• 대한치과기공학회지
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• 제45권3호
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• pp.81-86
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• 2023

Purpose: This study aimed to observe the effect of laminate veneer on patient's teeth based on the manufacturing of laminate veneer restorations, which are produced by fabricating a ceramic cast body using IPS Empress, a pressure casting method and then forming the veneer by layering. Subsequently, we assessed the potential of its clinical application. Methods: This study discusses and preserves various treatment plans, such as diagnostic wax-up and treatment room diagnosis, for patients who visit the hospital to improve the appearance of teeth due to diastema of maxillary teeth, inexperienced resin filling, lack of esthetics, and external teeth. A ceramic cast body is constructed using IPS Empress, which is an effective and aesthetic restoration pressure casting method to restore the veneer with a laminate made by layering. Results: Compared with the preoperative state, the frontal view of the patient after the final restoration showed the formation of a natural smile line; the space between the central and lateral incisors was filled in synchronously with the adjacent teeth. In addition, the emergence profile is maintained by reducing the over-contour as much as possible. Conclusion: The patient's quality of life is improved by providing them with a satisfactory natural smile.

• 구강회복응용과학지
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• 제31권4호
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• pp.364-370
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• 2015

최근 구치부 부분 무치악 환자의 임플란트 보철 수복은 기능적뿐만 아니라 심미적으로도 환자의 만족을 이끌어내야 하는 과제를 안고 있다. 이렇게 환자의 요구가 높아지면서 상실된 자연치아와 유사한 형태의 임플란트 보철을 사용한 구강회복이 보철수복의 중요한 이슈가 되고 있다. 이를 위해서는 기성 지대주 보다는 더 넓은 customized CAD/CAM 지대주를 사용함으로써 자연스러운 출현윤곽을 재현할 수 있다. 넓은 지대주를 지지해주기 위해서는 충분한 폭과 높이를 가지는 각화치은이 존재해야 하는데, 만약 긴 치아상실기간이나 골이식술 등으로 인해 임플란트 주위에 각화치은이 부족한 경우에는 연조직 증대술을 시행하는 것이 추천된다. 이러한 과정을 통해 심미적이고 기능적인 임플란트 보철 제작이 가능하며 구강위생관리를 용이하게 하고 향후 임플란트 주위염의 발생 가능성을 감소시킨다. 본 증례는 구치부 부분 무치악 환자에서 골이식술, 상악동 이식술, 임플란트 식립술 및 연조직 이식술을 사용하여 부족한 치조골과 각화치은 및 협측전정을 회복하였으며, customized CAD/CAM 지대주와 지르코니아 보철물을 이용하여 수복한 증례로 주기적인 내원 및 검사를 통해 기능적, 심미적으로 만족할만한 결과를 얻었기에 이 사례를 보고하고자 한다.

• Asian Journal of Innovation and Policy
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• 제9권3호
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• pp.308-338
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• 2020

The entrepreneurial journey is not short of challenges, and about 90% + tech start-ups experience failure (Startup Genome, 2019). The magnitude of the challenges varies across the tech start-up lifecycle stages, namely emergence, stability, and growth. This opens the research question, do the profiles of a start-up and its co-founder impact start-up success or failure across its lifecycle stages? This study aims to understand and identify the profiles of tech start-ups and their co-founders. We gathered primary data from 151 start-ups (Status: 101 failed and 50 successful ones), and they are across different lifecycle stages and represent six major start-up hubs in India. The chi-square test on status and start-up's lifecycle stage indicates a noticeable correlation, and they are not independent. The Kruskal Wallis test was used to distinguish statistically significant profile attributes. The parameters distinguishing success and failure are identified, and the need to deliver customer experience is emphasized by the start-up profile attributes: Product/service, high-tech nature of a start-up, investor fund availed, co-founder experience, and employee count. The importance of entrepreneurial experience is ascertained with entrepreneur profile attributes: Entrepreneurial expertise, the number of prior and current start-ups, their willingness to start again in the event of failure, and age of co-founder, which is a proxy to learning and experience. This study has implications for entrepreneurs, investors, and policymakers.

• 대한치과보철학회지
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• 제62권3호
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• pp.234-242
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• 2024

즉시 임플란트 식립과 수복은 치료 기간을 단축하고, 최종 수복 시까지 심미성을 유지할 수 있다는 장점이 있다. 하지만 상악 전치부에서의 단일 임플란트 수복은 심미적인 부분에서 어려움이 있을 수 있는데, 임플란트 식립 중 연조직과 경조직에 전달된 수술적 외상은 향후 심미적 결과에 영향을 미칠 수 있다. 이러한 전치부 임플란트 식립 및 수복 시 예측 가능한 결과를 얻기 위해서는 치간골의 높이, 치은의 특성, 환자 치아의 형태적 특성 등을 고려하여 수술 및 수복 계획을 세워야 한다. 본 증례에서는 경제적 문제로 PFM (Porcelain Fused-Metal) 수복을 원하는 환자의 계획보다 순측으로 식립된 상악 전치부 임플란트를 치은 형성과 디지털 인상을 통해 emergence profile 과 안정화된 연조직 형태를 재현하고자 했다.

• Journal of Smart Tourism
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• 제1권3호
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• pp.31-44
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• 2021

The emergence of the digital economy and easy accessibility to Web 2.0 tools has seen an expansion of the influencer ecosystem within the travel and tourism industry. Founded on the principles of reference groups and peer reference there is a growing trend amongst industry practitioners who are now opting to move away from many of the traditional approaches used to market their products and services and are instead taking advantage of the concept of e-word-of-mouth (eWOM). Whilst there is a growing body of academic literature addressing the notion of influencer marketing, there is little understanding of influencer marketers themselves. Consequentially, this study addresses this gap in the literature through the quantitative examination of those who promote products, services, or companies by distributing eWOM through their online digital channels and presence; otherwise known as travel influencers. A quantitative research approach involving an online survey yielded 255 responses from travel influencers. The research findings indicate that those who work in this field prefer not to be awarded the label "travel influencer," focusing instead on their specific method of influencing, such as blogging and vlogging or sharing Instagram updates. The research also demonstrates how the new influencers have a strong role in generating travel urge and desire. The research contributes to the wider body of academic literature and travel industry practitioners by establishing the general profile of influencers and their increasingly specialized role in tourism and hospitality marketing.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제47권1호
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• pp.20-24
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• 2021

Objectives: The aim of this study was to evaluate the profile of patients on antiresorptive therapies for cancer treatment and assess presence of oral lesions, oral hygiene status, and knowledge regarding medication-related osteonecrosis of the jaw (MRONJ). Materials and Methods: This was an observational cross-sectional study that evaluated patients treated with antiresorptive medication at a single cancer hospital. Clinical data were collected and oral examination was performed to assess patient oral health. Results: From July 2017 to December 2018, 90 patients were assessed; 64 were female and 26 were male, and the mean age was 61 years. The most common drug was an intravenous bisphosphonate, zoledronic acid. Among the 90 patients, 47 presented with some type of oral disease, isolated or associated. Among these 47 patients, 9 patients (10%) developed osteonecrosis. Oral hygiene was evaluated, and most patients, with or without MRONJ, presented with regular to poor condition. Regarding patient knowledge of the risks of MRONJ and the risks associated with dental surgery, 60% stated that they were not aware of the risks. Conclusion: Identifying the profile of patients and their needs facilitates not only the preventive process, but also the emergence of new therapeutic options. Our study shows that most patients are weakened both by metastatic disease and antineoplastic treatment as well as by issues associated with aging because most were over 60 years of age. Collectively, this information should be considered for management of preventive and therapeutic measures.

• 미생물학회지
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• 제48권1호
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• pp.22-28
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• 2012

장염비브리오는 우리나라에서 하절기에 발생하는 식중독의 주요 원인균으로 주로 해수 및 어패류를 통해 인체에 감염된다. 최근 지구 온난화로 해수의 온도가 상승하면서 해양환경 중 세균들의 분포도가 증가하고 또 다양한 항생제에 대한 내성을 보이는 병원균들이 확산되고 있어 국민보건 및 수산양식 등의 분야에 큰 문제로 대두되고 있다. 이에 본 연구에서는 경기, 인천지역 7곳에서 해수 및 어패류 시료를 채취하여 장염비브리오균의 분포도를 모니터링하고 이들의 항생제 내성 양상을 분석하였다. 총 966건의 시료를 $CHROMagar^{TM}$ 및 TCBS 평판배지와 multiplex PCR기법으로 동정했을 때 전체 해수 시료의 61.9%, 어패류 시료의 41.8% 등 총 47.7%의 시료에서 장염비브리오균이 검출되었다. 이들 분리균주들의 항생제 내성을 13종의 항생제에 대해 분석한 결과 97.3%와 87.3%가 각각 vancomycin과 ampicillin에 대해 내성을 보였고 cephalothin (48.8%)과 rifampin (46.1%)에 대한 내성비율도 기타 다른 항생제들에 비해 상대적으로 높은 것으로 나타났다. 분리균주들의 항생제 감수성은 chloramphenicol (91.7%)과 trimethoprim-sulfamethoxazole (91.8%)에 대해 가장 높았고, gentamycin (82.3%), tobramycin (74.8%), nalidixic acid (71.6%), tetracyclin (69.4%), cefotaxime (63.0%) 등의 순서로 감수성 비율이 높았다. 분리균주들의 약 69%가 vancomycin과 ampicillin을 포함하여 3개 이상의 항생제에 대해 다중내성을 보였고 특히 11개 항생제에 대해 내성을 보이는 균주도 2개 검색되었다. 항생제 내성 장염비브리오 분리균주들의 플라스미드 프로파일을 분석한 결과 55.1%가 플라스미드를 보유하고 있었으며, 이들은 총 24가지 유형으로 분류되었으나 플라스미드 프로파일과 항생제 내성 간의 뚜렷한 상관관계는 관찰되지 않았다.

• Journal of Microbiology and Biotechnology
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• 제24권10호
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• pp.1445-1454
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• 2014

Severe acute respiratory syndrome (SARS), a disease that spread widely in the world during late 2002 to 2004, severely threatened public health. Although there have been no reported infections since 2004, the extremely pathogenic SARS coronavirus (SARS-CoV), as the causative agent of SARS, has recently been identified in animals, showing the potential for the re-emergence of this disease. Previous studies showed that 27 single nucleotide polymorphism (SNP) mutations among the spike (S) gene of this virus are correlated closely with the SARS pathogenicity and epidemicity. We have developed a SNP DNA microarray in order to detect and genotype these SNPs, and to obtain related information on the pathogenicity and epidemicity of a given strain. The microarray was hybridized with PCR products amplified from cDNAs obtained from different SARS-CoV strains. We were able to detect 24 SNPs and determine the type of a given strain. The hybridization profile showed that 19 samples were detected and genotyped correctly by using our microarray, with 100% accuracy. Our microarray provides a novel method for the detection and epidemiological surveillance of SARS-CoV.

• 한국기계가공학회지
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• 제19권1호
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• pp.11-18
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• 2020

The emergence of the flow-through cell (FTC) method has made up for the limitations of previous dissolution test methods, but the high cost of the FTC dissolution devices have seriously hindered the progression of research and application of the FTC. This new design uses a peristaltic pump to simulate the sinusoidal flow rate of a piston pump. The flow profile of each peristaltic pump was sinusoidal with a pulsation of 120 ± 1 pulses per minute, and the flow rate ranged from 1.0 - 36.0 mL/min. The flow control of each channel was adjusted independently so the flow errors of the seven channels were close to 2%. The structure of the system was simplified, and the cost was reduced through manual sampling and immersing the FTC in a water bath. The dissolution rate of the theophylline and aminophylline films was determined, and good experimental results were obtained.

• 천문학회보
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• 제36권2호
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• pp.80.2-80.2
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• 2011

The sudden decrease of galactic cosmic ray (GCR) intensity observed by ground neutron monitor (NM) is called a Forbush decrease (FD) event. The intensity time profile of FD event looks like the geomagnetic storm visualized by geomagnetic storm index Dst. Oh et al. [2008] and Oh and Yi [2009] classified the FD events into two kinds by criteria of the overlapping simultaneity of main phase in universal time (UT). The FD event is defined simultaneous if the main phase parts observed by the stations distributed evenly around the Earth are overlapped in UT and non-simultaneous if ones are overlapped in each station's local time (LT). They suggested the occurrence mechanisms of two kind FD events related to the interplanetary magnetic structures such as the interplanetary shock (IP shock) and magnetic cloud. According to their model, the simultaneity of FD depends on the strength and propagation direction of interactive magnetic structures overtaking the Earth. Now the STEREO mission can visualize the emergence and propagation direction of the coronal mass ejection (CME) in 3-dimension in the heliosphere. Thus, it is possible to test the suggested mechanisms causing two different types of FD events. One simultaneous FD observed on February 17, 2011 may be caused by a CME heading directly toward the Earth observed on February 15, 2011 by the STEREO mission. The simultaneity of FD event is proved to be a useful analysis tool in figuring out the geo-effectiveness of solar events such as interplanetary CMEs and IP shocks.