Development and evaluation of next-generation cardiotoxicity assay based on embryonic stem cell-derived cardiomyocytes |
Ryu, Bokyeong
(Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University)
Choi, Seong Woo (Department of Medicine, School of Medicine, Konkuk University) Lee, Seul-Gi (Department of Medicine, School of Medicine, Konkuk University) Jeong, Young-Hoon (Department of Medicine, School of Medicine, Konkuk University) Kim, Ukjin (Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University) Kim, Jin (Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University) Jung, Cho-Rok (Gene Therapy Research Unit, Korea Research Institute of Bioscience and Biotechnology) Chung, Hyung-Min (Department of Medicine, School of Medicine, Konkuk University) Park, Jae-Hak (Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University) Kim, C-Yoon (Department of Medicine, School of Medicine, Konkuk University) |
1 | Scannell JW, Blanckley A, Boldon H and Warrington B (2012) Diagnosing the decline in pharmaceutical R&D efficiency. Nat Rev Drug Discov 11, 191-200 DOI |
2 | International Council of Harmonization (ICH) Guidelines (2005) The non-clinical evaluation of the potential for delayed ventricular repolarization (Qt Interval Prolongation) by human pharmaceuticals. S7B (https://database.ich.org/sites/default/files/S7B_Guideline.pdf) |
3 | International Council of Harmonization (ICH) Guidelines (2006) The clinical evaluation of QT/QTc interval prolongation and proarrhythmic potential for non-antiarrhythmic drugs. E14 4 (https://database.ich.org/sites/default/files/E14_Guideline.pdf) |
4 | Hoffmann P and Warner B (2006) Are hERG channel inhibition and QT interval prolongation all there is in drug-induced torsadogenesis? A review of emerging trends. J Pharmacol Toxicol Methods 53, 87-105 DOI |
5 | Guo L, Coyle L, Abrams RM, Kemper R, Chiao ET and Kolaja KL (2013) Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model. Toxicol Sci 136, 581-594 DOI |
6 | Mercola M, Colas A and Willems E (2013) Induced pluripotent stem cells in cardiovascular drug discovery. Circ Res 112, 534-548 DOI |
7 | Suter-Dick L, Alves PM, Blaauboer BJ et al (2015) Stem cell-derived systems in toxicology assessment. Stem Cells Dev 24, 1284-1296 DOI |
8 | Palpant NJ, Pabon L, Friedman CE et al (2017) Generating high-purity cardiac and endothelial derivatives from patterned mesoderm using human pluripotent stem cells. Nat Protoc 12, 15-31 DOI |
9 | Ronaldson-Bouchard K, Ma SP, Yeager K et al (2018) Advanced maturation of human cardiac tissue grown from pluripotent stem cells. Nature 556, 239-243 DOI |
10 | Sirenko O, Cromwell EF, Crittenden C, Wignall JA, Wright FA and Rusyn I (2013) Assessment of beating parameters in human induced pluripotent stem cells enables quantiative in vitro screening for cardiotoxicity. Toxicol Appl Pharmacol 273, 500-507 DOI |
11 | Burridge PW, Matsa E, Shukla P et al (2014) Chemically defined generation of human cardiomyocytes. Nat Methods 11, 855-860 DOI |
12 | Blinova K, Dang Q, Millard D et al (2018) International Multisite Study of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Proarrhythmic Potential Assessment. Cell Rep 24, 3582-3592 DOI |
13 | Millard D, Dang Q, Shi H et al (2018) Cross-Site Reliability of Human Induced Pluripotent stem cell-derived Cardiomyocyte Based Safety Assays Using Microelectrode Arrays: Results from a Blinded CiPA Pilot Study. Toxicol Sci 164, 550-562 DOI |
14 | Takasuna K, Asakura K, Araki S et al (2017) Comprehensive in vitro cardiac safety assessment using human stem cell technology: Overview of CSAHi HEART initiative. J Pharmacol Toxicol Methods 83, 42-54 DOI |
15 | Magdy T, Schuldt AJT, Wu JC, Bernstein D and Burridge PW (2018) Human Induced Pluripotent Stem Cell (hiPSC)- Derived Cells to Assess Drug Cardiotoxicity: Opportunities and Problems. Annu Rev Pharmacol Toxicol 58, 83-103 DOI |
16 | Burridge PW, Li YF, Matsa E et al (2016) Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicininduced cardiotoxicity. Nat Med 22, 547-556 DOI |
17 | Lian X, Hsiao C, Wilson G et al (2012) Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling. Proc Natl Acad Sci U S A 109, E1848-1857 DOI |
18 | Minami I, Yamada K, Otsuji TG et al (2012) A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xenofree conditions. Cell Rep 2, 1448-1460 DOI |
19 | Sagie A, Larson MG, Goldberg RJ, Bengtson JR and Levy D (1992) An improved method for adjusting the QT interval for heart rate (the Framingham Heart Study). Am J Cardiol 70, 797-801 DOI |
20 | Vandenberk B, Vandael E, Robyns T et al (2016) Which QT Correction Formulae to Use for QT Monitoring? J Am Heart Assoc 5, e003264 DOI |
21 | Park SJ, Bae D, Moon SH and Chung HM (2013) Modification of a purification and expansion method for human embryonic stem cell-derived cardiomyocytes. Cardiology 124, 139-150 DOI |
22 | Janssen M, Koster JF, Bos E and de Jong JW (1993) Malondialdehyde and glutathione production in isolated perfused human and rat hearts. Circ Res 73, 681-688 DOI |
23 | Lee JY, Kim MY, Shin SH et al (2017) Persicarin isolated from Oenanthe javanica protects against diabetes-induced oxidative stress and inflammation in the liver of streptozotocin-induced type 1 diabetic mice. Exp Ther Med 13, 1194-1202 DOI |
24 | Songbo M, Lang H, Xinyong C, Bin X, Ping Z and Liang S (2019) Oxidative stress injury in doxorubicin-induced cardiotoxicity. Toxicol Lett 307, 41-48 DOI |
25 | Ayala A, Munoz MF and Arguelles S (2014) Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal. Oxid Med Cell Longev 2014, 360438 DOI |
26 | Singh Y, Hall GL and Miller MG (1992) Species differences in membrane susceptibility to lipid peroxidation. J Biochem Toxicol 7, 97-105 DOI |
27 | Ruzsnavszky F, Hegyi B, Kistamas K et al (2014) Asynchronous activation of calcium and potassium currents by isoproterenol in canine ventricular myocytes. Naunyn Schmiedebergs Arch Pharmacol 387, 457-467 DOI |
![]() |