• 한국독성학회:학술대회논문집
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• 한국독성학회 2002년도 Current Trends in Toxicological Sciences
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• pp.94-94
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• 2002

Oxidative stress induced by reactive oxygen and/or nitrogen species has been considered as a major cause of cellular injuries in a variety of neurodegenerative disorders including Alzheimer's disease (AD). Inflammatory as well as oxidative tissue damage has been implicated in pathophysiology of AD, and non-steroidal anti-inflammatory drugs have been reported to have beneficial effects in the treatment or prevention of AD.(omitted)

• 한국독성학회:학술대회논문집
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• 한국독성학회 2003년도 춘계학술대회 논문집
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• pp.93-94
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• 2003

beta-Amyloid peptide is considered to be responsible for the formation of senile plagues that accumulate in the brains of patients with Alzheimers disease. There has been a paucity of evidence to support the involvement of reactive oxygen and/or nitrogen species (ROS and/or RNS) in beta-amyloid-induced neuronal cell death. (omitted)

• Toxicological Research
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• 제4권2호
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• pp.143-149
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• 1988

Cytolysin produced by Vibrio vulnificus ATCC 27562 was partially purified by sequential ammonium sulfate precipitation, gel filtration with Sephadex G-200, and ion exchange chromatography with DEAE-Sephadex. The partially purified cytolysin was inactivated by cholesterol. More than one molecule of the cytolysin was required to lyse a single erythrocyts. The antiserum against cytolysin enhanced the survival ratio of mice infected with low dose of V. vulnificus.

• 한국독성학회:학술대회논문집
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• 한국독성학회 2002년도 Molecular and Cellular Response to Toxic Substances
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• pp.142-142
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• 2002

Many studies have identified the phosphatidylinositol 3-kinase (PI3K) as a key regulator for various cellular functions including cell survival, growth and motility. We have previously shown that H-ras, but not N-ras, induces invasiveness and motility in human breast epithelial cells (MCF10A), while both H-ras and N-ras induce transformed phenotype.(omitted)

• 한국독성학회:학술대회논문집
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• 한국독성학회 2002년도 Molecular and Cellular Response to Toxic Substances
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• pp.188-189
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• 2002

This work aimed to identify neuronal cell toxicity induced by decrease of physiological NO production by differential phosphorylation of constitutive neuronal NO synthase (nNOS), which can be mediated by Ca2+-dependent PKC and/or CaM-KII activities activated by metals.(omitted)

• 환경영향평가
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• 제16권1호
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• pp.45-58
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• 2007

Despite the ubiquitous practice of environmental impact assessment around the world, social impact assessment has been alienated from assessment process from the beginning. Not until 1993 was 'Interorganizational Committee' established in the United States to prepare for 'Principles and Guidelines for Social Impact Assessment.' This study is an attempt to critically examine US 'Principles and Guidelines.' First, the study traces history of social impact assessment to reveal why the latter became "the orphan in the assessment process." Second, it critically reviews 'Principles and Guidelines' to find its merits and defects. For instance, a principle regarding environmental justice is perceived as necessary as society has become conscious of social justice and equity while putting too much emphasis on predictive traits of social impact assessments only fosters "checklist mentality." Third, the study reflects on 'Principles and Guidelines' in particular and social impact assessment in general in order to probe what is social impact assessment. To do so, it pays attention to scholars, who have criticized technocratic and procedural elements of 'Principles and Guidelines.' They show that social impact assessment is philosophically and methodologically teleological in that "fluid and contested meanings" between social impacts and the public are meaningful in itself. And simple procedural guarantee of the public involvement, they argue, is not enough to define social impacts. Lastly, from the critical analysis of 'Principles and Guideline,' the study looks for alternatives to improve how to assess social impacts in a Korean context.

• Journal of Forest and Environmental Science
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• 제25권3호
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• pp.157-165
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• 2009

Forests potentially contribute to global climate change through their influence on the global carbon (C) cycle. The Kyoto Protocol provides for the involvement of developing countries in an atmospheric greenhouse gas reduction regime under its Clean Development Mechanism (CDM). Carbon credits are gained from reforestation and afforestation activities in developing countries. Bangladesh, a densely populated tropical country in South Asia, has a huge degraded forestland, which can be reforested by CDM projects. To realize the potential of the forestry sector in developing countries like Bangladesh for full-scale emission mitigation, the carbon sequestration potential should be integrated with the carbon trading system under the CDM of the Kyoto Protocol. This paper discusses the prospects of carbon trading in Bangladesh, in relation to the CDM, in the context of global warming.

• Toxicological Research
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• 제24권2호
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• pp.129-135
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• 2008

The results of recent studies indicate that high levels of free fatty acids(FFAs) and adipokines may be the main causes of non-alcoholic liver disease; however, the molecular mechanism that links FFAs to lipotoxicity remains unclear. In the present study, we treated HepG2 cells with FFA(either palmitate or oleate) to investigate the mechanisms involved in lipotoxicity in the liver cells. We also treated cells with palmitate in the presence of a chemical chaperone, 4-phenylbutyric acid(PBA), to confirm the involvement of ER stress in lipotoxicity. Palmitate significantly induced cytotoxicity in dose- and time-dependent manners. Apoptosis was also significantly induced by palmitate as measured by caspase-3 activity and DAPI staining. Palmitate led to increased expressions of the spliced form of X-box-protein(Xbp)-1 mRNA and C/EBP homologous transcription factor(CHOP) protein, suggesting activation of the unfolded-protein response. PBA co-incubation significantly attenuated apoptosis induced by palmitate. The above data demonstrate that high levels of palmitate induce apoptosis via the mediation of ER stress in the liver cells and that chemical chaperones act to modulate ER stress and accompanying apoptosis.

• 한국생활과학회지
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• 제20권6호
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• pp.1153-1165
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• 2011

Decision making for gas boiler consumers depends on the characteristics of products such as the price and quality as well as the brand image. Although a gas boiler is a high involvement product in terms of price, in fact, it is a low involvement product which is greatly affected by installers. This study examined variables which affect the level of satisfaction and repurchase intention by surveying about 1,000 housewives through an on-line questionnaire. The results were as follows: first, gas boiler users' general knowledge of gas boilers showed a correct-answer rate of 54.5%. The average satisfaction score of product quality (mean=5.61 out of 7) was higher than that of the satisfactionscore of the company's service (mean=5.46). Second, the level of repurchase intention was above the mid-point (mean=4.72). Multivariate regression found that product satisfaction, service satisfaction, household size, and information sources explained repurchase intentions for gas boilers to be about 50.7%. Gas boiler marketers should pay attention to the survey result in that the level of repurchase intention depends mainly on both consumer satisfaction and information sources.

• Advances in environmental research
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• 제1권3호
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• pp.223-236
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• 2012

Biosorption of methylene blue (MB) from aqueous solution was studied with respect to the point of zero charge of coconut husk, dye concentration, particle size, pH, temperature, as well as adsorbent and NaCl concentration using coconut husk biomass. Amongst Langmuir and Freundlich adsorption isotherms studied, Langmuir adsorption isotherm showed better agreement. Pseudo second order kinetics model was found to be more suitable for data presentation as compared to pseudo first order kinetics model. Also, involvement of diffusion process was studied using intraparticle diffusion, external mass transfer and Boyd kinetic model. Involvement of intraparticle diffusion model was found to be more relevant (prominent) as compared to external mass transfer (in) for methylene blue biosorption by the coconut husk. Moreover, thermodynamic properties of MB biosorption by coconut husk were studied. Desorption of methylene blue from biomass was studied with different desorbing agents, and the highest desorption achieved was as low as 7.18% with acetone, which indicate stable immobilization. Under the experimental conditions MB sorption was not significantly affected by pH, temperature and adsorbent concentration but low sorption was observed at higher NaCl concentrations.