• 제목/요약/키워드: Effect-site Concentrations

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Effect-site Concentration of Alfentanil or Remifentanil for the Relief of Postoperative Pain in the Intensive Care Unit Patients

  • Jang, Hae-Lan;Kang, Hoon
    • International Journal of Contents
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    • 제11권2호
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    • pp.69-73
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    • 2015
  • This study was performed to determine the optimal doses of alfentanil or remifentanil (effect-site concentrations) required to prevent pain and other suffering after abdominal general surgery in ICU patients. A total of 52 general abdominal surgical patients (ASA IIIII) requiring artificial ventilatory care in the ICU were provided with either alfentanil (24 patients) or remifentanil (28 patients) through target controlled infusion (TCI). Alfentanil and remifentanil concentrations were titrated up and down until the pain score became less than 3 (VAS; Visual Analogue Score < 3). The effect-site concentrations (ng/ml) of alfentanil or remifentanil required to adequately control postoperative pain in the ICU were 64 +/- 12 and 1.9 +/- 0.5 for intubation with artificial ventilation, 57 +/- 9 and 1.7 +/- 0.7 for intubation with spontaneous ventilation, and 41 +/- 10 and 1.2 +/- 0.5 after extubation, respectively. Pain scores and the corresponding opioid concentrations were independent from respiratory condition. The three effect-site concentrations of alfentanil and remifentanil obtained from this clinical trial using the TCI technique can be a guideline in the administration of the same opioids to relieve the discomfort of ICU patients who have undergone abdominal general surgery.

대도시 및 주변 교외지역의 대기 중 휘발성 유기화합물 농도 비교에 관한 연구 (A Study on the Comparison of Atmospheric Concentrations of Volatile Organic Compounds in a Large Urban Area and a Sub-Urban Area)

  • 박지혜;서영교;백성옥
    • 한국대기환경학회지
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    • 제22권6호
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    • pp.767-778
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    • 2006
  • This study was carried out to evaluate the temporal variations of VOCs at an urban site, and to compare the concentrations of VOCs at an urban site in Daegu with those at a suburban site in Gyeongsan. Three hourly VOC samples in the ambient air were collected using a sequential tube sampler (STS 25, Perkin Elmer) throughout two weeks during May and July representing spring and summer seasons, respectively. The VOC concentrations were determined by an automatic thermal desorption apparatus with GC/MS analysis. A total of 12 VOCs of environmental concern were determined, which are chloroform, benzene, trichloroethylene, toluene, tetra-chloroethylene, ethylbenzene, m+p-xylenes, o-xylene, styrene, 1,3,5- and 1,2,4-trimethylbenzenes. Among 12 target VOCs, the most abundant compound appeared to be toluene, being followed by xylenes. The mean concentrations at the urbn site were 1.2 pub for benzene and 20.4 ppb for toluene (n=221) while the mean levels at the suburban site were 0.9 ppb and 4.3 ppb for benzene and toluene (n=96), respectively. The urban site concentrations were typically several-fold higher than those measured at the suburban site. It was found that general trends of VOC levels were significantly dependent on traffic conditions at the sampling site since VOC concentrations were at their maximum during rush hours, i.e. $9{\sim}12a.m$ and $6{\sim}9p.m$. Statistical investigations were conducted to investigate any significant relationships between VOC concentrations and affecting factors. Calculated correlation coefficients among VOCs were positively significant at a level of 0.05 in most cases. Increased concentrations of toluene in the urban site were estimated to reflect the effect of large industrial sources, mainly from textile industry.

산불이 토양의 물리ㆍ화학적 특성에 미치는 영향 (Effects of forest fire on physical and chemical properties of soil)

  • 박관수
    • 한국토양환경학회지
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    • 제4권1호
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    • pp.119-126
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    • 1999
  • This study was carried out to estimate the effect of forest fire on physical and chemical properties of soil The forest fire was in April 1995 at Kongju of Chungnam. Soil samples were collected at 0~5cm, 5~10cm, and 10~20cm soil depths in September 1998 from the burned and unburned sites. Soil organic matter concentrations at 0~5cm and 5~10cm soil depths were significantly greater in unburned site than in burned site. Soil concentrations were greater in unburned site than in burned site at all soil depths. Cation exchange capacity was significantly higher in unburned site than in burned site at 0~5cm soil depth. There were no differences in available soil P, exchangeable soil K, Ca, and Mg, and pH of soil between burned and unburned sites. Soil water content at 0~5cm soil depth was significantly greater in unburned site than in burned site. Bulk density at 0~5cm soil depth was significantly higher in burned site than in unburned site. Forest fire had an adverse effect on physical and chemical properties of soil in this study, Burning of vegetation and forest 리oor organic matter in burned site may reduce organic matter supply to soil and increase soil erosion. Consequently, forest fire may have adverse influence on long-term site productivity.

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2022년 5월 31일 발생한 밀양산불이 인근 도시 지역의 미세먼지 농도에 미치는 영향 (Effect of May 31, 2022 Miryang Forest Fire on Fine Particle Concentration in Nearby Urban Areas)

  • 전병일
    • 한국환경과학회지
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    • 제32권1호
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    • pp.37-46
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    • 2023
  • This study investigated the effect of May 31, 2022 Miryang wildfire on fine particle concentrations in Busan and Gimhae, which are neighboring urban areas. In addition, fine particle characteristics and air pollution concentrations were investigated in Miryang, where haze occurred. The Miryang city wildfire that occurred on May 31, 2022, at 0925 LST, was driven by strong north winds and increased fine particle concentrations in Dongsangdong and Jangyoodong, Gimhae City, which are approximately 35 km to the southeast and south, respectively, of the wildfire occurrence site. Furthermore, the fine particle concentration in Myeongjidong, which is approximately 50 km south-southeast of the wildfire site, exhibited a temporary increase at 1400 LST owing to the effects of wildfire smoke. On the morning of June 1, the day after the fire, the Miryang area had very bad visibility because of the smoke from the fire. Therefore the PM10 and PM2.5 concentrations in Naeildong, 3 km south of the wildfire site, were 276 ㎍/㎥ and 222 ㎍/㎥, respectively, at 1200 LST. In addition, the gases O3, CO, and SO2 showed high concentrations at the time of haze generation. This study provides insights into policy making in response to the rapid increase in fine dust when wildfire occurs near cities.

Composition and Characteristics of ionic Components of Aerosols Collected at Gosan Site in Jeiu Island, Korea

  • Kang, Chang-Hee;Kim, Won-Hyung;Hu, Chul-Goo;Kim, Yong-Pyo;Shim, Shang-Gyoo;Hong, Min-Sun;Kim, Ki-Hyun
    • Journal of Korean Society for Atmospheric Environment
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    • 제19권E4호
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    • pp.177-186
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    • 2003
  • The total of 1,454 aerosol samples were collected by high volume tape sampler at the Gosan Site in Jeju Island from 1992 to 1999, and the major water-soluble ionic components were chemically analyzed. The mean concentrations of nss-S $O_4$$^{2-}$, N $H_4$$^{+}$, and N $O_3$$^{[-10]}$ showed high values, which were 6.73, 1.45, and 1.45 ${\mu}{\textrm}{m}$/㎥, respectively, while $Ca^{2+}$ and $K^{+}$ concentrations were low with the values of 0.49 and 0.42 $\mu\textrm{g}$/㎥. The concentrations of most components increased in spring but decreased in summer, especially with the remarkable increase of $Ca^{2+}$ and N $O_3$$^{[-10]}$ concentrations in spring. The seasonal comparison of nss-S $O_4$$^{2-}$ concentrations showed higher values with the order of spring > fall 〉 winter〉 summer, but spring 〉 winter〉 fall 〉 summer for N $O_3$$^{[-10]}$ Meanwhile, the concentration levels of N $a^{+}$ and C $l^{[-10]}$ increased more in winter season. According to the investigation of wind direction effect, the concentrations of most aerosol ionic components showed higher values consistently at the westerly and northerly wind conditions. Based on the factor analysis, the atmospheric aerosols in the Gosan Site are considered to be largely affected by marine sources, followed by anthropogenic and soil sources.urces..

상류 댐 플러싱 방류가 금강의 겨울철 암모니아성 질소 농도 저감에 미치는 효과분석 (Impact of a Flushing Discharge from an Upstream Dam on the NH3-N Concentrations during Winter Season in Geum River)

  • 정세웅;김유경
    • 한국물환경학회지
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    • 제21권6호
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    • pp.609-616
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    • 2005
  • A high ammonia nitrogen ($NH_3-N$) concentration has been recursively observed every winter season in Geum River, which hindered chemical treatment processes at a water treatment plant. A flushing discharge from Daecheong Dam was often considered to dilute $NH_3-N$, but information on the quantitative effect of flushing on the downstream water quality was limited. In this study, the impact of a short-term reservoir flushing on the downstream water quality was investigated through field experiments and unsteady water quality modeling. On November 22, 2003, the reservoir discharge was increased from $30m^3/sec$ to $200m^3/sec$ within 6 hours for the purpose of the experiment. The results showed that flushing flow tends to reduce downstream $NH_3-N$ concentrations considerably, but the effectiveness was limited by flushing amount and time. An unsteady river water quality model was applied to simulate the changes of nitrogen concentrations in response to reservoir flushing. The model showed very good performance in predicting the travel time of flushing flow and the effect of flushing discharge on the reduction of downstream $NH_3-N$ concentrations at Maepo and Geumnam site, but a significant discrepancy was observed at Gongju site.

Water table: The dominant control on CH4 and CO2 emission from a closed landfill site

  • Nwachukwu, Arthur N.;Nwachukwu, Nkechinyere V.
    • Advances in environmental research
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    • 제9권2호
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    • pp.123-133
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    • 2020
  • A time series dataset was conducted to ascertain the effect of water table on the variability in and emission of CH4 and CO2 concentrations at a closed landfill site. An in-situ data of methane/carbon dioxide concentrations and environmental parameters were collected by means of an in-borehole gas monitor, the Gasclam (Ion Science, UK). Linear regression analysis was used to determine the strength of the correlation between ground-gas concentration and water table. The result shows CH4 and CO2 concentrations to be variable with strong negative correlations of approximately 0.5 each with water table over the entire monitoring period. The R2 was slightly improved by considering their concentration over single periods of increasing and decreasing water table, single periods of increasing water table, and single periods of decreasing water table; their correlations increased significantly at 95% confidence level. The result revealed that fluctuations in groundwater level is the key driving force on the emission of and variability in groundgas concentration and neither barometric pressure nor temperature. This finding further validates the earlier finding that atmospheric pressure - the acclaimed major control on the variability/migration of CH4 and CO2 concentrations on contaminated sites, is not always so.

폐기물 매립지 주변지역에서의 환경오염에 관한 지구화학 및 지구물리학적 연구 (A geochemical and Geophysical Study on the Environmental contamination in the Vicinity of Waste Dispodal Site)

  • 김경웅;손호웅
    • 자연과학논문집
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    • 제8권1호
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    • pp.87-92
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    • 1995
  • 대전시 신대동 일반 폐기물 매립지역 주변토양의 Cu, Pb와 Zn 함량은 대부분이 우리나라 토양내의 평균 함량보다는 높은 것으로 나타났으나 농작물을 통하여 인류 및 동물에 해를 끼칠 수 있는 정도는 아닌 것으로 나타났다. 지하수의 경우 Cu, Pb와 Zn이 검출되지는 않았고, F, CI, $NO_2$, $NO_3$$SO_4$함량도 음용수 수질기준보다 낮은 것으로 나타났다. 그러나 매립지 인근 D지역에서의 지하수의 pH가 5.58로 나타나 음용수로는 부적합 것으로 판명되었다. 전기 비저항 탐사를 행한 결과 토양오염이 진행된 지역에 함수층이 존재하고 있었으며 침출수의 배출에 의한 오염체의 이동에 의해 전기 비저항값이 더욱 낮게 나타났다. Gradiometer를 이용한 자력탐사 결과 전기비저항값이 낮은 오염지역에서 자력치와 그 미분값의 이상치가 나타났으며, 그 지점 지하수의 원소함량이 다른지역보다 높았다.

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Development of a One-step Two-site Enzyme Immunoassay for Measuring Human Alpha-fetoprotein by Eliminating Hook-effect

  • Kim, Se-Ho
    • BMB Reports
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    • 제34권1호
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    • pp.47-50
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    • 2001
  • A one-step, two-site enzyme immunoassay was developed for measuring human alpha-fetoprotein (AFP) in serum and amniotic fluid using monoclonal antibodies (McAb) by eliminating the high-dose hook effect. Three McAbs that recognize different epitopes were selected among 16 different clones on the basis of epitope mapping, two for immobilization and one for horseradish peroxidase conjugation. This one-step immunoassay system is more convenient and rapid compared to a conventional two-step sandwich immunoassay system. It did not exhibit the hook effect to around 2.7 mg/ml of AFP, which is probably one of the highest concentrations of AFP in the serum. The dose-response curve of the system was linear to 500 mg/ml of AFP and the system could differentiate as low as 1 mg/ml of AFP The intra- and inter-assay variations were in an acceptable range; 95~104% and 97~105% respectively Its correlation with other commercial systems was around 95%.

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Effects of Temperature and Heavy Metals on Extractable Lipofuscin in the Blue Crab, Callinectes sapidus

  • Ju, Se-Jong;Harvey, H.R.
    • Journal of the korean society of oceanography
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    • 제37권4호
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    • pp.232-241
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    • 2002
  • The potential role of environmental factors on extractable lipofuscin accumulation rate in the blue crab was studied by examining the effect of temperature on laboratory reared blue crabs and the effect of trace metals from samples collected at impacted sites (Baltimore Harbor) and a relatively pristine site (outdoor ponds at Horn Point Laboratory, Cambridge, MD, USA). Lipofuscin levels did not significantly related with sampling sites or heavy metal concentrations in the crab tissue. Heavy metal body burden was highly variable among sampling sites and tissue types but significantly higher for both impacted areas (Curtis Creek and Inner Harbor) in comparison to the reference site. Among tissue types, gills showed the highest metal concentrations with the exception of Hg, which was highest in muscle tissue. For two groups of crabs that were held at either ambient (4 to 1$0^{\circ}C$) or heated seawater (19$^{\circ}C$) for two months, normalized-lipofuscin levels were significantly different (P-0.001). Results suggest that temperature may affect lipofuscin accumulation (=0.25ng-lipofuscin/mg-protein/temperature-degree day). Therefore, temperature should be considered for accurate age calibration of crab populations using lipofuscin.