• Advances in Automotive Engineering
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• v.1 no.1
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• pp.123-141
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• 2018

Hardware-in-the-loop (HiL) simulation is a very powerful tool to design, test and verify automotive control systems. However, well-validated and high degree of freedom vehicle models have to be utilized in these simulations in order to obtain realistic results. In this paper, a vehicle dynamics model developed in the Carsim Real Time program environment and its validation has been performed using experimental results. The developed Carsim real time model has been employed in the Tofas R&D hardware-in-the-loop simulator. Experimental and hardware-in-the-loop simulation results have been compared for the standard FMVSS No. 126 test and the results have been found to be in good agreement with each other. Two electronic stability control (ESC) algorithms, named the Basic ESC and the Integrated ESC, taken from the earlier work of the authors have been tested and evaluated in the hardware-in-the-loop simulator. Different evaluation methods have been formulated and used to compare these ESC algorithms. As a result, the Integrated ESC system has been shown superior performance as compared to the Basic ESC algorithm.

• Journal of Auto-vehicle Safety Association
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• v.7 no.2
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• pp.32-38
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• 2015

A sine with dwell test is well known as a test scenario for evaluation of performance of electronic stability control(ESC) on passenger vehicles and heavy commercial vehicles. However, when it comes to ESC for medium commercial vehicles, the test scenario has not been established yet. In this paper, the sine with dwell test was modified considering characteristics of medium commercial vehicles. The three main modifications of the original test scenario are the steering angle level, steering frequency, and loading condition of the vehicle. These modifications are derived from simulation study for different medium commercial vehicles. From simulation study, it was shown that the ESC system for medium commercial vehicle is objectively evaluated by the proposed test scenario. A clear improvement on vehicle stability was seen in the results when ESC system was used.

• Journal of Korean Society of Transportation
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• v.35 no.4
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• pp.307-320
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• 2017

The objective of this study is to identify the effectiveness of ESC(Electronic Stability Control) based on a meta analysis technique. Accident Rate, Fatal Crash Rate, Loss of Control Crash Rate were set as indexes of traffic safety evaluation. Also, reviews on the effectiveness of ESC were collected using keyword, 'ESC'. As a result, the Effect size of accident rate odd ratio was 0.90. When ESC system was applied on vehicles, accident rate decreased by 10%. Also, the Effect size of fatal crash rate odd ratio was 0.64. When ESC system was applied on vehicles, fatal crash rate decreased by 36%. Lastly, the Effect size of loss of control crash rate odd ratio was 0.73. When ESC system was applied on vehicles, loss of control crash rate decreased by 27%. The outcome of this study would be effectively used for developing polices and regulations for ESC installation obligation of commercial vehicles.

• Journal of the Korea Safety Management & Science
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• v.13 no.3
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• pp.63-69
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• 2011

As environmental protection is becoming more and more important, green production has become a key issue for almost every manufacturer and will determine a manufacturer can be sustainable in the long term. Therefore a performance evaluation system for green suppliers is necessary to determine the suitability of suppliers to cooperate with the company. While the works on the evaluation and/or selection of suppliers are abundant, those that concern environmental issues are rather limited. The objective of this study is to construct a combined model based on fuzzy analytic hierarchy process (FAHP) and balanced scorecard (ESC) for evaluating green suppliers in the manufacturing industry. The ESC concept is applied to define the hierarchy with four major perspectives (i.e. financial, customer, internal business process, and learning and growth), and performance indicators are selected for each perspective. FAHP is then proposed in order to tolerate vagueness and ambiguity of information. Finally, FAHP is finally constructed to facilitate the solving process. With the proposed model, manufacturers can have a better understanding of the capabilities that a green supplier must possess and can evaluate and select the most suitable green supplier for cooperation.

• BMB Reports
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• v.53 no.8
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• pp.437-441
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• 2020

In accordance with requirements of the ICH S7B safety pharmacology guidelines, numerous next-generation cardiotoxicity studies using human stem cell-derived cardiomyocytes (CMs) are being conducted globally. Although several stem cell-derived CMs are being developed for commercialization, there is insufficient research to verify if these CMs can replace animal experiments. In this study, in vitro high-efficiency CMs derived from human embryonic stem cells (hESC-CMs) were compared with Sprague-Dawley rats as in vivo experimental animals, and primary cultured in vitro rat-CMs for cardiotoxicity tests. In vivo rats were administrated with two consecutive injections of 100 mg/kg isoproterenol, 15 mg/kg doxorubicin, or 100 mg/kg nifedipine, while in vitro rat-CMs and hESC-CMs were treated with 5 μM isoproterenol, 5 μM doxorubicin, and 50 μM nifedipine. We have verified the equivalence of hESC-CMs assessments over various molecular biological markers, morphological analysis. Also, we have identified the advantages of hESC-CMs, which can distinguish between species variability, over electrophysiological analysis of ion channels against cardiac damage. Our findings demonstrate the possibility and advantage of high-efficiency hESC-CMs as next-generation cardiotoxicity assessment.

• Journal of Aquaculture
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• v.18 no.2
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• pp.130-132
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• 2005

Genomics research has two ultimate applied goals: to Isolate and clone genes of economic importance for bio-technology and gene-assisted selection (GAS), and to locate and use markers for marker-assisted selection (MAS) in selective breeding programs. To this end, we have identified linked markers for feed conversion efficiency growth rate, and disease resistance to enteric septicemia of catfish (ESC). Three microsatellite markers Ip266, Ip384, and Ip607 were identified to be linked to feed conversion efficiency. Similarly one marker each was identified to be linked to growth rate (Ip607) and disease resistance to ESC (Ip477). Ip607 marker linked to both growth rate and feed conversion efficiency, indicating that the QTL for both growth rate and feed conversion efficiency may either be the same or located in the same chromosomal region in the catfish genome. On phenotypic evaluation, certain traits such as growth rate can be accurately evaluated by body weight evaluation while other traits such as disease resistance can be quite complex. The linked DNA markers will be highly useful for MAS programs and for directing further efforts of genomic mapping for important quantitative traits.

• BMB Reports
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• v.39 no.4
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• pp.426-431
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• 2006

Embryonic stem cells (ESCs), representing a population of undifferentiated pluripotent cells with both self-renewal and multilineage differentiation characteristics, are capable of spontaneous differentiation into cardiomyocytes. The present study sought to define the kinetic characterization of lactate dehydrogenase (LDH) and creatine kinase (CK) of ESC- and neonatal-derived cardiomyocytes. Spontaneously differentiated cardiomyocytes from embryoid bodies (EBs) derived from mouse ESC line (Royan B1) and neonatal cardiomyocytes were dispersed in a buffer solution. Enzymes were extracted by sonication and centrifugation for kinetic evaluation of LDH and CK with spectrophotometric methods. While a comparison between the kinetic properties of the LDH and CK of both groups revealed not only different Michaelis constants and optimum temperatures for LDH but also different Michaelis constants and optimum pH for CK, the pH profile of LDH and optimum temperature of CK were similar. In defining some kinetic properties of cardiac metabolic enzymes of ESC-derived cardiomyocytes, our results are expected to further facilitate the use of ESCs as an experimental model.

• Journal of Korean Society on Water Environment
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• v.35 no.6
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• pp.574-579
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• 2019

As interest in health issues increases, it is imperative to ensure good water quality from wastewater treatment plant effluent to preserve environmental health. In particular, currently there is a lack of water ecosystem risk assessment on pharmaceutical substances remaining in effluent. In this study, antidepressant escitalopram (ESC), antiepileptic carbamazepine (CBZ) and lead, which impact the behavior of aquatic organisms, were used to test their impact on the potential behavior of zebrafish. Zebrafish have been widely used in toxicological assessment studies due to the ease of handlinggenerically and genetically. It was possible to observe changes in the growth of organisms through monitoring the embryos' cognitive and behavior assessment. In this study, the embryo lethal dose test showed that the lethal concentration of ESC and CBZ was at 10 ppb, which is below the water quality criterion (100 ppb), increased by 32.5 % and 40 %, respectively. In the cognitive test, it was found that the cognitive ability function decreased by 22 % and 17% for ESC(500 ppb) and CBZ(1,000 ppb) respectively relative to control. Based on these results, it is necessary to initiate efforts to remove these trace pollutants from sewage treatment facilities to protect the health of aquatic organisms.

• Journal of Institute of Control, Robotics and Systems
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• v.16 no.7
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• pp.646-654
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• 2010

This paper describes an integrated chassis control for a maneuverability, a lateral stability and a rollover prevention of a vehicle by the using of the ESC and AFS. The integrated chassis control system consists of a supervisor, control algorithms and a coordinator. From the measured and estimation signals, the supervisor determines the vehicle driving situation about the lateral stability and rollover prevention. The control algorithms determine a desired yaw moment for lateral stability and a desired longitudinal force for the rollover prevention. In order to apply the control inputs, the coordinator determines a brake and active front steering inputs optimally based on the current status of the subject vehicle. To improve the reliability and to reduce the operating load of the proposed control algorithms, a multi-core ECU platform is used in this system. For the evaluation of this system, a closed loop simulations with driver-vehicle-controller system were conducted to investigate the performance of the proposed control strategy.

• Transactions of the Korean Society of Automotive Engineers
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• v.19 no.6
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• pp.30-36
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• 2011

The current test methods are insufficient to evaluate and ensure the safety and reliability of vehicle system for all possible dynamic situation including the worst case such as rollover, spin-out and so on. Although the known NHTSA Sine with dwell steering maneuvers are applied for the vehicle performance assessment, they aren't enough to estimate other possible worst case scenarios. Therefore, it is crucial for us to verify the various worst cases including the existing severe steering maneuvers. This paper includes useful worst case based upon the existing worst case scenarios mentioned above and worst case evaluation for vehicle dynamic controller in simulation basis and UCC HILS. The only human steering angle is selected as a design parameter here and optimized to maximize the index function to be expressed in terms of both yaw rate and side slip angle. The obtained scenarios were enough to generate the worst case to meet NHTSA worst case definition. It has been concluded that the new procedure in this paper is adequate to create other feasible worst case scenarios for a vehicle dynamic control system.