• Journal of Pharmaceutical Investigation
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• 제36권4호
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• pp.253-262
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• 2006

This study was performed to investigate the effects of treatment for dermatitis using the herbal gel preparations. Scutellariae Radix(SR) and Zingiberis Rhizoma(ZR) were used for the purpose of herbal preparations. Baicalin, baicalein are the ingredients of SR, having biological effects like anti-inflammatory, anti-oxidative, anti-bacterial and antiallergic action. 6-Gingerol is one of the ingredients of ZR having biologicai effects like anti-inflammatory and analgesic action. The three types of hydrogels(SRE, SRH, SZH) were formulated with Carbopol 940, Labrasol, Triethanolamine etc. Baicalin was hydrolysed to baicalein by $\beta$-glucuronidase for the purpose to increase rate of skin permeation. Content of ingredients by HPLC determination, rate of skin permeation using Franz type diffusion cell, anti-oxidative activity for the free radical, hydroxyl radical, superoxide, anti-inflammatory by using carrageenan injection, efficacy on the dermatitis induced by 2,4-dinitro-chlorobenzene(DNCB) were experimented. Baicalein showed higher permeability than baicalin, so it is considered that baicalein was more suitable form than baicalin for transdermal absorption by its lipophilic property. In the anti-oxidative experiments, SZH gel was the most effective scavenging activity than the other gels in all experiments. In anti-inflammatory test, SRM and SZH gel more decreased edma rapidly than SRE gel. In case of using SZH gel, treatment period for the dermatitis was more declined than that of other gel groups. These results suggests that the SZH hydrogel could be suitable preparations for the treatment of dermatitis.

• 보존과학회지
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• 제36권5호
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• pp.339-350
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• 2020

본 연구는 석조문화재 보존처리용(표면마감) 무기질바인더가 암석에 위해한 영향을 미치는 백화현상을 제어하기 위해 광물기반의 충전제와 발수제를 혼합한 하이브리드 기술을 적용하였다. 연구결과, 무기질바인더 성능개선에 효과적인 충전제(실리카흄 3.4%)와 발수제(실란-실록산 1%)를 선정하였으며, 해당 중량비율은 백화물질 제어에 효과가 있는 것으로 판단된다. 또한 압축강도 기준을(20 MPa) 상회하였고 흡수율은 낮아 투수저항성이 높은 것을 확인하였다. 이온용출 결과도 백화현상에 직·간접적으로 작용하는 이온의 검출량이 대조군보다 작게 검출되어 상대적으로 안정적인 것으로 판단된다.

• 한국산학기술학회논문지
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• 제13권5호
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• pp.2319-2324
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• 2012

본 논문에서는 가유전체 기판구조를 이용한 비대칭 브랜치 라인 커플러의 설계에 대하여 기술한다. 가유전체 기판구조에서는 주기적으로 다수의 비어홀들이 삽입되므로 등가적으로 유효유전율과 유효투자율이 증가하여, 여기에 전송선로를 구현할 경우 표준형 선로에 비하여 동일한 전기적 길이일 때 물리적 길이와 선폭이 감소하게 된다. 이런 특성을 이용하여 초고주파 회로들을 소형화하여 설계할 수 있는데, 본 논문에서는 2GHz대에서 동작하는 3:1 비대칭 브랜치 라인 커플러를 소형화하여 설계하는 것에 대하여 기술한다. 설계된 커플러는 표준형 전송선로를 이용하여 설계한 회로에 비하여 동일한 성능을 가지면서 약 53.4%의 크기를 갖는다. 비대칭 전력 분배 비율이 시뮬레이션과 측정 데이터에서 잘 일치하고 있으며, 측정된 손실도 불과 0.2dB 이내로 매우 적다.

• 한국표면공학회지
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• 제45권6호
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• pp.248-256
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• 2012

A Pd-based hydrogen membranes for hydrogen purification and separation need high hydrogen perm-selectivity. The surface roughness of the support is important to coat the pinholes free and thin-film membrane over it. Also, The pinholes drastically decreased the hydrogen perm-selectivity of the Pd-based composite membrane. In order to remove the pinholes, we introduced various surface pre-treatment such as alumina powder packing, nickel electro-plating and micro-polishing pre-treatment. Especially, the micro-polishing pretreatment was very effective in roughness leveling off the surface of the porous nickel support, and it almost completely plugged the pores. Fine Ni particles filled surface pinholes with could form open structure at the interface of Pd alloy coating and Ni support by their diffusion to the membrane and resintering. In this study, a $4{\mu}m$ surface pore-free Pd-Cu-Ni ternary alloy membrane on a porous nickel substrate was successfully prepared by micro-polishing, high temperature sputtering and Cu-reflow process. And $H_2$ permeation and $N_2$ leak tests showed that the Pd-Cu-Ni ternary alloy hydrogen membrane achieved both high permeability of $13.2ml{\cdot}cm^{-2}{\cdot}min^{-1}{\cdot}atm^{-1}$ permation flux and infinite selectivity.

• 한국구조물진단유지관리공학회 논문집
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• 제15권4호
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• pp.99-106
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• 2011

본 연구는 LB-DECK의 합성 전과 후 적절한 설계방법을 적용하기 위하여 PBD의 기초 개념에 근거하여 성능향상을 위한 연구를 수행하였다. 그 결과, 합성 전 폴리머 콘크리트를 활용함에 따라 휨 인장강도를 증가시켜 미세균열을 감소시킬 수 있으며, 심미적인 효과를 기대할 수 있고, 낮은 침투성으로 인하여 내구성을 향상시키고, 이에 따른 피복두께를 감소시킬 수 있을 것으로 평가되었다. 또한 합성 후 경험적 설계법을 적용한 LB-DECK 바닥판은 일반적인 바닥판보다 하중 저항능력이 우수하여 안전성이 증가되며, 강도설계법 적용시와 달리 지간이 증가되어도 철근배근방법과 철근배근량이 일정하기 때문에 시공성과 경제성을 동시에 확보할 것으로 기대된다.

• 한국구조물진단유지관리공학회 논문집
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• 제15권4호
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• pp.136-145
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• 2011

준설매립후 연직배수공법을 적용하여 지반개량을 수행하는 대규모 국가산업단지 조성 프로젝트를 대상으로, 각 심도별 채취된 불교란 시료를 이용하여 물리즉 특성 및 압밀 특성 등을 분석하기 위한 실내시험을 실시하였으며, 수평 압밀계수 및 현장 초기 응력 산정을 위한 콘 관입 및 소산시험을 수행하였다. 지층을 구성하고 있는 하부의 원지반 점토층과 상부의 준설 매립층은 유사한 해성점토로 구성되어 있으나, 초기 간극비와 초기 함수비, 초기 응력상태, 방향별 투수성과 압축성 등의 압밀특성에 있어서는 시간경과에 따른 압밀거동에 있어 매우 큰 차이를 보이는 다층 지반의 특성을 띠고 있다. 압밀과 관련된 응력이력이 다른 두지층의 초기응력을 산정하기 위하여 콘 관입시험 및 소산시험시의 간극수압 측정결과를 분석하였으며, 이를 통해 압밀이 진행중인 하부 원지반 점토층에서의 매립하중과 상부 성토에 의한 각 심도별 과잉간극수압 분포 및 이를 통한 초기응력을 산정할 수 있었다.

• 한국세라믹학회지
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• 제41권7호
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• pp.541-547
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• 2004

일반적으로 혼합분말의 소결에서 작은 입자에 큰 입자의 첨가는 소결성의 저하를 가져온다. 본 연구에서는 이러한 원리를 이용하여 작은 SiC 입자에 큰 SiC 휘스커 또는 큰 SiC 입자를 첨가하여 소결성을 저하시키고, YAG(Y$_3$A1$_{5}$O$_{12}$)상을 소결 첨가제로 사용함으로서 다공질 SiC 세라믹스를 제조하였다. 제조된 다공질 SiC 세라믹스의 기공율은 큰 입자의 함량과 소결 압력을 제어함으로서 0.3-39% 범위에서 제어할 수 있었다. 기공율은 큰 입자의 함량이 증가함에 따라 증가하였고, SiC 휘스커를 첨가하는 것이 큰 SiC 입자를 첨가하는 것 보다 기공율을 높이는데 효과적이었다. 제조된 다공질 세라믹스에서 기체의 통기성은 기공율이 증가함에 따라 증가하였고, 굽힘강도는 기공율이 증가함에 따라 감소하였다. 기공율이 18% 이상인 다공질 SiC 세라믹스의 경우에 주목할 만한 변형율이 관찰되었다.

• Journal of Ginseng Research
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• 제42권4호
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• pp.512-523
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• 2018

Background: 20(S)-Protopanaxadiol (20S-PPD) is a fully deglycosylated ginsenoside metabolite and has potent dermal antiaging activity. However, because of its low aqueous solubility and large molecular size, a suitable formulation strategy is required to improve its solubility and skin permeability, thereby enhancing its skin deposition. Thus, we optimized microemulsion (ME)-based hydrogel (MEH) formulations for the topical delivery of 20S-PPD. Methods: MEs and MEHs were formulated and evaluated for their particle size distribution, morphology, drug loading capacity, and stability. Then, the deposition profiles of the selected 20S-PPD-loaded MEH formulation were studied using a hairless mouse skin model and Strat-M membrane as an artificial skin model. Results: A Carbopol-based MEH system of 20S-PPD was successfully prepared with a mean droplet size of 110 nm and narrow size distribution. The formulation was stable for 56 d, and its viscosity was high enough for its topical application. It significantly enhanced the in vitro and in vivo skin deposition of 20S-PPD with no influence on its systemic absorption in hairless mice. Notably, it was found that the Strat-M membrane provided skin deposition data well correlated to those obtained from the in vitro and in vivo mouse skin studies on 20S-PPD (correlation coefficient $r^2=0.929-0.947$). Conclusion: The MEH formulation developed in this study could serve as an effective topical delivery system for poorly soluble ginsenosides and their deglycosylated metabolites, including 20S-PPD.

• Bulletin of the Korean Chemical Society
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• 제33권11호
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• pp.3676-3680
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• 2012

An Epstein-Barr virus (EBV)-based plasmid contains the EBV nuclear antigen 1 (EBNA1) gene and EBV replication origin (oriP) sequence. Since EBNA1 (the only EBV-encoded protein) is combined with oriP, it is replicated simultaneously with chromosomal DNA in human, primate, and canine cells and is faithfully segregated at a stable copy number upon cell division. Consequently, it can be used to stably express gene inserts over a prolonged time in target cells. We have previously shown that the polyamidoamine (PAMAM) dendrimer can be surface-modified with L-arginine. Arginine is present at a high frequency in the transactivator of transcription (Tat) sequences of human immunodeficiency virus (HIV). It presents high membrane permeability and permits effective transfer of DNA inside the cells. In this study, we constructed two kinds of recombinant DNA by inserting the luciferase gene and enhanced green fluorescence protein (eGFP) gene as reporter genes into the pCEP4 plasmid vector. We measured dynamic light scattering (DLS) and zeta potential after preparing PAMAM-based cationic polymer/EBV-based plasmid complexes. We performed transfection of HEK 293 cell lines with the polyplexes, and monitored luciferase activity and green fluorescence protein (GFP) expression. Our results show that PAMAM-based cationic polymer/EBV plasmid complexes provide enhanced and sustained gene expression.

• 한국해양공학회지
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• 제30권6호
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• pp.505-519
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• 2016

If the seabed is exposed to high waves for a long period, the pore water pressure may be excessive, making the seabed subject to liquefaction. As the water pressure change due to wave action is transmitted to the pore water pressure of the seabed, a phase difference will occur because of the fluid resistance from water permeability. Thus, the effective stress of the seabed will be decreased. If a composite breakwater or other structure with large wave reflection is installed over the seabed, a partial standing wave field is formed, and thus larger wave loading is directly transmitted to the seabed, which considerably influences its stability. To analyze the 3-D dynamic response characteristics of the seabed around a composite breakwater, this study performed a numerical simulation by applying LES-WASS-3D to directly analyze the wave-structure-soil interaction. First, the waveform around the composite breakwater and the pore water pressure in the seabed and rubble mound were compared and verified using the results of existing experiments. In addition, the characteristics of the wave field were analyzed around the composite breakwater, where there was an opening under different incident wave conditions. To analyze the effect of the changed wave field on the 3-D dynamic response of the seabed, the correlation between the wave height distribution and pore water pressure distribution of the seabed was investigated. Finally, the numerical results for the perpendicular phase difference of the pore water pressure were aggregated to understand the characteristics of the 3-D dynamic response of the seabed around the composite breakwater in relation to the water-structure-soil interaction.