• Journal of the korean academy of Pediatric Dentistry
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• v.38 no.2
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• pp.187-193
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• 2011

Neurofibromatosis is known as an autosomal dominant disorder caused by a mutation of a tumor suppressor gene on the long arm of chromosome 17 that affects the bone, nervous system, soft tissue, skin, and endocrine system. The most characteristic finding, which is helpful for clinical diagnosis as well, is the neurofibroma. Likewise brown macules called Cafe-au-lait spots with color of caffee latte, and Lisch nodules found around iris are useful to diagnose the disease. As known, the possibility of the neurofibromatosis occurred in oral cavity is relatively rare, and in most of cases it is related to soft tissue changes with single or multiple neurofibromatosis. The purpose of this report is to present characteristic dental findings which were found in a 4-year-old male and his father, both diagnosed as neurofibromatosis at Chonbuk National University Hospital before visiting our department, pediatric dentistry.

• Journal of Society of Preventive Korean Medicine
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• v.24 no.2
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• pp.57-62
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• 2020

Objectives : This study is retrospective chart review research on the combined-prescription of Western and Korean medicine in Public Health Center in rural area. Methods : Researchers reviewed medical records of patients who was prescribed Korean medicine and Western medicine from 1st, Jan, 2019 to 31st, Dec, 2019 in Public Health Center. 50 patients' medical records were included. Results : Total number of treatment is 3,808 cases and 1.3% of them is prescribed Korean medicine and Western medicine simultaneously. Prescription of Korean medicine is 153 cases and Western medicine is 160. Jowiseunggi-tang and Diroba tablet were the most frequently prescribed Korean medicine and Western medicine. Furthermore, Korean Medicine Doctors of Public Health Center use muscular skeletal disease system code(M code among KCD code) for prescription and Western Medicine Doctors use diseases of the circulatory system(I code among KCD code) frequently. Conclusions : We analyze 50 patients who were prescribed both Korean medicine and Western medicine. Mostly, patients were prescribed medicine for different diseases in each clinic. In western medicine clinic, drugs about circulatory or endocrine disease were prescribed frequently and in Korean Medicine clinic, drugs about muscular skeletal disease were most frequently prescribed. This result imply the real world's combination of prescription status that was different from result of National health insurance corporation database. Senior patients in rural area take medicine long period and have various underlying disease. We call for some attention about senior and rural area patients' prescription status in interaction studies of Korean medicine and Western medicine.

• Tuberculosis and Respiratory Diseases
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• v.66 no.4
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• pp.324-328
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• 2009

The syndrome of inappropriate secretion of the antidiuretic hormone (SIADH) is a well recognized paraneoplastic phenomenon related to impaired water excretion, and can result in dilutional hyponatremia as well as central nervous system symptoms. It is characterized by a decrease in plasma osmolarity with inappropriately concentrated urine. The causes of SIADH are associated with pulmonary and endocrine disorders, central nervous system diseases, and malignancies, including lung cancer. The other causes of SIADH include some drugs, particularly chemotherapy agents. Anticancer drugs, such as cisplatin, vincristine, and cyclophosphamide are well known causes of SIADH but the mechanisms are unclear. Recently, we encountered a patient with advanced non-small cell lung cancer who suffered from general weakness and altered mentality after an intravenous carboplatin and gemcitabine combination.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.26 no.1
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• pp.85-92
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• 2000

Common dental procedures(dental extraction & minor operation) are potentially stress-inducing in many patients, especially medically compromised patients. The body's response to dental stress involves the cardiovascular system(an increase in cardiovascular workload), the respiratory organ and the endocrine system(change in metabolism). To minimize the stress to the medical risk patient, the stress reduction protocol was established. The obtained contents were as follows: (1) Recognize the patient's degree of medical risk (2) Complete medical consultation before dental therapy (3) Schedule the patient's appointment in the morning (4) Monitor and record preoperative and postoperative vital signs (5) Use psychosedation during therapy (6) Use adequate pain control during therapy (7) Short length of appointment : do not exceed the patient's limits of tolerance (8) Follow up with postoperative pain/anxiety control (9) Telephone the higher medical risk patient later on the same day that treatment was given Though the stress reduction protocol above was applied to the dental extraction in medically compromised patients with the advanced infected teeth, the final responsibility for the complications(syncope, bleeding & infection, etc.) in a patient rests with the dentist who ultimately treats him. For the prevention of postextraction complications & poor prognosis, the authors treated the advanced infected teeth with the pulp extirpation, opening drainage through the canal and complete occlusal reduction. The final extraction and wound closure were then done after $1{\sim}2$ weeks. The final prognosis was comfortable without common complications.

• Journal of the Korean Society for Marine Environment & Energy
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• v.7 no.2
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• pp.104-110
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• 2004

This study was carried out to survey the pollution of bisphenol A(BPA) and total organic carbon(TOC) in surface sediments around Gwangyang bay. BPA is suspected chemicals as endocrine disruption. Gwangyang bay Is located on the mid south coast of Korea. It is a semi-closed bay which Yeosu petrochemical industrial complex, POSCO(Pohang Steel Company) and Gwangyang container harbor are located. The surface sediments were collected at 15 stations with gravity corer at October, 1999, February, May and August, 2000. Also, the stream and intertidal sediment were collected at 5 sites at August, 2000. Concentrations of BPA in surface sediments were in the range of 0.46 to 24.59 ng/g dry wt.. Seasonal range(mean value) of BPA are 0.59 to 9.00(1.88) ng/g dry wt. at October, 0.99 to 2.97(1.57) ng/g dry wt. at February, 0.46 to 24.59(2.53)ng/g dry wt. at May and 0.54 to 2.46 (1.29)ng/g dry wt. at August. BPA was seasonally fluctuated, and the highest mean value and range were detected at May, 2000. BPA was highly distributed in the inner part of Kwangyang bay than Yosu sound. Concentrations of BPA in stream and intertidal sediments showed the highest value in downstream near Yochon petrochemical industrial complex and Yondung stream. It suggests that the source of BPA are industrial wastewater and municipal sewage. TOC in surface sediments were in the range of 0.09∼1.22%. There was no any correlation between the BPA and TOC.

• Journal of Oral Medicine and Pain
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• v.34 no.2
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• pp.123-132
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• 2009

Purpose : To investigate the actual conditions of diagnosis and treatment of oral medicine inpatient with systemic disease. Methods : A total of 54 oral medicine subjects, inpatient due to systemic disease for diagnosis and treatment of oral disease was requested to answer the medical history and dental treatment record. Results : The ratio of gender is composed of male 44% and female 56%, the distribution of age is the order of the 50-59 group 37%, the 60-69 group 26%, the 40-49 group 22%. Systemic disease is composed of Endocrine, nutritional and metabolic diseases 36%, Diseases of the circulatory system 36%, Diseases of the nervous system 10%. Chief complain of oral disease is composed of routine check for oral health 26%, craniomandibular disorders 18%, soft tissue problem 18%. Oral disease is composed of Diseases of salivary glands 32%, Gingivitis and periodontal diseases 23%, Dentofacial anomalies 16% Conclusion : These findings indicate that oral medicine inpatient due to the systemic disease is significantly correlated to the oral disease. The patients of oral disease interrelationship between inpatient and outpatient of systemic disease should be validated by future research.

• Journal of the Korean Society of Hazard Mitigation
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• v.11 no.1
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• pp.107-112
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• 2011

In this study, photocatalytic degradation and mineralization of bisphenol A (BPA), which has been listed as one of endocrine disruptors, were carried out in the CPC system using $Tio_2$ slurry and UVA irradiation. The degradation efficiency has been investigated under the controlled parameters including initial concentration (5, 10, 20 mg/L), dosage of $Tio_2$ (0.1, 0.5, 1.0 g/L), UVA power (0, 80, 120 W) and temperature (0, 20, 30). At 10mg/L of initial concentration, BPA was degraded above 80% after 10min, BPA were degraded 97% and 49% at 20 mg/L and 30 mg/L, respectively. At $Tio_2$ dosage was 0.1 and 0.5 g/L, the degradations of BPA showed similar trend and were about 70% after 1 hr, and the degradation of BPA was above 80% after 30 min at 1 g/L of $Tio_2$ dosage. The increase of degradation seem to be due to the increase in the total surface area, namely number of active sites, available for the photocatalytic reaction as the dosage of photocatalyst increased. When the UVA power was 120 W, BPA was degraded rapidly above 60% after 10min of reaction time. To investigate the effect of temperature, carried out experiment controlled temperature, there were no significant differences depending on the temperature. After 1hr, the degradation of BPA were 46%, 67%, and 69% at 10, 20 and $30^{\circ}C$.

• The Korean Journal of Nuclear Medicine Technology
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• v.21 no.1
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• pp.65-69
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• 2017

Purpose KSNMT(Korea Society of Nuclear Medicine Technology) stepping first step in 1997, has published first journal related with nuclear medicine technology in 1985. With classifying In Vivo Session Dissertation reported in the entire journal, trend of the Dissertation will be studied. Materials and Methods Dissertations which published from 1985 to first half of 2016 in the journal are classified with presentation form and with scanner, And all the data is organized with Excel program. Through the data, the number of dissertations published in each year, the number of dissertation published in details, and keyword distributions in each period are analyzed. Results The number of In-vivo section dissertations was 1151 and the number of In-vivo section dissertations that have common subject with In-vitro section was 28. The number of In-vivo section dissertation in 1980s was 46, in 1990s was 149, in 2000 was 467 and from 2010 to the first half of 2016 was 517. The number of dissertation with original articles was 571, with abstract was 529, with symposium was 31, with special lecture was 25, with review was 11, with interesting image was 7, with poster was 3 and with case report was 2. With symposium and special lecture excluded, which count 56, the number of dissertation with PET was 319, with Planar was 302, with SPECT was 172, with radiopharmaceutical was 113, with guard and safety management 103, with BMD was 28, etc. was 86. The number of dissertation about oncology was 201, about scanner was 179, about cardiovascular and circulatory system was 102, about safe environment was 82, about musculoskeletal system was 76, about nervous nuclear medicine was 66, about quality assurance was 61, about genitourinary system was 56, about endocrine system was 49, about digestive system was 44, about Therapy, about industrial safety was 24, about molecular imaging was 15, infection and inflammation was 9, about respiratory system was 8 and etc. was 108. The mostly used keyword through 1999 to 2005 was PET and through 2006 to 2016 was PET/CT. Conclusion To encourage various dissertations to be submitted, Korea Society of Nuclear Medicine should analyze date about not only about dissertations that are already published, but also about various research materials. Moreover, Korea Society of Nuclear Medicine also have to provide technical support such as sharing big data from homepage and systematical support to its member to publish dissertation that has high impact factor. It is important each individual researcher to have continuing effort as well as each organization cooperation.

• Journal of Life Science
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• v.26 no.11
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• pp.1345-1354
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• 2016

Alopecia areata (AA) is a common and tissue-specific autoimmune disease of hair follicle resulting in the loss of hair on the scalp and elsewhere on the body. Hair follicles is a unique organ because it has its own immune system and hormonal milieu and has a different immune state at each hair cycle stage. The collapses of anagen-dependent hair follicle immune privilege arise autoimmune attack, inducing ectopic MHC class I expression in the hair follicle epithelium and autoantigen presentation to autoreactive CD8+T cells, which results in AA. Clinical and experimental studies have pointed that psychological stress may also influence the hair follicle immune/hormone systems and contribute to the induction of AA. The key pathogenesis of AA is associated with immune privilege guardians (including ACTH, ${\alpha}-MSH$, and $TGF-{\beta}$), natural killer group 2D-positive (NKG2D+) cells (including NK and CD8+T cells), and stress hormones (including CRH and substance P). Effective treatments for AA are still demanded. One of the future targets of treatment will be the modification of hair follicle immune privilege including stress. Recent studies have reported that JAK inhibitors and immunomodulators used in other autoimmune disease, such as psoriasis, atopic dermatitis, and rheumatoid arthritis, Tregs, platelet-rich plasma therapy, statins, and prostaglandin anaolgues are effective for AA. Here the article reviews the recent understanding in the pathogenesis associated with perifollicular endocrine/immunology and new treatments of AA.

• Journal of Korean Society of Environmental Engineers
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• v.27 no.11
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• pp.1193-1197
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• 2005

The low frequency noise below 200 Hz, including inaudible infra-sound, is known to affect human physiology ; circulation, respiration, nerve, endocrine, etc. Legislation has been introduced in several countries regarding evaluation guideline and measurement method of low frequency noise. In this work, low frequency characteristics of the Seoul subway transportation system was investigated in terms of the noise level and spectrum in the interior of running passenger car and the subway station. The interior sound pressure level of the passenger car was between 60 and 105 dB in the frequency range of $1{\sim}200\;Hz$ and varied with car speed. The marked sound pressure level peak at 8 Hz, infra-sound, observed for the most of Lines is shown to correspond to the resonance frequency of passenger car. The level of station platform noise was lower than the interior noise of running car because of the lower speed at arriving/departure. The results indicated that the interior noise level of running passenger car was inside the oppressive feeling region, proposed by Ochiai, in the frequency range of $20{\sim}80\;Hz$ which makes a little concern.