• Asian Pacific Journal of Cancer Prevention
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• v.15 no.18
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• pp.7959-7964
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• 2014

The significance of the single hormone receptor positive phenotype of breast cancer is still poorly understood. The use of hormone therapy has been found to be less effective for this type, which has a survival outcome midway between double positive and double negative phenotypes. The aim of this study was to investigate differences in patient and tumor characteristics and survival between double-receptor positive (ER+PR+), double receptor negative (ER-PR-) and single receptor positive (ER+PR- and ER-PR+) breast cancer in an Asian setting. A total of 1,992 patients with newly diagnosed stage I to IV breast cancer between 2003 and 2008, and where information on ER and PR were available, were included in this study. The majority of patients had ER+PR+ tumors (n=903: 45.3%), followed by 741 (37.2%) ER-PR-, 247 (12.4%) ER+PR-, and 101 (5.1%) ER-PR+ tumors. Using multivariate analysis, ER+PR- tumors were 2.4 times more likely to be grade 3 compared to ER+PR+ tumors. ER+PR- and ER-PR+ tumors were 82% and 86% respectively less likely to be grade 3 compared with ER-PR- tumors. ER-PR+ tumours were associated with younger age. There were no survival differences between patients with ER+PR+ and ER-PR+ tumors. However, ER+PR- tumors have poorer survival compared with ER+PR+ tumours. ER-PR- tumours had the worst survival. Adjuvant hormonal therapy with tamoxifen was found to have identical survival advantage in patients with ER+PR+ and ER-PR+ tumors whereas impact was slightly lower in patients with ER+PR- tumors. In conclusion, we found ER+PR- tumors to be more aggressive and have poorer survival when compared to ER+PR+ tumors, while patients with ER-PR+ tumours were younger, but had a similar survival to their counterparts with ER+PR+ tumours.

• Proceedings of the KSME Conference
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• 2002.08a
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• pp.321-324
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• 2002

Hydraulic valve control the pressure and the How of fluid by the hydraulic oil transfered from pump but the ER fluid consists of solid particles of micrometer in size and insulating oil so in the general hydraulic valve. We invented ER-Valve using ER fluid as working fluid. The ER fluid, working fluid of ER-Valve is a functional fluid to represent the feature of fluid according to strength of electric field. In this research we made our own 4 types of plate type ER-Valve which has same surface but different width and length and then we conducted performance test. We measured flow rate and pressure drop of fluid which is flowing in the ER-Valve according to the electric field strength to conduct this test. We modeling ER-Valve relating to ER-Valve system and yield shear stress according to the strength of electric field. We used the pressure drop according to the strength of electric field by differential pressure gauge in the our own made ER-Valve. This test reviewed experimental the special changes of ER-Fluid in the steady flow condition.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2002.11b
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• pp.453-458
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• 2002

This paper deals with the vibration reduction of hull mount system of ship structures brought by ER smart structures. The hull mount is used to isolate the vibration of equipment from the host structures. Utilizing the tunable characteristics of ER fluids, ER inserts are made in the hull mount structure. Different types of ER inserts are proposed and the vibration characteristics are investigated. A hull mount structure is made and the influence of ER inserts are experimentally studied. An extensive modal test is empirically conducted to identify natural frequencies and mode shapes according to the applied electric field and the types of ER insert. The frequency tunable characteristics of ER inserts can be applied to many mounting structures for vibration reduction.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 1998.04a
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• pp.608-613
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• 1998

Damping characteristics of ER dampers and flow rates inside ER valve with two different valve types were analyzed and compared with test results. Fluid flow inside ER valves was modeled by Bingham plastic model and Hagen-Poiseulli flow, while the equations of motion of total ER damper system were modeled by flow and hydraulic force balance. A general straight valve case was compared with a bended valve case which is newly tested for a possible improvement of ER damping force. As expected, the bended ER valve generates higher damping force and lower flow rates than the conventional straight ER valve due to additional flow restriction at the bended section. Analytical models of ER valve and ER damper generally predict reasonable performance characteristics of tested results. Therefore, developed analysis can be used for designing new ER dampers and simulation of ER semi-active suspension system as well.

• Proceedings of the Korean Society of Machine Tool Engineers Conference
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• 2001.04a
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• pp.66-71
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• 2001

In this work, an ER clutch has been constructed and its characteristics have been evaluated by adapting an electro-rheological fluid(ERF) as an operating medium. ER fluids are suspensions which show an abrupt increase in rheological properties under electric fields. An ER clutch system using ER fluid is a new conception device because an apparent viscosity of ER fluid can be changed by apply an electric field. As a first, Bingham properties of ER fluids are experimentally distilled as a function of electric field. We use the disk type ER clutch in which the ER fluid fills the annular space between a pair of coaxial disk electrodes and experiment results show that the measured revolution per minute was increased with the increase of the electric field. The ER fluid used in the present study consists of weight fraction 35% in zeolite suspended silicone oil.

• Transactions of the Korean Society of Machine Tool Engineers
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• v.16 no.5
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• pp.41-47
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• 2007

The structure of ER valve is simple that its designing and manufacturing are easy. The flow rate and pressure of ER fluids flowing in the ER valve are controlled only by electric field. In this study a three port ER valve is designed and manufactured. Then, the flow rate and pressure dorp of ER fluids flowing in the ER valve are measured. The system proposed controls flow rate and pressure fast. So, this system can be easily substituted for the existing hydaulic and pneumaitc control system.

• Journal of Yeungnam Medical Science
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• v.28 no.2
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• pp.153-164
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• 2011

Background: It has been reported that estrogen receptor beta ($ER{\beta}$) mRNA expression was down-regulated during carcinogenesis and was inversely related to estrogen receptor alpha ($ER{\alpha}$) expression in breast cancer. The association of $ER{\beta}$ mRNA expression to tamoxifen resistance has also been reported. In this study, the expression of $ER{\alpha}$ and $ER{\beta}$ via immunohistochemistry (IHC) and reverse transcription-polymerase chain reaction (RT-PCR) was prompted, and an attempt was made to find out the relationship between $ER{\beta}$ expression and recurrence in the hormonal therapy group, and between $ER{\beta}$ expression and known prognostic factors. Methods: Tumor specimens were obtained at surgery from 67 female breast cancer patients during the period of September 1995 to December 2000. All the specimens were frozen in liquid nitrogen and kept at $-70^{\circ}C$ until they were used. The medical records were analyzed retrospectively. The expressions of ER were analyzed using IHC and RT-PCR methods. Results: The median follow-up was at 93.0 months (range: 14-157 months). The percentage of $ER{\alpha}+/ER{\beta}+$, $ER{\alpha}+/ER{\beta}-$, $ER{\alpha}-/ER{\beta}+$, and $ER{\alpha}-/ER{\beta}$ group were 35.9% 9.4%, 47.2%, and 7.5%, respectively, in 53 patients with hormonal therapy. $ER{\beta}$ was positive in 42 (82.3%) of 51 ER-positive patients. In the hormonal therapy group, the recurrence rates of each group was 15.8%, 0%, 40.0%, and 0%, respectively. In this group, the $ER{\beta}$ expression tended to recur, but there was no clinical significance (p=0.084). Conclusion: The $ER{\beta}$ expression may be a predictive marker of a poor response to endocrine therapy in breast cancer patients, although this needs to be confirmed in additional studies.

• Transactions of the Korean Society of Machine Tool Engineers
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• v.14 no.1
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• pp.95-100
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• 2005

Making the best use of the features of the electro-rheological(ER) valve, a two-port pressure control valve using ER fluids is proposed and manufactured. The ER-Valve characteristics are evaluated by changing the intensity of the electric field and the number of electrode. In addition, the performance of the plate type ER-Valve is investigated by change the particle concentration of the ER fluid. As only with electrical signal change to the ER-Valve in which ER fluid flowing, ER fluid flow is controlled, so development of simple ER-Valves have been tried. The ER-Valves and pressure drop check method are considered to be applied to the fluid power control system. Using the minかnぉd pressure control valve, a one-link manipulator with FHA in robot system is driven. As a result, it is experimentally confirmed that the pressure control valve using ER fluids is applicable to use in driving actuator. If it applies characteristics of the ER fluids, it will be able to apply in the control system fir the ER Valve which occurs from industrial controller(PLC).

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.13 no.9
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• pp.679-687
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• 2003

Shock wave reduction in electrorheological(ER) smart structures is studied. ER insert is a composite structure comprising two elastic outer layers between which is sandwiched layer of ER fluid. When a voltage is applied across the outer layers. the shear modulus and the loss factor of the ER fluid are enabled, and thus the dynamic properties of the composite structure is altered. For the shock wave reduction in a hull mount of a submerged structure, ER inserts are made on the hull mount structure. To investigate the ER insert shape. many types of ER insert pattern are considered. Modal test of ER insert structures is performed to obtain the mode shapes, natural frequencies and the acceleration transmissibility. The acceleration transmissibility is reduced at such a frequency region when an electric field is applied. It is observed that the natural frequencies and mode shapes can be tunable by applying electric field. The ER-inserted hull mount is installed in an integrated system and the overall performance of shock wave reduction is tested. The possibility of shock wave reduction in the hull mount is demonstrated.

• Proceedings of the Korean Vacuum Society Conference
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• 2010.02a
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• pp.109-109
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• 2010

$Er^{3+}$ ion shows a stable and efficient luminescence at 1.54mm due to its $^4I_{13/2}\;{\rightarrow}\;^4I_{15/2}$ intra-4f transition. As this corresponds to the low-loss window of silica-based optical fibers, Er-based light sources have become a mainstay of the long-distance telecom. In most telecom applications, $Er^{3+}$ ions are excited via resonant optical pumping. However, if nanocluster-Si (nc-Si) are co-doped with $Er^{3+}$, $Er^{3+}$ can be excited via energy transfer from excited electrical carriers in the nc-Si as well. This combines the broad, strong absorption band of nc-Si with narrow, stable emission spectra of $Er^{3+}$ to allow top-pumping with off-resonant, low-cost broadband light sources as well as electrical pumping. A widely used method to achieve nc-Si sensitization of $Er^{3+}$ is high-temperature annealing of Er-doped, non-stoichiometric amorphous thin film with excess Si (e.g.,silicon-rich silicon oxide(SRSO)) to precipitate nc-Si and optically activate $Er^{3+}$ at the same time. Unfortunately, such precipitation and growth of nc-Si into Er-doped oxide matrix can lead to $Er^{3+}$ clustering away from nc-Si at anneal temperatures much lower than ${\sim}1000^{\circ}C$ that is necessary for full optical activation of $Er^{3+}$ in $SiO_2$. Recently, silicon-rich silicon nitride (SRSN) was reported to be a promising alternative to SRSO that can overcome this problem of Er clustering. But as nc-Si formation and optical activation $Er^{3+}$ remain linked in Er-doped SRSN, it is not clear which mechanism is responsible for the observed improvement. In this paper, we report on investigating the effect of separating the nc-Si formation and $Er^{3+}$ activation by using hetero-multilayers that consist of nm-thin SRSO or SRSN sensitizing layers with Er-doped $SiO_2$ or $Si_3N_4$ luminescing layers.