• 동의신경정신과학회지
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• 제32권2호
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• pp.95-109
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• 2021

Objectives: The coronavirus disease 2019 (COVID-19) has become a global pandemic. Mental sequelae occurring in patients with COVID-19 and the general population are important concerns. In Korea, herbal medicine is used nationwide to respond to this pandemic. It can be prescribed by COVID-19 telemedicine center of Korean medicine (KM). Among some herbal medicines, Gamiguibi-tang is the only herbal medicine prescribed for individuals with mental health, especially for those with insomnia. In this mini-review, the objective of this study was to summarize the evidence of some promising herbal medicines available for treating primary insomnia based on existing clinical and preclinical studies. Methods: A research team was formed for KM clinical practice guidelines for insomnia (version 1.0). Team members were provided with a list of references of relevant herbal medicines for insomnia. To gather evidence from clinical studies with appropriate sample sizes, among the list of references, randomized controlled trials for primary insomnia that included 50 subjects or more per arm and used herbal medicine were included in the final analysis. Moreover, pre-clinical studies examining the mechanism of action of each herbal medicine and studies on herb-drug interactions, were searched and summarized. Results: Four herbal medicines (Ondam-tang, Sanjoin-tang, Guibi-tang, and Hyeolbuchugeo-tang) were reviewed based on existing clinical and preclinical studies. Based on findings of existing studies, some suggestions of herbal medicines for insomnia in the COVID-19 era in Korea were suggested. Conclusions: Data of this study could be used to prepare a future revision of the manual of COVID-19 telemedicine center of KM.

• 대한예방한의학회지
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• 제26권1호
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• pp.59-74
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• 2022

Objectives : Evidence supporting the cold-heat symptom and sasang constitution type, which are diagnostic items of traditional Korean medicine, is needed to manage sleep disturbances, which is a typical symptom of mibyeong (subhealth). This study examined the association between each cold-heat symptom and sleep disturbances according to each sasang constitution type. Methods : This research was a cross-sectional study of 5,793 subjects from the Korean Medicine Data Center (KDC) community cohort survey. The association between each cold-heat symptom and sleep disturbances was analyzed by logistic regression analysis adjusted for several demographic variables. Subgroup analysis was then performed for each type of sasang constitution. Results : The soeum and soyang types were 1.53 and 1.26 times more likely to have sleep disturbances than the taeum type. Sleep disturbances were associated with 'coldness of the abdomen', 'watery mouth' in the cold domain items, and 'body feverishness', 'flushed face and eye', 'thirst', and 'scanty dark urine' in the heat domain items. The soeum and soyang types were 1.55 and 1.39 times more likely to sleep less than five hours per night than the taeeum type. In addition, the associations of those showed a different pattern for each sasang constitution type. Conclusions : Sleep disturbances are associated with specific cold-heat symptoms, and the associated cold-heat symptoms differ according to the sasang constitution type. These results may help traditional medicine specialists select customized interventions for patients with sleep disturbances.

• 동의신경정신과학회지
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• 제34권3호
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• pp.213-234
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• 2023

Objectives: To investigate current status of randomized controlled clinical trial (RCT) registration for suicide attempters. Methods: The World Health Organization International Clinical Trials Registry Platform (WHO-ICTRP) was used to search for data using 'suicide' as a search term. All registration information of RCTs registered up to April 2023 were collected. Results: Among a total of 68 RCTs registered, the United States ranked the highest in terms of quantity in this field (n=30, 46.15%), whereas Asia had only six (8.82%). A total of 62 (91.18%) RCTs involved individual interventions, while nine (13.24%) RCTs involved group interventions. Among individual interventions, 11 (16.18%) and 54 (79.41%) RCTs were on pharmacotherapy and psychotherapy, respectively. Within psychotherapy, there were a total of 17 (25%) studies utilizing digital media, with cognitive behavioral therapy (CBT) via phone being the most common approach. Among non-digital media-based studies, CBT was used the most frequently (n=11, 16.18%), followed by attempted suicide short intervention program (n=6, 8.82%). There were no studies using interventions from East Asian traditional medicine, including Korean medicine (KM). The most frequently used main outcome was the Beck scale for suicidal ideation. Conclusions: Studies on suicide attempts in Asia, especially in South Korea, are very scarce. Despite vigorous psychotherapeutic research in this field, KM psychotherapy has not been used. Thus, KM clinical trial for suicide attempters might be planned in the future based on our findings.

• International Journal of Industrial Entomology and Biomaterials
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• 제46권2호
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• pp.41-54
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• 2023

The blue-tailed damselfly, Ischnura elegans Van der Linden, 1820 (Odonata: Coenagrionidae), is a climate-sensitive indicator species in South Korea. In this study, we sequenced the complete mitochondrial genome (mitogenome) of I. elegans collected from South Korea for subsequent population genetic analysis, particularly to trace population movements in response to climate change. The 15,963 base pair (bp)-long complete mitogenome of I. elegans has typical sets of genes including a major non-coding region (the A+T-rich region), and an arrangement identical to that observed in ancestral insect species. The ATP6, ND3 and ND1 genes have the TTG start codon, which, although rare, is the canonical start codon for animal mitochondrial tRNA. The A/T content was 71.4% in protein-coding genes, 72.1% in tRNAs, 72.9% in the whole genome, 74.7% in srRNA, 75.3% in lrRNA, and 83.8% in the A+T-rich region. The A+T-rich region is unusually long (1,196 bp) and contains two subunits (192 bp and 176-165 bp), each of which is tandemly triplicated and surrounded by non-repeat sequences. Comparison of the sequence divergence among available mitogenomes of I. elegans, including the one from the current study, revealed ND2 as the most variable gene, followed by COII and COI, suggesting that ND2 should be targeted first in subsequent population-level studies. Phylogenetic reconstruction based on all available mitogenome sequences of Coenagrionidae showed a strong sister relationship between I. elegans and I. senegalensis.

• 문화기술의 융합
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• 제8권3호
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• pp.367-375
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• 2022

미디어 환경 및 문화 콘텐츠 소비가 변화하며 한류 현상 역시 시기별로 주목받는 콘텐츠의 유형과 장르가 변화하는 현실에서 이러한 한류의 변화된 흐름을 탐구해볼 시점이다. 더욱이 기존의 한류 연구들이 독립적인 개별 장르 현상만을 분석하거나 동아시아 국가에 집중해온 경향, 또한 한국 사회 입장을 중심으로 연구가 진행되어온 경향이 있는 가운데, 본 연구는 상대적으로 관심이 부족했던 비영어권 유럽 사회에서 한류 현상을 통해 수용자 자신이 처한 현실에서 실질적으로 갖는 사회적 의미에 대해 살펴보았다. 문화자본과 사회자본의 상호전환 관점에 기대어 분석한 결과, 한류 내러티브와 비-내러티브 모두 사회신뢰와 자국인 신뢰에는 부적인 영향이 있었지만 한국인 신뢰에 대해서는 정적인 영향을 미쳤으며, 대조적으로, 케이팝 대중음악은 사회신뢰와 자국인 신뢰뿐 아니라, 사회교류 활동 참여 및 연계적/결속적 관계망 모두에 정적인 영향을 미치는 경향이 있었다. 한류의 콘텐츠 유형/장르에 따른 문화소비는 사회자본과 한국에 대한 문화간 커뮤니케이션에 상이한 영향을 미치는 것으로 나타났다.

• 분석과 대안
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• 제1권1호
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• pp.44-64
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• 2017

Russia's push in the Asia-Pacific region stems from its interests that have the national, regional and global dimensions. In their turn, the aims of this policy are civilizational, geopolitical, economic and prospective, with a long-term outlook. In the course of their achievement, cooperation with Northeast Asia's countries will play one of the key roles owing to the factors of geographic proximity, Northeast Asia's economic potential, risk hedging and a growing influence Northeast Asia exerts upon the global development. A new cooperation paradigm between Russia and the states of Northeast Asia should be based upon establishing and cementing self-reproducing ties. This is the central aim of Russian initiatives in relations, with Japan, the Republic of Korea, Democratic People's Republic of Korea, Mongolia and China. However, numerous obstacles ranging from Russia's absence in the regional free trade agreements and supply-production chains of value-added production to the permanent international instability generated by Pyongyang's missile-nuclear developments hamper the practical implementation of this task. Realizing the necessity to give an additional impetus to this new cooperative paradigm, Russia has to develop directions with an apparent consolidating effect. The most promising may be the establishment of a permanent security forum based upon Northeast Asia Peace and Security Mechanism chaired by the Russian Federation. The urgency of this measure and its expected support stem from the necessity to strengthen security in Northeast Asia, a task neither the US-led hub-and-spoke system nor ASE-AN-led multilateral dialogue venues have been able to resolve. The issues addressed at the security forum must include the unification of approaches to North Korean nuclear issue and producing a document specifying actions of the claimants on the disputed maritime territories in the "direct contact" situations. At the expert level, Russia has elaborated on the idea to establish such a forum outlining the spectrum of the key directions of cooperation. With the urgency in the establishment of this dialogue venue, its agenda has to be coordinated with the agendas of the existing security systems presented by the US alliances and the ASE-AN-led multilateral negotiations. The practical implementation of this initiative will strengthen security in Northeast Asia as its challenges will be resolved in the pre-emptive way based on coordinated approaches. Therefore, Russia as the Eurasian state will be one of the role players in the advent of the Asian century.

• 한국경제지리학회지
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• 제26권2호
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• pp.110-122
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• 2023

본 연구에서는 몽골에 성공적으로 진출한 우리나라 유통기업인 CU의 사례를 통해 몽골 소매유통시장의 특성을 살펴보고, 몽골에 진출하려는 한국 기업에게 유용한 시사점을 제시하였다. 지금까지 몽골은 한국과 지리적으로 인접해 있음에도 불구하고, 작은 내수시장과 내륙국가라는 지리적 위치, 비효율적인 물류 인프라 및 유통산업과 관련된 법과 제도의 미비로 인해 소매유통업이 발전하기 어려운 환경을 가지고 있다고 알려져 있었다. 그러나 CU는 몽골 현지 기업과 마스터 프랜차이즈 계약을 활용하고, 글로컬라이제이션 전략을 추진함으로써 몽골 시장에 성공적으로 정착하였다. 몽골 CU는 단순한 편의점이 아니라 몽골인들이 글로벌 문화를 향유하고, 자신들의 소비 욕구를 충족시킬 수 있는 새로운 공간으로 재구성되고 있다.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2021년도 춘계학술대회
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• pp.54-54
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• 2021

The Melanoma Research Coalition reported melanoma affects humans of various races. This study was conducted to confirm the inhibitory effect of melanogenesis in B16 F10 cells of Nypa fruticans Wurmb of ethyl acetate fraction (NEF). Nypa fruticans Wurmb is an important component of the East Asian mangrove vegetation. It belongs to Araceae family. Traditionally, N. fruticans was used to treat various diseases such as asthma, sore throat, liver disease, a pain reliever, and can also be used as sedative and carminative. The present study, the inhibitory effect on melanogenesis was determined by Western blotting and RT-qPCR. The level of expression of tyrosinase, TRP-1, and TRP-2 is regulated by microphthalmia-associated transcription factor (MITF) and cAMP, and cAMP affects the activity of protein kinase A (PKA). Activated PKA stimulates the phosphorylation of cAMP-reactive element-binding protein (CREB) in the nucleus, thereby increasing the amount of MITF expression and enhancing melanogenesis. Western blotting and RT-qPCR analysis showed that NEF treatment decreased the expression of tyrosinase. Similarly, TRP-1 and TRP-2 levels were decreased, which were decreased significantly at compared with the untreated control. Also, NEF attenuated the IBMX mediated increase in the intracellular cAMP level and the phosphorylation of PKA. In conclusion, NEF significantly inhibited the expressions of melanogenesis through cAMP/PKA/CREB signaling pathways.

• Clinical Nutrition Research
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• 제11권1호
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• pp.32-41
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• 2022

We evaluated the association between obesity status by body mass index (BMI) or waist circumference (WC) and osteoporotic fracture risk. We collected data of 143,673 women with a mean age of 58.5 years without history of osteoporotic fracture from the Korean National Health Insurance Service Cohort. Participants were divided into four groups according to obesity by BMI and WC, normal BMI/WC (BMI 18.5-24.9 kg/m² and WC < 85 cm, reference), obese BMI/normal WC (BMI ≥ 25 kg/m² and WC < 85 cm), normal BMI/obese WC (BMI < 25 kg/m² and WC ≥ 85 cm), and obese BMI/WC (BMI ≥ 25 kg/m² and WC < 85cm). Cox proportional hazards regression analyses were performed to obtain hazard ratios (HRs) with 95% confidence intervals (CIs) for the subsequent median 6.0 years, which were adjusted for age, socioeconomic status, lifestyle, morbidity index, and osteoporosis medication. Compared with the normal group, normal BMI/obese WC was associated with a higher osteoporotic fracture risk after multivariable adjustment (HRs [95% CI], 1.13 [1.05-1.21]), and obese BMI/normal WC was associated with a lower osteoporotic fracture risk (0.89 [0.84-0.94]). Obese BMI/normal WC was associated with a lower risk for hip fractures (0.75 [0.57-0.99]). Obese BMI/normal WC was associated with decreased risk of osteoporotic fracture, whereas normal BMI/obese WC was associated with increased risk of osteoporotic fracture compared with the normal group among East Asian women in their late 40s or more.

• 아시안잔디학회지
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• 제26권2호
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• pp.89-95
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• 2012

화본과(Gramineae family)의 Zoysia속(Zoysia genus)에 속하는 한국잔디류는 동북아시아와 필리핀, 태국을 비롯한 동남아시아의 열대지역부터 온대지역에 걸쳐 비교적 폭넓게 분포하는 대표적인 잔디종의 하나이다. 세계적으로 방대한 잔디분야의 'The Turfgrass Information Center'의 database에 zoysia와 연관된 정보는 전문학술지 논문 638편과 학위논문 및 전문보고서 1,307편을 포함하여 총 5,340건으로 조사 되었다. Zoysiagrass에 관한 연구는 골프코스와 lawn care 관련산업에서의 이용과 그에 따르는 잡초, 병충해 등 방제에 따르는 농약에 관한 연구와 종자에 관한 database가 주를 이루고 있다. 본 연구는 한국잔디류에 대한 세계적 연구 추세와 지금까지 우리나라에서 연구된 한국잔디에 관한 연구내용을 정리 분석 하였다. 통계적으로 우리나라의 주요 학술지에 발표된 한국잔디에 관한 논문은 274편이었는데, 식물학적 연구가 102편이며 환경학적 연구와 재배학적 연구가 각 38편과 134편이었다. 그러나 우리나라 연구자의 외국 전문지 게재논문을 합하면 이보다 많으리라 사료된다. 외국에 비해 골프코스 잔디 관리분야와 plant protectant, 신품종 육종에 관한 연구가 활성화 되고, 환경 및 병 저항성 등 육종연구의 선도적 역할도 수행되어야 할 것으로 판단된다.