• Biotechnology and Bioprocess Engineering:BBE
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• v.10 no.5
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• pp.385-399
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• 2005

The phenotypic response of a cell results from a well orchestrated web of complex interactions which propagate from the genetic architecture through the metabolic flux network. To rationally design cell factories which carry out specific functional objectives by controlling this hierarchical system is a challenge. Transcriptome analysis, the most mature high-throughput measurement technology, has been readily applied In strain improvement programs in an attempt to Identify genes involved in expressing a given phenotype. Unfortunately, while differentially expressed genes may provide targets for metabolic engineering, phenotypic responses are often not directly linked to transcriptional patterns, This limits the application of genome-wide transcriptional analysis for the design of cell factories. However, improved tools for integrating transcriptional data with other high-throughput measurements and known biological interactions are emerging. These tools hold significant promise for providing the framework to comprehensively dissect the regulatory mechanisms that identify the cellular control mechanisms and lead to more effective strategies to rewire the cellular control elements for metabolic engineering.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.14 no.3
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• pp.1301-1312
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• 2020

Using decode-and-forward relaying in the cognitive radio networks, the spectrum efficiency can improve furthermore. The optimization algorithm of the spectrum sensing estimation time is presented for the cognitive relay networks in this paper. The longer sensing time will bring two aspects of the consequences. On the one hand, the channel parameters are estimated more accurate so as to reduce the interferences to the authorized users and to improve the throughput of the cognitive users. On the other hand, it shortens the transmission time so as to decease the system throughput. In this time, it exists an optimal sensing time to maximize the throughput. The channel state information of the sub-bands is considered as the exponentially distributed, so a stochastic programming method is proposed to optimize the sensing time for the cognitive relay networks. The computer simulation results using the Matlab software show that the algorithm is effective, which has a certain engineering application value.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.19 no.7
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• pp.1272-1281
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• 1994

CDMA technique has been largely focused for Wireless Data Network and PCN. ALOHA protocol also has been proven to be effective for Packet Radio Network regardless of low throughput due to channel colisions. In this paper, we evaluate the performance of CDMA_ALOHA scheme, denoted as S_CDMA_ALOHA(Soltted_CDAM_ALOHA) and MS_CDMA_ALOHA(Minislotted_CDMA_ALOHA) system, by analytic and simulation method. The superiority of the CDMA_ALOHA systems over conventional Slotted ALOHA system are clearely demonstrated for throughput, delay and stability performances. The MS_CDMA_ALOHA scheme provides better delay and throughput performance than the S_CDMA_ALOHA scheme.

• Journal of the Korean Operations Research and Management Science Society
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• v.28 no.2
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• pp.75-89
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• 2003

Media Access Control (MAC) Protocol in IEEE 802.11 Wireless LAN standard supports two types of services, synchronous and asynchronous. Synchronous real-time traffic is served by Point Coordination Function (PCF) that implements polling access method. Asynchronous nonreal-time traffic is provided by Distributed Coordination Function (DCF) based on Carrier Sense Multiple Access with Collision Avoidance (CSMA/CA) protocol. Since real-time traffic is sensitive to delay, and nonreal-time traffic to error and throughput, proper traffic scheduling algorithm needs to be designed. But it is known that the standard IEEE 802.11 scheme is insufficient to serve real-time traffic. In this paper, real-time traffic scheduling and admission control algorithm is proposed. To satisfy the deadline violation probability of the real time traffic the downlink traffic is scheduled before the uplink by Earliest Due Date (EDD) rule. Admission of real-time connection is controlled to satisfy the minimum throughput of nonreal-time traffic which is estimated by exponential smoothing. Simulation is performed to have proper system capacity that satisfies the Quality of Service (QoS) requirement. Tradeoff between real-time and nonreal-time stations is demonstrated. The admission control and the EDD with downlink-first scheduling are illustrated to be effective for the real-time traffic in the wireless LAN.

• Genomics & Informatics
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• v.12 no.2
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• pp.50-57
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• 2014

We present a new next-generation sequencing-based method to identify somatic mutations of lung cancer. It is a comprehensive mutation profiling protocol to detect somatic mutations in 30 genes found frequently in lung adenocarcinoma. The total length of the target regions is 107 kb, and a capture assay was designed to cover 99% of it. This method exhibited about 97% mean coverage at $30{\times}$ sequencing depth and 42% average specificity when sequencing of more than 3.25 Gb was carried out for the normal sample. We discovered 513 variations from targeted exome sequencing of lung cancer cells, which is 3.9-fold higher than in the normal sample. The variations in cancer cells included previously reported somatic mutations in the COSMIC database, such as variations in TP53, KRAS, and STK11 of sample H-23 and in EGFR of sample H-1650, especially with more than $1,000{\times}$ coverage. Among the somatic mutations, up to 91% of single nucleotide polymorphisms from the two cancer samples were validated by DNA microarray-based genotyping. Our results demonstrated the feasibility of high-throughput mutation profiling with lung adenocarcinoma samples, and the profiling method can be used as a robust and effective protocol for somatic variant screening.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.11 no.1
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• pp.7-13
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• 2011

While the TCP throughput degradation problem in coded wireless mesh networks is well-known, few effective solutions have been proposed. Most schemes proposed attempts to mask packet reordering by ordering packets at a lower layer or to adjust a packet transmission rate to solve the scarcity problem of coding opportunities. Through the throughput comparison of traditional standard TCP variants, we show that losses and duplication of TCP acknowledgements in coded wireless mesh networks can impact throughput. In addition, we show that a TCP variant that does not rely on duplicate acknowledgements is more suitable for coded wireless mesh networks.

• Journal of Communications and Networks
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• v.9 no.3
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• pp.265-273
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• 2007

This paper expands an analytical performance model of 802.11 to accurately estimate throughput and energy demand of 802.11-based wireless sensor network (WSN) when sensor nodes employ Reed-Solomon (RS) codes, one of block forward error correction (FEC) techniques. This model evaluates these two metrics as a function of the channel bit error rate (BER) and the RS symbol size. Since the basic recovery unit of RS codes is a symbol not a bit, the symbol size affects the WSN performance even if each packet carries the same amount of FEC check bits. The larger size is more effective to recover long-lasting error bursts although it increases the computational complexity of encoding and decoding RS codes. For applying the extended model to WSNs, this paper collects traffic traces from a WSN consisting of two TIP50CM sensor nodes and measures its energy consumption for processing RS codes. Based on traces, it approximates WSN channels with Gilbert models. The computational analyses confirm that the adoption of RS codes in 802.11 significantly improves its throughput and energy efficiency of WSNs with a high BER. They also predict that the choice of an appropriate RS symbol size causes a lot of difference in throughput and power waste over short-term durations while the symbol size rarely affects the long-term average of these metrics.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.29 no.9A
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• pp.1075-1082
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• 2004

Wireless LAN is a rather mature communication technology connecting mobile terminals. IEEE 802.11 is a representative protocol among Wireless LAN technologies. The basic medium access control (MAC) mechanism of IEEE 802.11 is called distnbuted coordination function (DCF). DCF shows poor throughput and high drop rate as the number of stations and offered traffic load increase. In this paper we propose an effective mechanism using dynamic mimmum contention window(CWmin) in wireless LAN~ and show that performance improves via simulations. Proposed dynamic CWmin scheme exhibits superior performance as the number of stations and offered load grow. As, our proposed scheme is expected to be more effective in highly densed wireless LAN environment.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.11 no.4
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• pp.227-236
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• 1986

In this paper, an integrated voice/data packet network with window flow control is modeled by a colsed multichain queueing system, and its performance is analyzed by the mean value analysis method. Particularly, for the analysis of a packet network having various kinds of messages with different priority classes, we introduce an approach based on the mean value analysis and the concept of effective capacity. By the mathematical analysis and computer simulation, we obtain the following network statistics in the steady state: Mean buffer occupancy at each node, utilization of link throughput of a virtual channel, and mean delay time of each message. Our iterative analysis method can predict the link data status in most cases within about 10 percent of accurady, and the statistics of voice messages and external data within 5 percent as compared to simulation results.

• Journal of Satellite, Information and Communications
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• v.6 no.2
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• pp.117-124
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• 2011

In this paper, we present more effective throughput enhancement technique to improve the data rate and reliability by using the multiple antenna technique. The conventional spatial diversity scheme is limited in according with the interference from each antenna channel status, and the orthogonality of spreading codes and subcarriers are destroyed due to the frequency selectivity. Proposed system is considered MC-CDMA system with 4 transmit antennas and 1 receive antenna. Proposed system based on SVD with the MS-RLS MMSE subcarrier combining method in order to achieve better performance with low computational complexity. Via computer simulation, we confirm that the proposed system is able to improve the BER performance by suppressing the interference of other antenna signals.