• 대한교통학회지
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• 제27권1호
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• pp.53-62
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• 2009

본 연구의 목적은 다이아몬드 입체교차점에서 회전교차로의 도입가능성을 비교 분석하는데 있다. 이를 위해 본 연구는 입체교차점에서 회전교차로와 비신호교차로 및 신호교차로의 효과를 aaSIDRA를 이용하여 성과를 비교 분석하였다. 주요 결과는 다음과 같다. 첫째, 4지 교차로 분석에서는 총 진입 교통량이 480pcph이상에서 1차로 회전교차로가 비신호교차로보다 효과적으로 분석되며, 진입교통량이 $480{\sim}1,880pcph$에서 2차로 회전교차로가 일반교차로보다 효과적으로 분석된다. 둘째, 3지 교차로 분석에서 1차로 교차로일 경우 총 진입교통량이 980pcph이상에서, 2차로 교차로의 경우 총 진입교통량이 $1,600{\sim}3,680pcph$에서 회전교차로가 다른 일반교차로보다 효과적으로 분석된다. 본 연구결과를 요약하면, 입체교차지점에서 회전교차로 설치 시 교차로 진입교통량의 범위를 고려하는 것이 중요하다.

• Radiation Oncology Journal
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• 제36권2호
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• pp.114-121
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• 2018

Purpose: To explore the feasibility of maximum diameter as a response assessment method for vestibular schwannomas (VS) after stereotactic radiosurgery or fractionated stereotactic radiotherapy (RT), we analyzed the concordance of RT responses between maximum diameters and volumetric measurements. Materials and Methods: Forty-two patients receiving curative stereotactic radiosurgery or fractionated stereotactic RT for VS were analyzed retrospectively. Twelve patients were excluded: 4 did not receive follow-up magnetic resonance imaging (MRI) scans and 8 had initial MRI scans with a slice thickness >3 mm. The maximum diameter, tumor volume (TV), and enhanced tumor volume (ETV) were measured in each MRI study. The percent change after RT was evaluated according to the measurement methods and their concordances were calculated with the Pearson correlation. The response classifications were determined by the assessment modalities, and their agreement was analyzed with Cohen kappa statistics. Results: Median follow-up was 31.0 months (range, 3.5 to 86.5 months), and 90 follow-up MRI studies were analyzed. The percent change of maximum diameter correlated strongly with TV and ETV (r(p) = 0.85, 0.63, p = 0.000, respectively). Concordance of responses between the Response Evaluation Criteria in Solid Tumors (RECIST) using the maximum diameters and either TV or ETV were moderate (kappa = 0.58; 95% confidence interval, 0.32-0.85) or fair (kappa = 0.32; 95% confidence interval, 0.05-0.59), respectively. Conclusions: The percent changes in maximum diameter and the responses in RECIST were significantly concordant with those in the volumetric measurements. Therefore, the maximum diameters can be used for the response evaluation of VS following stereotactic RT.

• 대한화학회지
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• 제45권2호
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• pp.183-188
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• 2001

• Asian Pacific Journal of Cancer Prevention
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• 제16권16호
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• pp.7343-7350
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• 2015

Genetic changes associated with acute lymphoblastic leukemia (ALL) provide very important diagnostic and prognostic information with a direct impact on patient management. Detection of chromosome abnormalities by conventional cytogenetics combined with fluorescence in situ hybridization (FISH) play a very significant role in assessing risk stratification. Identification of specific chromosome abnormalities has led to the recognition of genetic subgroups based on reciprocal translocations, deletions and modal number in B or T-cell ALL. In the last twelve years 102 newly diagnosed childhood/adult ALL bone marrow samples were analysed for chromosomal abnormalities with conventional G-banding, and FISH (selected cases) using specific probes in our hospital. G-banded karyotype analysis found clonal numerical and/or structural chromosomal aberrations in 74.2% of cases. Patients with pseudodiploidy represented the most frequent group (38.7%) followed by high hyperdiploidy group (12.9%), low hyperdiploidy group (9.7%), hypodiploidy (<46) group (9.7%) and high hypertriploidy group (3.2%). The highest observed numerical chromosomal alteration was high hyperdiploidy (12.9%) with abnormal karyotypes while abnormal 12p (7.5%) was the highest observed structural abnormality followed by t(12;21)(p13.3;q22) resulting in ETV6/RUNX1 fusion (5.4%) and t(9;22)(q34.1;q11.2) resulting in BCR/ABL1 fusion (4.3%). Interestingly, we identified 16 cases with rare and complex structural aberrations. Application of the FISH technique produced major improvements in the sensitivity and accuracy of cytogenetic analysis with ALL patients. In conclusion it confirmed heterogeneity of ALL by identifying various recurrent chromosomal aberrations along with non-specific rearrangements and their association with specific immunophenotypes. This study pool is representative of paediatric/adult ALL patients in Oman.

• 대한두경부종양학회지
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• 제33권2호
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• pp.101-105
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• 2017

Mammary analogue secretory carcinoma (MASC) of the salivary gland is a newly classified pathologic entity since 2010. Prior to its recognition, MASC was diagnosed as low-grade cystadenocarcinoma, acinic cell carcinoma, and mucoepidermoid carcinoma. MASC shares common histological and genetic characteristics with secretory carcinoma of the breast and has a distinct feature of the ETV6-NTRK3 fusion gene. Treatment of MASC in salivary gland is mainly wide surgical resection of the tumor. Prognosis of MASC is similar to other low-grade salivary gland carcinomas. Herein, we report a case of MASC developed in a parotid gland with a review of the literature.

• Asian Pacific Journal of Cancer Prevention
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• 제13권7호
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• pp.3349-3355
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• 2012

Background and objectives: Chromosomal abnormalities play an important role in genesis of acute lymphoblastic leukemia (ALL) and have prognostic implications. Five major risk stratifying fusion genes in ALL are BCR-ABL, MLL-AF4, ETV6-RUNX11, E2A-PBX1 and SIL-TAL1. This work aimed to detect common chromosomal translocations and associated fusion oncogenes in adult ALL patients and study their relationship with clinical features and treatment outcome. Methods: We studied fusion oncogenes in 104 adult ALL patients using RT-PCR and interphase-FISH at diagnosis and their association with clinical characteristics and treatment outcome. Results: Five most common fusion genes i.e. BCR-ABL (t 9; 22), TCF3-PBX1 (t 1; 19), ETV6-RUNX1 (t 12; 21), MLL-AF4 (t 4; 11) and SIL-TAL1 (Del 1p32) were found in 82/104 (79%) patients. TCF3-PBX1 fusion gene was associated with lymphadenopathy, SIL-TAL1 positive patients had frequent organomegaly and usually presented with a platelets count of less than $50{\times}10^9/l$. Survival of patients with fusion gene ETV6-RUNX1 was better when compared to patients harboring other genes. MLL-AF4 and BCR-ABL positivity characterized a subset of adult ALL patients with aggressive clinical behaviour and a poor outcome. Conclusions: This is the first study from Pakistan which investigated the frequency of5 fusion oncogenes in adult ALL patients, and their association with clinical features, treatment response and outcome. Frequencies of some of the oncogenes were different from those reported elsewhere and they appear to be associated with distinct clinical characteristics and treatment outcome. This information will help in the prognostic stratification and risk adapted management of adult ALL patients.

• 한국연소학회:학술대회논문집
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• 한국연소학회 2014년도 제49회 KOSCO SYMPOSIUM 초록집
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• pp.1-4
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• 2014

The present work focuses on the analysis of the pulverized coal combustion aerodynamics of the dual swirl burner by the control of the swirl-modes such as the outer swirl intensity (OSI). The detailed structure of pulverized coal swirling flames with swirl-mode was studied experimentally by particle image velocimetry and local flame colors based on $OH^*$, $CH^*$, and ${C_2}^*$ radicals. For all co-swirling conditions, the internal recirculation zone (IRZ) was observed near the inner shear layer with respect to the processing vortex core structure. Furthermore, a co-rotating vortex in the outer shear layer and the exhaust tube vortex (ETV) along the central axis were observed. The intensity of $CH^*$ signal was higher with small coal particle size, conversely, the size of the distribution of the $CH^*$ signal becomes larger. Therefore, the control of the aerodynamics with changing swirl intensities may play an important role in improving both environmental and combustion performances.

• 임상이비인후과
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• 제29권2호
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• pp.290-294
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• 2018

Mammary analogue secretory carcinoma (MASC) has histologic similarities to not only acinic cell carcinoma but also other low grade cystadenocarcinoma, and has similar features to breast secretory carcinoma. MASC was not described through the existing classification system previously. But, MASC was distinguished from other salivary gland tumors by Skalova et al. in 2010, MASC has ets variant gene 6-neurotrophic tyrosine kinase, receptor, type 3 (ETV6-NTRK3) translocation. So far, there are 4 cases of MASC recognized in the head and neck region in Korea. One of the four is a tumor from the submandibular gland, and the other three are of the parotid gland. In this case report, we report a 40-year-old man with a MASC of the parotid gland, who presented with right infra-auricular mass.

• Journal of Ginseng Research
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• 제45권2호
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• pp.273-286
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• 2021

Background: Prostate carcinoma is the second most common cancer among men worldwide. Developing new therapeutic approaches and diagnostic biomarkers for prostate cancer (PC) is a significant need. The Chinese herbal medicine Panax quinquefolius saponins (PQS) have been reported to show anti-tumor effects. We hypothesized that PQS exhibits anti-cancer activity in human PC cells and we aimed to search for novel biomarkers allowing early diagnosis of PC. Methods: We used the human PC cell line DU145 and the prostate epithelial cell line PNT2 to perform cell viability assays, flow cytometric analysis of the cell cycle, and FACS-based apoptosis assays. Microarray-based gene expression analysis was used to display specific gene expression patterns and to search for novel biomarkers. Western blot and quantitative real-time PCR were performed to demonstrate the expression levels of multiple cancer-related genes. Results: Our data showed that PQS inhibited the viability of DU145 cells and induced cell cycle arrest at the G1 phase. A significant decrease in DU145 cell invasion and migration were observed after 24 h treatment by PQS. PQS up-regulated the expression levels of p21, p53, TMEM79, ACOXL, ETV5, and SPINT1 while it down-regulated the expression levels of bcl2, STAT3, FANCD2, DRD2, and TMPRSS2. Conclusion: PQS promoted cells apoptosis and inhibited the proliferation of DU145 cells, which suggests that PQS may be effective for treating PC. TMEM79 and ACOXL were expressed significantly higher in PNT2 than in DU145 cells and could be novel biomarker candidates for PC diagnosis.

• 분석과학
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• 제11권1호
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• pp.1-7
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• 1998

본 논문은 현장에서 미량 원소분석을 수행할 수 있는 휴대용 원자방출분광계인 HCGD-AES(Hollow Cathode Glow Discharge-Atomic Emission Spectrometer)1에 적용할 분석 및 제어용 프로그램의 제작에 관한 연구결과를 요약하였다. 단색화 장치의 부피를 최소화할 수 있도록 분석할 원소의 선 필터(line filter)를 사용하여 제작된 검출계에서 실시간 분석이 가능한 소프트웨어의 개발이 이루어 졌으며, 원소 분석 및 검량선 작성의 자동화를 바탕으로 쉽게 사용할 수 있는 노트북용 소프트웨어를 Windows 95 환경에서 구현하였다. 사용한 주 언어인 Delphi 2.0을 바탕으로 그밖의 프로그램 언어도 복합적으로 사용되었다. 특히 측정된 자료들은 데이터 베이스를 구축하여 최적 실험 환경 조건을 얻을 수 있도록 하였으며 보고서 작성 기능도 추가되었다. 본 프로그램은 분석 수행에 있어서 사용자 편의를 위해 디자인되었으므로 빠르게 배우고 분광분석의 다른 분야에도 적용할 수 있도록 개발되어 응용성과 활용성이 대폭 확대될 수 있다는 이점이 있다.