• Title/Summary/Keyword: Effective size

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Estimation of Linkage Disequilibrium and Effective Population Size using Whole Genome Single Nucleotide Polymorphisms in Hanwoo (한우에서 전장의 유전체 정보를 활용한 연관불평형 및 유효집단크기 추정에 관한 연구)

  • Cho, Chung-Il;Lee, Joon-Ho;Lee, Deuk-Hwan
    • Journal of Life Science
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    • v.22 no.3
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    • pp.366-372
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    • 2012
  • This study was conducted to estimate the extent of linkage disequilibrium (LD) and effective population size using whole genomic single nucleotide polymorphisms (SNP) genotyped by DNA chip in Hanwoo. Using the blood samples of 35 young bulls born from 2005 to 2008 and their progenies (N=253) in a Hanwoo nucleus population collected from Hanwoo Improvement Center, 51,582 SNPs were genotyped using Bovine SNP50 chips. A total of 40,851 SNPs were used in this study after elimination of SNPs with a missing genotyping rate of over 10 percent and monomorphic SNPs (10,730 SNPs). The total autosomal genome length, measured as the sum of the longest syntenic pairs of SNPs by chromosome, was 2,541.6 Mb (Mega base pairs). The average distances of all adjacent pairs by each BTA ranged from 0.55 to 0.74 cM. Decay of LD showed an exponential trend with physical distance. The means of LD ($r^2$) among syntenic SNP pairs were 0.136 at a range of 0-0.1 Mb in physical distance and 0.06 at a range of 0.1-0.2 Mb. When these results were used for Luo's formula, about 2,000 phenotypic records were found to be required to achieve power > 0.9 to detect 5% QTL in the population of Hanwoo. As a result of estimating effective population size by generation in Hanwoo, the estimated effective population size for the current status was 84 heads and the estimate of effective population size for 50 generations of ancestors was 1,150 heads. The average decreasing rates of effective population size by generation were 9.0% at about five generations and 17.3% at the current generation. The main cause of the rapid decrease in effective population size was considered to be the intensive use of a few prominent sires since the application of artificial insemination technology in Korea. To increase and/or sustain the effective population size, the selection of various proven bulls and mating systems that consider genetic diversity are needed.

Estimation of Inbreeding Coefficients and Effective Population Size in Breeding Bulls of Hanwoo (Korean Cattle) (한우 씨수소의 근교계수와 유효집단크기의 추정)

  • Dang, Chang-Gwon;Lee, Jung-Jae;Kim, Nae-Soo
    • Journal of Animal Science and Technology
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    • v.53 no.4
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    • pp.297-302
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    • 2011
  • This study was carried out to estimate average inbreeding coefficients, relatedness and effective population size of breeding bulls and to suggest optimal alternatives on problems of current Hanwoo improvement system. Data on proven and young bulls were obtained from 1,128 heads of Livestock Improvement Main Center from 1983 to 2008. Pedigree information on proven and young bulls was obtained from 3,760 heads of Korea Animal Improvement Association. Average inbreeding coefficients and average relatedness of proven and young bulls were estimated at the range of 0.04-0.07%, 0.10-6.82%, respectively. Effective population size was estimated for 220 heads from the average rate of inbreeding of last 26 years. Average inbreeding coefficient is rising rapidly for the last two years as well as average relatedness. Effective population size was estimated for 47 heads for the last five years. These results suggest that selection criteria of proven bulls should include not only genetic evaluation of carcass performance from progeny-test, but also inbreeding and relationship coefficients, in order to maintain genetic variability of Hanwoo. In addition, effective population size should be increased by increasing the number of proven bulls.

A novel meso-mechanical model for concrete fracture

  • Ince, R.
    • Structural Engineering and Mechanics
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    • v.18 no.1
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    • pp.91-112
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    • 2004
  • Concrete is a composite material and at meso-level, may be assumed to be composed of three phases: aggregate, mortar-matrix and aggregate-matrix interface. It is postulated herein that although non-linear material parameters are generally used to model this composite structure by finite element method, linear elastic fracture mechanics principles can be used for modelling at the meso level, if the properties of all three phases are known. For this reason, a novel meso-mechanical approach for concrete fracture which uses the composite material model with distributed-phase for elastic properties of phases and considers the size effect according to linear elastic fracture mechanics for strength properties of phases is presented in this paper. Consequently, the developed model needs two parameters such as compressive strength and maximum grain size of concrete. The model is applied to three most popular fracture mechanics approaches for concrete namely the two-parameter model, the effective crack model and the size effect model. It is concluded that the developed model well agrees with considered approaches.

Effects of Additives on the Microstructure and Mechanical Properties in Porous Aluminum Titanate Ceramics (각종 첨가제가 다공성 Aluminum Titanate Ceramics의 미세구조 및 기계적 특성에 미치는 영향)

  • 김병훈;나용한
    • Journal of the Korean Ceramic Society
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    • v.31 no.2
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    • pp.137-146
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    • 1994
  • This experiments were focused on a modification of mechamical properties and structure in porous aluminum titanate ceramics by new additives which have been not researched yet. These were consisted of four kinds of additives i.e. Bi2O3, FeO, ZnO and NiO by addition amount of 1 wt% and 5 wt% respectively. The addition of Bi2O3 retarded a degree of syntehsis of aluminum titanate and accelerated in FeO, ZnO, NiO additives. Also, the most effective accelerator in synthesis of alunium titanate was FeO. A additives for the most effective of modification of microstructure, sharp distribtion of pore size and mechanical proterties was on ZnO addition and showed the lowest average pore size and narrowed pore size distribution. In order to improve of microstructure and pore size distribution in porous aluminum titanate ceramics was desired the addition amount of 1 wt% compare to 5 wt%.

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Preventing Premature Convergence in Genetic Algorithms with Adaptive Population Size (유전자 집단의 크기 조절을 통한 Genetic Algorithm의 조기 포화 방지)

  • 박래정;박철훈
    • Journal of the Korean Institute of Telematics and Electronics B
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    • v.32B no.12
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    • pp.1680-1686
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    • 1995
  • GAs, effective stochastic search algorithms based on the model of natural evolution and genetics, have been successfully applied to various optimization problems. When population size is not large, GAs often suffer from the phenomenon of premature convergence in which all chromosomes in the population lose the diversity of genes before they find the optimal solution. In this paper, we propose that a new heuristic that maintains the diversity of genes by adding some chromosomes with random mutation and selective mutation into population during evolution. And population size changes dynamically with supplement of new chromosomes. Experimental results for several test functions show that when population size is rather small and the length of chromosome is not long, this method is effective.

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Effective Partitioning of Static Global Buses for Small Processor Arrays

  • Matsumae, Susumu
    • Journal of Information Processing Systems
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    • v.7 no.1
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    • pp.85-92
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    • 2011
  • This paper shows an effective partitioning of static global row/column buses for tightly coupled 2D mesh-connected small processor arrays ("mesh", for short). With additional O(n/m (n/m + log m)) time slowdown, it enables the mesh of size $m{\times}m$ with static row/column buses to simulate the mesh of the larger size $n{\times}n$ with reconfigurable row/column buses ($m{\leq}n$). This means that if a problem can be solved in O(T) time by the mesh of size $n{\times}n$ with reconfigurable buses, then the same problem can be solved in O(Tn/m (n/m + log m)) time on the mesh of a smaller size $m{\times}m$ without a reconfigurable function. This time-cost is optimal when the relation $n{\geq}m$ log m holds (e.g., m = $n^{1-\varepsilon}$ for $\varepsilon$ > 0).

Design of an Ammonia/water Bubble Absorber with Binary Nanofluids (이성분 나노유체를 이용한 암모니아/물 기포 흡수기 설계)

  • Kim Jin-Kyeong;Kim Sung-Soo;Kang Yong-Tae
    • Korean Journal of Air-Conditioning and Refrigeration Engineering
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    • v.18 no.7
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    • pp.556-562
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    • 2006
  • The objectives of this paper are to analyze simultaneous heat and mass transfer performance for a plate type bubble absorber with binary nanofluids numerically and to investigate the effects of binary nanofluids and surfactants on the size of the bubble absorber. The effective absorption ratio represents the effect of binary nanofluids and surfactants on the absorption performance. The kinds and concentrations of nano-particles and surfactants are considered as the key parameters. The results show that the addition of surfactants can reduce the size of absorber up to 74.4%, the application of binary nanofluids does the size up to 63.6%. Combination of binary nanofluids and surfactants can reduce the size of absorber up to 77.4%.

Effect of some welding parameters on nugget size in electrical resistance spot welding

  • Savas, Omer
    • Steel and Composite Structures
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    • v.18 no.2
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    • pp.345-355
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    • 2015
  • In this study, the effects of weld parameters on nugget size and tensile-shear strength of welding joint in electrical resistance spot welding of galvanized DP 600 steel sheets having 1.2 mm were investigated. Taguchi design method has been employed to examine the effects of five parameters of welding current, electrode pressure, welding time, clamping time and holding time by using the $L_{27}(5^3)$ orthogonal array. Results showed that the most effective parameters on tensile shear strength and the nugget size ratio (hn/dn) were found as welding current and welding time, whereas electrode pressure, clamping time and holding time were less effective factors. Max. 545 MPa strength was obtained through proposed optimum conditions by Taguchi technique.

Effective Detective Quantum Efficiency (eDQE) Evaluation for the Influence of Focal Spot Size and Magnification on the Digital Radiography System (X-선관 초점 크기와 확대도에 따른 디지털 일반촬영 시스템의 유효검출양자효율 평가)

  • Kim, Ye-Seul;Park, Hye-Suk;Park, Su-Jin;Kim, Hee-Joung
    • Progress in Medical Physics
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    • v.23 no.1
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    • pp.26-32
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    • 2012
  • The magnification technique has recently become popular in bone radiography, mammography and other diagnostic examination. However, because of the finite size of X-ray focal spot, the magnification influences various imaging properties with resolution, noise and contrast. The purpose of study is to investigate the influence of magnification and focal spot size on digital imaging system using eDQE (effective detective quantum efficiency). Effective DQE is a metric reflecting overall system response including focal spot blur, magnification, scatter and grid response. The adult chest phantom employed in the Food and Drug Administration (FDA) was used to derive eDQE from eMTF (effective modulation transfer function), eNPS (effective noise power spectrum), scatter fraction and transmission fraction. According to results, spatial frequencies that eMTF is 10% with the magnification factor of 1.2, 1.4, 1.6, 1.8 and 2.0 are 2.76, 2.21, 1.78, 1.49 and 1.26 lp/mm respectively using small focal spot. The spatial frequencies that eMTF is 10% with the magnification factor of 1.2, 1.4, 1.6, 1.8 and 2.0 are 2.21, 1.66, 1.25, 0.93 and 0.73 lp/mm respectively using large focal spot. The eMTFs and eDQEs decreases with increasing magnification factor. Although there are no significant differences with focal spot size on eDQE (0), the eDQEs drops more sharply with large focal spot than small focal spot. The magnification imaging can enlarge the small size lesion and improve the contrast due to decrease of effective noise and scatter with air-gap effect. The enlargement of the image size can be helpful for visual detection of small image. However, focal spot blurring caused by finite size of focal spot shows more significant impact on spatial resolution than the improvement of other metrics resulted by magnification effect. Based on these results, appropriate magnification factor and focal spot size should be established to perform magnification imaging with digital radiography system.

Policy Suggestions to the Urban-rural Form City Governments' Policy for Small and Medium-size Firms;Based on the Entrepreneurs' Perceptions in Hwaseong City, Kyonggi-do Province (도농복합형 중소도시의 중소기업육성정책 개선방안;경기도 화성시 중소기업인의 인식을 중심으로)

  • Yoon, Eui-Young
    • Journal of Agricultural Extension & Community Development
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    • v.12 no.2
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    • pp.163-172
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    • 2005
  • Since the financial turmoil in 1997, both the national and local governments have initiated a variety of policy measures to support small and medium-size firms to strengthen the national and regional economies. It is no doubt that such policies contributed to establish better business environment for them. However, many analytical reports and academic studies in recent years diagnose that the economy conditions for the small and medium-size firms are in crisis because many policy measures are made based on the supply-side approach rather than demand-side consideration. In order for the governments' efforts to be more realistic and effective, it is necessary to see what the policy target groups(that is. the small and medium-size entrepreneurs) want. This study surveyed entrepreneurs in Hwaseung city, Kyonggi-do, which has more than three-thousands of small and medium-size firms. It finds that in spite of locational advantages and a variety of policy supports from the provincial and local governments, they need more financial supports, more effective mass transportation system for commuting workers. less bureaucratic barriers, and so on.

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