• Title/Summary/Keyword: Endocrinology

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Expression of Oct-4 in the Pregnancy of Korean Native Cattle

  • H. J. Chung;Kim, B. K.;Park, J. H.;J. H Woo;Park, M. Y.;H. H. Seong;W. K. Chang
    • Proceedings of the KSAR Conference
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    • 2003.06a
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    • pp.51-51
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    • 2003

  • Oct-4 is a maternally expressed octamer-binding protein encoded by the murine Oct-4 gene. It is present in unfertilized oocytes, but also in the inner cell mass and in primordial germ cells. In addition, Oct-4 is the first transcrition factor described that is specific for the blastocysts stage bovine embryos. The spatial and temporal expression patterns were further determined using Immunohistochemistry. With this technique Oct-4 protein expression is detected in the oocyte, in the blastocyst. After pregnancy Oct-4 expression is restricted ovary and placental tissue. Therefore Oct-4 is a transcription factor that is specifically expressed in cells participating in the pregnancy of Korean native cattle. These result suggest that Oct-4 localization and expression may contribute to the defects in the developmental normal seen in Korean native cattle.

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Goiter Frequency Is More Strongly Associated with Gastric Adenocarcinoma than Urine Iodine Level

  • Tabaeizadeh, Mohammad;Haghpanah, Vahid;Keshtkar, Abbasali;Semnani, Shahryar;Roshandel, Gholamreza;Adabi, Khadijeh;Heshmat, Ramin;Rohani, Davood;Kia, Alireza;Hatami, Ehsan;Jahangirrad, Ataollah;Nabizadeh, Ramin;Larijani, Bagher
    • Journal of Gastric Cancer
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    • v.13 no.2
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    • pp.106-110
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    • 2013

  • Purpose: We designed our study to evaluate the hypothesis that gastric cancer is correlated with iodine deficiency or thyroid dysfunction. Materials and Methods: We investigated the total body iodine reserve, thyroid function status and autoimmune disorder in 40 recently diagnosed gastric adenocarcinoma cases versus 80 healthy controls. The participants came from a region with high gastric cancer rate but sufficient iodine supply due to salt iodination. The investigation included urine iodine level, thyroid gland clinical and ultrasonographic examination, and thyroid function tests. Results: Goiter was detected more frequently in the case group (P=0.001); such a finding, however, was not true for lower than normal urine iodine levels. The free T3 mean level was significantly lower in the case group compared to the control group (P=0.005). Conclusions: The higher prevalence of goiter rather than low levels of urinary iodine in gastric adenocarcinoma cases suggests that goiter, perhaps due to protracted but currently adjusted iodine deficiency, is more likely to be associated with gastric adenocarcinoma compared to the existing iodine deficiency itself.

  • https://doi.org/10.5230/jgc.2013.13.2.106 인용 PDF KSCI