• 생명과학회지
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• 제16권7호
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• pp.1071-1079
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• 2006

야생 돌복숭아(Prunus persica Batsch var. davidiana Max.)의 생리활성 추출물질이 선천성 고혈압 흰쥐(SHR)의 지질대사 이상 및 고혈압 예방과 개선효과 등에 생리생화학적 효능이 있을 것으로 추정되어 Wistar 계 수컷 SHR을 사용하여, 기본식이와 물만을 급여한 대조군인 Control군과 SHR에 돌복숭아 5.0g% 추출액을 급여한 군(5g% Ex.군) 및 SHR에 돌복숭아 10.0g% 추출액을 섭취시킨 10g% Ex.군을 33일간 실험 사육하여 혈청 지질성분 및 혈압 저하 효과를 생리적 측면에서 검토하기 위하여 본 실험을 수행하였다. 혈청 중의 총 콜레스테롤 농도, 중성지방, LDL-콜레스테롤, 유리 콜레스테롤 및 동맥경화지수 등에서 돌복숭아 생리활성물질 5.0g%, 10.0g% 추출액을 섭취시킴으로서 유의적인 농도 등의 감소 효과를 보였으며, HDL-콜레스테롤 농도 및 총 콜레스테롤에 대한 HDL-콜레스테롤 비는 상승되는 것으로 나타났다. 한편, 간장 및 뇌 중의 총 콜레스테롤, 중성지방 농도는 돌복숭아 5.0g%, 10.0g% 추출액을 섭취시킨 군에서 감소되는 것으로 나타났다. 반면, 혈청 apolipoprotein(Apo) A-I, Apo A-II 농도 등은 돌복숭아 5.0g%, 10.0g% 추출액을 섭취시킨 군에서 유의적으로 증가되는 것으로 나타났다. 또한 Apo C-II, Apo C-III, Apo E 및 Apo A-I에 대한 Apo B의 농도 비는 감소되었으며, 혈압의 변화는 SHR에 돌복숭아 5.0g% 및 10.0g% 추출액을 섭취시킴으로서 혈압이 저하됨을 관찰할 수가 있었다. 돌복숭아 5.0g% 농도(5g% Ex.군)와 10.0g% 농도(10g% Ex.군)의 추출액 섭취에 따른 두 군간에 각종 지질성분과 apolipoprotein 분획 농도 및 혈압 변화의 비교는 유의적인 차이는 없었다 따라서 야생 돌복숭아 중의 생리활성물질 추출액 섭취가 선천성 고혈압 흰쥐에 대한 혈청 지질개선 및 심장순환기계 질환, 고혈압의 예방과 치료개선에 효과가 있을 것으로 생각된다.

• 한국식품과학회지
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• 제38권6호
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• pp.799-804
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• 2006

새송이버섯의 전체, 갓, 대 3부분으로 구분하여 일반성분과 총 폴리페놀함량을 측정하고 분획별 추출물의 수율 측정, 전자공여능, SOD 유사활성, 아질산염 소거능 및 항균활성을 측정하였다. 총 폴리페놀은 에틸아세테이트 추출물을 제외하고는 갓, 전체, 대의 순이었고 용매별로는 전체와 갓에서는 부탄올, 물, 에탄올 추출물의 함량이 높았다. 반면 대에서는 에틸아세테이트와 부탄올 추출물의 함량이 높았다. 전자공여능은 0.02% tocopherol, 0.02% BHT와 비교하여 전체와 갓의 물 추출물과 갓의 에탄올 추출물은 유사한 활성을 나타내었으며 에탄올, 부탄올, 물 추출물에서 활성이 높았다. SOD 유사활성과 아질산염 소거능은 갓의 부탄올, 물, 에탄올 추출물에서 높았다. SOD 유사활성은 대조군인 0.02% tocopherol 및 BHT 보다 낮았다. 전반적으로 대보다는 갓 부위의 추출물에서 항산화능이 높게 나타났다. 항균활성 측정에서 그램 양성균에서는 미비하였지만 그램 음성균 특히 Escherichia coli, Pseudomonas aeruginosa에서 에틸아세테이트와 물 추출물의 높은 항균활성이 나타내어 새송이버섯이 높은 항산화 및 항균효과가 확인되었다. 이를 바탕으로 가공 식품에 사용되는 합성 항산화제, 보존제 같은 첨가제로 새송이버섯을 이용한 천연 첨가제의 개발이 가능할 것으로 사료되며 높은 생리활성을 바탕으로 기능성 식품의 소재로 개발가능성이 시사되었다.

• 한국산학기술학회논문지
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• 제22권1호
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• pp.363-371
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• 2021

본 연구는 12주간 복합운동 중 혈류제한을 적용한 것과 적용하지 않은 것이 65세 이상 여성노인들의 운동수행능력(심폐지구력, 하체근력)과 평형성(동적평형성, 낙상위험지수)에 미치는 영향을 알아보기 위해 실시하였다. 연구대상자는 혈류제한을 통한 복합운동(14명), 혈류제한을 하지 않은 복합운동(14명)과 통제집단(15명)으로 총 43명이 연구에 참여하였다. 혈류제한 복합운동 그룹과 복합운동 그룹 모두 주 3회 총 12주 동안 복합운동을 실시하였고, 통제집단은 훈련기간 동안 일상적인 생활을 하였다. 본 연구의 자료처리는 SPSS/ver22를 사용하였으며 사전값의 동질성 검사 후 이원반복측정분산분석(Two-way Repeated Measures ANOVA)과 대비검증(contrast)을 이용하여 분석하였고, 모든 자료의 유의수준은 α=.05로 설정하였다. 연구결과 혈류제한을 적용한 복합운동 집단과 적용하지 않은 복합운동 집단의 운동수행능력(심폐지구력, 하체근력)과 평형성(동적평형성)은 유의하게 증가하였고, 두 집단 모두 낙상위험지수는 유의하게 감소하였다. 하지만 통제집단에서는 유의한 변화가 없었다. 추가적으로 두 운동집단 중 혈류제한을 적용한 복합운동 집단이 사전과 사후 변화량(%△)과 효과크기(effect size)가 일반복합운동 집단 보다 높이 나왔다. 이는 혈류제한을 적용한 복합운동집단이 혈류제한을 적용하지 않은 복합운동보다 운동수행력과 평형성에 더욱 긍정적인 효과를 나타냈다.

• Journal of Nutrition and Health
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• 제57권1호
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• pp.27-42
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• 2024

본 연구에서는 중강도 운동을 한 비만 흰쥐를 대상으로 정향 투여에 따른 염증 관련 단백질, 근육 합성 및 분해 관련 단백질에 미치는 영향을 평가하였다. 규칙적인 중강도 운동은 혈청 내 산화 스트레스와 leptin 수준을 억제시켰다. 또한, 염증 관련 단백질을 감소시켰으며, 근육 합성 관련 단백질을 활성화 및 근육 분해 관련 단백질 억제를 통해 근육 대사를 조절하였다. 여기에 정향의 투여는 혈청 내 염증성 사이토카인 IL-1β를 유의적으로 감소시켜 염증을 효과적으로 개선하는 효과를 발휘하였다.

• Nuclear Engineering and Technology
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• 제29권5호
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• pp.399-405
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• 1997

In this study a new phase separated spectral analysis algorithm is proposed to identify CSB vibration mode directly from ex-core neutron signals. Ex-core neutron signals can be decomposed into the global, core support barrel (CSB) beam mode, and CSB shell mode components by the new phase separation algorithm based on the characteristics of Fourier transform. By using the proposed algorithm and the conventional spectral analysis the vibration mode of the CSB and the fuel assembly of Ulchin-1 NPP were identified from measured ex-core neutron signals.

• 미국학
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• 제43권1호
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• pp.115-143
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• 2020

The U.S. Congress has been known to effectively control the bureaucracy. On one hand, Congress adjusts the degree of discretion provided to the bureaucracy when making agencies or legislation: ex ante control. On the other hand, it also performs the oversight activities to punish or correct undesirable behaviors of bureaucrats: ex post control. While the dynamics of each control mechanism is widely examined theoretically, few have attempted to empirically investigate this with a special attention to partisan politics in Congress. I attempt to fill this gap by measuring the two types of control mechanisms, testing theoretical assertions, and analyzing the dynamics under the two control mechanisms.

• 대한약리학회지
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• 제10권2호
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• pp.43-54
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• 1974

The cactus family Cactaceae, numbering about 1,500 species, is a fleshy-stemmed perennial plant which is principally distributed in the south and north America. On the other hand, the cactus plant is presumed to be introduced into Korea in 1912-1945, thereafter it has been cultivated merely in favor of ornamentation with the exception of being occasionally used as medication among laymen. Opuntia elata which belongs to Opuntia genus, the Cactaceae family is one of the cacti being cultivated a great deal in Korea. Cho et. al. reported in 1974 that Opuntia dilenii manifested the cardiac inhibitory effect and oxytocic effect, and its mechanism might be partially due to the direct action. Besides this, there are few reports on the pharmacological research concerning Opuntia genus to be demonstrated in Korea. However, some other cacti have the remarkable pharmacological effects; the active ingredients, mescaline, anhalamine, anhalanine, etc. from Peyote cactus (Lophophora williamsii) belonging to Lophophora genus have the psychotomimetic and sympathomimetic effects, and the cardioactive glycosides from Cactus Grandifolius (Selenicereus grandiflorus) belonging to Cereus genus have the cardioactive and diuretic effects. The authors hereby inquired into this study to find out the propriety of the pharmacological properties of the ethanol extract of Opuntia elata (EX) on the heart, blood pressure, respiration, intestine and uterus in the experimental animals. The results of the experiment were as follows: 1. Administration of EX manifested the cardiac inhibitory effect caused by the negative inotropic action in the isolated heart of frog, and the pretreatment of atropine did not affect the inhibitory effect produced by EX. 2. Administration of EX manifested the transient hypotensive effect in the intact rabbit, and the pretreatment of atropine did not affect the hypotensive effect produced by EX. 3. Administration of the small dose of EX manifested no significant effect, but moderate dose or more the stimulating effect, and the large dose the asphyxia on the respiratory motility in the intact rabbit. 4. Administration of EX manifested the sustained augmentation of contractility in the excised duodenum of rabbit, and the pretreatment of atropine did not affect the stimulating effect produced by EX. 5. Administration of EX manifested the sustained augmentation of contractility in the excised pregnant uterus of rabbit, and the pretreatment of atropine and oxytocin did not affect the oxytocic effect produced by EX, but that of barium chloride more or less stimulated the oxytocic effect produced by EX.

• Asian-Australasian Journal of Animal Sciences
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• 제12권3호
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• pp.395-399
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• 1999

Three experiments were conducted to determine the effects of conditioning a complex (20% whey, 10% lactose, 4% plasma protein, 4% wheat gluten and 2% blood meal) diet on growth performance of weanling pigs. In Exp. 1,180 pigs (average initial BW of 6.4 kg) were fed the experimental diet (1.7% lysine) during a 7-d growth assay. Treatments were a meal control (M), standard (ST), and expander (EX) conditioned mash or pellets. Rate and efficiency of gain were decreased by 39% and 21% (p<0.005) respectively, for pigs fed EX diets compared to those fed the ST diet. In Exp. 2,196 pigs (average initial BW of 6.5 kg) were used to determine the effects of EX operating conditions on nutritional value of a pelleted complex diet. When steam conditioning temperature (prior to expanding) was $54^{\circ}C$, increasing cone pressure of the EX from 0 to 7 to 14 kg/cm2 resulted in linear decreases in rate of gain of weaned pigs (p<0.006), suggesting heat damage of the diet. Increasing conditioning temperature (i.e., adding steam) of the diets from 46 to 54 to $63^{\circ}C$ (cone pressure at $12kg/cm^2$) resulted in improved rate of gain (p<0.04) of the pigs. However, none of the pigs fed expanded diets compared favorably to the pigs fed the conditioned $(54^{\circ}C)$ pellets processed with no cone pressure. In Exp. 3,168 pigs (average initial BW of 6.6 kg) were used to determine the effects of expanding the various components of the diet. Treatments were M and ST pellets as controls, EX-corn, EX-corn soybean-meal, EX corn-soybean meal-oil, and EX-complete diet. Efficiency of gain was increased by 13% with EX portions of the diet compared to the mash control, but there was a marked decrease in performance when the complete diet was expanded (p<0.001). Expanded corn-soybean meal-oil supported the greatest ADG with a 19% increase compared to the average of the EX corn and EX corn-soybean meal treatments (p<0.005). In conclusion, our results suggest no benefit from expanding complete phase-I diets.

• 유통과학연구
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• 제16권11호
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• pp.65-72
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• 2018

Purpose - The purpose of this research is to investigate the effect of ex ante governance mechanisms that can be exercised by franchisers on franchise contract compliance and various relationship outcomes. There are many previous studies on control mechanisms in inter-firm relationship, however, most studies focus on ex post governance mechanisms and identify the effects of behavior control and outcome control on performances. Based on transaction cost theory and agency theory, this study defines the ex ante governance mechanisms of franchisers as contractual completeness and extra contractual incentives. The author have examined the two ex ante control mechanisms on contract compliance, recontract intention, multi-shop running intention and opportunistic behaviors of franchisee. Research design, data, and methodology - In this study, 137 questionnaires of food and beverage franchise stores were collected through a specialized research company. The reliability and validity of the variables were analyzed using SPSS 18.0 and AMOS 18.0 programs and hypotheses were verified through the structural equation modeling. Results - As a result of hypothesis testing, contractual completeness and extra contractual incentives have a positive effect on the contract compliance of the franchisee. It is shown that franchisee's contract compliance has a positive effect on recontract intention and multi-shop running intention and has a negative effect on opportunistic behaviors. Conclusions - This study examines the ex ante governance mechanisms such as contractual completeness and extra contractual incentives, which is relatively rare compared to ex post governance mechanism in B2B relationship. According to the results of this research, these two tools can be used as ex ante control mechanisms for franchise headquarters to use their franchisees. In addition, franchisee's contract compliance affects various relationship outcomes between franchisor and franchisees.

• Journal of Periodontal and Implant Science
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• 제39권3호
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• pp.349-358
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• 2009

Purpose: This study was aimed to evaluate the effect of the Freeze Dried Bone Allograft and Demineralized Bone Matrix on osseous regeneration in the rat calvarial defects. Methods: Eight mm critical-sized calvarial defects were created in the 80 male Sprague-Dawley rats. The animals were divided into 4 groups of 20 animals each. The defects were treated with Freeze Dried Bone Allograft($SureOss^{TM}$), Demineralized Bone Matrix($ExFuse^{TM}$ Gel, $ExFuse^{TM}$ Putty), or were left untreated for sham-surgery control and were evaluated by histologic and histomorphometric parameters following a 2 and 8 week healing intervals. Statistical analysis was done between each groups and time intervals with ANOVA and paired t-test. Results: Defect closure, New bone area, Augmented area in the $SureOss^{TM}$, $ExFuse^{TM}$ Gel, $ExFuse^{TM}$ Putty groups were significantly greater than in the sham-surgery control group at each healing interval(P < 0.05). In the New bone area and Defect closure, there were no significant difference between experimental groups. Augmented area in the $ExFuse^{TM}$ Gel, $ExFuse^{TM}$ Putty groups were significantly greater than $SureOss^{TM}$ group at 2weeks(P < 0.05), however there was no significant difference at 8 weeks. Conclusions: All of $SureOss^{TM}$, $ExFuse^{TM}$ Gel, $ExFuse^{TM}$ Putty groups showed significant new bone formation and augmentation in the calvarial defect model.