• 감성과학
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• 제20권4호
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• pp.89-100
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• 2017

초연결사회의 시대가 도래하여 시간과 공간의 제약없이 효율적으로 정보를 전달할 수 있는 스마트 디바이스의 사용이 보편화되었다. 스마트 디바이스는 사람과 사물 간의 상호작용을 통하여 정보를 전달할 수 있도록 점차 웨어러블 형태로 발전하고 있으며, 의복 형태의 스마트 디바이스인 스마트의류는 인체에 가장 밀착한 상태로 각종 생체신호 등의 측정이 가능하기 때문에 미래 일상생활에서 사용도가 높아질 것으로 주목받고 있다. 기존에 개발된 스마트의류는 의복에 전자장치를 부착한 형태로 개발되어 기기 이물감으로 인해 착용 시 사용자의 불편을 야기하여 지속적으로 생체신호를 측정하기에 한계가 있었다. 이에 따라 점차 전자장치가 텍스타일 내의 한 요소로 통합되어 있는 스마트 텍스타일을 기반으로 한 스마트의류의 개발이 요구된다. 본 연구에서는 현재 소비자에게 가장 근접한 웨어러블 디바이스인 스마트워치 사용자를 대상으로 하여 사용경험에 기반한 감성을 통해 웨어러블 디바이스에서 사용자가 필요로 하는 요구조건을 탐색하고자 하였다. 스마트워치 사용자의 경험에 기반한 감성에 대해 구체적인 답변을 얻고자 반구조화 된 심층인터뷰를 통해 질적 연구를 수행하였으며, 심층인터뷰 내용을 바탕으로 사용자감성을 기능적, 심미적, 사회적, 경험적 네 가지 측면으로 분류하였다. 측면별로 감성키워드를 설정하여 빈도 수 확인을 통해 스마트워치 사용자의 관심도를 알아보았다. 본 연구의 결과를 미래의 웨어러블 디바이스로 주목받고 있는 스마트의류 제작에 필요한 스마트 텍스타일 개발을 위한 기초자료로 활용하고자 한다.

• BMB Reports
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• 제54권2호
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• pp.118-123
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• 2021

The bacterial effector protein RavZ from a pathogen can impair autophagy in the host by delipidating the mammalian autophagy-related gene 8 (mATG8)-phosphatidylethanolamine (PE) on autophagic membranes. In RavZ, the membrane-targeting (MT) domain is an essential function. However, the molecular mechanism of this domain in regulating the intracellular localization of RavZ in cells is unclear. In this study, we found that the fusion of the green fluorescent protein (GFP) to the MT domain of RavZ (GFP-MT) resulted in localization primarily to the cytosol and nucleus, whereas the GFP-fused duplicated-MT domain (GFP-2xMT) localized to Rab5- or Rab7-positive endosomes. Similarly, GFP fusion to the catalytic domain (CA) of RavZ (GFP-CA) resulted in localization primarily to the cytosol and nucleus, even in autophagy-induced cells. However, by adding the MT domain to GFP-CA (GFP-CA-MT), the cooperation of MT and CA led to localization on the Rab5-positive endosomal membranes in a wortmannin-sensitive manner under nutrient-rich conditions, and to autophagic membranes in autophagy-induced cells. In autophagic membranes, GFP-CA-MT delipidated overexpressed or endogenous mATG8-PE. Furthermore, GFP-CA△α3-MT, an α3 helix deletion within the CA domain, failed to localize to the endosomal or autophagic membranes and could not delipidate overexpressed mATG8-PE. Thus, the CA or MT domain alone is insufficient for stable membrane localization in cells, but the cooperation of MT and CA leads to localization to the endosomal and autophagic membranes. In autophagic membranes, the CA domain can delipidate mATG8-PE without requiring substrate recognition mediated by LC3-interacting region (LIR) motifs.

• 패션비즈니스
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• 제14권5호
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• pp.78-92
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• 2010

The culture phenomenon, which the desire of self expression is noticeable and the diversity of gender identity is widely accepted, simply makes a difference in the lifestyle of one human being rather than the dichotomous classification of male and female. Now, the delicate and aesthetic sensitivity classified as the feminine characteristics is no longer the exclusive property of female and this refers to substituting it as a social gender from the concept of biological sex. This phenomenon has influenced on the male culture and is creating various codes according to the cultural gender extended from the gender as a social role. Also, the transition into the western lifestyle has extended the aesthetic emotion to accommodate new codes from the diversification and globalization of lifestyle. The mansumer power, which does not care too much about the money for the emotionally attached items, has enabled various fashion styles. After analyzing the diversified clothing behavior conducted by these people in connection with the social phenomenon, First, this shows the phenomenon of emotional value pursuit that finds pleasure over the clothing as the item of augmented reality is added to the concept of play, in which the real space referred to as garment and virtual space of playing the rock, paper and scissors game meet together within the augmented reality. Second, the convergence concept has enabled the coordination of new style by obscuring the area of design concept and this refers to the changes in design from the development of new items and transformation into double-style details. Third, the divergence that intensively provides specific use/convenience and specialized value shows a change in the fashion market from the phenomenon that admits various gene rations of culture and specifically, takes differently about the recognition of middle-aged males. Fourth, the variety seeking tendency receives attention as the value of future design together with the phenomenon of discriminative value pursuit. In the male fashion, it is linked to the collaboration with the design area and this tells that the fashion with the narcissistic cross-dressing and motto of neutral gender without being sided to male/female is rising.

• 동의신경정신과학회지
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• 제30권3호
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• pp.209-220
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• 2019

Objectives: As a general emotion, everyone can temporarily experience depression, but depressive disorder is a disease that excessively affects daily life. Among the various causes of depression, the deficiency of monoamine-based neurotransmitters such as serotonin and epinephrine are considered significant. Thus, antidepressants that target monoamines are used frequently. However, side effects such as nausea, vomiting, insomnia, anxiety, and sexual dysfunction are observed. Thus, it is necessary to develop a new therapeutic agent with fewer side effects. In this study, we investigated the antidepressant effect of JG02, used to treat depression by normalizing the flow of qi (氣) in Korean medicine. Methods: C57BL/6 mice were selected and randomly divided into six groups: normal, control, amitriptyline, and JG02 (50, 125, 250 mg/kg), respectively. Except for normal, depression was induced by applying restraint stress at the same time for six hours daily for 14 consecutive days. Saline, amitriptyline or JG02 samples were orally administered two hours before applying the stress. After that, a forced swimming test and an open field test were performed. Additionally, serum corticosterone, serotonin mRNA, BDNF mRNA, and protein in the hippocampal region were measured and compared. Results: JG02 decreased immobility time rate in the FST and increased the zone transition number and travel distance in the OFT. Also, JG02 inhibited the release of serum corticosterone, and increased serotonin, BDNF gene expression, and BDNF protein in the hippocampus. Conclusions: In this study, JG02 showed significant antidepressant effects on the chronic restraint stress mice model. When further research is performed based on JG02, the development of a new antidepressant is considered highly possible.