• Biomolecules & Therapeutics
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• v.13 no.2
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• pp.113-117
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• 2005

Organosulfur compounds have been shown to exert an anti-cancer activity. In an attempt to develop novel chemopreventive and anti-cancer agents for liver cancer, we synthesized allylthiopyridazine derivatives. We have previously shown that allylthiopyridazine derivatives exert inhibitory effects on proliferation, invasion and migration of SK-Hep-1 hepatocarcinoma cells in vitro. The in vivo anti-tumor effect of 3-methvl-6-allylthiopy-ridazine, named as K6, was also reported. In this study, we further investigated the preclinical anti-cancer efficacy of K6 for hepatocarcinoma using nude mice xenografted with Hep-G2 hepatocellular carcinoma cells. K6(20-100 mg/kg, orally administered everyday for 30 days) markedly decreased the tumor volume of Hep-G2 cell-transplanted nude mice as evidenced by ultrasonographic and plethysmogranhic analyses. The inhibitory effect on tumor volume was lower than that exerted by doxorubicin (2 mg/kg), intravenously injected) which was used as a positive control. This study shows that K6 efficiently suppresses xenograft tumor growth, revealing K6 as apotential anti-cancer agent for suppressing in vivo progression of liver cancer. Given that hepatocarcinoma is among the most prevalent and lethal malignancies and there is no effective treatment to date, our study may contribute to the potential drug development for liver cancer.

• Proceedings of the KSRS Conference
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• 2005.10a
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• pp.22-25
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• 2005

The 10 Year Implementation Plan for a Global Earth Observation System of Systems (GEOSS), which was endorsed at the Third Earth Observation Summit in Brussels in February, 2005, emphasizes the importance of data management facilities for diverse and large-volume Earth Observation data from inhomogeneous information sources. A three year research plan for addressing this key target of GEOSS has just approved as the first step by the Japanese government. The goals of this research are, (1) to develop a data management core system consisting of data integration and information fusion functions and interoperability and information service functions; (2) to establish data and information flows between data providers and users; (3) to promote application studies of data integration and information fusion, especially in the fields of weather forecasting, flood forecasting, agricultural management, and climate variability and changes. The research group involves leading scientists on information science and technology, who have been developing giant data archive servers, storage area networks, metadata models, ontology for the earth observations. They are closely cooperating with scientists on earth sciences, water resources management, and agriculture, and establishing an effective collaborative research framework.

• Proceedings of the Korea Concrete Institute Conference
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• 2004.05a
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• pp.524-527
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• 2004

Recently, precast concrete products have been increasingly used in the construction of bridges except for special bridges like long-span bridge due to their easy and high-quality construction. Specially the use of precast prestressed concrete hollow box slab bridges is also increased due to the merits in their construction. Thus, an experimental evaluation of flexural behavior of the precast PSC hollow box slab bridges and a development of effective analytical technique for the behavior are necessary. For the development, experimental study on the flexural behavior of the precast bridges up to ultimate states is needed. In this study, two full-scale precast PSC hollow box slab girders are manufactured and full-scale flexural failure tests of the girders subjected to cyclic loading are carried out. For the failure analysis of the girders, the so-called volume control method is applied to finite element analysis of the precast PSC hollow box slab girders discretized using multi-layered shell elements. The analytical results by the volume control method is verified by comparing with test results.

• International Journal of Highway Engineering
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• v.16 no.5
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• pp.121-131
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• 2014

PURPOSES : The goal of this study is to analyze the travel cost according to transferring from rotary to roundabout in Korea. METHODS : This study gives particular attentions to investigating the existing 48 rotaries in Korea and building the networks of before and after improvements using VISSIM, and analyzing their travel costs. RESULTS : The main results are as follows. First, from the field survey, the domestic rotaries were analyzed to need many improvements of geometric structure for the effective operation. Second, the difference of travel cost at 3-legged rotaries were evaluated to be less than other types of rotaries due to low traffic volume. Finally, the travel cost of 4-legged and multi-legged rotaries were analyzed to rapidly increase by increasing volume. CONCLUSIONS : This study analyzes the effects using both real and simulation data unlike the existing studies. Also, this study suggests the future research topics which compare and evaluate the relations between real data and simulation outputs.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.23 no.8
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• pp.124-129
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• 2009

Recently, there has been a growing global interest in environmental conservation, and the field of electric power equipment has been working to become more environment-friendly. Accordingly the 154[kV] low noise transformer is developed through the research. The low noise transformer decreases the audible noise level but the low noise transformer has several changes in the increase of weight and volume and the application of rubber damper. Therefore it is necessary to inspect the test, transportation, installation and operation about field application. In this paper, we investigate the standards of the audible noise level, the weight and volume of the transportation, the installation space and operation in order for effective field application.

• Journal of Korean Society for Atmospheric Environment
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• v.8 no.1
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• pp.45-51
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• 1992

A study on acidity in fog, dew and frost was carried out. Samples were taken during May 1990-February 1991 at two sites in Chongwon, Choongbook. The acidity of dew and of fog collected from grass at site A was 4.89 and 5.46, respectively. Dew in summer showed very strong acidity. The volume of dew deposited on grass was much less than the volume of rain, but dew is effective to diffuse acid predursors and acid materials. Dew and fog can remove more effectively atmospheric acid materiasl deoposited on grass by diurnal turbulent motion rather than direct absorption of acid predursors and materials in the atmosphere. In a polluted area, acidic dew and fog can be occurred by the direct absorption and oxidation of acidic predursors in the atmosphere as well as the role of wet removal on grass surface. Acidity of frost collected on teflon surface showed little difference to acidity of dew and fog on teflon surface. This suggests a similar absorption mechanism of atmospheric precursors and materials into dew and frost in the atmosphere. Strong acidity in dew, fog and frost appeared to occur from local pollution sources of several ten kilometres. In particular, strong acidity in dew, fog, and frost together with acid rain can accelerate a damage in ecosystems. Discussion is made on scientific analyses and seasonal variations of acidity of fog, dew and frost. A mechanism on acidification of fog, dew and frost is also discussed.

• Proceedings of the Korean Society of Agricultural Engineers Conference
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• 2001.10a
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• pp.99-105
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• 2001

The purpose of this study is to investigate the effects of pending depth treatment on water balance in paddy fields. The pending depth treatments were very shallow, shallow and deep. The experimental plots were three $80m{\times}25m$ rectangular plots. Daily values of rainfall amount, pending depth, irrigation water, drainage water, evapotranspiration, infiltration, and piezometeric head were measured in the field. The pending depth was continuously observered by water level logger during the growing season. The ET was measured in 1m diameter PVC lysimeters. Irrigation water volume was measured by 75m pipe flow meter and the drainage water volume was measured by 25mm and 75mm pipe flow meters and a recording Parshall fulume. PVC pipe piezometers with 12mm diameter were used. The results of the water balance showed that irrigation water of 881.1mm, 735.4mm, and 532.6mm in very shallow, shallow, and deep pending, respectively. The effective rainfall was 182.6mm(44.6%), 254.7mm(62.2%), and 188.6mm(46.0%) in very shallow, shallow, and deep pending, respectively. The results show that the shallow pending depth looks the best of the three treatments.

• Journal of KIISE:Information Networking
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• v.31 no.5
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• pp.438-449
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• 2004

With the growing deployment of network and internet, the importance of security is also increased. But, recent intrusion detection systems which have an important position in security countermeasure can't provide proper analysis and effective defence mechanism. Instead, they have overwhelmed human operator by large volume of intrusion detection alerts. In this paper, we propose an efficient alert analysis system that can produce high level information by analyzing and processing the large volume of alerts and can detect large-scale attacks such as DDoS in early stage. And we have measured processing rate of each elementary module and carried out a scenario-based test in order to analyzing efficiency of our proposed system.

• Korean Journal of Bronchoesophagology
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• v.5 no.2
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• pp.113-118
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• 1999

Background & Objectives : Nasal resistance which is halfly responsible for airway resistance is known to be influenced by hypoxia, hypercapnia, exercise, pregnancy, alcohol, ammonia and smoking. Smoking is a common part of our sociocultural environment and we have many a times been introduced to its various adverse effects, which have usually been more focused on lung problems. The purpose of this study is to determine any relationship between smoking and nasal resistance and to evaluate it's effective sites. Materials and Methods : Acoustic rhinometry was performed in 25 smokers and 25 nonsmokers who had no nasal symptoms nor abnormal rhinoscopic findings, and used an acoustic rhinometry to measure the distance from nose-piece to the C-notch, cross sectional area at the C-notch, and volume of the nasal cavity from nose-piece to 7cm. The authors compared the data between the two groups. Results : The cross sectional area at the C-notch was significantly decreased(p<0.05) in smoking group. The distance to the C-notch and the volume of nasal cavity were decreased likely in smoking group but there were no significant difference(p>0.05). Conclusion : Smoking reduced the cross sectional area at the C-notch, so increased the nasal resistance. The underlying mechanisms seems to be decreased nasal mucosal reactivity and congestion of the nasal mucosa. The authors believe there should follow more studies on pathophysiologic mechanisms and the histopathologic changes which involve the effect of smoking on nasal structures.

• Korean Journal of Materials Research
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• v.21 no.4
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• pp.196-201
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• 2011

It is known that the relative dielectric constant of insulating polyethylene matrix composites with conducting materials (such as carbon black and metal powder) increases as the conducting material content increases below the percolation threshold. Below the percolation threshold, dielectric properties show an ohmic behavior and their value is almost the same as that of the matrix. The change is very small, but its origin is not clear. In this paper, the dielectric properties of carbon black-filled polyethylene matrix composites are studied based on the effect medium approximation theory. Although there is a significant amount of literature on the calculation based on the theory of changing the parameters, an overall discussion taking into account the theory is required in order to explain the dielectric properties of the composites. Changes of dielectric properties and the temperature dependence of dielectric properties of the composites made of carbon particle and polyethylene below the percolation threshold for the volume fraction of carbon black have been discussed based on the theory. Above the percolation threshold, the composites are satisfied with the universal law of conductivity, whereas below the percolation threshold, they give the critical exponent of s = 1 for dielectric constant. The rate at which the percentages of both the dielectric constant and the dielectric loss factor for temperature increases with more volume fraction below the percolation threshold.