• 대한기계학회논문집B
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• 제35권9호
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• pp.915-922
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• 2011

본 연구에서는 연속 뜸의 열자극 특성을 분석하기 위하여 복합대류 열전달 간이 모형을 만들어 ANSYS-FLUENT 를 이용하여 수치해석을 수행하였다. 연속 뜸의 주기가 열자극 효과에 미치는 영향을 파악하기 위해서 여러 장의 뜸을 다양한 주기로 적용하였다. 수치해석을 통하여 뜸의 장수가 증가할수록 유효자극영역의 깊이가 증가하기 위해서는 교체온도가 체온과 같거나 체온보다 커야 함을 확인하였고, 뜸의 적용 수가 증가함에 따른 유효자극 영역 깊이의 증가율은 감소함을 보였다. 또한, 유효자극의 지속시간이 최대가 되는 연속 뜸의 최적의 교체 주기가 존재함을 확인하였다.

• 한국전문물리치료학회지
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• 제3권1호
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• pp.12-23
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• 1996

High Voltage Pulsed Current Stimulation(HVPCS) and Microcurrent Electrical Neuromuscular Stimulation(MENS) have been used to promote the healing of decubitus ulcer and surgical wounds. The benefits of HVPCS and MENS are thought to include an inhibitive effect on bacterial growth. The purpose of this study was to compare the inhibitive effect of two different electrical stimulation techniques growth in vitro. Using agarose-based media, the two bacterial species Staphylococcus aureus, Esherichia coli - which are commonly isolated from open wounds were incubated in an incubator for 24 hours following exposure to HVPCS(400 V, 120 pps, $70{\mu}s$) and MENS($100{\mu}A$, 0.3 Hz). We then measured the zone of inhibition around each electrode. Both HVPCS and MENS produced an inhibitive effect on bacterial growth in this vitro study. However MENS was more effective than HVPCS.

• Annals of Clinical Neurophysiology
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• 제23권2호
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• pp.69-81
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• 2021

Cortico-cortical evoked potential (CCEP) mapping is a rapidly developing method for visualizing the brain network and estimating cortical excitability. The CCEP comprises the early N1 component the occurs at 10-30 ms poststimulation, indicating anatomic connectivity, and the late N2 component that appears at < 200 ms poststimulation, suggesting long-lasting effective connectivity. A later component at 200-1,000 ms poststimulation can also appear as a delayed response in some studied areas. Such delayed responses occur in areas with changed excitability, such as an epileptogenic zone. CCEP mapping has been used to examine the brain connections causally in functional systems such as the language, auditory, and visual systems as well as in anatomic regions including the frontoparietal neocortices and hippocampal limbic areas. Task-based CCEPs can be used to measure behavior. In addition to evaluations of the brain connectome, single-pulse electrical stimulation (SPES) can reflect cortical excitability, and so it could be used to predict a seizure onset zone. CCEP brain mapping and SPES investigations could be applied both extraoperatively and intraoperatively. These underused electrophysiologic tools in basic and clinical neuroscience might be powerful methods for providing insight into measures of brain connectivity and dynamics. Analyses of CCEPs might enable us to identify causal relationships between brain areas during cortical processing, and to develop a new paradigm of effective therapeutic neuromodulation in the future.

• 대한본초학회지
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• 제32권1호
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• pp.69-74
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• 2017

Objectives : This study aimed to investigate the effects of Angelicae sinensis Radix on longitudinal bone growth rate in rats. We have screened traditional medicinal herbs to develop the longitudinal bone growth stimulator by well-established rat model. A. sinensis was identified as one of the effective herbs in the screening process. Methods : Adolescent female rats were administered A. sinensis at doses of 30 mg/kg and 300 mg/kg for 10 consecutive days. To observe the rate of longitudinal bone growth, tetracycline was injected intraperitoneally on day 8 to stain a fluorescent band on the anew formed bone. To elucidate the mode of action, we observed insulin-like growth factor-1 (IGF-1) and bone morphogenetic protein-2 (BMP-2) expression after A. sinensis administration in growth plate. Results : In the 300 mg/kg A. sinensis group, the length between the proximal endpoint of the tetracycline label and the division line between growth plate and bone was significantly increased compared with vehicle-treated control group. Height of the proximal tibial growth plate was higher in the A. sinensis group compared with control group. A. sinensis also upregulated the expressions of IGF-1 and BMP-2 in the proliferative zone and hypertrophic zone of the proximal tibial growth plate. Conclusions : A. sinensis increases longitudinal bone growth rate in rats. According to immunohistochemistry, A. sinensis increases local IGF-1 and BMP-2 expressions in the growth plate which can be considered as direct stimulation of GH on the local growth plate.

• 한국해양환경ㆍ에너지학회지
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• 제6권2호
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• pp.16-27
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• 2003

해상에 유출된 유류의 생물정화방법은 자연상태로 존재하고 유류분해능력이 있는 박테리아, 균류 또는 효모와 같은 토착미생물의 환경요인을 최적화하거나, 병원성 또는 유전자조작미생물을 제외한 특별한 환경정화능력을 가진 미생물을 오염된 지역에 투입하여 유류오염물질을 자연적으로 분해함으로써 오염된 환경을 원래의 상태로 회복시키는 기술이다. 현재 우리나라규정에는 해양오염사고시 생물정화제제를 사용할 수 있는 제도적인 근거가 마련되어 있지 않아 실제사용 뿐만 아니라 관련 기술개발에 있어 많은 제약이 따르고 있다. 본 연구에서는 생물정화제제의 개발과 활용을 위해 관련규정에 대한 법률적 개정방향을 제시하였고 사람의 건강과 생태계의 유해한 성분을 포함하고 있는지 혹은 발생가능성이 여부를 확인하기 위하여 4단계의 생물정화제제 성능시험방법, 검정기준 및 형식승인절차를 제시하였다. 1, 2단계의 절차를 통해 생물급성독성 및 유류분해성능을 평가하여 형식승인을 여부를 결정하고 3, 4단계 절차를 통해 현장적용 가능성을 평가하는 단계로 구분하였다.