Proceedings of the KSAR Conference (한국동물번식학회:학술대회논문집)

The Korean Society of Animal Reproduction (한국동물번식학회)
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Expression of Oct-4 in the Pregnancy of Korean Native Cattle

  • H. J. Chung (National Livestock Research Institute, Department of Endocrinology) ;
  • Kim, B. K. (National Livestock Research Institute, Department of Endocrinology) ;
  • Park, J. H. (National Livestock Research Institute, Department of Endocrinology) ;
  • J. H Woo (National Livestock Research Institute, Department of Endocrinology) ;
  • Park, M. Y. (National Livestock Research Institute, Department of Endocrinology) ;
  • H. H. Seong (National Livestock Research Institute, Department of Endocrinology) ;
  • W. K. Chang (National Livestock Research Institute, Department of Endocrinology)
  • Published : 2003.06.01
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Abstract

Oct-4 is a maternally expressed octamer-binding protein encoded by the murine Oct-4 gene. It is present in unfertilized oocytes, but also in the inner cell mass and in primordial germ cells. In addition, Oct-4 is the first transcrition factor described that is specific for the blastocysts stage bovine embryos. The spatial and temporal expression patterns were further determined using Immunohistochemistry. With this technique Oct-4 protein expression is detected in the oocyte, in the blastocyst. After pregnancy Oct-4 expression is restricted ovary and placental tissue. Therefore Oct-4 is a transcription factor that is specifically expressed in cells participating in the pregnancy of Korean native cattle. These result suggest that Oct-4 localization and expression may contribute to the defects in the developmental normal seen in Korean native cattle.

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