Journal of Periodontal and Implant Science

Korean Academy of Periodontology (대한치주과학회)
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The effect of the freeze dried bone allograft and gel/putty type demineralized bone matrix on osseous regeneration in the rat calvarial defects

백서 두개골 결손부에서 동결건조골과 gel/putty 형 탈회골기질의 골재생효과

  • Kim, Deug-Han (Department of Periodontology, Graduate School of Medicine, Ewha Womans University) ;
  • Hong, Ji-Youn (Department of Periodontology, Graduate School of Medicine, Ewha Womans University) ;
  • Pang, Eun-Kyoung (Department of Periodontology, Graduate School of Medicine, Ewha Womans University)
  • 김득한 (이화여자대학교 의학전문대학원 치과학교실 치주과) ;
  • 홍지연 (이화여자대학교 의학전문대학원 치과학교실 치주과) ;
  • 방은경 (이화여자대학교 의학전문대학원 치과학교실 치주과)
  • Published : 2009.09.30
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Abstract

Purpose: This study was aimed to evaluate the effect of the Freeze Dried Bone Allograft and Demineralized Bone Matrix on osseous regeneration in the rat calvarial defects. Methods: Eight mm critical-sized calvarial defects were created in the 80 male Sprague-Dawley rats. The animals were divided into 4 groups of 20 animals each. The defects were treated with Freeze Dried Bone Allograft($SureOss^{TM}$), Demineralized Bone Matrix($ExFuse^{TM}$ Gel, $ExFuse^{TM}$ Putty), or were left untreated for sham-surgery control and were evaluated by histologic and histomorphometric parameters following a 2 and 8 week healing intervals. Statistical analysis was done between each groups and time intervals with ANOVA and paired t-test. Results: Defect closure, New bone area, Augmented area in the $SureOss^{TM}$, $ExFuse^{TM}$ Gel, $ExFuse^{TM}$ Putty groups were significantly greater than in the sham-surgery control group at each healing interval(P < 0.05). In the New bone area and Defect closure, there were no significant difference between experimental groups. Augmented area in the $ExFuse^{TM}$ Gel, $ExFuse^{TM}$ Putty groups were significantly greater than $SureOss^{TM}$ group at 2weeks(P < 0.05), however there was no significant difference at 8 weeks. Conclusions: All of $SureOss^{TM}$, $ExFuse^{TM}$ Gel, $ExFuse^{TM}$ Putty groups showed significant new bone formation and augmentation in the calvarial defect model.

Keywords

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