• Journal of Pharmaceutical Investigation
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• 제28권4호
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• pp.249-255
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• 1998

Solid Lipid Nanoparticle(SLN), one of the colloidal carrier systems, has many advantages such as good biocompatibility, low toxicity and stability. In this paper, the effects of drug lipophilicity and surfactant on the drug loading capacity, particle size and drug release profile were examined. SLNs were prepared by homogenization of melted lipid dispersed in an aqueous surfactant solution. Ketoprofen, ibuprofen and pranoprofen were used as model drugs and tweens and poloxamers were tested for the effect of surfactant. Mean particle size of prepared SLNs was ranged from 100 to 150nm. The drug loading capacity was improved with the most lipophilic drug and low concentration of surfactant. Particle size and polydispersity of SLNs were changed according to the used lipid and surfactant. The rates of drug release were controlled by the loading drug and surfactant concentration. SLN system with effective drug loading efficiency and proper particle size for the intravenous or oral formulation can be prepared by selecting optimum drug and surfactant.

• 한국주조공학회지
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• 제25권6호
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• pp.240-248
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• 2005

The rheocasting characteristics are strongly influenced by the microstructural morphology such as particle size, form factor and contiguity. In this study, the effect of structural morphology on fluid flow characteristics of A356 semi-solid alloy was investigated with a vacuum suction fluidity test. Semi-solid metal slurry was made by the mechanical stirring, the liquidus casting, and H-NCM to be analysed. H-NCM could obtain uniform and fine globular microstructures of 0.9 form factor and 55 ${\mu}m$ particle size. Inoculation was found to be effective for reducing particle size, however, for H-NCM it should be avoided due to the cause of increasing contiguity. The fluidity test indicated that the non-stirring method had higher fluidity and smaller liquid segregation in the same solid faction of 0.4 than the stirring method, for smaller particle size and higher form factor. It was observed that liquid segregation decreased as the particle size is smaller and form factor is higher. The results of die-casting experiment were a good agreement with those of fluidity test.

• Asian-Australasian Journal of Animal Sciences
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• 제22권9호
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• pp.1256-1266
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• 2009

Effects of particle size and physical effective fibre (peNDF) of rice straw in diets on chewing activities, feed intake, flow, site and extent of digestion and rumen fermentation in goats were investigated. A 4${\times}$4 Latin square design was employed using 4 mature Liuyang black goats fitted with permanent ruminal, duodenal, and terminal ileal fistulae. During each of the 4 periods, goats were offered 1 of 4 diets that were similar in nutritional content but varied in particle sizes and peNDF through alteration of the theoretical cut length of rice straw (10, 20, 40, and 80 mm, respectively). Dietary peNDF contents were determined using a sieve for particle separation above 8 mm, and were 17.4, 20.9, 22.5 and 25.4%, respectively. Results showed that increasing the particle size and peNDF significantly (p<0.05) increased the time spent on rumination and chewing activities, duodenal starch digestibility and ruminal pH, and decreased ruminal starch digestibility and $NH_{3}$-N concentration. Intake and total tract digestibility of nutrients (i.e. dry matter, organic matter, and starch) and ruminal fermentation were not affected by the dietary particle size and peNDF. Increased particle size and peNDF did not affect ruminal fibre digestibility, but had a great impact on the intestinal and total tract fibre digestibility. The study suggested that rice straw particle size or dietary peNDF was the important influential factor for chewing activity, intestinal fibre and starch digestibility, and ruminal pH, but had minimal impact on feed intake, duodenal and ileal flow, ruminal and total tract digestibility, and ruminal fermentation.

• 펄프종이기술
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• 제33권1호
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• pp.53-61
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• 2001

This study was carried out to evaluate the effect of coating pigments on the printability by investigating the pore structure of casting layer such as the number, size and distribution of pores and the pore rate. The coating structure was mainly determined by the interaction between pigment and binder. It means that the structure of pores was chiefly affected by the shape and size distribution of pigments and their packing rate. The physical properties of pore have close relationships with ink set-off, the speed of ink penetration and printing gloss. The results suggested that the rate and number of pores were greatly affected by the particle size distribution and shape of pigments. The rate of pore increased with the reduction of particle size distribution of pigments. Calcite was effective to improve greatly the printability of coated paper.

• 한국정밀공학회지
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• 제20권4호
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• pp.183-188
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• 2003

Particulate contamination is known to be a significant cause of failures of removable storage media. In this work, the effect of particles on the surface damage of removable hard disk media was investigated. The particles of different materials and size were introduced to the Head Disk Interface (HDI) using a particle injection system. It was round that the particles of particulate size and property serious damaged the media. This study showed that cleaning pad is effective for reducing particle contamination, except fer the particles of specific size and property. As a means to remove the particles of specific sire. the concept of using a stepped taper at the leading edge of the slider is proposed.

• 한국신뢰성학회지:신뢰성응용연구
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• 제16권2호
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• pp.155-161
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• 2016

Purpose: Purpose of this study is to analyze the effect of particle size as well as number of pass on surface microstructure and hardness of SiC(p)/AZ31 surface composite fabricated by friction stir process (FSP). Method: SiC(p)/AZ31 surface composite containing different size of SiC particle (i. e., $2{\mu}m$ and $8{\mu}m$) was fabricated by multi-pass FSP. Microstructure was observed by scanning electron microscope and surface hardness was determined by Vickers hardness tester. Results: For all the FSPed specimens with and without hardening particles, grain size was refined due to dynamic recrystallization behavior. Surface hardness was observed to increase with decreasing particle size in the composite layer. Increasing number of FSP pass was effective for homogeneous distribution of the hardening particles and for resulting increase in surface hardness. Conclusion: FSP was effective to modify surface microstructure for improving surface hardness of SiC/AZ31 composite.

• 한국자동차공학회논문집
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• 제22권7호
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• pp.144-151
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• 2014

Recently, according to the advances of vehicle manufacturing technology and the fuel-efficient vehicles, the weight of the vehicle body has been reduced and quietness of the vehicle has been increased. So that, as the emotional qualities of cars, such as NVH, are emphasized in recent years. Also required to be established of the effective measure for brake Judder. The Judder was caused by the increase in DTV by the uneven thermo metamorphosis of brake disc and the partial abrasion of disc. In this study, the disc aggression by friction materials was confirmed and the improving methods of friction materials in connection with the abrasive characteristics reviewed of $ZrSiO_4$ each particle size(under $3{\mu}m$, $5{\sim}10{\mu}m$ and over $15{\mu}m$). In addition, the study is institute make use of limit for $ZrSiO_4$ raw-material particle size and vol% in friction materials. At the result, the optimum size of $ZrSiO_4$ particles was confirmed about 5 to $10{\mu}m$.

• 대한원격탐사학회:학술대회논문집
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• 대한원격탐사학회 2003년도 Proceedings of ACRS 2003 ISRS
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• pp.594-596
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• 2003

Due to the fact that the composition and variability of aerosols is considered rather complex, it is difficult to employ a simple and straightforward physical model in calculating the aerosol size distribution in the absence of actual data. This complicates the already difficult retrieval of various atmospheric parameters from remotely sensed data. Thus, the main purpose of this study is trying to find an effective aerosol size coefficient that is stable, and can depict the particle size distribution. This paper also attempts to construct an 'effective aerosol size coefficient' database for each respective season, where it can quickly and effectively supply pertinent information of the atmosphere's opacity.

• 한국분말재료학회지
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• 제31권2호
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• pp.132-136
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• 2024

This study investigated the effects of revolution speed and ball size in planetary milling on the microstructure and dehydrogenation behavior of TiH₂ powder. The particle size analysis showed that the large particles present in the raw powder were effectively refined as the revolution speed increased, and when milled at 500 rpm, the median particle size was 1.47 ㎛. Milling with a mixture of balls of two or three sizes was more effective in refining the raw powder than milling with balls of a single size. A mixture of 3 mm and 5 mm diameter balls was the optimal condition for particle refinement, and the measured median particle size was 0.71 ㎛. The dependence of particle size on revolution speed and ball size was explained by changes in input energy and the number of contact points of the balls. In the milled powder, the endothermic peak measured using differential thermal analysis was observed at a relatively low temperature. This finding was interpreted as the activation of a dehydrogenation reaction, mainly due to the increase in the specific surface area and the concentration of lattice defects.

• Geomechanics and Engineering
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• 제25권2호
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• pp.159-170
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• 2021

Particle size of tailings in different areas of dams varies due to sedimentation and separation. Saturated hydraulic conductivity of high-stacked talings materials are seriously affected by void ratio and particle breakage. Conjoined consolidation permeability tests were carried out using a self-developed high-stress permeability and consolidation apparatus. The hydraulic conductivity decreases nonlinearly with the increase of consolidation pressure. The seepage pattern of coarse-particle tailings is channel flow, and the seepage pattern of fine-particle tailings is scattered flow. The change rate of hydraulic conductivity of tailings with different particle sizes under high consolidation pressure tends to be identical. A hydraulic conductivity hysteresis is found in coarse-particle tailings. The hydraulic conductivity hysteresis is more obvious when the water head is lower. A new hydraulic conductivity-void ratio equation was derived by introducing the concept of effective void ratio and breakage index. The equation integrated the hydraulic conductivity equation with different particle sizes over a wide range of consolidation pressures.