• Transactions of the Korean Society of Automotive Engineers
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• v.24 no.4
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• pp.392-400
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• 2016

In this paper, a study based on engine operating conditions versus hybrid excavator engines was conducted about the engine performance and fuel consumption via the 1-D engine simulation model. First of all, engine operating points with performance and emission were determined by driving patterns. The 1-D HFEM(High Frequency Engine Model) was developed for deep insight into engine combustion and the energy conversion phenomena. In accordance with changing operating points, especially High Idle and Rated output conditions, engine parameters and systems such as turbocharger(Waste Gate Turbocharger and Variable Geometry Turbocharger) injection strategies and EGR(Exhaust Gas Recirculation) should be considered. Therefore, various configurations and parametric analysis with optimization methods in hybrid excavator were simulated and optimized by NLPQL(Non-linear Programming by Quadratic Lagrangian algorithm) in 1-D HFEM. As a result, the fuel consumption with the developed hybrid electric excavator engine could be significantly decreased and bsfc(Brake Specific Fuel Consumption) was also reduced about 5 % to 7 % without any performance degradation.

• Journal of Institute of Convergence Technology
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• v.7 no.1
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• pp.15-18
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• 2017

As emission gas regulation of deisel vehicles is strengthened to Euro-6, It becomes difficult to deal with NOx regulated value mainly by EGR without additional after-treatment system. In addition, RDE(Real Driving Emissions) test will be introduced after september 2017. Therefore, It is essential to develop the after-treatment of diesel vehicles which reduce NOx emissions. It is possible to use DOC, DPF, LNT or DOC, DPF and SCR as a after-treatment system for reducing NOx. However, It is expected that the SCR will be applied widely because LNT alone does not have sufficient NOx purification efficiency. In this study, It tried to analyze the efficiency of reducing NOx emissions during the mode test by attaching a NOx sensor to test vehicle. As a result, It was confirmed that NOx emissions was significantly reduce through the after-treatment system from engine. And the NOx reduction efficiency of SCR was about 4.5 times better than DOC, DPF.

• Transactions of the Korean hydrogen and new energy society
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• v.19 no.6
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• pp.474-481
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• 2008

수소 기관에서 역화없이 고성능과 저$NO_x$를 실현시키기 위하여 밸브 타이밍 변화에 따른 흡기관 분사식 수소 기관의 성능을 파악하고 가솔린의 경우와 비교하였다. 그 결과 흡기밸브 타이밍은 역화억제와 성능향상에 큰 영향을 미치는 것을 확인하였다. 흡기밸브타이밍의 진각은 역화를 억제하며 효율과 출력을 동시에 향상된다. 비록 흡기밸브 타이밍 변화에 의해 NOx는 증가하지만, 희박영역인 출 ${\Phi}=0.5$에서 현저히 감소된다. 또한 열효율은 ${\Phi}=0.5$ 토크는 ${\Phi}=1.0$에서 가장 높게 나타난다. 흡기밸브 타이밍을 $ATDC20^{\circ}$에서 TDC로 변화시켰을 때, ${\Phi}=1.0$에서 토크는 약 28% 증가되고, ${\Phi}=0.5$에서 효율은 약 7%향상된다.

• Transactions of the Korean hydrogen and new energy society
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• v.27 no.1
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• pp.106-113
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• 2016

Lean burn engine, classified into port injection and direct injection, is recognized as a promising way to meet better fuel economy. Especially, LPG direct injection engine is becoming increasingly popular due to their potential for improved fuel economy and emissions. Also, LPDi engine has the advantages of higher power output, higher thermal efficiency, higher EGR tolerance due to the operation characteristics of increased volumetric efficiency, compression ratio and ultra-lean combustion scheme. However, LPDi engine has many difficulties to be solved, such as complexity of injection control mode (fuel injection timing, injection rate), fuel injection pressure, spark timing, unburned hydrocarbon and restricted power. This study is investigated to the influence of spark timing, fuel injection position and fuel injection rate on the combustion stability of LPDi engine. Piston shape is constituted the bowl type piston. The characteristics of combustion is analyzed with the variations of spark timing, fuel injection position and fuel injection rate (early injection, late injection) in a LPDi engine.

• Journal of Life Science
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• v.14 no.1
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• pp.26-31
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• 2004

Redox factor-1 (Ref-1), known as a redox regulator, controls the DNA binding of AP-1 and is activated in HT29 colon cancer cells by hypoxia in vitro. REF-1 also increases tile DNA binding affinity of Hypoxia-inducible Factor-lalpha$ (HIF-lalpha$), HIF-like Factor (HLF) and early growth response-1 (Egr-1) which induce expression of the genes involved in angiogenesis, so that we speculate that REF-1 may play a role in hypoxia-induced angiogenesis. In this research we tried to detect novel proteins interacting with REF-1 using Yeast two-hybrid system using full-length REF-1 cDNA as bait. As result of such screening we detected 3 positive clones. DNA sequencing and GeneBank search revealed that one of the clones contained the same sequences as M.musculus cDNA for tioredoxin.

• BMB Reports
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• v.39 no.6
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• pp.649-655
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• 2006

The NSAID activated gene (NAG-1), a member of the TGF-$\beta$ superfamily, is involved in tumor progression and development. The over-expression of NAG-1 in cancer cells results in growth arrest and increase in apoptosis, suggesting that NAG-1 has anti-tumorigenic activity. This conclusion is further supported by results of experiments with transgenic mice that ubiquitously express human NAG-1. These transgenic mice are resistant to the development of intestinal tumors following treatment with azoxymethane or by introduction of a mutant APC gene. In contrast, other data suggest a pro-tumorigenic role for NAG-1, for example, high expression of NAG-1 is frequently observed in tumors. NAG-1 may be like other members of the TGF-$\beta$ superfamily, acting as a tumor suppressor in the early stages, but acting pro-tumorigenic at the later stages of tumor progression. The expression of NAG-1 can be increased by treatment with drugs and chemicals documented to prevent tumor formation and development. Most notable is the increase in NAG-1 expression by the inhibitors of cyclooxygenases that prevent human colorectal cancer development. The regulation of NAG-1 is complex, but these agents act through either p53 or EGR-1 related pathways. In addition, an increase in NAG-1 is observed in inhibition of the AKT/GSK-$3{\beta}$ pathway, suggesting NAG-1 alters cell survival. Thus, NAG-1 expression is regulated by tumor suppressor pathways and appears to modulate tumor progression.

• BMB Reports
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• v.50 no.11
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• pp.590-595
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• 2017

High-mobility group box-1 (HMGB-1) is expressed in almost all cells, and its dysregulated expression correlates with inflammatory diseases, ischemia, and cancer. Some of these conditions accompany HMGB-1-mediated abnormal angiogenesis. Thus far, the mechanism of HMGB-1-induced angiogenesis remains largely unknown. In this study, we performed time-dependent DNA microarray analysis of endothelial cells (ECs) after HMGB-1 or VEGF treatment. The pathway analysis of each gene set upregulated by HMGB-1 or VEGF showed that most HMGB-1-induced angiogenic pathways were also activated by VEGF, although the activation time and gene sets belonging to the pathways differed. In addition, HMGB-1 upregulated some VEGFR signaling-related angiogenic factors including EGR1 and, importantly, novel angiogenic factors, such as ABL2, CEACAM1, KIT, and VIPR1, which are reported to independently promote angiogenesis under physiological and pathological conditions. Our findings suggest that HMGB-1 independently induces angiogenesis by activating HMGB-1-specific angiogenic factors and also functions as an accelerator for VEGF-mediated conventional angiogenesis.

• Transactions of the Korean Society of Automotive Engineers
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• v.19 no.1
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• pp.117-124
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• 2011

Automotive engines require strategies to fulfill the emission regulations in terms of NOx and PM. A dramatic reduction in NOx and PM emissions could be achieved with high pressure injection, innovative combustion strategies and EGR. Recently, Lean NOx Trap (LNT) and Urea-SCR are considered as more practical strategy to suppress the engine-out emissions substantially for copying with severe regulation. These systems need to reduce the reducing agent injection system which has a huge impact on NOx purification efficiency. In this paper, different three injectors have been used to investigate spray characteristics and engine emission test was conducted to clarify the effect of these injectors on the NOx reduction.

• Transactions of the Korean Society of Automotive Engineers
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• v.19 no.4
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• pp.72-77
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• 2011

This study is to investigate the effect of the distillation temperature in ultra low sulfur diesel fuel on exhaust emissions in the low-temperature diesel combustion with 1.9L common rail direct injection diesel engine. Low temperature diesel combustion was achieved by adopting an external high EGR rate with a strategic injection control. The engine was operated at 1500 rpm 2.6 bar BMEP. The 90% distillation recovery temperature (T90) was $270^{\circ}C$ and $340^{\circ}C$ for the respective cetane number (CN) 30 and 55. It was found that there exists no distinctive discrepancy on exhaust emissions with regards to the different T90s. The high CN (CN55) fuels follow the similar trend of exhaust emissions as observed in CN30 fuels' except that high T90 fuel (CN55-T340) produced higher PM compared to low T90 fuel (CN55-T270). This may come from that high T90 plays an active role in aggravating the degree of fuel-air mixture preparedness before ignition.

• Biomolecules & Therapeutics
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• v.30 no.6
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• pp.593-602
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• 2022

The human papillomavirus (HPV)-18 E7 (E7) oncoprotein is a major transforming protein that is thought to be involved in the development of cervical cancer. It is well-known that E7 stimulates tumour development by inactivating pRb. However, this alone cannot explain the various characteristics acquired by HPV infection. Therefore, we examined other molecules that could help explain the acquired cancer properties during E7-induced cancer development. Using the yeast two-hybrid (Y2H) method, we found that the Elk-1 factor, which is crucial for cell proliferation, invasion, cell survival, anti-apoptotic activity, and cancer development, binds to the E7. By determining which part of E7 binds to which domain of Elk-1 using the Y2H method, it was found that CR2 and CR3 of the E7 and parts 1-206, including the ETS-DNA domain of Elk-1, interact with each other. As a result of their interaction, the transcriptional activity of Elk-1 was increased, thereby increasing the expression of target genes EGR-1, c-fos, and E2F. Additionally, the colony forming assay revealed that overexpression of Elk-1 and E7 promotes C33A cell proliferation. We expect that the discovery of a novel E7 function as an Elk-1 activator could help explain whether the E7 has novel oncogenic activities in addition to p53 inactivation. We also expect that it will offer new methods for developing improved strategies for cervical cancer treatment.