• Journal of Engineering Education Research
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• v.23 no.5
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• pp.51-60
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• 2020

The purpose of this study is to develop and validate an Engineering Empathy Instrument. Engineering empathy is defined as the ability that encompasses the following three qualities, a skill to interpret social issues and phenomenon that may occur in the process of interactions between human beings and engineering systems, a practical orientation that enables one to take stakeholders' perspectives to carry out an engineering project, and a professional way of being that acknowledges empathic skills and associated practice orientations. Based on this notion, we develop a scale to measure engineering empathy and have surveyed 429 engineering students. Evidence for the validity and reliability of the scale is presented. In conclusion, we find that engineering empathy can be measured and conceptualized as three domains: a Learnable Skill (ELS), a Practical Orientation (EPO), and a Professional Way (EPW). We also find that sophomores show the highest level of engineering empathy as compared with other graders. While students accumulate technical knowledge, their understanding about engineering in social and interpretational contexts gets weakened. This implies that engineering education necessarily emphasizes the impacts of engineering solutions in interpersonal, societal, technologies, and environmental contexts.

• Proceedings of the Korea Contents Association Conference
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• 2008.05a
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• pp.851-854
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• 2008

Science-based Industry which is future growth industry leading national competitiveness in knowledge-based society is highly science-dependent field when developing technologies. And highly science-based field is absolutely dependent on core scholarly papers. Due to researchers' need of academic papers related to developing technologies and advances of linking technologies, it is possible to link service between patents and scholarly papers. This paper's purpose is to describe on implementation linking service between EPO patent and papers that cited on search reports. First, it describe case study of other linking services. Second, it describes a kinds of data used in linking services. Lastly, it describe implementation of linking different kinds of contents (patents and papers) in KISTI.

• Journal of the Korea Institute of Military Science and Technology
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• v.25 no.2
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• pp.169-176
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• 2022

Laser ablation propulsion(LAP) is the method to create impulse by laser ablation. It can be used to deorbit the space debris(SD), as its long-range property and versatility on any material. In this paper, we find out several requirements of the LAP system(LAPS) to deorbit the SD by simple numerical calculations of the SD orbit and laser beam flux. As a result, minimum operable altitude angle turned out to be a crucial variable to the LAPS. Moreover, if minimum operable altitude angle is 10°, and if the minimum distance between the LAPS and the SD is below 450 km, 1 m/s² is sufficient to deorbit the SD by once. With 18 kJ/3 ns pulsed laser and cube shaped 100 kg SD, 1 m/s² acceleration can be achieved by increasing the pulse repetition rate over 34~53 Hz, depending on the size of the SD. This capability could compare with the conceptual design of the Japan Establishment for a Power-laser Community Harvest(J-EPoCH) facility, which include 8 kJ, 5 PW@100 Hz laser.

• Toxicological Research
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• v.14 no.3
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• pp.393-400
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• 1998

As a series of safety studies on DA-3585, a recombinant human erythropoietin, its local irritancy was examined in rabbits after the following treatments; application into the conjunctival sac of the eye(single), subcutaneous injection (single and -day repeated)and intravenous injection (7-day repeated.)In addition, perivascular irritation of DA-3585 was investigated in mice. In the result of ocular irritation test, 10,000IU/ml solution of DA-3585 could be considered as a non-irritating material. The local irritation of DA-3585 by a single and 7-day repeated subcutaneous injection was negligible and not so much different from that of saline. In the vascular irritancy test, macro-and microscopic observations revealed that local irritation of DA-3585 was comparable to that of saline when injected into retroauricular vein of rabbits for 7 consecutive days. Furthermore the perivascular administration of DA-3585 upto the concentration of 10,000 IU/ml did not induce any morphological abnormalities at injection sites. The results obtained from the present study suggest that the local irritancy of DA-3585 is not different from that of saline when injected through intravenous or subcutaneous route for clinical practice.

• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.6
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• pp.1613-1616
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• 2004

The cellular response to hypoxia is controlled to a large degree by the transcription factor Hypoxia-inducible factor-1(HIF-1). HIF-1 is a transcription factor that is activated by hypoxia and plays a critical role in the development of the cancer phenotype. HIF-1 regulates transcription of a number of genes crucial for tumor survival under hypoxic conditions, including vascular endothelial growth factor(VEGF), erythropoietin(Epo) and several glycolytic enzymes. Tumors in which hypoxia can not induce HIF-1 transcriptional activity remain small and fail to metastasize. In this study, we examined whether aqueous root extract of Ailanthus altissima (REA) downregulate HIF-1, VEGF and p53, and raise the possibility that depletion of these proteins and the anti proliferative activities of REA have any effects on inhibition of angiogenesis in MCF-7 cells. Pharmacologic targeting of specific signal transduction pathways related to oncogenic transformation is a promising approach in cancer treatment. Therefore, REA could be a candidate drug for further clinical development.

• Journal of the Korea Fashion and Costume Design Association
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• v.22 no.1
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• pp.33-44
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• 2020

The purpose of this study is to guide the research direction for securing the competitiveness of the textile industry by analyzing the trends of patent technology development for flexible materials and platform technologies of domestic and overseas textiles used for wearable devices. The study is based on patents from Korea (KIPO), USA (USPTO), Japan (JPO), Europe (EPO), PCT (WO), and China (SIPO), which were registered as of December 31, 2017. The analysis utilized 3,643 patents acquired from the WINTELIPS search DB. The technology classification system for patent analysis was divided into evangelist-based textile technology developments: human body (AA), fiber attachment patch development (AB), and service platform development (AC). The analysis findings are as follows: 1. The development of flexible materials and platform technologies for textile-based wearable devices has increased since 2000. In particular, China (SIPO) had the most patents. 2. In China, Japan, and Korea, most patent applicants are applied for by natives, but the US has a high proportion of foreigners applying for patents. 3. As for the amount of development of the evangelist-based textile technology (AA) was the most common with 1,203 (33%) cases. As a result of the above IP historical analysis, it can be seen that as a result of the global competition, domestic companies need to acquire IRP and standard technology, and promote commercialization by applying their products to smart wearables devices and other products.

• The Journal of the Korea Contents Association
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• v.8 no.4
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• pp.264-272
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• 2008

In ubiquitous geographic information environment, the users are provided with geographic information anywhere and any time on their needs by any types of devices and communication media. The unique location ID, ePosition, is a new technology to support UBGI environment, using a logical location ID instead of physical location of a point of interest. Domain names of plural ePosition servers, where location information with its ePosition is stored, needs to be registered in DNS for some service through Internet. For better ePosition service of the type of public service like email service, a set of DNS resource records can be newly defined. This paper suggests a new DNS resource record EPO for implementation of the ePosition service through Internet.

• Biomolecules & Therapeutics
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• v.4 no.1
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• pp.78-83
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• 1996

The pharmacokinetics and tissue distribution of DA-3285 (recombinant human erythropoietin, recently manufactured by Research Laboratories of Dong-A Pharmaceutical Company) were studied in the laboratory animals. The plasma, urine, and tissue concentration of DA-3285 were measured by a double-antibody sandwich enzyme immunoassay. After intravenous administration of DA-3285, 20, 100, 500 and 2500 units/kg to rats, the plasma concentrations declined polyexponentially with the terminal half-lives of 2.15, 2.10, 2.31, and 2.35 hr, respectively. Total body clearance (20.7∼26.6 mι/hr/kg) and apparent volume of distribution at steady state (57.2∼70.1 mι/kg) were independent of the dose and AUC increased proportionally with the dose. The renal clearance was much lower than total body clearance, suggesting that extrarenal clearance, presumably metabolism , plays a significant role in elimination of DA-3285. In all rat tissues, the tissue to plasma ratios were smaller than unity, indicating less affinity of DA-3285 to rat tissues and was proved by considerably less value of Vdss. After 3 times a week for consecutive 3 weeks i.v. administration of DA-3285, 100 units/kg to rats, the plasma concentrations and pharmacokinetic parameters of DA-3285 were not significantly different from those in a single administration. After s.c. administration to the rat, plasma concentrations of DA-3285 peaked at 6 hr and the extent of bioavailability was 26.7%. In mice, rabbits and dogs, at DA-3285 dose of 100 units/kg, the mean terminal haw-lives were 2.78, 3.05, and 4.01 hr, respectively. Compared with reported data in the literatures, DA-3285 has similar properties to rh-EPO manufactured by other companies in view of pharmacokinetics.

• Biotechnology and Bioprocess Engineering:BBE
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• v.10 no.1
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• pp.29-33
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• 2005

A DNA vaccine methodology using eukaryote expression vectors to produce immunizing proteins in the vaccinated hosts is a novel approach to the development of vaccine and immuno-therapeutics, and it has achieved considerable success over several infectious diseases and various cancers. To further enhance its efficiency, attempts were made to develop novel plasmid vectors containing multiple immunostimulatory CpG motifs, for rapid and strong immune response. First, a 2.9 kb compact plasmid vector (pVAC), containing CMV promoter, polycloning site, BGH poly(A) terminator, ampicillin resistance gene and pBR322 origin was constructed. A pVAC-hEPO was also constructed, which contained a human erythropoietin gene, for evaluating the transfection efficiency of naked plasmid DNA both in vitro and in vivo. To examine the adjuvant effect of multi-CpG motifs on naked plasmid DNA, 22 and 44 enriched and unmethylated CpG motifs were introduced into pVAC to generate pVAC-ISS1 and pVAC-ISS2, respectively. $100{\mu}g$ of pSecTagB, pVAC, pVAC-ISS1 or pVAC-ISS2 were each injected intramuscularly into the tibilias anterior muscle of Balb/c mice. The level of interleukin-6 induced in the mice injected with pVAC-ISS1 and pVAC-ISS2 were significantly elevated after 12 hours, which were almost 2 and 2.5 times higher than that in the mice injected with pSecTagB, respectively. These results suggest that DNA vaccine plasmids with enriched CpG motifs can induce rapid secretion of interleukin-6 by lymphocytes. In conclusion, these vectors can contribute to the development of adjuvant-free DNA vaccinations against infectious diseases and various cancers.

• The Journal of Korean Medicine
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• v.22 no.3
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• pp.156-168
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• 2001

Objectives : To evaluate the diverse actions of stimulation on the hematopoietic system, 4 formulas (KH I, KH 2, KH 3, KH 4) were studied. Method and Result : RT-PCR was performed to measure the gene expression of hematopoietic cytokines (TPO, GM-CSF, SCF, IL-3). When bone marrow cells were treated with KH 1, 2, 3, 4, the gene expressions of TPO, SCF, IL-3, and GM-CSF were increased. Flow cytometric analysis was performed to measure the expression of CD34+ cell activity. After 72 hrs culture supplemented with KH 1, 2, 3, 4, the percent of CD34+ cell of KH 2, 3, 4 were increased. To measure the expression of colony forming units - granulocyte erythrocytes, macrophages, megakaryocytes (CFU-GEMM) and burst forming unit-erythroid (BFU-E), semisolid clonogenic assay was performed. After 14 days of culture the number of CFU-GEMM and BFU-E of KH I, 2, 3, 4 were significantly increased compared to those of EPO groups (KH 1 P<0.0l, KH 2 P<0.05, KH 3 P<0.001, KH 4 P<0.0l). To determine the intracelluar TPO expression by KH 3, KH 4 in bone marrow cells, intracelluar staining and flow cytometric analysis were performed. After 24 hrs cultures, the TPO expression of the KH 3 and KH 4 treated groups were increased over those of the controlled groups (control : 50%, KH 3 : 87%, KH 4 : 78%). Conclusion : These results suggest that KH I, KH 2, KH 3, KH 4 have hematopoietic effects through increasing the production of hematopoietic cytokines and stimulating the activity of $CD34^{+}$ cells. This study also shows that KH 3 has a more effective hematopoietic effect than KH 1, 2, 4. These results suggest that the formulas (KH I, 2, 3, 4) can be applied to the patients with inappropriate hematopoietic system, and that KH 3 can be the most effective formula among these 4 in treating bone marrow disease in clinics.