• 대한방사성의약품학회지
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• 제7권2호
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• pp.99-103
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• 2021

In this study, the initial in vivo pharmacokinetic changes according to the routes of drug administration were investigated using bioimaging techniques. The purpose of this study was to quantify the degree of distribution of each major organ in normal mice over time by acquiring Positron Emission Tomography/Computed Tomography images while administering routes F-18 fluorodeoxyglucose such as intravenous, intraperitoneal and per oral, a representative diagnostic radiopharmaceutical. Dynamic Positron Emission Tomography images were acquired for 90 minutes after drug administration. Radioactivity uptake was calculated for major organs using the PMOD program. In the case of intravenous administration, it was confirmed that it spread quickly and evenly to major organs. Compared to intravenous administration, intraperitoneal administration was about three times more absorbed and distributed in the liver and intestine, and it was showed that the amount excreted through the bladder was more than twice. In the case of oral administration, most stayed in the stomach, and it was showed that it spread slowly throughout the body. In comparison with intravenous administration, it was presented that the distribution of kidneys was more than 9 times and the distribution of bladder was 66% lower. Since there is a difference in the initial in vivo distribution and excretion of each administration method, we confirmed that the determination of the administration route is important for in vivo imaging evaluation of new drug candidates.

• 대한두경부종양학회:학술대회논문집
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• 대한두경부종양학회 1998년도 제3차 춘계심포지움
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• pp.112-114
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• 1998

• 대한핵의학회지
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• 제31권3호
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• pp.291-298
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• 1997

• 대한위암학회:학술대회논문집
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• 대한위암학회 2004년도 제17회 춘계학술대회
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• pp.34-34
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• 2004

• 대한치과보철학회:학술대회논문집
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• 대한치과보철학회 1999년도 Asian Academy of Prosthodntics. Korean Academy of Prosthodontics
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• pp.33-33
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• 1999

• 대한핵의학회:학술대회논문집
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• 대한핵의학회 1990년도 제29차 춘계학술대회
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• pp.213.1-213.1
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• 1990

• 대한핵의학회지
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• 제19권1호
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• pp.7-19
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• 1985

• Tuberculosis and Respiratory Diseases
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• 제80권4호
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• pp.368-376
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• 2017

Background: A ground-glass nodule (GGN) represents early-stage lung adenocarcinoma. However, there is still no consensus for preoperative staging of GGNs. Therefore, we evaluated the need for the routine use of positron emission tomography/computed tomography (PET)/computed tomography (CT) scans and brain magnetic resonance imaging (MRI) during staging. Methods: A retrospective analysis was undertaken in 72 patients with 74 GGNs of less than 3 cm in diameter, which were confirmed via surgery as malignancy, at the Samsung Medical Center between May 2010 and December 2011. Results: The median age of the patients was 59 years. The median GGN diameter was 18 mm. Pure and part-solid GGNs were identified in 35 (47.3%) and 39 (52.7%) cases, respectively. No mediastinal or distant metastasis was observed in these patients. In preoperative staging, all of the 74 GGNs were categorized as stage IA via chest CT scans. Additional PET/CT scans and brain MRIs classified 71 GGNs as stage IA, one as stage IIIA, and two as stage IV. However, surgery and additional diagnostic work-ups for abnormal findings from PET/CT scans classified 70 GGNs as stage IA, three as stage IB, and one as stage IIA. The chest CT scans did not differ from the combined modality of PET/CT scans and brain MRIs for the determination of the overall stage (94.6% vs. 90.5%; kappa value, 0.712). Conclusion: PET/CT scans in combination with brain MRIs have no additional benefit for the staging of patients with GGN lung adenocarcinoma before surgery.

• 한국정보처리학회논문지
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• 제5권12호
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• pp.3275-3284
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• 1998

본 논문에서는 각종 단층 촬영 의료영상 장비로 촬영한 2차원 단면화상 데이터들을 차원 재구성 알고리즘을 사용하여 3차원 영상으로 재구성한 다음, 웹 서버의 데이터베이스에 저장하고 관리하며, 인터넷 가상현실 표준언어인 VRML(Virtual Reality Modeling Language)로 표현된 3차원 의료영상을 비롯한 각종 의료영상 정보를 웹브라우저를 사용하여 검색해 볼 수 있는 의료영상정보시스템(Medical Image Information System)에 관하여 기술한다. 본 연구를 통하여 개발한 의료영상정보시스템에서는 단층 촬영된 2차원 단면화상을 처리한 다음, 3차원 의료 영상을 생성하기 위하여 표면기반 랜더링 방법(Surface-based Rendering Method)을 사용하였다. 인터넷을 통하여 전송되는 영상파일의 크기를 줄이기 위하여 삼각형 매쉬(Triangle Meshes)을 이루는 다각형의 개수를 줄이는 알고리즘을 사용하며, 3차원 의료영상 데이터의 크기를 약 50%이상 줄일 수 있다. 아울러, 3차원 영상 데이터 파일을 압축을 하게 되면 파일의 크기를 80%이상 줄일 수 가 있으므로 웹상에서 신속하게 3차원 의료영상 데이터를 검색할 수 있고, 의료영상을 VRML을 사용하여 표현하므로 고성능의 그래픽 카드가 없는 일반 PC에서도 인터넷을 통하여 디스플레이 할 수 있다. 또한, CGI(Common Gateway Interface)방식을 사용하여 서버의 데이터베이스에 저장되어 있는 CT(Computerized Tomography), MRI(Magnetic Resonance Imaging), PET(Positron Emission Tomography), SPECT(Single Photon Emission Computed Tomography)등의 단층 촬영 장비로 촬영한 다양한 종류의 디지털 의료영상을 사용자에게 의료영상정보시스템을 통하여 2차원 단면화상 또는 3차원 영상으로 표현하여 보여주고, 환자에 관한 각종 정보와 진단정보 등을 신속하게 제공한다. 본 논문에서 제안하는 의료영상정보시스템은 초고속 정보통신 망을 통하여 원격의료시스템을 구축하는데 활용될 수 있을 것이다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권14호
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• pp.5599-5605
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• 2015

In oncology various imaging modalities play a crucial role in diagnosis, staging, restaging, treatment monitoring and follow up of various cancers. Stand-alone morphological imaging like computerized tomography (CT) and magnetic resonance imaging (MRI) provide a high magnitude of anatomical details about the tumor but are relatively dumb about tumor physiology. Stand-alone functional imaging like positron emission tomography (PET) and single photon emission tomography (SPECT) are rich in functional information but provide little insight into tumor morphology. Introduction of first hybrid modality PET/CT is the one of the most successful stories of current century which has revolutionized patient care in oncology due to its high diagnostic accuracy. Spurred on by this success, more hybrid imaging modalities like SPECT/CT and PET/MR were introduced. It is the time to explore the potential applications of the existing hybrid modalities, developing and implementing standardized imaging protocols and train users in nuclear medicine and radiology. In this review we discuss three existing hybrid modalities with emphasis on their technical aspects and clinical applications in oncology.