Browse > Article
http://dx.doi.org/10.7231/jon.2019.30.3.209

Antidepressant Effects of JG02 on Chronic Restraint Stress Animal Model  

You, Dong Keun (Department of Oriental Neuropsychiatry, College of Korean Medicine, Daejeon University)
Seo, Young Kyung (Department of Oriental Neuropsychiatry, College of Korean Medicine, Daejeon University)
Lee, Ji-Yoon (Department of Oriental Neuropsychiatry, College of Korean Medicine, Daejeon University)
Kim, Ju Yeon (Department of Oriental Neuropsychiatry, College of Korean Medicine, Daejeon University)
Jung, Jin-Hyeong (Departmant of Neuropsychiatry Medicine, Cheonan Korean Medicine Hospital of Daejeon University)
Choi, Jeong June (Laboratory of Molecular Medicine, College of Korean Medicine, Daejeon University)
Jung, In Chul (Department of Oriental Neuropsychiatry, College of Korean Medicine, Daejeon University)
Publication Information
Journal of Oriental Neuropsychiatry / v.30, no.3, 2019 , pp. 209-220 More about this Journal
Abstract
Objectives: As a general emotion, everyone can temporarily experience depression, but depressive disorder is a disease that excessively affects daily life. Among the various causes of depression, the deficiency of monoamine-based neurotransmitters such as serotonin and epinephrine are considered significant. Thus, antidepressants that target monoamines are used frequently. However, side effects such as nausea, vomiting, insomnia, anxiety, and sexual dysfunction are observed. Thus, it is necessary to develop a new therapeutic agent with fewer side effects. In this study, we investigated the antidepressant effect of JG02, used to treat depression by normalizing the flow of qi (氣) in Korean medicine. Methods: C57BL/6 mice were selected and randomly divided into six groups: normal, control, amitriptyline, and JG02 (50, 125, 250 mg/kg), respectively. Except for normal, depression was induced by applying restraint stress at the same time for six hours daily for 14 consecutive days. Saline, amitriptyline or JG02 samples were orally administered two hours before applying the stress. After that, a forced swimming test and an open field test were performed. Additionally, serum corticosterone, serotonin mRNA, BDNF mRNA, and protein in the hippocampal region were measured and compared. Results: JG02 decreased immobility time rate in the FST and increased the zone transition number and travel distance in the OFT. Also, JG02 inhibited the release of serum corticosterone, and increased serotonin, BDNF gene expression, and BDNF protein in the hippocampus. Conclusions: In this study, JG02 showed significant antidepressant effects on the chronic restraint stress mice model. When further research is performed based on JG02, the development of a new antidepressant is considered highly possible.
Keywords
Depression; Depressive disorder; JG02; Jigyul-tang; Zhiju-tang; FST; OFT; Corticosterone; Serotonin; BDNF;
Citations & Related Records
Times Cited By KSCI : 7  (Citation Analysis)
연도 인용수 순위
1 The Korean Society of Oriental Neuropsychiatry Textbook Compilation Committee. Oriental Neuropsychiatry. 3rd ed; Gyeonggi: Jipmoondang, 2016.
2 Korea Institute of Oriental Medicine. Korean Medicine Clinical Practice Guideline of Depression. Seoul: Elsevier Korea L.L.C.. 2016.
3 Ministry of Health and Welfare. The Survey of Mental Disorders in Korea in 2016. 2017.
4 Health Insurance Review and Assessment Service Medical Statistics Information. http://opendata.hira.or.kr/op/opc/olapJdgeChargeInfo.do
5 Statistics korea. The cause of death statistics. Statistics korea. 2010.
6 Mass JW, Fawcett JA, Dekirmenjian H. 3-Methoxy-4-hydroxyphenyl-glycol(MHPG) excretion in depressive states. Arch.Gen.Psychiatry. 1968;19:129-34.   DOI
7 Goodwin FK, Rubovits R, Jimerson DC. 5-HT and norepinephrine "subgroups" in depression. Metabolites findings and clinical pharmacological correlation. Sci.Proc. Am.Psychiatr.Assoc. 1977;130:108-31.
8 Bouvier, N., T. Trenque, and H. Millart, Development of antidepressant drugs. Experience and prospects. Presse Med, 2003;32(11):519-22.
9 Min SG. Latest psychiatry. 5thed; Seoul: Iljokak, 2006.
10 Lee MS, Pharmacological Treatment of Depression. Journal of the Korean Medical Association. 2003;46(1):69-75.   DOI
11 Park WM, Kim CY. Clinical Neuropsychopharmacology. 2nded; Seoul: SigmaPress, 2014.
12 The Korean Neuropsychiatric Association. Textbook of neuropsychiatry. 3rd ed; Seoul: iMiS Company, 2017.
13 Lee JS, Management issues in new antidepressant side effects.. Korean J Psychopharmacol. 1999;10(Suppl 1):35-47.
14 Yun HY. Bupleurum falcatum prevents depression and anxiety-like behaviors in the rats exposed to repeated restraint stress. Master Dissertation. Kyung Hee University. 2012.
15 Kang HW, Jang HH, Kang IS, Moon HC, Hwang YJ, et al.. A Study on The Oriental-medical Understanding of Depression. J of Oriental Neuropsychiatry. 2001;12(2):1-15.
16 Heo J. Donguibogam. Gyeongnam: Donguibogam Publishing House. 2006:1382-6.
17 Chang MK, Kim GW, Koo BS. Anti-depressant Effect of the Extracts of Aconitum carmichaeli. J of Oriental Neuropsychiatry. 2009;20(3):9-64.
18 The Textbook Compilation Committee of Herbalogy of Oriental Medical Schools in Nation. Herbalogy. Seoul:Younglim Publisher. 2016.
19 Eun Hee Lee, Woo Chang Choi, In Chul Jung. Preliminary Study to Develop the Instrument on Pattern Identifications. 2013;24(4):435-50.   DOI
20 Hun Soo Lee, Wee Chang Kang, In Chul Jung. Reliability and Validity Analysis of the Instrument on Pattern Identifications for Depression. 2015;26(4):407-16.   DOI
21 Lee JW, Hong MC, Shin MK, Bae HS. Comparison of Nelumbinis Semen Extract with Hypericum Perforatum and Fluoxetine in Animal Model of Depression. Korean J. Oriental physiology & Pathology. 2006;20(4):830-43.
22 Lee DK, Gwak DG, Park SD. Antidepressant effect of Licium chinense Mill. and its influence on serotonin and its metabolite of depression model rats. Herbal Formula Science. 2004;11(2):185-96.
23 Min NK, Lee TH. Effects of Paeoniae Radix Rubra on CRF, c-Fos and TH in the Forced Swimming Test. Kor. J. Herbology. 2010;25(4):61-7.
24 Kwon YU, Lee TH. Antidepressant Effects of Citri Reticulatae Viride Pericarpium in the Forced Swimming Test. Kor. J. Herbology. 2008;23(4):59-70.
25 Sim EY, Lee TH. Effects of Mixture of Lycii Radicis Cortex and Moutan Cortex on Corticotropin-Releasing Factor, c-Fos, and Tyrosine Hydroxylase in Forced Swimming Test. Kor. J. Herbology. 2011;26(2):59-66.
26 Lim JW, Jung IC, Lee SR. The Effects of BunSimGiEum-Gami-Bang(Fenxinqiyinjiameifang) on Serotonin of P815 cell. J of Oriental Neuropsychiatry. 2011;22(2):147-62.   DOI
27 Kim IJ, Lee DW. Experimental Study on the Antidepressant Effect of Ginseng Radix Alba and Cyperi Rhizoma. J of Oriental Neuropsychiatry. 2004;15(1):101-19.
28 Seong WY, Whang WW, Park EH, Lee JR, Kim HT, Kim JW. The Effects of Quibitang in the Chronic Mild Stress Model of Depression in Rats. J of Oriental Neuropsychiatry. 2002;13(2):121-47.
29 Ryu JM, Kim JW, Chi SE, Kim EJ, Park EH, Hwang UW. The effects of Jowiseungchungtang versus fluoxetine in the chronic mild stress model of depression in rats. J of Oriental Neuropsychiatry. 2004;15(1):27-41.
30 Sim TK, Jung IC, Lee SR. The Effect of Gamisoyo-san (Jiaweixiaoyaosan) on Serotonin Metabolism. J of Oriental Neuropsychiatry. 2011;22(1):37-51.   DOI
31 Porsolt RD, Anton G, Blavet N, Jalfre M. Behavioural despair in rats: A new model sensitive to antidepressant treatments. European Journal of Pharmacology. 1978; 47:379-91.   DOI
32 Duman RS, Malberg J, Nakagawa S, D'Sa C. Neuronal plasticity and survival in mood disorders. Biol Psychiatry. 2000;48:732-9.   DOI
33 Woo YS, Park WM. Treatment of Depression. Kor J Medicine, 2005;70(2):239-42.
34 Textbook of depressive disorder. Korean society for depressive and bipolar disorders. 1st ed; Seoul: Sigmapress, 2012.
35 Lee SH, Kim BY, Kee JI, Kwen SJ, Chung DK. A Case of Mixed Anxiety and Depressive Disorder. J of Oriental Neuropsychiatry. 2003;14(2):127-34.
36 Lee JH, Kim GW, Koo BS. Experimental Study on the Anti-depressive Effect of Bee Venom Injection. J of Oriental Neuropsychiatry. 2010;21(2):61-73.
37 Murer MG, Yan Q, Raisman-Vozari R. Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Par kinson's disease. Prog Neurobiol. 2001;63:71-124.   DOI
38 Shimizu E, Hashimoto K, Okamura N, Koike K, Komatsu N, Kumakiri C, Nakazato M, Watanabe H, Shinoda N, Okada S, Iyo M. Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants. Biol Psychiatry. 2003;54:70-5.   DOI
39 Nibuya M, Takahashi M, Russell DS, Duman RS. Repeated stress increases catalytic TrkB mRNA in rat hippocampus. Neurosci Lett. 1999;267:81-4.   DOI
40 Choi KM, Joo Y, Lee YH, et al. Chronic immobilization stress induces anxiety- and depression-like behaviors and decreases transthyretin in the mouse cortex. Neuroscience Letters. 2009;461(2):121-5.   DOI
41 Smith MA, Makino S, Kim SY, Kvetnansky R. Stress increases brain-derived neurotropic factor messenger ribonucleic acid in the hypothalamus and pituitary. Endocrinology. 1995;136:3743-50.   DOI
42 Nibuya M, Nestler EJ, Duman RS. Chronic antidepressant admini stration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus. J Neurosci. 1996;16:2365-72.   DOI
43 Smith MA, Makino S, Kvetnansky R, Post RM. Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus. J Neurosci. 1995;15:1768-77.   DOI
44 Lee YM. Association Study Between Brain-Derived Neurotrophic Factor Genetic Polymorphism and Treatment Responses of Selective Serotonin Reuptake Inhibitor in Major Depressive Disorder. J Korean Geriatric Psychiatry. 2008;12: 34-9.
45 Nibuya M, Morinobu S, Duman RS. Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antide pressant drug treatments. J Neurosci. 1995;15:7539-47.   DOI
46 Yong-Ku Kim. Outlook of Future Serotonergic Drugs and Their Clinical Usefulness - Focused on Schizophrenia and Depression -. Korean J Psychopharmacol. 2006;17(3):273-82.
47 Russo-Neustadt A, Beard RC, Cotman CW. Exercise, antidepressant medications, and enhanced brain derived neurotrophic factor expression. Neuropsychopharmacology. 1999;21:679-82.   DOI