• Clinical and Experimental Pediatrics
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• 제59권11호
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• pp.432-439
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• 2016

Asthma is recognized as a complex disease resulting from interactions between multiple genetic and environmental factors. Accumulating evidence suggests that respiratory viral infections in early life constitute a major environmental risk factor for the development of childhood asthma. Respiratory viral infections have also been recognized as the most common cause of asthma exacerbation. The advent of molecular diagnostics to detect respiratory viruses has provided new insights into the role of human rhinovirus (HRV) infections in the pathogenesis of asthma. However, it is still unclear whether HRV infections cause asthma or if wheezing with HRV infection is simply a predictor of childhood asthma. Recent clinical and experimental studies have identified plausible pathways by which HRV infection could cause asthma, particularly in a susceptible host, and exacerbate disease. Airway epithelial cells, the primary site of infection and replication of HRV, play a key role in these processes. Details regarding the role of genetic factors, including ORMDL3, are beginning to emerge. This review discusses recent clinical and experimental evidence for the role of HRV infection in the development and exacerbation of childhood asthma and the potential underlying mechanisms that have been proposed.

• 한국주거학회논문집
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• 제9권3호
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• pp.97-105
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• 1998

Recent mass construction of high-rise apartments across the country are questionable whether this housing type is appropriate for Korean families as one of housing alternatives. Therefore, cross-cultural analysis is needed for the evaluation of high-rise apartment living. The purpose of this study is to identify factors related to the evaluation of residential satisfaction, and to examine the differences of satisfaction between Korean and American high-rise resident groups on these factors and personal characteristics. The review of literature and factor analysis identified six important environmental factors. 413 subjects were selected from the major two resident groups in major U.S. cities, and Seoul, Korea. An examination by major factors indicated that five except for neighborhood environmental qualities were significant relationship. It was also found that personal characteristics of these two groups were significantly different. Multiple-regression analysis found that both physical quality of dwelling unit and management/maintenance were important predictors of residential satisfaction.

• 경영과학
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• 제16권2호
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• pp.149-169
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• 1999

The purpose of this study, based on a domestic sample of businesses using EDI systems, is to identify success factors, which affect the implementation of EDI system by Korean business entities. This paper also intends to provide useful guidelines for the establishment and management of EDI systems. This paper, first, develops a conceptual framework based on pervious research to identify factors which affect successful implementation of EDI system. Second, it integrates the constructs from previous research studies into a single survey instrument. Third, it presents the findings regarding the degree to which each factor influences the successful implementation of EDI system. It's revealed in the study that such factors as EDI vendor support, EDI education and training, participation by transactional partners, the size of organization, and the level of decentralization among organizational and environmental characteristics influence successful implementation of EDI systems in Korean business environment.

• Genomics & Informatics
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• 제17권3호
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• pp.24.1-24.8
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• 2019

Early environmental exposure is recognized as a key factor for long-term health based on the Developmental Origins of Health and Disease hypothesis. It considers that early-life nutrition is now being recognized as a major contributor that may permanently program change of organ structure and function toward the development of diseases, in which epigenetic mechanisms are involved. Recent researches indicate early-life environmental factors modulate the microbiome development and the microbiome might be mediate diet-epigenetic interaction. This review aims to define which nutrients involve microbiome development during the critical window of susceptibility to disease, and how microbiome modulation regulates epigenetic changes and influences human health and future prevention strategies.

• Mycobiology
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• 제39권4호
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• pp.249-256
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• 2011

Microorganisms are significantly affected when the ambient pH of their environment changes. They must therefore be able to sense and respond to these changes in order to survive. Previous investigators have studied various fungal species to define conserved pH-responsive signaling pathways. One of these pathways, known as the Pal/Rim pathway, is activated in response to alkaline pH signals, ultimately targeting the PacC/Rim101 transcription factor. Although the central signaling components are conserved among divergent filamentous and yeast-like fungi, there is some degree of signaling specificity between fungal species. This specificity exists primarily in the downstream transcriptional targets of this pathway, likely allowing differential adaptation to species-specific environmental niches. In this review, the role of the Pal/Rim pathway in fungal pH response is discussed. Also highlighted are functional differences present in this pathway among human fungal pathogens, differences that allow these specialized microorganisms to survive in the various micro-environments of the infected human host.

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
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• 제3권5호
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• pp.53-66
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• 1997

The purpose of this study is to provide the direction of facilities planning for the elderly regarding color planning and its general pattern. Color is an very important factor to provide the quality of living and induces an emotional response as environmental elements of facilities. At first, the general color theory was developed through the literature of review and it was applied to the facilities through the survey. Secondly, the collected data were analyzed and the results were derived.

• 한국지반환경공학회 논문집
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• 제20권1호
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• pp.13-17
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• 2019

This paper presents case history of railway embankment excess settlement on soft clay during service in southern region of Korea. A lot of field observations show that the measured settlements are a lot larger than settlements actually calculated in this area. Back analysis is carried out to verify the soil parameters which are intended to investigate in the subsurface exploration phase and later in a laboratory test program. Recommendations and causes for the engineering practice are suggested to review the determination of excess settlements and, consequently, to improve the settlement prediction. This enormous discrepancy is due to the passing over secondary consolidation, and the design filling did not meet to real construction filling. Immediate settlement could be subsidiary factor of excess settlement.

• 산학경영연구
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• 제20권1호
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• pp.33-53
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• 2007

환경문제가 세계 각국의 중요한 이슈가 되고 있으며, 이를 해결하기 위해서는 자원순환형 사회시스템이 구축되어야 하며, 물류분야에서도 그 중요성이 부각되고 있다. 간 연구의 목적은 순환형 사회시스템 구축요인인 근원적 감축, 재사용, 재활용과 기업의 물류운영 특성인 통합성, 혁신성, 대응성과의 관계 및 물류성과와의 관계, 이들 요소가 기업규모별로 물류성과에 미치는 효과와 그 영향요인을 분석하여 방향을 제시하고자 하는데 있다. 이 목적을 달성하기 위하여 제조기업을 대상으로 문헌연구와 실증연구를 병행하였다. 본 연구는 기존의 물류 연구들과 달리 순환형 사회시스템 구축요인과 물류운영특성이 물류성과에 미치는 영향을 분석하였다는 데 의의가 있다고 하겠다.

• 대한설비관리학회지
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• 제23권4호
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• pp.5-19
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• 2018

Recently, utilizing the supply chain among companies, major companies support their sub-vendors to establish an environmental management system and transfer the clean production technology(know-how) to them for strengthening of environmental competitiveness. Thus, Green Supply Chain Management(GSCM) became a key successful factor for companies to be environmentally sustainable. This research endeavors to identify the relationship among the inside and outside GSCM implementation activities of Korean manufacturing companies and their financial, operational and environmental performances. Based on a the review of previous research findings, twenty one hypotheses are developed and examined. Total 251 valid responses from 1,634 survey responses are identified and the structural equation models(SEM) are developed and analysed for examining our hypotheses. The result shows that inside GSCM has a positive effect on outside GSCM. Also, it reveals that companies' performances are more positively affected by inside GSCM than by outside GSCM.

• 한국산업보건학회지
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• 제31권3호
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• pp.266-273
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• 2021

Objective: The objective of this study was to suggest improvement methods for investigations and systems through a review of musculoskeletal risk factor investigation reports conducted in the workplace. Methods: A total of 34 reports on musculoskeletal risk factor investigations were reviewed. To confirm the appropriateness of the evaluation, reevaluation was conducted through a field investigation using other evaluation tools. In order to understand the effectiveness of the improvement plan, a survey was conducted with those in charge of tasks with ergonomic burdens. Results: As a result of performing a field survey using the work sampling method recommended by the KOSHA (Korea Occupational Safety and Health Agency) for ten tasks, eight tasks were determined to pose an ergonomic burden. When 30 tasks were evaluated with RULA (rapid entire body assessment), 90% of them were evaluated at a higher level than the results of the workplace survey. Among the improvement measures, only 36% of the field workers affirmed them, and in only 19% of the workplaces were actual improvements made. Conclusions: In order to improve the ergonomic investigation system for risk factors in the ergonomic burden task, it is necessary to secure the objectivity of the evaluation performed by the institution and enable the active participation of workers in improvement activities.