• Journal of the Korean earth science society
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• v.36 no.4
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• pp.404-416
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• 2015

We investigated the cognitive frame of high school students and inservice high school science teachers about effective teaching method, and we also explored how they understood about the teaching methods suggested by the 2009 revised Science Curriculum. Data were collected from 275 high school science teachers and 275 high school students. We analyzed data in terms of the words and the cognitive frame using the Semantic Network Analysis. The results were as follows. First, the teachers perceived that an activity oriented class was the effective science class that helped improve students' problem-solving abilities and their inquiry skills. The students had the cognitive frame that their teacher had to present relevant and enough teaching materials to students, and that they should also receive assistance from teachers in science class to better prepare for college entrance exam. Second, both students and teachers retained the cognitive frame about the efficient science class that was not reflected 2009 revised Science Curriculum exactly. Especially, neither groups connected the elements of 'convergence' as well as 'integration' embedded across science subject areas to their cognitive frame nor cognized the fact that many science learning contents were closed related to one another. Therefore, various professional development opportunities should be offered so that teachers succinctly comprehend the essential features and the intents of the 2009 revised Science Curriculum and thereby implement it in their science lessons effectively.

• Journal of KIISE
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• v.41 no.11
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• pp.943-957
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• 2014

Removing noise, called denoising, is an essential factor for the more intuitive and more accurate results in boundary image matching. This paper deals with a partial denoising problem that tries to allow a limited amount of partial noise embedded in boundary images. To solve this problem, we first define partial denoising time-series which can be generated from an original image time-series by removing a variety of partial noises and propose an efficient mechanism that quickly obtains those partial denoising time-series in the time-series domain rather than the image domain. We next present the partial denoising distance, which is the minimum distance from a query time-series to all possible partial denoising time-series generated from a data time-series, and we use this partial denoising distance as a similarity measure in boundary image matching. Using the partial denoising distance, however, incurs a severe computational overhead since there are a large number of partial denoising time-series to be considered. To solve this problem, we derive a tight lower bound for the partial denoising distance and formally prove its correctness. We also propose range and k-NN search algorithms exploiting the partial denoising distance in boundary image matching. Through extensive experiments, we finally show that our lower bound-based approach improves search performance by up to an order of magnitude in partial denoising-based boundary image matching.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.11
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• pp.870-877
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• 2020

A suction bucket foundation, especially useful at depths of more than 20m, is a method of construction. The method first places an empty upturned bucket at the target site. Then, the bucket is installed by sucking water or air into it to create negative pressure. For stability, it is crucial to secure the verticality of the bucket. However, inclination by the bucket may occur due to sea-bottom conditions. In general, a repeated intrusion-pulling method is used for securing verticality. However, it takes a long time to complete the job. In this paper, we propose a real-time suction bucket verticality monitoring system. Specifically, the system consists of a sensor unit that collects raw verticality data, a controller that processes the data and wirelessly transmits the information, and a display unit that shows verticality information of a circular steel pipe. The system is implemented using an inclination sensor and an embedded controller. Experimental results show that the proposed system can efficiently measure roll/pitch information with a 0.028% margin of error. Furthermore, we show that the system properly operates in a suction bucket-based model experiment.

• Journal of Gastric Cancer
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• v.9 no.3
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• pp.88-95
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• 2009

Purpose: p53 and bcl-2 are important markers of apoptosis. The expression of p53 and bcl-2 in gastric adenocarcinoma was examined in relation to prognosis and survival rate. Materials and Methods: The clinicopathologic data from 238 patients who underwent gastrectomies for gastric adenocarcinoma between December 1999 and July 2007 were reviewed. Immunohistochemical staining of gastric adenocarcinoma tissues embedded in paraffin blocks was performed using an Envision kit (DAKO, Glostrup, Denmark). Statistical comparisons were made between age, gender, tumor invasion, lymph node metastasis, TNM stage, Lauren's classification, cell differentiation, and the relationship with p53 and bcl-2. Results: The expression of p53 was related to cell differentiation (P=0.028) and UICC TNM stage (P<0.001). The expression of bcl-2 was related to UICC TNM stage (P=0.005). The co-expression of p53 and bcl-2 was related to UICC TNM stage (P=0.002). The co-expression group exhibited a greater reduction in the survival rate (P=0.001). Conclusion: The expression of p53 and bcl-2 nuclear proteins has significant relationships with other conventional prognostic factors and the survival rate. bcl-2 will be characterized through analysis of a greater number of patients and comparison with survival data over a longer period of time.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.45 no.6
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• pp.80-88
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• 2008

In this paper, the block cipher algorithms, 3-DES(Triple Data Encryption Standard), AES(Advanced Encryption Standard), SEED, HASH(SHA-1), which are domestic and international standards, have been implemented as an integrated cryptographic engine for smart card applications. For small area and low power design which are essential requirements for portable devices, arithmetic resources are shared for iteration steps in each algorithm, and a two-level clock gating technique was used to reduce the dynamic power consumption. The integrated cryptographic engine was verified with ALTERA Excalbur EPXA10F1020C device, requiring 7,729 LEs(Logic Elements) and 512 Bytes ROM, and its maximum clock speed was 24.83 MHz. When designed by using Samsung 0.18 um STD130 standard cell library, the engine consisted of 44,452 gates and had up to 50 MHz operation clock speed. It was estimated to consume 2.96 mW, 3.03 mW, 2.63 mW, 7.06 mW power at 3-DES, AES, SEED, SHA-1 modes respectively when operating at 25 MHz clock. We found that it has better area-power optimized structure than other existing designs for smart cards and various embedded security systems.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.3
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• pp.1061-1075
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• 2016

Context: There are no recent authoritative data about incidence and prevalence of various types of cancers in Pakistan. Aim: To determine the frequency of malignant tumors seen in our practice and provide a foundation for building a comprehensive cancer care strategy. Materials and Methods: 10,000 successive cases of solid malignant tumors reported in 2014 were included. All cases had formalin fixed, paraffin embedded specimens available and diagnosis was based on histological examination of H&E stained slides plus ancillary studies at the Section of Histopathology, Department of Pathology and Laboratory Medicine, Aga Khan University Hospital, Karachi. The latest WHO classifications were used along with the latest CAP protocols for reporting and the most updated TNM staging. Results: There were 9,492 (94.9%) primary tumors while 508 (5.1%) were metastatic. Some 5,153 (51.5%) were diagnosed in females and 4,847 (48.5%) in males. The commonest malignant tumors in females were breast (32%), esophagus (7%), lymphomas (6.8%), oral cavity (6.7%) and ovary (4.8%), while in males they were oral cavity (13.9%), lymphomas (12.8%), colorectum (7.9%), stomach (6.9%) and esophagus (6.6%). Malignant tumors were most common in the 5th, 6th and 7th decades. About 8% were seen under 20 years of age. Conclusions: Oral cavity and gastrointestinal cancers continue to be extremely common in both genders. Breast and esophageal cancers are prevalent in females. Lung and prostate cancer are less common than in the west. Ovarian cancer was very common but cervix cancer was less so.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.46 no.3
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• pp.41-50
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• 2009

The flash memory has many advantages such as low power consumption, strong shock resistance, fast I/O and non-volatility. And it is increasingly used in the mobile storage device. Many researchers are studying the YAFFS, NAND flash file system, which is widely used in the embedded device. However, the existing YAFFS has two problems. First, it takes long time to mount the YAFFS file system because it scans whole spare areas in all pages. Second, the cleaning policy of the YAFFS does not consider the wear-leveling so that it cannot guarantee the duration of data completely. In order to solve these problems, this paper proposes a new content-based YAFFS that consists of a mounting time reduction technique and a content-cleaning policy by using content-based block management. The proposed method only scans partial spare areas of some special pages and provides the block swapping which enables the wear-leveling of data blocks. We performed experiments to compare the performance of the proposed method with those of the JFFS2 system and YAFFS system. Experimental results show that the proposed method reduces the average mounting time by 82.2% comparing with JFFS2 and 42.9% comparing with YAFFS. Besides, it increases the life time of the flash memory by 35% comparing with the existing YAFFS whereas no overheat is added.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.13
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• pp.5449-5454
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• 2014

Although genetic characteristics are considered to be a factor influencing the geographic variation in the prevalence of gallbladder cancer (GBC), they have not been well studied in Bolivia, which has a high prevalence rate of GBC. The purpose of this study was to examine the frequency of TP53 and K-ras mutations in Bolivian patients with GBC and to compare them with our previous data obtained in other high-GBC-prevalence countries, namely Japan, Chile, and Hungary. DNA was extracted from cancer sites in paraffin-embedded tissue from 36 patients using a microdissection technique. TP53 mutations at exons 5 to 8 and K-ras mutations at codons 12, 13 and 61 were examined using direct sequencing techniques. The data obtained were compared with those in the other high-GBC-prevalence countries. Of the 36 patients, 18 (50.0%) had a TP53 mutation (one mutation in each of 17 patients and three mutations in one patient), and only one (2.8%) had a K-ras mutation. Of the 20 TP53 mutations, 12 were of the transition type (60.0%). This rate was significantly lower than that in Chile (12/12, P<0.05). In addition, three mutations were of the CpG transition type (15.0%), which is a feature of endogenous mutation. All three were found in the hot spot region of the TP53 gene. In contrast, G:C to T:A transversion was found in Bolivia, suggesting the presence of exogenous carcinogens. Our findings suggest that the development of GBC in Bolivia is associated with both exogenous carcinogens and endogenous mechanisms. The identification of an environmental risk factor for GBC is needed to confirm these findings.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.sup3
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• pp.155-160
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• 2016

Breast cancer (BC) is the second most common cancer in the world and by far the most frequent cancer among women, with an estimated 1.67 million new cancer cases diagnosed in 2012 (25% of all cancers). Polygene expression analysis is used to predict the prognosis and determine the most appropriate treatment regimen. The objective of this study was to examine the gene expression profiles of SIRT3, HRAS, LSP1, SCUBE2 and AP2A2 in Iranian women with BC.A total of 136 patients including healthy controls were categorized into three groups based on the relapse of the disease. Expression of desired genes in formalin-fixed, paraffin embedded tissues collected from all groups of participants was analyzed via the RT PCR method. RNA extraction and cDNA synthesis were performed then real-time quantitative PCR was carried out. Gene expression analysis revealed that the expression of SIRT3 was equal among patient and control groups. LSP1 was down regulated in all patient groups relative to controls but reduced expression in the metastatic group relative to the non-metastatic one was not significant. HRAS was significantly overexpressed in total and metastatic tumor samples versus normal but not in non-metastatic cases. SCUBE2 expression showed significant over-expression in both overall tumor samples and the non-metastatic group as compared to normal tissues. Gene expression level of AP2A2 in all groups was not detectable. Our data are compatible with a tumor suppressor role of LSP1 related to potential prognostic factor for tumor recurrence and outcome. This study for the first time assayed the prognostic value and changes in the expression of SIRT3, LSP1, HRAS, SCUBE2 and AP2A2 genes in women with breast cancer in the Iranian population and findings confirmed potential biomarker and prognostic capability of these genes. Such expression profiling data can critically improve prognosis and treatment decisions in cancer patients.

• The KIPS Transactions:PartA
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• v.12A no.5 s.95
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• pp.451-460
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• 2005

We present a methodology to design energy-efficient data paths using FPGAs. Our methodology integrates domain specific modeling, coarse-grained performance evaluation, design space exploration, and low-level simulation to understand the tradeoffs between energy, latency, and area. The domain specific modeling technique defines a high-level model by identifying various components and parameters specific to a domain that affect the system-wide energy dissipation. A domain is a family of architectures and corresponding algorithms for a given application kernel. The high-level model also consists of functions for estimating energy, latency, and area that facilitate tradeoff analysis. Design space exploration(DSE) analyzes the design space defined by the domain and selects a set of designs. Low-level simulations are used for accurate performance estimation for the designs selected by the DSE and also for final design selection We illustrate our methodology using a family of architectures and algorithms for matrix multiplication. The designs identified by our methodology demonstrate tradeoffs among energy, latency, and area. We compare our designs with a vendor specified matrix multiplication kernel to demonstrate the effectiveness of our methodology. To illustrate the effectiveness of our methodology, we used average power density(E/AT), energy/(area x latency), as themetric for comparison. For various problem sizes, designs obtained using our methodology are on average $25\%$ superior with respect to the E/AT performance metric, compared with the state-of-the-art designs by Xilinx. We also discuss the implementation of our methodology using the MILAN framework.