• Korean Circulation Journal
• /
• 제54권9호
• /
• pp.565-576
• /
• 2024

Background and Objectives: The K-ELUVIA study aimed to investigate the clinical effectiveness and safety of Eluvia^TM, a polymer-coated, paclitaxel-eluting stent, for femoropopliteal artery disease using data from a prospective Korean multicenter registry. Methods: A total of 105 patients with femoropopliteal artery disease who received endovascular treatment (EVT) with Eluvia^TM stents at 7 Korean sites were enrolled in a prospective cohort and followed for 2 years. The primary endpoint was the 2-year clinical patency. The secondary endpoint was 2-year freedom from clinically driven target lesion revascularization (TLR). Results: Mean patient age was 68.2±10.4 years, and most patients (82.7%) were male. Mean lesion length was 168.3±117.6 mm. Chronic total occlusion was found in 57.7% of patients. Trans-Atlantic Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II) type C or D lesions were present in 46.1% of patients. Procedural success was achieved in 99.0% of patients. The clinical patency rate was 84.4% at 1 year after EVT and 76.3% at 2 years post-EVT. The freedom from TLR rate was 89.1% at 1 year after EVT and 79.1% at 2 years post-EVT. Chronic total occlusion (hazard ratio [HR], 3.53; 95% confidence interval [CI], 1.08-11.67; p=0.039) and smaller mean stent diameter (HR, 0.40; 95% CI, 0.16-0.98; p=0.044) were identified as independent predictors of loss of clinical patency at 2 years. Conclusions: The K-ELUVIA study demonstrated favorable 2-year clinical effectiveness and safety outcomes of Eluvia stent for femoropopliteal artery lesions in real-world practice.

• Journal of Chest Surgery
• /
• 제42권5호
• /
• pp.677-683
• /
• 2009

메이-터너 증후군은 좌측 장골정맥이 우측 총장골동맥에 눌러져 발생하는 장골-대퇴정맥의 심부정맥 혈전증이다. 비록 카테터를 이용한 혈전제거 술과 혈전용해 및 스텐트 삽입술이, 기술적 수월함과 낮은 재발율로 인해 급성기 혹은 아급성기의 메이-터너 증후군 환자들에게 보편적인 치료법으로 인식되고 있지만 일부 환자에서는 치명적인 합병증을 일으킬 수 있다. 더군다나 만성 메이-터너 증후군 환자에서의 궁극적인 적절한 치료법은 아직 정립되어 있지 않다. 저자들은 2예의 만성 메이-터너 증후군 환자에서 혈관 내 치료법 실패 후 수술적 혈전제거 술과 스텐트 삽관술, 동정맥루 조성술을 적용하였다. 이러한 수술적 치료법은 일부 혈관 내 치료가 적응증이 될 수 없는 환자에게 유의한 치료법으로 이용될 수 있을 것이다.

• Journal of Korean Neurosurgical Society
• /
• 제66권6호
• /
• pp.735-742
• /
• 2023

Nephrotic syndrome (NS) is associated with cerebral venous sinus thrombosis (CVST), which is a rare cerebrovascular disorder in children. Systemic anticoagulation with heparin is the standard therapy for CVST, and mechanical thrombectomy (MT) has been described as a salvage treatment for adult anticoagulant refractory CVST, However, it has never been reported in children. We describe a case of MT for refractory CVST in a child with NS. A 13-year-old boy with newly diagnosed NS presented to an emergency department with acute headache. A head computed tomography showed acute thrombus in the superior sagittal sinus, straight sinus and transverse sinus. The child was started on heparin therapy, but clinically deteriorated and became unresponsive. In view of the rapid deterioration of the condition after anticoagulation treatment, the patient received intravascular treatment. Several endovascular technologies, such as stent retriever and large bore suction catheter have been adopted. After endovascular treatment, the patient's neurological condition was improved within 24 hours, and magnetic resonance venography of the head demonstrated that the CVST was reduced. The child recovered with normal neurological function at discharge. This case highlights the importance of considering MT for refractory CVST, and we suggest that MT may be considered for refractory CVST with NS in children.

• 대한영상의학회지
• /
• 제82권3호
• /
• pp.527-540
• /
• 2021

대퇴슬와동맥의 말초동맥폐쇄질환은 일반적으로 죽상경화증에 의해 발생하며, 질병의 정도에 따라 간헐적 파행에서부터 심각한 사지 허혈 또는 조직 손상에 이르는 다양한 증상으로 나타날 수 있다. 따라서, 증상을 개선하고 사지를 형태적, 기능적으로 보존하기 위해서는 적절한 치료가 필요하다. 대퇴슬와동맥 질환에서 시행되는 대표적인 인터벤션 치료로는 혈관 성형술, 스텐트 삽입술, 죽종절제술 등이 있다. 수년에 걸쳐, 혈관 내 재개통술은 최소 침습적이라는 이점과 더불어 시술 방법 및 사용 기기의 지속적인 발전을 토대로 말초동맥폐쇄질환의 치료에 널리 시행되고 있다. 이번 종설에서는 대퇴슬와동맥 질환의 다양한 혈관 내 치료 방법에 대해 소개하고, 문헌 고찰을 통해 현재까지 나온 임상 연구의 결과들을 논의하며, 대퇴슬와동맥질환의 치료에 적용되는 시술 방법에 대한 영상을 제시하여 독자의 이해를 돕고자 한다.

• Journal of Cerebrovascular and Endovascular Neurosurgery
• /
• 제25권2호
• /
• pp.160-174
• /
• 2023

Objective: Carotid artery stenting (CAS) is currently widely used for the treatment of carotid artery stenosis. The objective of this study was to analyze the outcomes of CAS performed in a single institution. Methods: We retrospectively analyzed 313 CAS cases from January 2007 to December 2020, including 206 (66%) symptomatic and 107 (34%) asymptomatic cases. Procedure-related morbidity and mortality were assessed. Rates of periprocedural (≤30 days after CAS) and postprocedural ipsilateral strokes (>30 days after CAS) were also assessed. Logistic regression analysis was used to identify risk factors for the periprocedural complication, in-stent restenosis (ISR), and ipsilateral stroke. Results: The success rate of CAS was 98%. Among 313 cases, 1 patient died due to hyperperfusion-related intracerebral hemorrhage (ICH). The CAS-related mortality rate was 0.31%. The overall incidence of periprocedural complications is 5.1%. A risk factor for periprocedural complication was a symptomatic carotid artery stenosis (7.3% vs. 0.9%, p=0.016). Twenty cases of ISR occurred during 63.7±42.1 months of follow-up. The overall incidence of ISR was 10.2% (20/196). A risk factors for ISR were diabetes mellitus (17.6% vs. 5.7%, p=0.008) and patients who used Open-cell stents (19.6% vs. 6.9%, p=0.010). The overall incidence of ipsilateral stroke is 5.6%. A risk factors for ipsilateral stroke was ISR (95% CI, p=0.002). Conclusions: CAS is a safe and effective procedure for carotid artery stenosis. Although the incidence of complications is low, fatal complication such as hyperperfusion-related ICH can occur. To prevent hyperperfusion-related ICH, several methods such as strict blood pressure (BP) control, intentional less widening of stenotic segment should be used. To prevent ISR or stroke occurrence, special attention should be paid to patients who have ISR or ipsilateral stroke risk factors.

• Journal of Chest Surgery
• /
• 제43권6호
• /
• pp.774-777
• /
• 2010

확장성 심근증이 있던 70세 남자 환자가 좌측 신장결석으로 입원하여 검사 중 신상부 복부대동맥류가 발견되었다. 환자의 상태가 좋지 않아 혈관 내 스텐트를 이용한 하이브리드 수술을 시행하였다. 수술은 비뇨기과에서 좌측 신장결석을 제거 후에 복부대동맥의 내장동맥과 양측 신동맥등 복부대동맥의 가지혈관의 근위부를 결찰하고 이어 좌측 외장골동맥 근위부로부터 2개의 Y-그라프트를 이용하여 역행성 우회수술로 가지혈관들의 재관류를 하고는 복부대동맥에는 스텐트 그라프트를 설치하였다. 이에 저자들은 신상부 복부대동맥류 환자의 하이브리드 술식을 치험하였기에 보고하는 바이다.

• Journal of Korean Neurosurgical Society
• /
• 제61권2호
• /
• pp.201-211
• /
• 2018

Objective : The purpose of this study was to analyze the variability of clopidogrel responses according to duration of a clopidogrel drug regimen after stent-assisted coil embolization (SAC), and to determine the correlation between the variability of clopidogrel responses and thromboembolic or hemorrhagic complications. Methods : A total of 47 patients who underwent SAC procedures to treat unruptured intracranial aneurysms were enrolled in the study. Preoperatively, patients received more than seven days of aspirin (100 mg) and clopidogrel (75 mg), daily. P2Y12 reaction unit (PRU) was checked with the VerifyNow test one day before the procedure (pre-PRU) and one month after the procedure (post-PRU). PRU variability was calculated as the difference between the initial response and the follow-up response. Patients were sorted into two groups based on their response to treatment : responsive and hypo-responsive. Results : PRU variability was significantly greater in the hypo-responsive group when compared to the responsive group (p=0.019). Pre-PRU and serum platelets counts were significantly correlated with PRU variation (p=0.005 and p=0.004, respectively). Although thromboembolic complication had no significant correlated factors, hemorrhagic complication was correlated with pre-PRU (p=0.033). Conclusion : In conclusion, variability of clopidogrel responses during clopidogrel medication was correlated to serum platelet counts and the initial clopidogrel response. Thromboembolic and hemorrhagic complications did not show correlation with the variability of clopidogrel response, or the clopidogrel response after one month of medication; however, hemorrhagic complication was associated with initial clopidogrel response. Therefore, it is recommended to test patients for an initial clopidogrel response only, as further tests would be insignificant.

• Journal of Chest Surgery
• /
• 제43권5호
• /
• pp.546-549
• /
• 2010

70세 남자 환자가 심한 복부 및 배부 통증으로 흉부 대동맥류 파열 의심 하에 전원되었다. 환자는 6개월 전 타 병원에서 하행대동맥류 의심 하에 대동맥 스텐트를 삽입하였던 병력이 있었으나 전산화 단층촬영 소견은 후종격동 악성 종양을 시사하였다. 개흉 후 이와 같은 진단이 확인되었으며 종격동의 육종은 거기에 둘러싸인 대동맥과 함께 성공적으로 절제되었다. 본 증례는 최근 주목을 받고 있는 대동맥 스텐트 그라프트 삽입에 대한 맹목적인 선호에 대하여 주의를 환기시키는 교훈적인 경우라고 판단된다.

• Journal of Chest Surgery
• /
• 제44권2호
• /
• pp.148-153
• /
• 2011

Background: The number of cases employing thoracic endovascular aortic repair (TEVAR) has been increasing due to lower morbidity and mortality compared to open repair technique. The aim of this study is to evaluate the outcome of TEVAR for thoracic aortic diseases. Materials and Methods: Sixteen patients underwent TEVAR from October 2003 to April 2010. Mean age at operation was 59 years (20~78 years), and 11 were male. Indications for TEVAR were large aortic diameter (>5.5 cm) upon presentation in 6 patients, increasing aortic diameter during the follow-up period in 4, traumatic aortic rupture in 3, persistent chest pain in 2, and ruptured aortic aneurysm in one. The mean diameter, length and the number of the stents were 33 mm (26~40 mm), 12 cm (9.5~16.0 cm), and 1.25 (1~2), respectively. Aortography employing Multi-detector computerized tomography (MDCT) technique was performed at one week, and patients were followed up in the out-patient department at one month, 6 months, and one year postoperatively. Results: Primary technical success showing complete exclusion of the aneurysm was achieved in 15 patients. One patient showed a small endo-leak (type 1). Four patients developed perioperative stroke: Three recovered without sequelae, and one showed mild right-side weakness. There was no operative mortality. Diameter of the thoracic aorta covered by stent graft changed within 10% range in 12 patients, decreased by more than 10% in 3, and increased by more than 10% in one during mean follow-up duration of 18 months (1~73 months). There was no recurrence-related death during this period. Conclusion: Intermediate-term outcome after TEVAR was encouraging. Indications for TEVAR could be extended for other thoracic aortic diseases.

• 대한의용생체공학회:의공학회지
• /
• 제22권6호
• /
• pp.535-542
• /
• 2001

스텐트를 이용한 동맥류 색전술은 방추형 동맥류 등 목이 넓은 광경동맥류의 치료에 최근 사용되고 있다. 동맥류 내부의 혈류유동은 혈전의 형성 및 동맥류 폐색에 중요한 역할을 하므로 스텐트의 삽입으로 인한 동맥류 내부 혈류 유동의 변화를 고찰하기 위하여 광색성 염료를 이용한 유동가시화 방법을 사용하였다. 제작된 방추형 동맥류 모델에 대해 맥동 유동시 동맥류 벽 다섯 위치에서 유동장의 정성적 관탈 및 벽 전단변형률의 측정이 수행되었다. 스텐트의 삽입은 동맥류 내부의 유동을 감소시켰으며 동맥류 내부의 느린 와류유동이 감속후기가지 지속되었다. 또한 스텐트가 삽입된 모델은 스텐트가 없는 모델에 비하여 벽 전단변형률이 감소하였으며. OSI는 증가하였다 이러한 혈류유동의 변화는 혈전의 형성 및 내막거식증대가 일어나기 쉬운 혈류역학적 환경을 제공한다. 따라서 스텐트의 삽입으로 인한 동맥류 내부의 혈류 유동은 혈전의 형성 및 동맥류 폐색을 촉진하도록 변화함을 알 수 있었다..