• The Journal of the Acoustical Society of Korea
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• v.34 no.1
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• pp.36-45
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• 2015

Recently, a lot of studies have been made about the methods used to generate turbulent velocity fields stochastically in order to effectively predict broadband flow noise. Among them, the FRPM (Fast Random Particle Mesh) method which generates turbulence with specific statistical properties using turbulence kinetic energy and dissipation obtained from the steady solution of the RANS (Reynolds Averaged Navier-Stokes) equations has been successfully applied. However, the FRPM method cannot be applied to the flow noise problems involving intrinsic unsteady characteristics such as centrifugal fan. In this paper, to effectively predict the broadband noise generated by centrifugal fan, U-FRPM (unsteady FRPM) method is developed by extending the FRPM method to be combined with the unsteady numerical solutions of the unsteady RANS equations to generate the turbulence considered as broadband noise sources. Firstly, an unsteady flow field is obtained from the unsteady RANS equations through CFD (Computational Fluid Dynamics). Then, noise sources are generated using the U-FRPM method combined with acoustic analogy. Finally, the linear propagation model which is realized through BEM (Boundary Element Method) is combined with the generated sources to predict broadband noise at the listeners' position. The proposed technique is validated to compare its prediction result with the measured data.

• Journal of Ginseng Research
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• v.44 no.2
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• pp.258-266
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• 2020

Background: Oxidative stress-induced cardiomyocytes apoptosis is a key pathological process in ischemic heart disease. Glutathione reductase (GR) reduces glutathione disulfide to glutathione (GSH) to alleviate oxidative stress. Ginsenoside Rb1 (GRb1) prevents the apoptosis of cardiomyocytes; however, the role of GR in this process is unclear. Therefore, the effects of GRb1 on GR were investigated in this study. Methods: The antiapoptotic effects of GRb1 were evaluated in H9C2 cells by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, annexin V/propidium iodide staining, and Western blotting. The antioxidative effects were measured by a reactive oxygen species assay, and GSH levels and GR activity were examined in the presence and absence of the GR inhibitor 1,3-bis-(2-chloroethyl)-1-nitrosourea. Molecular docking and molecular dynamics simulations were used to investigate the binding of GRb1 to GR. The direct influence of GRb1 on GR was confirmed by recombinant human GR protein. Results: GRb1 pretreatment caused dose-dependent inhibition of tert-butyl hydroperoxide-induced cell apoptosis, at a level comparable to that of the positive control N-acetyl-L-cysteine. The binding energy between GRb1 and GR was positive (-6.426 kcal/mol), and the binding was stable. GRb1 significantl reduced reactive oxygen species production and increased GSH level and GR activity without altering GR protein expression in H9C2 cells. Moreover, GRb1 enhanced the recombinant human GR protein activity in vitro, with a half-maximal effective concentration of ≈2.317 μM. Conversely, 1,3-bis-(2-chloroethyl)-1-nitrosourea co-treatment significantly abolished the GRb1's apoptotic and antioxidative effects of GRb1 in H9C2 cells. Conclusion: GRb1 is a potential natural GR agonist that protects against oxidative stress-induced apoptosis of H9C2 cells.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.22 no.6
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• pp.353-360
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• 2010

The Kyunggi Bay in mid-west of Korea is a relatively large estuarine system that connects the Han River system with Yellow Sea. Due to macro-tidal range of more than 8 m, the urban estuary shows deep tidal channels and wide tidal flats. Since last 30 years, the coastal development is undergoing, yielding noticeable change in environment. Particularly the tidal flat dynamics are generally accepted as being related with tidal residual flows in this area (Kim et al., 2009). We have estimated the annual variation and vertical structure of residual currents with one-year long observed flows in two major tidal channels of Kyunggi Bay. The moving average method and tidal current harmonic analysis yield nearly the same results on residual flow. The residual flow in Jangbong channel ranges from 20 cm/s in summer to 30 cm/s in winter. It is noticeable that the residual flow in Jangbong channel is flood dominant throughout the year, while the flow in Seokmo channel is ebb-dominant residual flow with current speed range of 20-40 cm/s. Due to the baroclinic response of relatively shallow estuary, significant reduction of energy in bottom layers have been observed, indicating the importance of residual circulation to the tidal flat behavior.

• The Korean Journal of Physiology and Pharmacology
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• v.16 no.6
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• pp.413-422
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• 2012

The purpose of this study is to investigated the mechanism of pharmacological action of local anesthetic and provide the basic information about the development of new effective local anesthetics. Fluorescent probe techniques were used to evaluate the effect of lidocaine HCl on the physical properties (transbilayer asymmetric lateral and rotational mobility, annular lipid fluidity and protein distribution) of synaptosomal plasma membrane vesicles (SPMV) isolated from bovine cerebral cortex, and liposomes of total lipids (SPMVTL) and phospholipids (SPMVPL) extracted from the SPMV. An experimental procedure was used based on selective quenching of 1,3-di(1-pyrenyl)propane (Py-3-Py) and 1,6-diphenyl-1,3,5-hexatriene (DPH) by trinitrophenyl groups, and radiationless energy transfer from the tryptophans of membrane proteins to Py-3-Py. Lidocaine HCl increased the bulk lateral and rotational mobility of neuronal and model membrane lipid bilayes, and had a greater fluidizing effect on the inner monolayer than the outer monolayer. Lidocaine HCl increased annular lipid fluidity in SPMV lipid bilayers. It also caused membrane proteins to cluster. The most important finding of this study is that there is far greater increase in annular lipid fluidity than that in lateral and rotational mobilities by lidocaine HCl. Lidocaine HCl alters the stereo or dynamics of the proteins in the lipid bilayers by combining with lipids, especially with the annular lipids. In conclusion, the present data suggest that lidocaine, in addition to its direct interaction with proteins, concurrently interacts with membrane lipids, fluidizing the membrane, and thus inducing conformational changes of proteins known to be intimately associated with membrane lipid.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.5
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• pp.26-35
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• 2016

As a potential clean energy resource, the production and consumption of hydrogen gas are expected to gradually increase, so that hydrogen related studies are also increasing. The thermal and chemical properties of hydrogen result in its high flammability; in particular, there is a high risk if leaks occur within an enclosed space. In this study, we applied the computational fluid dynamics method to conduct a numerical study on the leakage behavior of hydrogen gas and compared these numerical study results with an experimental study. The leakage hole diameter was selected as an important parameter and the hydrogen gas dispersion behavior in an enclosed space was investigated through various analytical methods. Moreover, the flammable regions were investigated as a function of the leakage time and leakage hole size. We found that the growth rate of the flammable region increases rapidly with increasing leakage hole size. We also investigated the relation between the mass flow rate and the critical time when the hydrogen gas reaches the ceiling. The analysis of the monitoring points showed that the hydrogen gas dispersion behavior is isotropic and independent of the geometry. We found that the concentration of gas in an enclosed space is affected by both the leakage flow rate and amount of gas accumulated in the enclosure.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.9
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• pp.126-132
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• 2016

This study numerically investigates the characteristics of chemical reactions and thermal deformation in a steam reformer. These phenomena are significantly affected by the high-temperature burner gas and the process gas conditions. Because the high temperature of the burner gas ranges from 800 to 1000 K, the reformer tubes undergo substantial thermal deformation, eventually resulting in structural failure. Thus, it is necessary to understand the characteristics of the reaction and thermal deformation under the operating conditions to evaluate the reformer tubes for sustainable, stable operation. Extensive numerical simulations were carried out using commercial CFD code (ANSYS FLUENT/MECHANICA Ver. 13.0) while considering three-dimensional turbulent flows and combined heat transfer including conduction, convection, and radiation. Structural analysis considering conjugated heat transfer between solid tubes and fluid flows was conducted using the Fluid-Solid Interaction (FSI) method. The results show that when the injection temperature of the process gas and burner gas decreased, the hydrogen production rate decreased significantly, and thermal deformation decreased by at least 15 to 20%.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.10
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• pp.229-235
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• 2019

A floating photovoltaic generation system is a new concept that combines existing photovoltaic generation technology with floating technology. This is installed in the water not on conventional land and a building. The system is designed as a unit module type that can be connected to other modules according to the power generation capacity, thereby forming a large-scale power generation facility. As a renewable energy source, it is composed of a floating structure, mooring device, photovoltaic power generation facility, and underwater cable. Because this system is installed outdoors, the effect of the wind load on the structure is very large. In this study, the wind loads most affected on the floating photovoltaic generation structure were obtained by computational fluid dynamic analysis. The flow characteristics and wind loads were analyzed for a range of wind orientations and angles of inclination. The analysis showed the position and magnitude of the maximum wind load to the wind direction and the flow characteristics around the solar panel and floating system. The wind load increased with increasing angle of inclination of the panel to the ground.

• Ecology and Resilient Infrastructure
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• v.6 no.2
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• pp.109-119
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• 2019

Eutrophication has occurred due to the inflow of various water pollutants in many Korean reservoirs with low depth, and algal blooms of surface layer and low oxygenation of deep layer have repeated every year. There are several existing technologies to alleviate the stratification of reservoirs, but it is difficult to apply them in field sites due to the necessity of electric power and low economic efficiency. In this study, a non-powered water circulation system using natural energy of wind and water flow has been developed, and two test-beds constructed in the reservoirs with different conditions and examined its field applicability. Through computational fluid dynamics (CFD) simulation, it has been shown that the water circulation system could induce the downward flow to mitigate the stratification between surface and deep layers, and its influence radius could reach about 30 m. As a result of long-term monitoring of the test-beds, various water quality improvement effects have been observed such as moderation of DO fluctuation by water circulation, reduction of DO supersaturation and prevention of excessive pH rising. In order to improve the applicability of the water circulation system, it is considered necessary to review countermeasures against flood and depth conditions of each reservoir.

• Membrane and Water Treatment
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• v.10 no.3
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• pp.207-212
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• 2019

Non-aqueous solvents (NASs) are generally known to be barely miscible, and reactive with polar compounds, such as water. However, water can interact with some NASs, which can be used as a new means for water recovery from saline water. This study explored the fate of water and salt in NAS, when saline water is mixed with NAS. Three amine solvents were selected as NAS. They had the same molecular formula, but were differentiated by their molecular structures, as follows: 1) NAS 'A' having the hydrophilic group ($NH_2$) at the end of the straight carbon chain, 2) NAS 'B' with symmetrical structure and having the hydrophilic group (NH) at the middle of the straight carbon chain, 3) NAS 'C' having the hydrophilic group ($NH_2$) at the end of the straight carbon chain but possessing a hydrophobic ethyl branch in the middle of the structure. In batch experiments, 0.5 M NaCl water was blended with NASs, and then water and salt content in the NAS were individually measured. Water absorption efficiencies by NAS 'B' and 'C' were 3.8 and 10.7%, respectively. However, salt rejection efficiency was 98.9% and 58.2%, respectively. NAS 'A' exhibited a higher water absorption efficiency of 35.6%, despite a worse salt rejection efficiency of 24.7%. Molecular dynamic (MD) simulation showed the different interactions of water and salts with each NAS. NAS 'A' formed lattice structured clusters, with the hydrophilic group located outside, and captured a large numbers of water molecules, together with salt ions, inside the cluster pockets. NAS 'B' formed a planar-shaped cluster, where only some water molecules, but no salt ions, migrated to the NAS cluster. NAS 'C', with an ethyl group branch, formed a cluster shaped similarly to that of 'B'; however, the boundary surface of the cluster looked higher than that of 'C', due to the branch structure in solvent. The MD simulation was helpful for understanding the experimental results for water absorption and salt rejection, by demonstrating the various interactions between water molecules and the salts, with the different NAS types.

• Journal of Korea Water Resources Association
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• v.54 no.9
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• pp.681-692
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• 2021

Vegetation processes have a significant impact on rainfall runoff processes through evapotranspiration control, but are rarely considered in the conceptual lumped hydrological model. This study evaluated the model performance of the Hapcheon Dam watershed by integrating the ecological module expressing the leaf area index data sensed remotely from the satellite into the hydrological partition module. The proposed eco-hydrological model has three main features to better represent the eco-hydrological process in humid regions. 1) The growth rate of vegetation is constrained by water shortage stress in the watershed. 2) The maximum growth of vegetation is limited by the energy of the watershed climate. 3) The interaction of vegetation and aquifers is reflected. The proposed model simultaneously simulates hydrologic components and vegetation dynamics of watershed scale. The following findings were found from the validation results using the model parameters estimated by the SCEM algorithm. 1) Estimating the parameters of the eco-hydrological model using the leaf area index and streamflow data can predict the streamflow with similar accuracy and robustness to the hydrological model without the ecological module. 2) Using the remotely sensed leaf area index without filtering as input data is not helpful in estimating streamflow. 3) The integrated eco-hydrological model can provide an excellent estimate of the seasonal variability of the leaf area index.