• 한방안이비인후피부과학회지
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• 제20권1호통권32호
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• pp.239-249
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• 2007

Background : Allergic rhinitis is the most frequently occuring immunological disorder. It affects men, women and children and represents significant cost in terms of suffering and loss of productivity. Objective & Methods : We referred to the information through Entrex Pubmed from 2004 to 2007 January about alternative medicine for allergic rhinitis, 9 treatises. Results : About 9 treatises, 2 treatises were for the acupuncture treatment, I treatise was for the acupuncture and chinese herbal medicine, 2 treatises were for the single substance(butterbur, soy sauce ingredients), 1 treatise was for the homeopathic preparation, 1 treatise was for the ayur-veda herbal treatment, 1 treatise was for the ultraviolet light phototherapy, 1 treatise was for the systematic review of alternative medicine. Except 2 treatises for the acupuncture treatment, 6 treatises used the double-blind, randomized, placebo-controlled methods. As a result, we found 5 treatises that treat group had more improvement than control group, 3 treatises that treat group had no difference control group on effect significantly. 1 review article exhibited the most of alternative medical literatures were inadequate methodologically and therapeutic efficacy alternative treatment for allergic rhinitis was not supported by currently available evidence. Conclusion : We found that treatises about the alternative medicine for allergic rhinitis were more and more published. We were supposed that many internal treatises were published adequately by methodology to prove Korean medical treatment effects for allergic rhinitis.

• Journal of Acupuncture Research
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• 제24권5호
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• pp.127-136
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• 2007

Objectives : To review the history, the theoretical basis and the technique of Intramuscular Stimulation (IMS), papers and books on IMS were searched. Methods : 15 papers were searched with the keyword 'Gunn CC' at Pubmed(http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed). Several full texts of them and other papers were found at the internet homepage of The Institute for the Study and Treatment of Pain (http://www.istop.org/). 16 Korean papers on IMS were searched at KoreaMed(http://www.koreamed.org/SearchBasic.php) and Koreanstudies Infomation Service System(http://kiss.kstudy.com/KsiKiss.asp). Results : Dr. Gunn has made unique model which can explain the pathology of chronic pain and the mechanism of acupuncture treatment. In this model, he postulated that most of chronic pain is radiculopathy due to spondylosis and acupuncture treatment to the hyperalgesic muscle can restore the normal function of involved muscles and nerves. Conclusions : IMS is an acupuncture technique in which the muscles under the Ah-shi or tender points in periphery and intrasegmental paravertebral muscles are stimulated with needles.

• 대한한의학회지
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• 제23권4호
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• pp.15-26
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• 2002

There is much confusion in the field of atopic dermatitis (AD) regarding how to best measuredisease severity objectively. Therefore, we aimed to establish a new adequate scoring system for AD, that should be based on comparisonand analysis of various scoring systems. We report as follows. Methods: We searched for data relating to severity scoring systems for atopic dermatitis in Entrez PubMed From 1990 to 2001 Results and Conclusions: 1. Properties of severity scoring systems were validity, reliability, sensitivity of change and ease of use. 2. The essential items of severity scoring systems were extent. intensity and subjective symptoms. 3. The surface extent of the lesion was evaluated by the percentage of involvement of each of 10 areas. 4. The criteria of severity were divided into intensity and subjective symptoms. Intensity items are erythema, papulation, lichenification, oozing, dryness, excoriations, and pigmentation. The subjective symptom is pruritus, evaluated according to sleep loss. 5. The significant items of severity scoring system were symptomsrather than areas. As it were, we assumed extent accounted for around 30% of each total score, with intensity and subjective symptoms representing 70%.

• 정보과학회 논문지
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• 제41권9호
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• pp.652-665
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• 2014

생물학 도메인은 약어 표현이 빈번하며, 실제로 문서에서 중요한 의미를 지니는 개체명들이 약어로 표현되는 경우가 많다. 본 연구에서는 토픽과 링크 정보를 이용하여 약어 중의성을 해결하고 동일한 의미를 가지는 다양한 형태의 약어 원형들(variant forms)에 대한 그룹핑을 시도한다. 이를 위하여 LDA(latent Dirichlet allocation) 기반 의미적 의존 링크 토픽 모델(semantic dependency topic model)을 제안한다. 해당 모델은 생성 모델(generative model)의 일종으로 문서 집합의 각 문서에 등장하는 단어들은 문서에서 발생하는 토픽 분포와 토픽 당 단어 분포에 의해 생성되어 있는 것으로 가정하고, 관측 가능한 문서 집합의 단어들로부터 문서에 내재된 숨어있는 토픽 구조를 추론하여 단어 생성과 토픽 파라미터를 연결시킨다. 본 연구에서는 토픽 정보 외에 단어들 사이에 존재하는 의미적 의존성(semantic dependency)을 링크로 정의하고, 단어 간에 존재하는 링크 정보, 특히 원형과 문장에서 공기하는 단어들 사이의 링크를 파라미터화하여 중의성 해결에 이용하였다. 결과적으로 주어진 문서에 등장하는 약어에 대해 가장 가능성 있는 원형은 해당 모델을 이용하여 추론된 단어-토픽, 문서-토픽, 단어-링크 확률에 의해서 결정된다. 제안하는 모델은 MEDLINE 초록으로부터 Entrez 인터페이스를 이용해 22개의 약어 집합과 186개의 가능한 약어 원형을 이용하여 질의를 생성하고, 이를 이용해 검색된 문서들을 대상으로 학습과 테스트에 이용하였다. 실험은, 주어진 문서에 등장하는 해당 약어에 대한 원형이 무엇인지 예측하는 방식으로 98.3%의 정확률의 높은 성능을 보였다.

• 대한한방부인과학회지
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• 제20권4호
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• pp.175-190
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• 2007

Purpose: Ovarian cysts are fluid-filled sacs or pockets within or on the surface of an ovary. Most cysts present little or no discomfort and are noncancerous and harmless. So non-surgical treatments with herbal medicine or acupuncture and moxa therapy are important and suitable in this pathology. But there are few RCT articles about ovarian cyst in Korean Medicine(KM) clinical and research field. Methods: To review treatment method and other research tendency about ovarian cyst in journals related with KM and Traditional Chinese Medicine(TCM) through web-searching. Searching was done through web site #http://omis.ksucc.ac.kr# and pub-med(http://www.ncbi.nlm.nih.gov/sites/entrez) with key words #ovarian cyst#, #TCM#, #herb#, #CAM#, and #acupuncture#. Results: Seven articles were searched in journals related with KM, then six of them were simple case report and the other one was about diagnosis for ovarian cyst and another gynecologic disease such as uterine myoma and infertility through the iris diagnosis. And two articles were searched in journals related with TCM, then one of them was simple case report but the other is RCT article. Conclusion: KM and TCM therapies have some beneficial effect to resolve cyst, but objective power as a evidence is weak in the viewpoint of EBM. So continuous clinical trials such as RCT and multi center trials are needed.

• 정보처리학회논문지D
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• 제11D권4호
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• pp.765-774
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• 2004

이질의 생물 정보원을 통합하기 위해서는 각 정보원의 이질적인 내용을 숨기고 하나의 관점으로 표현하는 뷰를 정의해야 한다. 본 논문은 생물 정보원 통합 미들웨어를 설계함에 있어서 XML 기반의 뷰 정의모델을 제시하고 그 동작 원리를 보인다. 제시된 모델은 통합시스템 구축을 위한 융통성을 증대시키고, 보다 추상화된 수준에서 통합 질의를 수행할 수 있도록 하기 위하여 사용자 정의 XML 뷰를 지원한다. 제시된 뷰 정의 모델을 기반으로 관계형 데이터베이스와 웹 자원에 대한 랩핑 모델을 제시하고, 아울러 응용 프로그램에 대해서도 같은 모델을 사용한 램핑 결과를 제시한다.

• 한방안이비인후피부과학회지
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• 제20권3호
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• pp.147-160
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• 2007

Background and Objective : The facial nerve grading system proposed by House and Brackmann is most widely accepted for the clinical assessment of facial nerve injury. Because of the limitations and subjectivity of the House-Brackmann scale, several new scales of varying degrees of objectivity and ease of use have been introduced. To assess methods of evaluating the function of the facial nerve that have been introduced over the past 20 years, We compared with the House-Brackmann scale. Method : We referred to the information through Entrez Pubmed and Korean studies information(KSI) from 1985 to 2006 about methods of evaluating facial nerve function. We choose 7 scales that focused on objective and easy of use. Result and conclusion : Sunnybrook scale is a weighted, subjective scale with incorporation of secondary defects into a single composite score. Sunnybrook scale can be recommended over House-Brackmann scale.

• Molecules and Cells
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• 제21권2호
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• pp.269-275
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• 2006

A recent report of the Korean Intellectual Property Office(KIPO) showed that the number of biological sequence-based patents is rapidly increasing in Korea. We present biological features of Korean patented sequences though bioinformatic analysis. The analysis is divided into two steps. The first is an annotation step in which the patented sequences were annotated with the Reference Sequence (RefSeq) database. The second is an association step in which the patented sequences were linked to genes, diseases, pathway, and biological functions. We used Entrez Gene, Online Mendelian Inheritance in Man (OMIM), Kyoto Encyclopedia of Genes and Genomes (KEGG), and Gene Ontology (GO) databases. Through the association analysis, we found that nearly 2.6% of human genes were associated with Korean patenting, compared to 20% of human genes in the U.S. patent. The association between the biological functions and the patented sequences indicated that genes whose products act as hormones on defense responses in the extra-cellular environments were the most highly targeted for patenting. The analysis data are available at http://www.patome.net

• 대한한방소아과학회지
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• 제20권1호
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• pp.1-14
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• 2006

Objective : As prevalence of atopic dermatitis(AD) rises and medicine of atopic dematitis develops, the methods of measurement for atopic dermatitis have developed. Therefore, we aimed to establish a new sconring system in oriental medicine for a childhood atopic dematitis, by comparison, analysis of various sconing systems. Method : We searched for the data related to severity sconing systems of atopic dermatitis in Entrez PubMed on abroad thesis and KISS(Korenstdued Information Service System) on domestic thesis from 1990 to 2005. Result : Severity sconing systems for atopic dermatitis satisfy validity, reliability, sensitivity of change and verification of this. The essential items of severity sconing systems are extent, intensity and subjective symptoms. The lesion is divided into 9 areas(head and neck, upper limbs, elbow, hands, trunk, hip and inguinal, lower limbs, knee, feet). The items of intensity are erythema, oedema and induration and papulation, oozing and weeping and erosion, excorition, scaling, lichenification. The subjective symptom is pruritis, evaluated according to sleep loss and obstruction of play and study. The extent and intensity is evaluated in combination. We suggested that extent and intensity occupied for 70% and subject symptoms accounted for 30% of total score.

• 동의생리병리학회지
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• 제20권1호
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• pp.235-244
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• 2006

There is much confusion in the field of Rhinitis regarding how to best measure disease severity objectively, Therefore, we aimed to establish a new adequate scoring system for Rhinitis, that should be based on comparison analysis of various scoring systems. We report as follows. We researched for data relating to severity scoring systems for rhinitis in Entrez PubMed from 1995 to 2005 and in Kiss Kstudy. Results and Conclusions: Properties of severity scoring systems were validity, sensitivity of change and ease of use. The essential items of severity scoring systems were subjective symptoms. The criterion of severity were divided into subjective symptoms and complication and Quality of Life. Intensity items are nasal obstruction, rhinorrhea, sneezing, itching, Postnasal drip, nasal mucosa swelling, nasal mucosa color, complication. Subjective symptoms is difficulty of Life. The significant items of severity scoring system are nasal symptoms. The whole score does with the maximum 30 scores. As it were, we assumed nasal symptoms accounted for around 80% of each total score, with complication and difficulty of Life representing 20%.