• Title/Summary/Keyword: Early reference

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Change of Chitotriosidase activity in Gaucher Patients by Enzyme Replacement Therapy (Caucher 환자의 효소 대치요법에 따른 Chititriosidase 활성도 변화)

  • YOO, Han Wook;IM, Dae Seong;YANG, Song Hyun
    • Journal of The Korean Society of Inherited Metabolic disease
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    • v.6 no.1
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    • pp.58-62
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    • 2006
  • Gaucher disease is an inherited disorder due to a deficiency in the activity of glucocerebrosidase (EC. 3.2.1.45) by genetic mutation which resulted from missense, nonsense, frameshift, deletion in long arm 21 of chromosome 1 (1q21). Gaucher disease is classified into the main three types as type 1 (nonneuronopathic), type 2 (acute neuronopathic) and type 3 (subacute neuronopathic) according to the progressive phase of manifestations and nervous system involvement. Gaucher disease patients had been treated by using the method as splenectomy and bone marrow transplantation. But enzyme replacement therapy as a more effective treatment has been available since the early 1990's. In order to treat Gaucher disease efficiently by using ERT, it is necessary to chase the progress of the therapy. In this study, therefore, we tried to chase the progress of the ERT by using the measurement of chitotriosidase activity in Gaucher disease patients.

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A Study on the Medical Reference Books Used in the Medical Compilations of the Joseon Dynasty (조선조 의학유서 편찬에 사용된 참고의서 고찰)

  • Ahn, Sang-Woo
    • The Journal of Korean Medical History
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    • v.33 no.2
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    • pp.105-127
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    • 2020
  • The three major medical compilations of the Joseon Dynasty, Hyangyak-jipseongbang, Uibang-yuchwi, and Dongui-bogam, directly cited a total of 376 kinds of medical books. Among them, 11 medical books were commonly referred: Gyeongheom-yangbang, Deukyobang, Saminbang, Seonmyeongnon, Seongje-chongnok, Seonghyebang, Eoui-chwaryo, Yeongnyu-geombang, Wisaeng-bogam, Cheongeumbang, and Tangaek-boncho. Most of them were medical classics and formularies representing the period from the Song to the early Ming Dynasties, which most likely influenced the establishment of Joseon's medical tradition throughout the Joseon Dynasty. The reason why the majority of the medical reference books was formularies seems to be that prescription practices and the use of medicinals value knowledge with accumulated experience over a long period, whereas medical ideas and doctrines change with time. Besides, except for Eoui-chwaryo compiled in the Goryeo Dynasty, the three significant compilations referred to Chinese medical books, which indicates that the compilers made efforts to accommodate the newly introduced foreign knowledge. At the same time, the former compilations, Hyangyak-jipseongbang and Uibang-yuchwi, later appeared as primary references in Dongui-bogam's Medical Formularies of Successive Generations. However, in order to avoid overlapping the same contents, the compilers tried to form a differentiated version by extracting only the unique contents.

An Inquiry into the Types of Ceremonial Costume Worn for the Performance of Sejong Hoi-ryeyeon (세종 회례연 공연을 위한 의례복식의 유형 고찰)

  • Baik, Young-Ja
    • Journal of the Korean Society of Costume
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    • v.60 no.1
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    • pp.135-144
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    • 2010
  • This study is on the reproduction of King Sejong's costume presented in at the National Classical Music Institute in the late of 2008. The performance was presented focusing on the idea of ceremonial music of hoi-ryeyeon produced in the reign of king(1433). The reproduction of King Sejong's costume was undertaken to keep pace with the times and to pay due regard to the performance costume. The implications of the study are as follows. King Sejong's Hoi-ryeyeon ceremonial costume is a royal robe(gonryongpo), the best one of king's clothing. The basic type of gonryongpo is that of fastening four yongbos to danryoung. The type of gonryongpo is, therefore, made with reference to unearthed articles and portrait of the first king of the Yi dynasty. The yongbo is larger one than the late period of the Yi dynasty in the light of portrait of the first king of the Yi dynasty. The supporting type of gonryongpo is that of gonryongpo, dapho, and chulrik, king's dress granted by Myeong dynasty. In the late period jikryeong was used as supporting dress and fixed to be lining and included jikryeong. Therefore the order of supporting dress was jikryeong, dapho and chulrik and was reproduced with reference to unearthed articles in the early Yi dynasty, as did the small piece of crown, belt and shoes.

Realization of New Korean Horizontal Geodetic Datum: GPS Observation and Network Adjustment

  • Lee, Young-Jin;Lee, Hung-Kyu;Jung, Gwang-Ho
    • Proceedings of the Korean Institute of Navigation and Port Research Conference
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    • v.1
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    • pp.529-534
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    • 2006
  • New geocentric geodetic datum has recently been realized in Korea, Korean Geodetic Datum 2002- KGD2002, to overcome problems due to the existing Tokyo datum, which had been used in this country since early 20th century. This transition will support modern surveying techniques, such as Global Navigation Satellite Systems (GNSS) and ensures that spatial data is compatible with other international systems. For this realization, very long baseline interferometry (VLBI) observations were initially carried out in 1995 to determine the coordinates of the origin of KGD2002 based on the International Terrestrial Reference Frame (ITRF). Continuous GPS observations were collected from 14 reference stations across Korea to compute the coordinates of 1st order horizontal geodetic control points. During the campaign, GPS observations were also collected at about 9,000 existing geodetic control points. In 2006, network adjustment with all data obtained using GPS and EDM since 1975 has been performed under the condition of fixing the coordinates of GPS continuous observation stations to compute coordinate measurements of the 2nd and 3rd geodetic control points. This paper describes the GPS campaigns which have been undertaken since 1996 and details of the network adjustment schemes. This is followed

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A Study on the Solar Water Heating System in the Military Facilities (병영시설의 태양열급탕시스템에 관한 연구)

  • Kim, Doo-Chun;Seo, Jin-Seok
    • The Magazine of the Society of Air-Conditioning and Refrigerating Engineers of Korea
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    • v.11 no.4
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    • pp.6-18
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    • 1982
  • The performance of two typical types of solar hot water heating system was tested in Seoul. Types of systems studied are single-tank internal external heat exchanger system and single-tank internal heat exchanger system. Comparing to experimental results, a transient system simulation program was made to analyze the performance of the selected system. The climate data, Standard Weather Year for Seoul, required for the simulation was provided. Computer simulations were used to estimate the effect of significant parameters upon system performance. The followings are obtained. 1. In the domestic solar water Heating system, the value $20-40kg/m^2\;h$ for flow rate through the collector is much better than the recommended value $72kg/m^2\;h$ in the solar heating system. 2. The effectiveness of collector heat exchanger and storage tank size are found to have only a small effect upon system performance. 3. The hot water draw pattern has a significant effect on system performance. A higher system efficiency achieved when draw-off occurred around noon than when it occurred around early morning. Using the above results, the reference solar hot water system which provides $300\ell$ of hot water per day, was selected as a guide for designer. And simplified graphical method was developed based on the modified f-chart method to determine required collector area. When the system design parameters of the proposed system differs from the reference system, required collector area can be calculated from area adjustment factors.

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Reference Ranges of Microalbumin Using Fasting Urine (Fasting Urine을 사용한 Microalbumin의 참고치에 관한 연구)

  • Kim, Ji-Young;Jin, Kwang-Ho;Bae, Ae-Young;Kim, Ye-Na;Seo, Sang-Won;Lee, Na-Ree;Jeon, Ha-Young;Shin, Sook-Hee
    • Korean Journal of Clinical Laboratory Science
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    • v.38 no.3
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    • pp.208-211
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    • 2006
  • Microalbuminuria is most frequently caused by kidney damage from diabetes. Moreover, many other conditions can lead to kidney damage, such as high blood pressure, heart failure, cirrhosis, or systemic lupus erythematosus (SLE). The measurement of the microalbumin in urine may be useful for the early diagnosis or as a predictor of nephropathy in diabetes. The most common method for getting a quantitative measurement of urinary protein relies on a 24-hour urine collection. The result of this method is accurate. But 24hr urine collection is difficult to obtain and variations in volume are frequent. Also the patients complain about urine collection. We tried to measure reference values for microalbumin using fasting urine and compare them with the albumin/creatinine ratio using 24hr urine. The concentrations of microalbumin in fasting urine and 24hr urine were $7.1{\pm}3.8mg/L$, $5.7{\pm}2.9mg/L$ (r=0.61, p=0.27), respectively. The albumin/creatinine ratios using fasting urine and 24hr urine were $8.7{\pm}4.2{\mu}g/mg$, $8.7{\pm}4.0{\mu}g/mg$ (r=0.76, p=0.88), respectively. This study indicated that the measurement of microalbumin in fasting urine was an easy and simple method for early diagnosis or to predict nephropathy in diabetes. Thus, setting up the reference value using fasting urine may be useful in the screening test for the diabetic nephropathy patients instead of using the 24hr albumin excretion rate (AER).

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Development of a Model-Based Motor Fault Detection System Using Vibration Signal (진동 신호 이용 모델 기반 모터 결함 검출 시스템 개발)

  • ;A.G. Parlos
    • Journal of Institute of Control, Robotics and Systems
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    • v.9 no.11
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    • pp.874-882
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    • 2003
  • The condition assessment of engineering systems has increased in importance because the manpower needed to operate and supervise various plants has been reduced. Especially, induction motors are at the core of most engineering processes, and there is an indispensable need to monitor their health and performance. So detection and diagnosis of motor faults is a base to improve efficiency of the industrial plant. In this paper, a model-based fault detection system is developed for induction motors, using steady state vibration signals. Early various fault detection systems using vibration signals are a trivial method and those methods are prone to have missed fault or false alarms. The suggested motor fault detection system was developed using a model-based reference value. The stationary signal had been extracted from the non-stationary signal using a data segmentation method. The signal processing method applied in this research is FFT. A reference model with spectra signal is developed and then the residuals of the vibration signal are generated. The ratio of RMS values of vibration residuals is proposed as a fault indicator for detecting faults. The developed fault detection system is tested on 800 hp motor and it is shown to be effective for detecting faults in the air-gap eccentricities and broken rotor bars. The suggested system is shown to be effective for reducing missed faults and false alarms. Moreover, the suggested system has advantages in the automation of fault detection algorithms in a random signal system, and the reference model is not complicated.

Reconfigurable Flight Control Design for the Complex Damaged Blended Wing Body Aircraft

  • Ahn, Jongmin;Kim, Kijoon;Kim, Seungkeun;Suk, Jinyoung
    • International Journal of Aeronautical and Space Sciences
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    • v.18 no.2
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    • pp.290-299
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    • 2017
  • Reconfigurable flight control using various kinds of adaptive control methods has been studied since the 1970s to enhance the survivability of aircraft in case of severe in-flight failure. Early studies were mainly focused on the failure of actuators. Recently, studies of reconfigurable flight controls that can accommodate complex damage (partial wing and tail loss) in conventional aircraft were reported. However, the partial wing loss effects on the aerodynamics of conventional type aircraft are quite different to those of BWB(blended wing body) aircraft. In this paper, a reconfigurable flight control algorithm was designed using a direct model reference adaptive method to overcome the instability caused by a complex damage of a BWB aircraft. A model reference adaptive control was incorporated into the inner loop rate control system enhancing the performance of the baseline control to cope with abrupt loss of stability. Gains of the model reference adaptive control were polled out using the Liapunov's stability theorem. Outer loop attitude autopilot was designed to manage roll and pitch of the BWB UAV as well. A 6-DOF dynamic model was built-up, where the normal flight can be made to switch to the damaged state abruptly reflecting the possible real flight situation. 22% of right wing loss as well as 25% loss for both vertical tail and rudder control surface were considered in this study. Static aerodynamic coefficients were obtained via wind tunnel test. Numerical simulations were conducted to demonstrate the performance of the reconfigurable flight control system.

Growth Characteristics of Creeping bentgrass Cultivars (크리핑 벤트그래스 품종의 생육 특성)

  • 이혜원;정대영;심상렬
    • Asian Journal of Turfgrass Science
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    • v.17 no.2_3
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    • pp.87-97
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    • 2003
  • The growth characteristics of creeping bentgrass seeded in the seaside landfill golf course are as follows. 1. As a result of analysis on the chemical characteristics of soil mixture used for turfgrass ground in this experiment, soil pH was 7.9, which is somewhat higher than the creeping bentgrass reference value of pH 5.5∼6.5; T-N(%) was 0.02, which is proper for the reference value, and trace element too lacked. 2. The cultivar with the fastest water infiltration was Seaside II recorded as 226.2cm/sec, while that with the slowest water infiltration was Pennlinks recorded as 141.1 cm/hr which was too faster than the USGA water infiltration reference value of 15∼30cm/hr. For the surface hardness of turfgrass ground with different cultivars, no statistically significant variation was found between the Penncross grass and the Pennlinks recorded as 18.6mm and 19.1 mm, respectively. The soil penetration was the highest in Pennlinks recorded as 7.6kg/$\textrm{cm}^2$ and lowest in Penn A-1 as 6.1kg/$\textrm{cm}^2$. 3. As a result of evaluation on visual quality at the early stage of growth, Penncross showed the most excellent visual quality compared to the others. However, Penn A-1 showed the most excellent visual quality at a late stage of growth around Sep. 17, 2003, and it was also excellent in the evaluation of visual color. Seaside II showed higher density around the root and the longest root length and was highly resistant to salt compared to others, but the initial sprouting rate was not satisfied, and the visual quality in the summer season was inferior to others. 4. As a result of measurement of the traffic injury, Penncross showed the most tolerant to the traffic stress and Pennlinks showed the most susceptible.

The Efficiency of Long Short-Term Memory (LSTM) in Phenology-Based Crop Classification

  • Ehsan Rahimi;Chuleui Jung
    • Korean Journal of Remote Sensing
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    • v.40 no.1
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    • pp.57-69
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    • 2024
  • Crop classification plays a vitalrole in monitoring agricultural landscapes and enhancing food production. In this study, we explore the effectiveness of Long Short-Term Memory (LSTM) models for crop classification, focusing on distinguishing between apple and rice crops. The aim wasto overcome the challenges associatedwith finding phenology-based classification thresholds by utilizing LSTM to capture the entire Normalized Difference Vegetation Index (NDVI)trend. Our methodology involvestraining the LSTM model using a reference site and applying it to three separate three test sites. Firstly, we generated 25 NDVI imagesfrom the Sentinel-2A data. Aftersegmenting study areas, we calculated the mean NDVI values for each segment. For the reference area, employed a training approach utilizing the NDVI trend line. This trend line served as the basis for training our crop classification model. Following the training phase, we applied the trained model to three separate test sites. The results demonstrated a high overall accuracy of 0.92 and a kappa coefficient of 0.85 for the reference site. The overall accuracies for the test sites were also favorable, ranging from 0.88 to 0.92, indicating successful classification outcomes. We also found that certain phenological metrics can be less effective in crop classification therefore limitations of relying solely on phenological map thresholds and emphasizes the challenges in detecting phenology in real-time, particularly in the early stages of crops. Our study demonstrates the potential of LSTM models in crop classification tasks, showcasing their ability to capture temporal dependencies and analyze timeseriesremote sensing data.While limitations exist in capturing specific phenological events, the integration of alternative approaches holds promise for enhancing classification accuracy. By leveraging advanced techniques and considering the specific challenges of agricultural landscapes, we can continue to refine crop classification models and support agricultural management practices.