• Genomics & Informatics
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• v.4 no.3
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• pp.97-102
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• 2006

In acute leukemia patients, several successful methods of expression profiling have been used for various purposes, i.e., to identify new disease class, to select a therapeutic target, or to predict chemo-sensitivity and clinical outcome. In the present study, we tested the peripheral blood of 47 acute leukemia patients in an attempt to identify differentially expressed genes in AML and ALL using a Korean-made 10K oligo-nucleotide microarray. Methods: Total RNA was prepared from peripheral blood and amplified for microarray experimentation. SAM (significant analysis of microarray) and PAM (prediction analysis of microarray) were used to select significant genes. The selected genes were tested for in a test group, independently of the training group. Results: We identified 345 differentially expressed genes that differentiated AML and ALL patients (FWER<0.05). Genes were selected using the training group (n=35) and tested for in the test group (n=12). Both training group and test group discriminated AML and ALL patients accurately. Genes that showed relatively high expression in AML patients were deoxynucleotidyl transferase, pre-B lymphocyte gene 3, B-cell linker, CD9 antigen, lymphoid enhancer-binding factor 1, CD79B antigen, and early B-cell factor. Genes highly expressed in ALL patients were annexin A 1, amyloid beta (A4) precursor protein, amyloid beta (A4) precursor-like protein 2, cathepsin C, lysozyme (renal amyloidosis), myeloperoxidase, and hematopoietic prostaglandin D2 synthase. Conclusion: This study provided genome wide molecular signatures of Korean acute leukemia patients, which clearly identify AML and ALL. Given with other reported signatures, these molecular signatures provide a means of achieving a molecular diagnosis in Korean acute leukemia patents.

• Smart Structures and Systems
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• v.17 no.6
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• pp.981-994
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• 2016

Two field research stations based upon atmospheric corrosivity monitoring combined with reinforced concrete corrosion rate sensors have been established in Kuwait. This was established for the purpose of remote monitoring of building materials performance for concrete under Kuwait atmospheric environment. The two field research sites for concrete have been based upon an outcome from a research investigation intended for monitoring the atmospheric corrosivity from weathering station distributed in eight areas, and in different regions in Kuwait. Data on corrosivity measurements are essential for the development of specification of an optimized corrosion resistance system for reinforced concrete manufactured products. This study aims to optimize, characterize, and utilize long-term concrete structural health monitoring through on line corrosion measurement and to determine the feasibility and viability of the integrated anode ladder corrosion sensors embedded in concrete. The atmospheric corrosivity categories supported with GSM remote data acquisition system from eight corrosion monitoring stations at different regions in Kuwait are being classified according to standard ISO 9223. The two nominated field sites where based upon time of wetness and bimetallic corrosion rate from atmospheric data where metals and rebar's concrete are likely to be used. Eight concrete blocks with embeddable anodic ladder corrosion sensors were placed in the atmospheric zone adjacent to the sea shore at KISR site. The anodic ladder corrosion rate sensors for concrete were installed to provide an early warning system on prediction of the corrosion propagation and on developing new insights on the long-term durability performance and repair of concrete structures to lower labor cost. The results show the atmospheric corrosivity data of the environment and the feasibility of data retrieval of the corrosion potential of concrete from the embeddable sets of anodic ladder corrosion sensors.

• Smart Structures and Systems
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• v.25 no.6
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• pp.751-764
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• 2020

Real-time monitoring of stiffness and strength in cement based system has received significant attention in past few decades owing to the development of advanced techniques. Also, use of environment friendly supplementary cementitious materials (SCM) in cement, though gaining huge interest, severely affect the strength gain especially in early ages. Continuous monitoring of strength- and stiffness- gain using an efficient technique will systematically facilitate to choose the suitable time of removal of formwork for structures made with SCM incorporated concrete. This paper presents a technique for monitoring the strength and stiffness evolution in hydrating fly ash blended cement systems using electro-mechanical impedance (EMI) based technique. It is important to observe that the slower pozzolanic reactivity of fly ash blended cement systems could be effectively tracked using the evolution of equivalent local stiffness of the hydrating medium. Strength prediction models are proposed for estimating the strength and stiffness of the fly ash cement system, where curing age (in terms of hours/days) and the percentage replacement of cement by fly ash are the parameters. Evaluation of strength as obtained from EMI characteristics is validated with the results from destructive compression test and also compared with the same obtained from commonly used ultrasonic wave velocity (UPV). Statistical error indices indicate that the EMI technique is capable of predicting the strength of fly ash blended cement system more accurate than that from UPV. Further, the correlations between stiffness- and strength- gain over the time of hydration are also established. From the study, it is found that EMI based method can be effectively used for monitoring of strength gain in the fly ash incorporated cement system during hardening.

• Journal of the Korea Society of Computer and Information
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• v.19 no.2
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• pp.21-30
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• 2014

The use of induction motors has been recently increasing in a variety of industrial sites, and they play a significant role. This has motivated that many researchers have studied on developing fault detection and classification systems of induction motors in order to reduce economical damage caused by their faults. To early identify induction motor faults, this paper effectively estimates spectral envelopes of each induction motor fault by utilizing a linear prediction coding (LPC) analysis technique and an expectation maximization (EM) algorithm. Moreover, this paper classifies induction motor faults into their corresponding categories by calculating Mahalanobis distance using the estimated spectral envelopes and finding the minimum distance. Experimental results show that the proposed approach yields higher classification accuracies than the state-of-the-art conventional approach for both noiseless and noisy environments for identifying the induction motor faults.

• Phonetics and Speech Sciences
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• v.3 no.1
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• pp.145-151
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• 2011

In view of the hypothesis that the effects of Parkinson's disease on voice production can be detected before pharmacological intervention, the prosodic features of patients with idiopathic Parkinson's disease (IPD) and a healthy aging group were diagnostically analyzed with the long term object of establishing, for clinical purposes, early disease-progression biomarkers. Twenty patients (male 8; female 12) with IPD (prior to pharmacological intervention) and a healthy control group of 22 (male 10; female 12) were selected. Ten sentences were recorded with a head-worn microphone. One sentence was chosen for the analysis of this paper. Relevant parameters, i.e. 3-dimensional model (F0, intensity, duration) and pitch and intensity related slopes (maxEnergy, maxF0, meanAbS, semiT, meanEnergy, meanF0), were analyzed by two-group discriminant analysis. The stepwise estimation method of discriminant analysis was performed by gender. The discriminant functions predicted 83.9% of the male test data correctly while the prediction rate was 93.1% for the female group. The results showed that meanF0_slope and semiT_slope were more important parameters than the others for the male group. For the female group, the meanEnergy_slope and maxEnergy_slope were the important ones. These findings indicate that significant parameters are different for the male and female group. Gender lifestyle may be responsible for this difference. Dysprosodic features of IPD show not simultaneously but progressively in terms of F0, intensity and duration.

• Korean Journal of Social Welfare
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• v.68 no.3
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• pp.105-125
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• 2016

School absenteeism is considered one of the early predictors of school drop-out and serious delinquency or criminal behavior. The primary goal of the current study was to explore the protective and risk factors related to changing school absenteeism over time based on the ecological-systemic perspective. The data was derived from the Korean Children and Youth Panel Survey (KCYPS) using the 2011 and 2012 survey waves collected from 2,378 elementary school students. Using this data, Panel Fixed Effects Analysis was conducted. Major findings indicated that daily computer usage, parental abuse, school activity attendance, and school grades had an effect on students missing school days over time. Specifically, high levels of computer usage and parental abuse were related to increased school absenteeism, while high levels of school activity attendance and school grades were associated with decreased school absenteeism. These findings emphasized the importance of predictive intervention for children and suggested the need to construct a school absenteeism monitoring system in South Korea.

• Journal of the Korea Convergence Society
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• v.11 no.5
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• pp.153-158
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• 2020

The present study identify the predictive power of confrontational naming and generative naming as screening tests for normal and early cognitive impairment. The subjects were analyzed for 203 healthy elderly, 106 mild cognitive impairment (MCI), 31 mild dementia. The confrontational naming was measured by the short-term Korean Boston Name Waiting Test, and the generative naming was measured by the Control Associative Word Test. As a result of polynomial logistic regression, both confrontational naming and generative naming had a significant effect on discriminating cognitive impairment (MCI, mild dementia) in general elderly (p<0.05). On the other hand, when distinguishing mild dementia from mild cognitive impairment, the generative naming-phonetic test had no significant odds ratio. The results of this study suggest that when discriminating mild dementia in mild cognitive impairment group, it is not meaningful to look only at the total score of generative naming test.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.8 no.4
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• pp.938-945
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• 2004

On the relationship between the red tide occurrence and the oceanographic factors in the middle coastal area in the South Sea of Korea, the favorable oceanographic conditions for the red tide formation are considered as follows； the calm weather increases sea water temperature in summer and early-fall which the red tide occurs frequently, and the heavy precipitation brings some riverine water to ween: low salinity, high suspended solid, low phosphorus and high nitrogen, respectively. We decided the potential areas in the coastal zones vulnerable to the red tide occurrence based on the limited factors controlling the growth of phytoplankton. By using GIS through the overlap for three subject figures (phosphorus, nitrogen and suspended solids), it was founded that the potential areas are the Yeosu∼Dolsan coast, the Gamak bay, the Namhae coast, the Narodo coast, the Goheung and Deukryang bay. This result has very well coincided to the results of the satellite and in-situ data.

• The Transactions of the Korean Institute of Electrical Engineers D
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• v.55 no.1
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• pp.35-41
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• 2006

Although reachers have studied for a long time, they don't make criteria for anesthesia depth. anesthetists can't make a prediction about patient's reaction. Therefor, patients have potential risk such as poisonous side effect late-awake, early-awake and strain reaction. EEG are received from twenty-five patients who agreed to investigate themselves during operation with Enflurane-anesthesis in progress of anesthesia. EEG are divided pre-anesthesia, before incision of skin, operation 1, operation 2, awaking, post-anesthesia by anesthesia progress step. EEG is applied pre-processing, base line correct, linear detrend to get more reliable data. EEG data are handled by electronic processing and the EEG data are calculated by bicoherence. During pre-anesthesia and post anesthesia, appearance rate of bicoherence value is observed strong appearance rate in high frequency range($15\~30Hz$). During the anesthesia of patient, a strong appearance rate is revealed the low frequency area(0~10Hz). After bicoherence is calculated by percentage of a appearance rate, that is, Bicpara$\#$1, Bicpara$\#$2, Bicpara$\#$3 and Bicpara$\#$4 parameter are extracted. In result of bicoherence analysis, Bicpara$\#$2 and Bicpara#4 are considered that the best parameter showed progress of anesthesia effectively. And each separated bicoherence are calculated by average bicoherence's numerical value, divide by 2 area, appear by each BicHz$\#$1, BicHz$\#$2, and observed BicHz$\#$1/BicHz$\#$2's change. In result of bicoherence analysis, BicHz$\#$1, BicHz$\#$2 and BicHz$\#$1/BicHz$\#$2 are considered that the best parameter showed progress of anesthesia effectively. In conclusion, I confirmed the anesthesia progress phase, concluded to usefulness of parameter on bispectrum and bicoherence analysis and evaluated the depth of anesthesia. In the future, it is going to use for doctor's diagnosis and apply to protect an medical accident owing to anesthesia.

• Korean Journal of Community Nutrition
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• v.11 no.6
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• pp.779-784
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• 2006

Several studies about hospital malnutrition have been reported that about more than 40% of hospitalized patients are having nutritional risk factors and hospital malnutrition presents a high prevalence. People in a more severe nutritional status ended up with a longer length of hospital stay and higher hospital cost. Nutrition screening tools identify individuals who are malnourished or at risk of becoming malnourished and who may benefit from nutritional support. For the early detection and treatment of malnourished hospital patients , few valid screening instruments fur Koreans exist. Therefore, the aim of this study was to develop a simple, reliable and valid malnutrition screening tool that could be used at hospital admission to identify adult patients at risk of malnutrition using medical electrical record data. Two hundred and one patients of the university affiliated medical center were assessed on nutritional status and classified as well nourished, moderately or severely malnourished by a Patient-Generated subjective global assessment (PG-SGA) being chosen as the 'gold standard' for defining malnutrition. The combination of nutrition screening questions with the highest sensitivity and specificity at prediction PG-SGA was termed the nutrition screening index (NSI). Odd ratio, and binary logistic regression were used to predict the best nutritional status predictors. Based on regression coefficient score, albumin less than 3.5 g/dl, body mass index (BMI) less than $18.5kg/m^2$, total lymphocyte count less than 900 and age over 65 were determined as the best set of NSI. By using best nutritional predictors receiver operating characteristic curve with the area under the curve, sensitivity and 1-specificity were analyzed to determine the best optimal cut-off point to decide normal or abnormal in nutritional status. Therefore simple and beneficial NSI was developed for identifying patients with severe malnutrition. Using NSI, nutritional information of the severe malnutrition patient should be shared with physicians and they should be cared for by clinical dietitians to improve their nutritional status.