• Environmental Analysis Health and Toxicology
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• 제20권4호통권51호
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• pp.279-286
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• 2005

Earthworm (Eisenia fetida) acute toxicity test was carried out and ecological risk assessment in soil was performed with national monitoring data. 14 day - $LC_{50}$ of nonylphenol and bisphenol A were 288.1 mg/kg and 90.1 mg/kg, respectively. And NOECs of nonylphenol and bisphenol A were 250 mg/kg and 50 mg/kg, respectively. Significant weight decrement was appeared at 70 mg/kg of bisphenol A, however, nonylphenol at concentrations tested did not severe adverse effect on the weight decrement. The environmental monitoring has been carrying out by NIER since 1999. Exposure levels of nonylphenol in soil were ND$\sim$10.55 $\mu$g/kg and those of bisphenol A were ND$\sim$15.50$\mu$g/kg in National Monitoring data which had been performed from 2000 to 2004. The measured soil exposure level was applied to evaluate the environmental risk assessment. The values of PNEC for bisphenol A and nonylphenol were determined as 0.5 mg/kg and 2.5 mg/kg, respectively using the safety factors which were suggested in EU and OECD. The values of HQ (PEC/PNEC) were determined to be below I for bisphenol A and nonylphenol when the maximum exposure levels for bispheol A (15.50$\mu$g/kg) and nonylphenol (10.55$\mu$g/kg) were applied. Conclusively, the environmental risk assessment of bisphenol A and nonylphenol was not critical in soil.

• 한국환경성돌연변이발암원학회지
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• 제19권2호
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• pp.95-101
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• 1999

Risk Assessment is an important area in toxicology and the methodology for risk assessment has been developed. Mathematical models used for risk assessment include one-hit multi-hit, two-stage, probit logistic, multistage, and linearized multistage models. For the assessment of exposure dose, environmental monitoring has been applied, but it has limitation to accurately assess exposure level because the levels in the air, water, foods, and soil may vary depending on time of sampling. In addition, humans can be exposed to various sources of exposure and thus it will be impossible to estimate the total level of exposure in humans by environmental monitoring. To eliminate the limitation of environmental monitoring, a direct measurement of toxic materials or modified biomolecules (called biomarkers) associated with the exposure of toxic materials is needed. Here, scientific basis of biomarkers and future direction have been considered for the assessment of carcinogen exposure and cancer risk in humans.

• 한국환경보건학회지
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• 제45권4호
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• pp.370-380
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• 2019

Objective: This study was performed to investigate the distribution of individual exposure characteristics according to an exposure assessment classification for humidifier disinfectant and to identify the factors that influence assessment classification. Methods: We examined the exposure characteristics of 4,482 subjects who applied for the 4-1 and 4-2 assessments of environmental exposure to humidifier disinfectant conducted by the Korea Environmental Industry & Technology Institute (KEITI). Environmental exposure assessment classification was assessed using the following seven criteria: 1) Distance from humidifier to face; 2) Spray direction; 3) Time used, daytime 4) Time used, during sleep; 5) Time used, cumulative; 6) Exposure intensity; and 7) Cumulative exposure level. Each criteria was then classified as 'high' or low'. When participants answered for more than four criteria, exposure assessment was determined as 'definite,' 'probable,' or 'possible' depending on the ratio of 'high' responses. If participants' responses were inconsistent, exposure assessment was listed as 'unlikely.' If participants answered for less than four criteria, exposure assessment was considered 'indeterminate.' Results: For the exposure assessment classes, definite was assigned to 38.5% (1,725 subjects), probable assigned to 32.9% (1,474 subjects), 25.0% (1,122 subjects) were assigned to as possible, unlikely assigned to 0.1% (3 subjects), and indeterminate assigned to 3.5% (158 subjects). Overall, participants who used 'Oxy Ssakssak New Gaseupgi Dangbun,' 'Aekyung Gaseupgi Mate,' 'Homeplus Gaseupgi Chungjungje,' and 'E-Mart Gaseupgi Salgyunje' totaled 2,996, 557, 176, and 162 subjects, respectively. There was a statistical difference in the type of humidifier disinfectant products between high-exposed and low-exposed participants. Based on the assessment criteria of humidifier disinfectant exposure, subjects were likely to be in the highly exposed classes (definite and probable) when the subjects were exposed 1) for more than ten hours per day and 2) for more than four hours at night 3) when the total cumulative exposure time was higher than the average, 4) when the direction of humidifier spray was toward the face, 5) when the respiratory position was less than 1 meter of distance from the humidifier, 6) when the concentration of indoor contaminants (ug/m3) was higher than the average exposure intensity, and 7) when overall exposure level ($ug/m3^*hr$) was higher than the average exposure level. Conclusion: This study suggests that each exposure assessment criteria was able to appropriately estimate cumulative exposure levels.

• 한국환경보건학회지
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• 제48권5호
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• pp.266-271
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• 2022

Background: The selection of distributions of input parameters is an important component in probabilistic exposure assessment. Goodness-of-fit (GOF) methods are used to determine the distribution of exposure factors. However, there are no clear guidelines for choosing an appropriate GOF method. Objectives: The outcomes of probabilistic consumer exposure assessment were compared by using five different GOF methods for the selection of input distributions: chi-squared test, Kolmogorov-Smirnov test (K-S), Anderson-Darling test (A-D), Akaike information criterion (AIC) and Bayesian information criterion (BIC). Methods: Individual exposures were estimated based on product usage factor combinations from 10,000 respondents. The distribution of individual exposure was considered as the true value of population exposures. Results: Among the five GOF methods, probabilistic exposure distributions using the A-D and K-S methods were similar to individual exposure estimations. Comparing the 95th percentiles of the probabilistic distributions and the individual estimations for 10 CPs, there were 0.73 to 1.92 times differences for the A-D method, and 0.73 to 1.60 times differences (excluding tire-shine spray) for the K-S method. Conclusions: There were significant differences in exposure assessment results among the selection of the GOF methods. Therefore, the GOF methods for probabilistic consumer exposure assessment should be carefully selected.

• Environmental Analysis Health and Toxicology
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• 제20권4호통권51호
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• pp.375-383
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• 2005

염화제일철은 2004년 OECD SIDS 프로그램으로 한국에서 위해성평가가 수행된 대량생산 화학물질로 1998년 화학물질 유통량조사에 의하면 우리나라에서 연간 100,000톤이 생산되었다. 본 연구에서는 염화제일철의 인체 및 환경적 영향에 대한 독성잠재성을 평가하기 위하여 OECD테스트가이드라인에 따라 독성시험을 수행하였다. 인체영향을 확인하기 위한 급성경구독성시험과 급성경피독성시험에서 랫드의 반수치사량은 각각 300$\sim$2,000 mg/kg b.w.과 >2,000mg/kg b.w.이었다. 반복독성시험의 무유해용량 (NOAEL)은 수컷 랫드는 125mg/kg b.w./day, 암컷 랫드는 250mg/kg b.w./day였고, 생식 및 발생독성시험에서 무유해용량은 암수 랫드 모두 500mg/kg b.w./day로 관찰되었다. 약한 피부자극성을 보였으며, 안부식성 물질임이 관찰되었다. S. typhimurium과 E. coli 균주를 이용한 복귀돌연변이시험에서 최고 농도인 5,000$\mu$g/plate에서 유전독성을 보이지 않았으며, 마우스를 이용한 생체내 (in vivo)소핵시험에서도 최고 농도인 50mg/kg bw/day에서 소핵유발빈도의 증가를 보이지 않아 본 시험물질은 돌연변이 유발 물질이 아닌 것으로 평가되었다. 어류(Oryzis latipes), 물벼룩 (Daphnia magna), 조류 (Pseudokirchneriella subcapitata)를 이용한 수생생물에 대한 급성독성시험 결과, 96시간 Oryzias latires의 반수치사농도는 46.6 mg/L이었고, 48시간 Daphnia magna의 반수영향농도는 19.0 mg/L이었다. 또한 Pseudokirchneriella subcapitata의 72시간 반수영향농도는 성장률을 이용한 계산법으로 6.9mg/L이었으며, 면적계산법으로는 3.8mg/L의 성장저해가 관찰되었다. 어류와 조류의 경우는 부분적으로 pH의 변화에 따른 영향으로 평가할 수 있는데 어류시험에서 pH중성시험용액에서는 100mg/L이상의 독성값을 나타내었고, 조류에서는 농도 12mg/L이상에서 pH 7아래로 떨어짐을 확인할 수 있었다. 염화제일철은 생산 및 사용공정에서 작업자에게 흡입 혹은 피부로 노출될 가능성이 있으나 밀폐공간에서 사용되므로 노출이 적은 것으로 평가되었다. 3종의 수생생물의 독성결과로부터 염화제일철은 수생환경에서 중간정도의 해가 있으며, 우리나라에서는 직접적인 염화제일철의 소비자 노출은 없으나 환경중 노출이 우려됨에 따라 제19차 OECD대량생산화학물질 초기위해성평가회의에서 환경 분야에 대해서는 추가연구 후보물질로 권고되었고, 인체 분야에서는 인체에 대한 유해성과 사용 패턴을 고려하여 추가연구 우선순위가 낮은 물질로 권고되었다.

• Molecular & Cellular Toxicology
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• 제3권3호
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• pp.185-189
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• 2007

Gene expression levels of choriogenin, vitellogenin and estrogen receptor were determined using Reverse transcription (RT)-PCR technique after exposure to estrogenic chemical bisphenol A in the Korean wild medaka (Oryzias sinensis). These genes have been known to be induced in male test fish when the fish are exposed to estrogenic chemicals. Therefore they can be suggested as a possible biomarker of endocrine disruption in fish, however, relatively little has been known about these genes expression by estrogenic chemicals in Korean wild fish. Mature male Oryzias sinensis were treated with bisphenol A at nominal concentrations of 0.02, 0.2 and 2 mg/L for 6 days and total RNA was extracted from the livers of treated fish for RT-PCR. When the five biomarker genes were amplified by RT-PCR in the same condition, mRNA induction level of each gene was elevated with different sensitivities. Conclusively, the results of this work indicated that measurement of vitellogenin and choriogenin using RT-PCR is effective as a simple tool for the screening of estrogenic chemicals and suggested that O. sinensis would be a suitable model fish for the environmental risk assessment of potential endocrine disruptors.

• 환경영향평가
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• 제14권5호
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• pp.347-353
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• 2005

The risk assessment is the qualitative or quantitative evaluation of the risk posed to human health and the environment by the actual or potential presence or release of hazardous substances, pollutants or contaminants. The environmental impact assessment (EIA) is assessed by the environmental criteria, and risk assessment is assessed by the risk rate. Risk rate based on dose-response values may not be easy to apply on regulatory basis like EIA for uncertainty. Internationally there is an example of OECD program. Risk assessment of High Production Volume (HPV) Chemicals has started since the OECD Program with the 1990 Council Act on the Co-operative Investigation and Risk Reduction of Existing Chemicals. These HPV chemicals include all chemicals produced or imported at levels greater than 1,000 tonnes per year in at least one Member country or in the European Union region. The SIDS called the Screening Information Data Set is regarded as the minimum information needed to assess an HPV chemical to determine whether any further work should be carried out or not. All the data elements of SIDS including assessment for environment and health are prepared as three formats of the full SIDS Dossier, the SIDS Initial Assessment Report (SIAR), and the SIDS Initial Assessment Profile (SIAP) of an HPV chemical. In 1998 the global chemical industry through the International Council of Chemical Associations (ICCA) has joined to work with OECD. The OECD has assessed approximately 1,000 chemicals from 1991 through 2004 with ICCA. Till the February of 2005, 592 chemicals of those chemicals completed SIDS reports. Member countries have been targeted the goal of 1,000 new chemicals from 2005 to 2010 and Korea shared 36 chemicals from the 1,000 new chemicals. Currently Korea has completed SIDS reports of 7 chemicals among sponsored 24 chemicals. In conclusion SIDS project will be linked to national program for outputs application with more reliable production. Both the OECD and industry will carry out their commitment to complete assessments for more and the remaining chemicals assessment. The major outputs will contribute to cope with international chemical management.

• 환경영향평가
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• 제14권4호
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• pp.195-202
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• 2005

The health risks from the magnetic fields exposure have been brought out difficulties in the construction of transformer substation. According to several epidemiologic studies and the relevant international organizations, magnetic fields should not exceed the exposure limits of 3mG for the people living near electric power lines. The rigid regulation of the exposure levels for the elementary school and residental areas has been established already in Switzerland and Italy. Since 1998, the environmental impact assessment system in Korea has been reviewed for power-frequency magnetic field by precautionary policies. In this study, the possible application of Prior Environmental Performance Review System for the transformer substation was reviewed from the points of the properties of the powerfrequency magnetic fields. The ranges and survey methods of the assessment for the transformer substation were proposed. The ranges of magnetic fields was between 300m to 500m for the 345kV transformer substation. It is necessary to develop further specific assessment methods for various high-voltage transformer substations.

• Toxicological Research
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• 제26권2호
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• pp.95-100
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• 2010

Nanoparticle exposure assessment presents a unique challenge in the field of occupational and environmental health. With the commercialization of nanotechnology, exposure usually starts from the workplace and then spreads to environment and consumer exposure. This report discusses the current trends of nanoparticle exposure assessment, including the definition of nanotechnology relevant terms, essential physicochemical properties for nanomaterial characterization, current international activities related nanomaterial safety, and exposure assessment standard development for nanotechnology. Further this report describes challenges of nanoparticle exposure assessment such as background measurement, metrics of nanoparticle exposure assessment and personal sampling.

• 한국환경보건학회지
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• 제50권1호
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• pp.43-53
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• 2024

Background: Exposure assessment is an important part of risk assessment for consumer products. Exposure models are used when estimating consumer exposures by considering exposure routes, subjects, and circumstances. These models differ based on their tiers, types, and target populations. Consequently, exposure estimates may vary between models. Objectives: This study aimed to compare the results of different exposure models using identical exposure factors. Methods: Chemical exposure from consumer products was calculated using four consumer exposure assessment models: Targeted Risk Assessment 3.1, Consumer Exposure Model 2.1 (CEM), ConsExpo web 1.1.1, and the Korean Exposure Algorithm (primary and detailed) issued by the Ministry of Environment, No. 972 (MOE). The same exposure factors were used in each model to calculate inhalation and dermal exposures to acetaldehyde, d-limonene, and naphthalene in all-purpose cleaners, leather coating sprays, and sealants. Results: In the results, TRA provided the highest estimate. Generally, MOE (detailed), CEM and ConsExpo showed lower exposures. The inhalation exposure for leather coating spray showed the largest differences between models, with differences reaching up to 1.2×10⁷ times. Since identical inputs were used for the calculations, it is likely that the models significantly influenced the estimated results. Conclusions: Despite using the same exposure factors to calculate dermal and inhalation exposures, the results varied substantially based on the model's exposure algorithm. Therefore, selecting an exposure model for assessing consumer products should be done with careful consideration.