[KSCI] Korea Science Citation Index Service

Effects on Inhibition of Angiogenesis in MCF-7 Cells by the Aqueous Root Extract of Ailanthus Altissima

Jeong Ji Hak (Department of Biology, College of Natural Sciences, Kyungpook National University)
Yun Young Gab (Department of Oriental medicine in Wonkwang University)
Jeon Byung Hun (Department of Oriental medicine in Wonkwang University)
Park Hae Ryoun (Department of Oral Pathology, College of Dentistry, Pusan National University)
An Won Gun (Department of Biology, College of Natural Sciences, Kyungpook National University)

Publication Information

Journal of Physiology & Pathology in Korean Medicine / v.18, no.6, 2004 , pp. 1613-1616 More about this Journal

Abstract

The cellular response to hypoxia is controlled to a large degree by the transcription factor Hypoxia-inducible factor-1(HIF-1). HIF-1 is a transcription factor that is activated by hypoxia and plays a critical role in the development of the cancer phenotype. HIF-1 regulates transcription of a number of genes crucial for tumor survival under hypoxic conditions, including vascular endothelial growth factor(VEGF), erythropoietin(Epo) and several glycolytic enzymes. Tumors in which hypoxia can not induce HIF-1 transcriptional activity remain small and fail to metastasize. In this study, we examined whether aqueous root extract of Ailanthus altissima (REA) downregulate HIF-1, VEGF and p53, and raise the possibility that depletion of these proteins and the anti proliferative activities of REA have any effects on inhibition of angiogenesis in MCF-7 cells. Pharmacologic targeting of specific signal transduction pathways related to oncogenic transformation is a promising approach in cancer treatment. Therefore, REA could be a candidate drug for further clinical development.

Keywords

Ailanthus altissima; hypoxia; Hypoxia-inducible factor-1 (HIF-1); vascular endothelial growth factor(VEGF); p53; angiogenesis;

Citations & Related Records

Reference

1	Hypoxia-inducible factor(HIF-1)<TEX>$\alpha$</TEX>: its protein stability and biological functions / [ Lee J.W.;Bae S.H.;Jeong J.W.;Kim S.H.;Kim K.W. ] / Exp. Mol. Med.
2	Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1 / [ Semenza G.L.;Roth P.H.;Fang H.M.;Wang G.L. ] / J. Biol. Chem.
3	/ [ 赤松金芳 ] / 新訂和漢藥
4	/ [ 許鴻源 ] / 少用中藥之硏究
5	Hypoxia modulated gene expression: angiogenesis, metastasis and therapeutic exploitation / [ Dachs G.U.;Tozer G.M. ] / Eur J Cancer. ScienceOn
6	HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus / [ Semenza G.L. ] / Cell.
7	Mammalian oxygen sensing, signaling and gene regulation / [ Wenger R.H. ] / J. Exp. Biol.
8	p-regulation of hypoxia-inducible factors HIF- 1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function / [ Krieg M.;Haas R.;Brauch H.;Acker T.;Flamme I.;Plate K.H. ] / Oncogene. ScienceOn
9	/ [ 李尙仁 ] / 本草學
10	/ [ 陸昌洙(外) ] / 韓國本草學
11	/ [ 전국한의과대학 교수(공저) ] / 본초학
12	Virus-Cell Fusion Inhibitory Compounds from Ailanthus altissima Swingle / [ Chang Y.S.;Moon Y.H.;Woo E.R. ] / Kor. J. Pharmacogn.
13	Studies on Antibacterial activities in Alianthus altanthus altissima Swingle Tar / [ Choo H.K.;Kim S.K.;Rho Y.S. ] / Bull. K H Pharma Sci.
14	Oxygen(es) and the hypoxia- inducible factor-1 / [ Wenger R.H.;Gassmann M. ] / J. Biol, Chem.
15	/ [ 안덕균 ] / 본초도감
16	/ [ 保建社會部 ] / 大韓藥典外韓藥(生藥)規格集
17	/ [ 陸昌洙 ] / 原色韓國藥用植物圖鑑
18	/ [ 江蘇新醫學原院(中國) ] / 中葯大辭典下冊
19	Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha / [ Iyer N.V.;Kotch L.E.;Agani F.;Leung S.W.;Laughner E.;Wenger R.H.;Gassmann M.;Gearhart J.D.;Lawler A.M.;Yu A.Y.;Semenza G.L. ] / Genes Dev.
20	Signal transduction to hypoxia-inducible factor 1 / [ Semenza G. ] / Biochem. Pharmacol. ScienceOn
21	von Hippel-Lindau tumor suppressor: not only HIF's excutioner / [ Czyzyk-Krzeska M.F.;Meller J. ] / Trends Mol. Med. ScienceOn
22	Influence of the p53 status on hypoxia-induced gene expression / [ Liu J.;Shibata T.;Qu R.;Ogura M.;Hiraoka M. ] / J. Radiat Res (Tokyo).
23	Studies on the Biologic Activities of the Constituents of Ailanthi Cortex Radicis(I) - Effects of Methanol Extract and its Chloroform Fraction on Expoxide Hydrolyzing System in Liver / [ Kim J.;Choi J.W.;Kim H.K.;Park S.W.;Lee C.K. ] / Kor. J. Pharmacogn.
24	Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha / [ An W.G.;Kanekal, Simon M.C.;Maltepe E.;Blagosklonny M.V.;Neckers L.M. ] / Nature.
25	Transcriptional regulation by hypoxia- inducible factor 1: molecular mechanism of oxygen homeostasis / [ Semenza G.L. ] / Trends Cardiovasc. Med. ScienceOn

KSCI

Effects on Inhibition of Angiogenesis in MCF-7 Cells by the Aqueous Root Extract of Ailanthus Altissima 저근백피 추출물이 유선암 세포에서의 신생혈관 미치는 영향

Effects on Inhibition of Angiogenesis in MCF-7 Cells by the Aqueous Root Extract of Ailanthus Altissima