• Molecules and Cells
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• v.38 no.12
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• pp.1029-1036
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• 2015

Appropriate vessel development and its coordinated function is essential for proper embryogenesis and homeostasis in the adult. Defects in vessels cause birth defects and are an important etiology of diseases such as cardiovascular disease, tumor and diabetes retinopathy. The accumulative data indicate that ETV2, an ETS transcription factor, performs a potent and indispensable function in mediating vessel development. This review discusses the recent progress of the study of ETV2 with special focus on its regulatory mechanisms and cell fate determining role in developing mouse embryos as well as somatic cells.

• Journal of The Korean Society of Agricultural Engineers
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• v.47 no.1
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• pp.3-9
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• 2005

The purpose of this study was to analyze the climatic water balance of the Korean peninsula using meteorological data and the evapotranspiration (ET) derived from NOAA/AVHRR, Quantifying water balance components is important to understand the basic hydrology, In this study, a simple method to estimate actual ET was proposed based on a regression approach between NDVI and Morton's actual ET using NOAA/AVHRR data, The Mortons actual ET for land surface conditions was evaluated using a daily meteorological data from 77 weather stations, and the monthly averaged Morton's ETs for each land cover was compared with the monthly NDVIs during the year 2001. According to the climatic water balance analysis, water deficit and surplus distributed maps were created from spatial rainfall, soil moisture, and actual and potential ETs map, The results clearly showed that the temporal and spatial characteristics of dryness and wetness may be detected and mapped based on the wetness index.

• Journal of Climate Change Research
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• v.7 no.2
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• pp.121-135
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• 2016

Korean Emission Trading Scheme entered into force on 1 January 2015. As other Emission Trading Systems, Korean Emission Trading System also have some deficiencies to be complemented and improved. Thus, the issues that are related to legal characteristics of emission allowance and its status as a financial instrument, terminology, requisites for the designation of the business entities eligible for allocation, banking and borrowing, and the non-permanence problems in the forestry offset mechanism are reviewed and the directions of the improvement are presented. The review of the Korean Emission Trading Scheme and its relevant act and the presidential decree at its early stage may be helpful for the Korean ETS to be firmly settled and to operate properly.

• Proceedings of the Korean Society of Tobacco Science Conference
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• 1998.05a
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• pp.20-20
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• 1998

• Proceedings of the Korean Society of Tobacco Science Conference
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• 2003.05a
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• pp.35-35
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• 2003

• Bulletin of the Korean Chemical Society
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• v.23 no.10
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• pp.1496-1511
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• 2002

• Journal of Periodontal and Implant Science
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• v.40 no.1
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• pp.39-44
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• 2010

Purpose: Bone tissues for clinical application can be improved by studies on osteoblast differentiation. Runx2 is known to be an important transcription factor for osteoblast differentiation. However, bone morphogenetic protein (BMP)-2 treatment to stimulate Runx2 is not sufficient to acquire enough bone formation in osteoblasts. Therefore, it is necessary to find other regulatory factors which can improve the transcriptional activity of Runx2. The erythroblast transformation-specific (ETS) transcription factor family is reported to be involved in various aspects of cellular proliferation and differentiation. Methods: We have noticed that the promoters of osteoblast differentiation markers such as alkaline phosphatase (Alp), osteopontin (Opn), and osteocalcin (Oc) contain Ets binding sequences which are also close to Runx2 binding elements. Luciferase assays were performed to measure the promoter activities of these osteoblast differentiation markers after the transfection of Runx2, myeloid Elf-1-like factor (MEF), and Runxs+MEF. Reverse-transcription polymerase chain reaction was also done to check the mRNA levels of Opn after Runx2 and MEF transfection into rat osteoblast (ROS) cells. Results: We have found that MEF, an Ets transcription factor, increased the transcriptional activities of Alp, Opn, and Oc. The addition of Runx2 resulted in the 2- to 6-fold increase of the activities. This means that these two transcription factors have a synergistic effect on the osteoblast differentiation markers. Furthermore, early introduction of these two Runx2 and MEF factors significantly elevated the expression of the Opn mRNA levels in ROS cells. We also showed that Runx2 and MEF proteins physically interact with each other. Conclusions: Runx2 interacts with MEF proteins and binds to the promoters of the osteoblast markers such as Opn nearby MEF to increase its transcriptional activity. Our results also imply that osteoblast differentiation and bone formation can be increased by activating MEF to elicit the synergistic effect of Runx2 and MEF.

• Korean Journal of Environmental Agriculture
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• v.28 no.4
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• pp.378-385
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• 2009

Arsenic (As) is known to be very toxic and carcinogenic to human beings. Arsenic contaminated soil was collected from a timber mill site at Busan Metropolitan City, Korea, where chromated copper arsenate (CCA) had been used to protect wood from rotting caused by insects and microbial agents. The soil was stabilized using both natural oyster shells (NOS) and calcinated oyster shells (POS). The calcination of natural oyster shells was accomplished at a high temperature in order to activate quicklime from calcite. Two different oyster shell particle sizes (-#10 mesh and -#20 mesh) and curing periods of up to 28 days were investigated. The stabilization effectiveness was evaluated based on the Korean Standard Test (KST) method (1N HCl extraction). The stabilization results showed that the POS treatment was more effective than the NOS treatment at immobilizing the As in the contaminated soils. A significant As reduction (96%) was attained upon a POS treatment at 20 wt% and passed the Korean warning standard of 20 mg/kg ('Na' area). However, an As reduction of only 47% (169 mg/kg) was achieved upon a NOS treatment at 20 wt%. The -#20 mesh oyster shells seem to perform better than the -#10 materials. The scanning electron microscopy (SEM)-energy dispersive X-ray spectroscopy (EDX) results showed that As immobilization was strongly associated with Ca and O in the presence of Al and Si.

• Journal of the Korean Society for Aviation and Aeronautics
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• v.24 no.1
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• pp.47-54
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• 2016

Global aviation is projected to grow in demand by an annual average of 4.1% between 2014 and 2034. It can be said that environmental impact from aviation will therefore be expected to increase on a similar scale. As regards civil aviation emissions, the sector contributes between 2~3% to International aviation GHG emissions. In the European Union(EU), aviation emissions account for about 3% of the EU's total green house gas emissions, of which a majority are said to come from international flights. In terms of traffic volume in 2013, Korea's international aviation industry 11th with regard to passengers and 3rd with regard to cargo, attaining the overall rank of 5th in the world. GHG emissions has been increasing steadily over the last 4 years, averaging 3.9 percent a year, due to the growth of low cost carriers and the increased demand for air transportations. As for aviation in Korea, there are a number of means intended to attain the Government's emission control objective in an efficient manner, such as AVA (Agreement of Voluntary Activity), TMS (Target Management System) and ETS (Emission Trading Scheme). In addition, the Government intends to better adapt to ICAO's Global MBM(Market-based Measures) that will come into performance on Year 2020. In the study, we focused on GHG mitigation measures that is fulfilling the AVA, TMS, ETS in the Government and suggest the effective measures to reduction the aviation GHG emissions.

• THE JOURNAL OF KOREAN ORIENTAL ONCOLOGY
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• v.5 no.1
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• pp.61-75
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• 1999

To examine the effect of Xuefuzhuyutang on the metastasis of cancer, the following experiments were carried out. Before the main experiments, the cytotoxicity was measured by putting Xuefuzhuyutant sample in HT1080. Then zymography was made to examine the change of gelatinolytic activity. Western blotting was carried out to examine the changes of Fos, Jun, Ets, Erk, md JNK. In vitro invasion assay with transwells coated by collagen and matrigel was carried out. From the above results the following conclusions were obtained. 1. The experimental result about cytotoxicity of Xuefuzhuyutang agaitst HT1080 was a below. The stained cell count after being treated by by Xuefuzhuyutang sample $400{\mu}g/ml$ for 24 hours was 0.9% of total cells, and the stained cell count by Xuefuzhuyutang sample $100{\mu}g/ml$ was 1.5% of total cells. Both were near the level of control group which showed 0.6% stained. 2. The result of collagenase assay was as below. In Xuefuzhuyutang sample $400{\mu}g/ml$, MMP2 was reduced as compared with TPA control group, and the band of MMP-9 induced by TPA disapappeared. In Xuefuzhuyutang samle $800{\mu}g/ml$ both bands of MMP-2 and MMP-9 disapeared. 3. The results of western blots for Jun, Fos, Ets, Erk, JNK were a below. In Xuefuzhuyutang sample $200{\mu}g/ml$, Ets was reduced, and Jun, Fos were increased. 4 The result of invasion assay was as below. The number of cells which migrated across transwell membrane in Xuefuzhuyutang-treated group was less than that of control(+TPA) group. From the above results, it was concluded that Xuefuzhuyutang might inhibit the activity of collagenase not by the MMP-2, MMP-9 promoter but by the other way.