• Biomolecules & Therapeutics
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• v.21 no.1
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• pp.1-9
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• 2013

Polyamines, putrescine, spermidine and spermine, are ubiquitous in living cells and are essential for eukaryotic cell growth. These polycations interact with negatively charged molecules such as DNA, RNA, acidic proteins and phospholipids and modulate various cellular functions including macromolecular synthesis. Dysregulation of the polyamine pathway leads to pathological conditions including cancer, inflammation, stroke, renal failure and diabetes. Increase in polyamines and polyamine synthesis enzymes is often associated with tumor growth, and urinary and plasma contents of polyamines and their metabolites have been investigated as diagnostic markers for cancers. Of these, diacetylated derivatives of spermidine and spermine are elevated in the urine of cancer patients and present potential markers for early detection. Enhanced catabolism of cellular polyamines by polyamine oxidases (PAO), spermine oxidase (SMO) or acetylpolyamine oxidase (AcPAO), increases cellular oxidative stress and generates hydrogen peroxide and a reactive toxic metabolite, acrolein, which covalently incorporates into lysine residues of cellular proteins. Levels of protein-conjuagated acrolein (PC-Acro) and polyamine oxidizing enzymes were increased in the locus of brain infarction and in plasma in a mouse model of stroke and also in the plasma of stroke patients. When the combined measurements of PC-Acro, interleukin 6 (IL-6), and C-reactive protein (CRP) were evaluated, even silent brain infarction (SBI) was detected with high sensitivity and specificity. Considering that there are no reliable biochemical markers for early stage of stroke, PC-Acro and PAOs present promising markers. Thus the polyamine metabolites in plasma or urine provide useful tools in early diagnosis of cancer and stroke.

• Horticultural Science & Technology
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• v.18 no.5
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• pp.591-593
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• 2000

This study was conducted to investigate the effect of training time on the growth and yield of 'Sinsakigake-2' pepper (Capsicum annuum L.). Plants were either left untrained as control or trained at the third node leaving four shoots per plant. Plants were traind at 20, 45, 70, or 95 days after transplanting (DAT). The earlier the training time, the more the branch number of the plant. Fruit weight was not affected by training time. However, the percentage of marketable fruits and the number of marketable fruits per plant were the highest in plants trained at 70 DAT, and the lowest in the control. Early marketable yield was the highest in the control, and the lowest in plants trained at 45 DAT.

• Journal of Chest Surgery
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• v.9 no.2
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• pp.198-206
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• 1976

A Total of Forty eight patients underwent open-heart surgery for correction of tetralogy of Fallot at the Seoul National University Hospital from January 1974 to October 1976, with an overall survival rate of 77 per cent. Operative mortality varied according to severity of the lesion, age of the patient, nature of previous surgical treatment and presence or absence of an outflow tract patch across the pulmonary valve ring. Eleven patients died in the early postoperative period and thirty seven patients were discharged from the hospital alive. A patch of the right ventricular outflow tract and pulmonary annulus was required to relieve pulmonic stenosis in 24 patients. There were 10 deaths in this group (42%) as compared to 1 death in the group of 24 patients who were corrected without a patch. Operative mortality was especially higher when an inlay patch was placed across the pulmonary valve ring. This may be related to the possibly greater anatomic severity of these cases and to the longer operating time when a patch was used. The electrocardiogram showed right ventricular hypertrophy in 35 cyanotic patients. Intraventricular conduction was normal in 34 patients before operation. It was normal postoperatively in only 5 of 34 patients in this group who survived surgery. Complete right bundle branch block appeared at operation in 21 patients, and 8 patients developed incomplete right bundle branch block. Major causes of death were progressive cardiac failure (4), Complete atrioventricular dissociation (3), bleeding (2), cardiac tamponade (1), and sudden cardiac arrest (1)

• Journal of Astronomy and Space Sciences
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• v.15 no.1
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• pp.53-58
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• 1998

The $H{\beta}$ and some metal line indices, such as Mg2, Fe52 of single-age and single-metallicity populations are computed based on the method of evolutionary population synthesis, with careful consideration of the variation of the horizontal-branch morphology with metallicity and age. We find (a) that while metal lines are little af-fected, the $H{\beta}$ index is severely enhanced (up to 30%)by the presence of the blue horizontal-branch stars, frustrating the current age-estimations from this index with out careful consideration of these stars, and (b) that there is a systematic trend in the sense that the globular clusters in giant elliptical galaxies appear to be older than those in our Galaxy by several billion years. We also calculate these indices for the stellar populations with a metallicity spread, by adopting metallicity distribution functions predicted by chemical evolution models. The comparison of the models with the observed indices of the central regions of the early-type galaxies yields the results (a) that the ages of the giant elliptical galaxies would be older than the previous estimations by several billion years, and (b) that there is a considerable age spread among elliptical galaxies, in the sense that the giant elliptical galaxies are older than small ones.

• Journal of the Korea Society of Computer and Information
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• v.21 no.9
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• pp.1-9
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• 2016

Recent embedded processors employ set-associative L1 instruction cache to improve the performance. The energy consumption in the set-associative L1 instruction cache accounts for considerable portion in the embedded processor. When an instruction is required from the processor, all ways in the set-associative instruction cache are accessed in parallel. In this paper, we propose the technique to reduce the energy consumption in the set-associative L1 instruction cache effectively by accessing only one way. Gshare branch predictor is employed to predict the instruction flow and determine the way to fetch the instruction. When the branch prediction is untaken, next instruction in a sequential order can be fetched from the instruction cache by accessing only one way. According to our simulations with SPEC2006 benchmarks, the proposed technique requires negligible hardware overhead and shows 20% energy reduction on average in 4-way L1 instruction cache.

• Journal of Gastric Cancer
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• v.15 no.1
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• pp.53-57
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• 2015

Laparoscopic distal gastrectomy has become widespread as a treatment for early gastric cancer in eastern Asia, but a standard method for setting the stomach transection line has not been established. Here we report a novel method of setting this line based on anatomical landmarks. At the start of the operation, two anatomical landmarks along the greater curvature of the stomach were marked with ink: the proximal landmark at the avascular area between the last branch of the short gastric artery and the first branch of the left gastroepiploic artery, and the distal landmark at the point of communication between the right and left gastroepiploic arteries. Just before specimen retrieval, the stomach was transected from the center of these two landmarks toward the lesser curvature. Then, about two-third of the stomach was reproducibly resected, and gastroduodenostomy was successfully performed in 26 consecutive cases. This novel method could be used as a standard technique for setting the transection line in laparoscopic distal gastrectomy.

• Journal of Electrical Engineering and Technology
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• v.13 no.1
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• pp.1-10
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• 2018

Wide-area monitoring of tree-related high impedance fault (THIF) efficiently contributes to increase reliability of large-scaled network, since the failure to early location of them may results in critical lines tripping and consequently large blackouts. In the first place, this wide-area monitoring of THIF requires managing the placement of sensors across large power grid network according to THIF detection objective. For this purpose, current paper presents a framework in which sensors are distributed according to a predetermined risk map. The proposed risk map determines the possibility of THIF occurrence on every branch in a power network, based on electrical conductivity of trees and their positions to power lines which extracted from spectral data. The obtained possibility value can be considered as a weight coefficient assigned to each branch in sensor placement problem. The next step after sensors deployment is to on-line monitor based on moving data window. In this on-line process, the received data window is evaluated for obtaining a correlation between low frequency and high frequency components of signal. If obtained correlation follows a specified pattern, received signal is considered as a THIF. Thereafter, if several faulted section candidates are found by deployed sensors, the most likely location is chosen from the list of candidates based on predetermined THIF risk map.

• The Bulletin of The Korean Astronomical Society
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• v.46 no.1
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• pp.35.1-35.1
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• 2021

RR Lyrae stars are sensitive probe for the precision stellar astrophysics and also for the cosmic distance scale thanks to their well-defined near-infrared Period-Luminosity relations (PLRs). These horizontal branch variables can be used for primary calibration of the first-rung of population II distance ladder providing an evaluation of the ongoing tension between Cepheid-Supernovae based Hubble constant and the Planck results. Therefore, absolute calibration of RR Lyrae PLRs is now crucial to complement or test the tip of the red giant branch based distances, and in turn, population II star based Hubble constant measurements. While the pulsation models of RR Lyrae can reproduce most observables, they predict a significant metallicity effect on their JHKs-band PLRs that is inconsistent with so-far limited observational studies. We remedy this inconsistency of metallicity dependence in RR Lyrae PLRs by combining their near-infrared observations in the globular clusters of different mean-metallicities with the new parallaxes from the Gaia early data release 3 (EDR3). Our empirical results on Period-Luminosity-Metallicity (PLZ)relations are consistent with theoretical predictions but the precision of absolute calibrations is still affected by the parallax uncertainties and the systematic zero-point offset present in the Gaia EDR3.

• Nutrition Research and Practice
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• v.4 no.2
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• pp.155-162
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• 2010

Epidemiological evidence of the effects of dietary sodium, calcium, and potassium, and anthropometric indexes on blood pressure is still inconsistent. To investigate the relationship between dietary factors or anthropometric indexes and hypertension risk, we examined the association of systolic and diastolic blood pressure (SBP and DBP) with sodium, calcium, and potassium intakes and anthropometric indexes in 19~49-year-olds using data from Korean National Health and Nutrition Examination Survey (KNHANES) III. Total of 2,761 young and middle aged adults (574 aged 19~29 years and 2,187 aged 30~49 years) were selected from KNHANES III. General information, nutritional status, and anthropometric data were compared between two age groups (19~29 years old and 30~49 years old). The relevance of blood pressure and risk factors such as age, sex, body mass index (BMI), weight, waist circumference, and the intakes of sodium, potassium, and calcium was determined by multiple regression analysis. Multiple regression models showed that waist circumference, weight, and BMI were positively associated with SBP and DBP in both age groups. Sodium and potassium intakes were not associated with either SBP or DBP. Among 30~49-year-olds, calcium was inversely associated with both SBP and DBP (P = 0.012 and 0.010, respectively). Our findings suggest that encouraging calcium consumption and weight control may play an important role in the primary prevention and management of hypertension in early adulthood.

• Archives of Reconstructive Microsurgery
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• v.12 no.1
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• pp.19-29
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• 2003

Soft tissue reconstruction of dorsum of the foot and ankle has long presented challenging problems for the reconstructive surgeon. Limitations of available local tissue, the need for specialized tissue, and donor site morbidity restrict the options. In an effort to solve these difficult problems, we have begun to use adipofascial flap based on the perforating branch of the peroneal artery. We present our early experience of 5 patients treated with this flap. Our patients ranged from 6 to 26 years in age and included 3 males and 2 females. The etiologies of the wounds were secondary to traffic accident, and crushing injury. The flaps had reverse flow in all patients. The flap and the adjoining raw area were covered with a full-thickness skin graft, while the donor site at the lateral aspect of the leg was closed primarily without grafting. The skin graft was taken from the inguinal area, which was closed primarily. Compared with other flap, this adipofascial flap is thinner, producing less bulkiness to the recipient site and minor aesthetic sequelae to the donor site. In our opinion, this flap is versatile, effective, and an addition to the armamentarium of the reconstructive surgeon for coverage of difficult wounds of the foot and ankle.