• Asian Pacific Journal of Cancer Prevention
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• v.15 no.22
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• pp.9813-9815
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• 2014

Background: This analysis was conducted to evaluate the efficacy and safety of cisplatin based chemotherapy for treating patients with cutaneous squamous cell carcinoma. Methods: Clinical studies evaluating the efficacy and safety of cisplatin based regimens on response and safety for patients with cutaneous squamous cell carcinoma were identified using a predefined search strategy. Pooled response rates (RR) of treatment were calculated. Results: In cisplatin based regimens, 4 clinical studies which including 50 patients with advanced cutaneous squamous cell carcinoma were considered eligible for inclusion. Regimens included cisplatin, doxorubicin, or vindesine. Pooled analysis suggested that, in all patients, the pooled RR was 60% (30/50) in cisplatin based regimens. Nausea and vomiting were the main side effects. No grade III or IV renal or liver toxicity were observed. No treatment related death occurred with the cisplatin based treatments. Conclusion: Evidence based analysis suggests that cisplatin based regimens are associated with a good response rate and acceptable toxicity for treating patients with cutaneous squamous cell carcinoma.

• Journal of KSNVE
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• v.10 no.3
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• pp.480-485
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• 2000

This paper presents the application of the substrctural analysis based on the frequency responses for the prediction of the interior noise in a car. The complex trimmed body with the high modal density is presented by the experimental data. Finite element model presents the powertrain and its subframes with the lower modal density. The substructural analysis based on the frequency responses combines the frequency response functions from the numerical analysis and the experiments. It describes the interior noise successwfully. Using this method we can pick up the most dominant paths for the booming noise and predict the effects of the design changes easily.

• Proceedings of the Korea Concrete Institute Conference
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• 2002.05a
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• pp.285-290
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• 2002

The double composite box girder is a structural system filled with concrete at the bottom of the steel box in the negative moment region increasing the flexural strengths. Flexural strengths of the double composite steel box girders are investigated through a series of the experimental tests and the numerical analysis. The experimental tests are performed on the three kinds of steel box girders with the different concrete depths including loom, 15cm, and 20cm. Moment-curvature relations are calculated based on the sectional analysis method describing the nonlinear natures of concrete and steel. In the finite element analysis the nonlinear nature of concrete is described based on the three dimensional four-parameter constitutive model recently developed and that of steel is described based on von Mises failure criterion. The ultimate flexural capacities of the box girders predicted using sectional analysis and finite element analysis show good agreement with those of the experiments.

• 한국전산유체공학회:학술대회논문집
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• 2001.05a
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• pp.1-8
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• 2001

A CFD-based design method for transonic axial compressor blades was developed based on three-dimensional Navier-Stokes flow physics. The method employs a sectional three-dimensional (S3D) analysis concept where the three-dimensional flow analysis is performed on the grid plane of a span station with spanwise flux components held fixed. The S3D analysis produced flow solutions nearly identical to those of three-dimensional analysis, regardless of the initialization of the flow field. The sectional design based on the S3D analysis can include three-dimensional effects of compressor flows and thus overcome the deficiencies associated with the use of quasi-three-dimensional flow physics in conventional sectional design. The S3D design was first used in the inverse triode to find the geometry that produces a specified target pressure distribution. The method was also applied to optimize the adiabatic efficiency of the blade sections of Rotor 37. A new blade was constructed with the optimized sectional geometries at several span stations and its aerodynamic performance was evaluated with three-dimensional analyses.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2004.05a
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• pp.712-717
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• 2004

Recently, the concern for the environmental noise has increased due to the growing of the living standard. The environmental noise regulations based on the equivalent noise level are widely used. However, the noise level, which Is based mainly on the magnitude with A-weighting, the important characteristics of noises in frequency and time domains and the impulsive nature cannot be assessed properly. These can have substantial effects on how human respond to noise. Therefore, the noise evaluation methodology based on the sound quality rather than the equivalent noise level can be more suitable to represent human response to the environmental noise. This paper describes the study on environmental noise quality analysis for various noises. A cluster analysis was carried out and the noises were classified into several clusters using the values of sound quality metrics. The classification was confirmed by comparing time and frequency characteristics of the noises. And then the result of Jury testing was analysis.

• Journal of the Korea Society of Computer and Information
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• v.20 no.3
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• pp.177-184
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• 2015

This study aims to identify the effects of job factors related to children's teachers on job satisfaction and present suggestions through an analysis of the modulating effects according to the type of institute. In order to achieve this purpose, this study set up a cause and effect model on teacher's efficacy, emotional intelligence, friendship, and a reward system as factors of job satisfaction and analysed them based on interviews using a questionnaire. To look into the results of the analysis, it was discovered that a reward system had the greatest effect on job satisfaction for the subjects, followed by emotional intelligence, friendship, and teacher's efficacy. In an analysis of modulating effects according to the type of institute, the effect of emotional intelligence differed significantly depending on kindergartens and day care centers. Teacher's efficacy, friendship and a reward system were not significantly different. Based on the results above, this study provides basic data for the development of strategies for children's teachers to effectively achieve job satisfaction.

• Journal of Rheumatic Diseases
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• v.24 no.4
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• pp.192-202
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• 2017

Objective. Rebampide is a gastroprotective agent used to treat gastritis. It possesses anti-inflammatory and anti-arthritis effects, but the mechanisms of these effects are not well understood. The objective of this study was to explore mechanisms underlying the therapeutic effects of rebamipide in inflammatory arthritis. Methods. Collagen-induced arthritis (CIA) was induced in DBA/1J mice. DBA/1J mice were immunized with chicken type II collagen, then treated intraperitoneally with rebamipide (10 mg/kg or 30 mg/kg) or vehicle (10% carboxymethylcellulose solution) alone. Seven weeks later, plasma samples were collected. Plasma metabolic profiles were analyzed using ultra performance liquid chromatography/quadrupole time-of-flight mass spectrometry-based metabolomics study and metabolite biomarkers were identified through multivariate data analysis. Results. Low dose rebamipide treatment reduced the clinical arthritis score compared with vehicle treatment, whereas high dose rebamipide in CIA aggravated arthritis severity. Based on multivariate analysis, 17 metabolites were identified. The plasma levels of metabolites associated with fatty acids and phospholipid metabolism were significantly lower with rebamipide treatment than with vehicle. The levels of $15-deoxy-^{{\Delta}12,14}$ prostaglandin J2 and thromboxane B3 decreased only in high dose-treated groups. Certain peptide molecules, including enterostatin (VPDPR) enterostatin and bradykinin dramatically increased in rebamipide-treated groups at both doses. Additionally, corticosterone increased in the low dose-treated group and decreased in the high dose-treated group. Conclusion. Metabolomics analysis revealed the anti-inflammatory effects of rebamipide and suggested the potential of the drug repositioning in metabolism- and lipid-associated diseases.

• Physical Therapy Korea
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• v.10 no.3
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• pp.91-107
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• 2003

We processed meta-analysis to test if the effects of laser therapy and mobilization techniques are evidence-based practice for treating tennis elbow. By researching and collecting the results of previous studies on tennis elbow, we inquired into the difference in the effects of each treatment methods on pain, grip strength, and ROM. A total of 10 international and domestic articles on the treatments of tennis elbow were selected for this study, including 7 articles on the effect of laser therapy and 3 on mobilization techniques. According to the qualitative meta-analysis, all 7 of the articles on laser therapy and 1 of the mobilization technique were double-blinded and randomized the subjects, and all of the 10 studies were designed in a high quality research, using statistics. The results of the studies on laser therapy showed in terms of statistical significance: 4 out of 7 did not decrease pain after therapy, and 3 out of 5 did not increase grip strength after therapy. In the studies on the effects of mobilization technique, both the 2 studies significantly increased grip strength after therapy. For other studies which measured ROM and tension, the mobilization therapy increased ROM significantly, and decreased tension significantly. The results of our study are shown in a diverse form in terms of the effects of different therapy techniques. This is related to the accuracy of the measurement tools for assessments and diagnoses. Further qualitative studies on the evidence-based practice and researches on tennis elbow are needed.

• Journal of the Korean Dietetic Association
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• v.26 no.2
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• pp.153-173
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• 2020

The purpose of this study was to objectively quantify the effects of nutrition and dietary life education on preschoolers through meta-analysis. In addition, it provides basic data for the implementation of nutrition education and development of systematic nutrition and dietary life education programs. In this study, a meta-analysis of 27 papers was conducted that conformed to the selection criteria in the study conducted from January 2012 to August 2019 to derive objective data on the effects of education. As a result of the analysis, the overall effective size of nutrition and dietary life education for preschoolers was 0.829, which indicates a strong effect. According to the education method, the effect size of general education was 0.562, which indicates a medium effect size, the vegetable playing-based experience education was 0.685, which indicates a medium effect size, and cooking activity-based experience education was 1.101, which indicates a large effect size. Judging from this result, experience activity education was more effective than general nutrition education. In addition, the combined size of convergence education conducted through a combination of general and experience education was found to be the most effective at 1.301. In terms of educational effect, it was confirmed that the effect size was 0.898 for improving nutrition knowledge, 0.858 for improving dietary habits, 0.836 for improving unbalanced diet, and 0.756 for improving food preference and intake, and the sizes of effects were all found to be large. As frequency of education increased, the number of education participants decreased and the effect of education increased.

• Journal of the Society of Naval Architects of Korea
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• v.57 no.2
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• pp.70-79
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• 2020

The offshore installation units may be subjected to various accidental loads such as collision from supply vessels, impact from dropped objects, blast load from gas explosion and thermal load from fire. This paper deals with the design and strength evaluation method of the stiffened plate structures in response to a blast load caused by a gas explosion accident. It is a comprehensive review of various items used in actual project such as the size and type of the explosive loads, general design procedure/concept and analysis method. The structural analyses using simple analysis methods based on SDOF model and nonlinear finite element analysis are applied to the particular FPSO project. Also validation studies on the design guidance given by simple analysis method based on SDOF model have also considered several items such as backpressure effects, material behavior and duration time of the overpressure. A good correlation between the prediction made by simple analysis method based on SDOF model and nonlinear finite element analysis can be generally obtained up to the elastic limit.