• 2018

본 연구는 한국 암 생존자의 삶에서 경험하는 행복감을 진화론적 개념분석 방법을 통해서 확인하고자 하였다. 분석 자료는 2000년 1월부터 2017년 9월까지 본 연구의 목적에 부합되는 11개의 논문을 분석하였다. 그 결과 한국 암 생존자의 행복감에서 나타나는 속성은 마음의 평정을 이루는 주관적 경험, 삶의 만족감과 안녕감을 위한 긍정적 마음, 작은 것의 소중함과 고마움을 깨닫게 되는 삶의 의미, 타인을 이해하고 도우며 더불어 살아가는 삶을 위한 관계형성이었다. 선행요인으로는 삶의 위기를 수용하고 현실에 대처하며 자기성찰과 환경적 지지가 이루어지는 것이며, 결과요인은 내면의 힘이 증가하고, 사랑을 느끼며, 새로운 삶을 추구하고, 자기실현을 이루게 된다. 본 연구는 한국 암 생존자의 행복감을 증진시킬 수 있는 단계적 사정을 위한 기본틀을 제시하였다는데 의의가 있으며, 다학제적 융합프로그램을 통한 암 생존자 관리가 이루어져야 할 것이다.

• 지질공학
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• 제24권3호
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• pp.343-351
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• 2014

터널 시공 중 막장 매핑은 터널의 위험도 판단과 향후 지보패턴 결정에 중요한 역할을 한다. 본 연구에서는 막장관찰기록지를 이용한 기존의 수기 매핑 방식을 탈피하여 모바일을 이용한 디지털 매핑 시스템을 제시하였다. 현장에서 디바이스를 기반으로 작성된 매핑 자료는 메인서버와 연동되어 자동으로 데이터베이스화가 되며 담당자 및 관련전문가들 사이에서 실시간 피드백이 가능하도록 구현하였다. 매핑의 정밀한 표현 방식 및 다량의 데이터 누적에 의한 속도 저하 문제는 Douglas-Peucker 알고리즘 등을 이용하여 해결하고자 하였다. 본 시스템은 향후 다양한 현장 검증 및 추가적인 기능 개선 등을 통해 완성도가 높아질 것으로 기대된다.

• Toxicological Research
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• 제34권4호
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• pp.343-354
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• 2018

Aluminum oxide nanoparticles ($Al_2O_3$ NPs) are among the most widely used nanomaterials; however, relatively little information about their risk identification and assessment is available. In the present study, we aimed to investigate the potential toxicity of $Al_2O_3$ NPs following repeated inhalation exposure in male Sprague-Dawley rats. Rats were exposed to $Al_2O_3$ NPs for 28 days (5 days/week) at doses of 0, 0.2, 1, and $5mg/m^3$ using a nose-only inhalation system. During the experimental period, we evaluated the clinical signs, body weight change, hematological and serum biochemical parameters, necropsy findings, organ weight, and histopathology findings. Additionally, we analyzed the bronchoalveolar lavage fluid (BALF), including differential leukocyte counts, and aluminum contents in the major organs and blood. Aluminum contents were the highest in lung tissues and showed a dose-dependent relationship in the exposure group. Histopathology showed alveolar macrophage accumulation in the lungs of rats in the $5mg/m^3$ group during exposure and recovery. These changes tended to increase at the end of the recovery period. In the BALF analysis, total cell and neutrophil counts and lactate dehydrogenase, tumor necrosis factor-${\alpha}$, and interleukin-6 levels significantly increased in the 1 and $5mg/m^3$ groups during exposure. Under the present experimental conditions, we suggested that the no-observed-adverse-effect level of $Al_2O_3$ NPs in male rats was $1mg/m^3$, and the target organ was the lung.

• 한국산업보건학회지
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• 제30권1호
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• pp.67-74
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• 2020

Objectives: Previous study has shown that the positive rate of latent tuberculosis infection(LTBI) among former workers in dusty environments was higher than that among high-risk groups of tuberculosis(TB). The objective of the present study was to identify the development of active TB among former workers in dusty environments diagnosed with LTBI. Methods: Between January 2015 and May 2017, 796 former workers in dusty environments who had been subjects of epidemiology research for work-related chronic obstructive pulmonary disease(COPD) had received the QuantiFERON-TB® Gold In-Tube(QFT-GIT) from the Institute of Occupation and Environment(IOE) under the Korea Workers' Compensation and Welfare Service(KCOMWEL). Among them, 437 participants who received a health examination for work-related pneumoconiosis between January 2015 and December 2018 were selected as study subjects. Active TB was defined as a positive result for active PTB and non-tuberculosis mycobacteria infection in the result of the Pneumoconiosis Examination Council's assessment by KCOMWEL. Results: A total of 437 subjects were followed up for 2.1 years. Four of them(4/437, 0.9%) developed active TB during the follow-up period. The attack rate of active TB among subjects who were diagnosed LTBI positive and those who were diagnosed LTBI negative were 0.9%(3/320) and 0.9%(1/115), respectively. Conclusions: Most previous studies reported that the attack rate of the development of active TB in subjects who had been diagnosed LTBI positive was higher than that among subjects who had been diagnosed LTBI negative. To the contrary, the present study found that the rate of developing active TB among former workers in dusty environments diagnosed as LTBI positive was not higher than that in those who were diagnosed LTBI negative.

• Toxicological Research
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• 제17권
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• pp.293-297
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• 2001

The international pharmaceutical and regulatory communities had been recognizing the limited utility of conventional rodent carcinogenicity study particularly on the second species, mouse, after intense investigation of carcinogenicity data base worldwide, and a new scheme for carcinogenicity testing for pharmaceuticals was proposed at the Expert Working Group on Safety in the International Conference on Harmonization (ICH) in 1996. CB6F 1-Tg rasH2 mouse carrying human prototype c-Ha-ras gene with its own promoter/enhancer is one oj the new carcinogenicity assay model for human cancer risk assessment. Studies have been conducted since 1992 to validate the transgenic (Tg) mice for rapid carcinogenicity test-ing, short term (26 weeks) studies with genotoxic (by Salmonella), non-genotoxic carcinogens, genotoxic non-carcinogens, non-genotoxic non-carcinogens revealed relatively high concordance oj the response of the Tg mouse with classical bioassay across classes of carcinogenic agents. Mechanistic basis for carcinogensis in the model are being elucidated in terms of the role of overexpression and/or point mutation of the transgene. This report review the initial studies of validation of the model and preliminary results of on-going ILSI HESI ACT project will be presented.

• 한국안전학회지
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• 제27권5호
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• pp.148-157
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• 2012

Reliability-based design optimization (RBDO) problem is usually formulated as an optimization problem to minimize an objective function subjected to probabilistic constraint functions which may include deterministic design variables as well as random variables. The challenging task is that, because the probability models of the random variables are often assumed based on limited data, there exists a possibility of selecting inappropriate distribution models and/or model parameters for the random variables, which can often lead to disastrous consequences. In order to select the most appropriate distribution model from the limited observation data as well as model parameters, this study takes into account a set of possible candidate models for the random variables. The suitability of each model is then investigated by employing performance and risk functions. In this regard, this study enables structural design optimization and fitness assessment of the distribution models of the random variables at the same time. As the first paper of a two-part series, this paper describes a new design method considering probability model uncertainties. The robust performance of the proposed method is presented in Part 2. To demonstrate the effectiveness of the proposed method, an example of ten-bar truss structure is considered. The numerical results show that the proposed method can provide the optimal design variables while guaranteeing the most desirable distribution models for the random variables even in case the limited data are only available.

• Journal of Microbiology and Biotechnology
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• 제15권5호
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• pp.1130-1134
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• 2005

To monitor the possibility of horizontal gene transfer between transgenic potato and bacteria in the environment, the gene flow from glufosinate-tolerant potato to bacteria in soils was investigated. The soil samples treated with the leaf tissue of either glufosinate-tolerant or glufosinate-sensitive potato were subjected to PCR and Southern hybridization to determine possible occurrence of glufosinate-resistant soil bacteria and to detect the bar (phosphinothricin acetyltransferase) gene, conferring tolerance to glufosinate. The bar gene was not detected from genomic DNAs extracted at different time intervals from the soil samples, which had been treated with the leaf tissue of either transgenic or non-transgenic potato for 2 to 8 weeks. In addition, the level of glufosinate-resistant bacteria isolated from the soil samples treated with the leaf tissue of transgenic potato was similar to that of the samples treated with non-transgenic potato after 4 months of incubation at $25^{\circ}C$. The bar gene was not detected in the genomic DNAs extracted from colonies growing on the plate containing glufosinate, indicating that the bacteria could acquire the resistant phenotype to glufosinate by another mechanism without the uptake of the bar gene from glufosinate-tolerant potato.

• 한국농공학회지
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• 제43권2호
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• pp.94-104
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• 2001

A pilot study was performed at the experimental field of Konkuk University in Seoul, to examine the feasibility of the constructed wetland system for sewage and the effect of treated sewage irrigation on the paddy rice culture and its soil characteristics. The constructed wetland performed well, in that effluent concentrations of pollutants were significantly lower than concentrations of the influent. Median removal efficiencies of BOD$_{5}$ was about 78% and slightly lower during winter. Removal efficiencies form TN and TP were approximately 48 and 21%, respectively, and relatively less effective than that of BOD$_{5}$. Irrigation of treated sewage to paddy rice culture did not affect adversely in both growth and yield of rice. Instead, plots of treated sewage irrigation showed up to 50% more yield in average than the control plot. It implies that treated sewage irrigation might be beneficial to rice culture rather than detrimental as long as it is treated adequately and used properly. Soil was sampled and analyzed before transplanting and after harvesting. pH was slightly increased due to irrigation water, but it may not be concerned as long as the treated sewage is within the normal range. EC was increased in first year but decreased in second year, therefore salts accumulation in the soil could be less concerned. OM and CES was slightly increased, which might be beneficial on growing plants. TN did not show apparent pattern. Available phosphorus was decreased after rice culture, but the quantity of phosphorus(TP-available phosphorus) was rather increased which implies that excessive phosphorus supply may result in phosphorus accumulation in the soil. Overall, the constructed wetland was thought to be an effective sewage treatment alternative, and treated sewage could be reused as a supplemental source of irrigation water for paddy rice culture without causing adverse effect as long as it is treated adequately and used properly. For full-scale application, further investigation should be followed on environmental risk assessment, tolerable water quality, and fraction of supplemental irrigation.ion.

• Spatial Information Research
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• 제2권2호
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• pp.165-174
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• 1994

GIS를 이용하여 토양 유실에 대한 환경영향 분석과 평가가 부여군의 금강유역을 대상으로 실시되었다. 수작업 계산으로 처리되고 있는 지금까지의 토양 유실량 산출방법은 토양 유실을 야기시키는 여러 자연환경 요소들의 정량적 분석과 또한 이러한 요소들의 복잡한 상관 관계들을 명쾌하게 규명하기에는 많은 어려움이 있다. 금번 연구에서 GIS의 활용은 이러한 환경분석 기술들을 변화시키고 자료들을 조직화할 뿐만 아니라, 기존의 분석과정들을 자동화시키는 이상의 변화를 가져오게 할 수 있었다. 연구지역에서 아주 경제적으로 생산된 최종 토양 유실 분석도는 여러 사용자들에게 GIS의 유용성과 활용성을 보여주는 계기를 제공하고 있다. 본 연구에서 도입된 토양 유실 공식(USLE)은 분수계내에서 실제 유실량 계산을 목적으로하고 있으나, 금번에 개발된 토양 유실 계수(Soil Loss Index)는 위으 공식 적용에 있어서 야기될 수 있는 자료들의 부정확성을 보완할 수 있음은 물론, 다른 분수계들에 대해서 상대적 토양 유실 분석에도 활용될 수 있다. 동시에 본 연구결과는 토사 유실에 따른 대책 수립에 커다란 기여가 예상되며, 지질 재해 예방에 적극 활용될 것이다. 앞으로 국내에서는 본 연구를 기초로 환경관리 분야에 대한 GIS 응용기술의 적극 개발과 환경분석 전문가 시스템 개발이 요구될 전망이다.