• Asian Pacific Journal of Cancer Prevention
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• 제17권2호
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• pp.873-876
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• 2016

Background: Studies of quality of life (QoL) of oncological patients is carried out using questionnaires approved in many international clinical studies. The European Organization for Research and Treatment of Cancer EORTC QLQ-C30 (Quality of Life Questionnary-Core 30) and its special brain cancer module EORTC QLQ-BN20 are widely used in the world neurooncologic practice. They are available in more than 80 official versions of 30 languages of the world. Previously we used the official versions in Russian, which often causes difficulty in understanding for native Kazakh language speakers, who comprise more than 60% of our respondents. This was the reason for creating a version of Kazakh language. Therefore, in 2014 for the first time the process of adaptation of questionnaires to the Kazakh language was initiated. Materials and Methods: The translation process of questionnaires to Kazakh language was held in accordance with the requirements of the European Organization for Research and Treatment of Cancer EORTC on QoL and consisted of the following stages: preparation - translation - pilot testing - approval. The official permission of authors and "Guideline on translation" was obtained which was developed by the working group of the EORTC on QoL. The pilot testing of EORTC QLQ-C30 and QLQ-BN20 questionnaires was conducted on the basis of the Department of Central Nervous System Pathology of the "National Centre for Neurosurgery" in patients with malignant tumors of the central nervous system. Results: The official versions of the EORTC QLQ-C30 and QLQ-BN20 questionnaires in Kazakh language were introduced and adapted in practical neurosurgical operations in Kazakhstan. Conclusions: The approved versions of the questionnaires in Kazakh language are now available for mainstream use on the official website EORTC.com. The versions of these questionnaires can be used in domestic cohort studies and clinical practice in the Republic of Kazakhstan. The use of these tools for assessing QoL will help professionals in the planning of individual treatment strategies and selection of the necessary therapy.

• Asian Pacific Journal of Cancer Prevention
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• 제15권6호
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• pp.2739-2745
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• 2014

Background: Health-related quality of life (HRQL) is a fundamental outcome in oncology patients and quality of life (QOL) assessment requires clinically relevant questionnaires. The purpose of this study was translation and definition of measurement properties and the clinical validity of Quality of Life Questionnaire (QLQ)-OG25 module in Persian patients with oesophagus, oesophagogastric junction (OGJ) or gastric cancers. Materials and Methods: The translation procedure followed European Organization for Research and Treatment of Cancer (EORTC) guidelines. Both EORTC QLQ-OG25 and a core questionnaire (EORTC QLQ-C30) were administered to patients with oesophagus (150), OG junction (93) and gastric (32) cancer undergoing multi-modal treatments. Convergent and discriminant validity, Cronbach's alpha coefficient and known-groups comparisons were used to examine reliability and validity. Results: In all, 275 patients (mean age 62 years) completed both questionnaires. Compliance rate was high and the questionnaire module was well accepted. We found good reliability for multi-item subscales of QLQ-OG25 (Cronbach's alpha coefficients 0.76-0.89). About 73% had TNM staging and scales distinguished between clinically distinct groups of patients. However, patients in palliative group experienced compromised functional status and worse treatment-associated symptoms than those in the potentially curative group. Test-retest scores were consistent. Multi-trait scaling analysis demonstrated good convergent and discriminant validity. Conclusions: Overall, the Persian version of QLQ-OG25 demonstrated psychometric and clinical validity that supports its application as a supplement to the original tool (EORTC QLQ-C30) when assessing HRQL in patients with upper-gastrointestinal (GI) cancer both in curative and palliative phases.

• Asian Pacific Journal of Cancer Prevention
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• 제17권3호
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• pp.1405-1410
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• 2016

Background: The European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Bone Metastases Module (EORTC QLQ-BM22) is a recently designed supplement to EORTC Quality of Life Questionnaire-C30 (EORTC QLQ-C30). Additional psychometric properties, especially using confirmatory factor analysis (CFA) and the Rasch model, are warranted. Materials and Methods: A total of 573 patients with bone metastases were enrolled from eight countries with a mean${\pm}$SD age of $55.8{\pm}13.7years$. Slightly more than two thirds of them were female (n=383; 66.8%). CFA was used to examine the BM22 framework; Rasch models were applied to understand misfit items and differential item functioning (DIF). Results: The fit indices were satisfactory in CFA (comparative fit index=0.972, Tucker-Lewis index=0.964, root mean square error of approximation=0.076, and standardized root mean square residual=0.045). All items fit well in the Rasch models (mean square values were between 0.5 and 1.5), and only one item (number 17) displayed DIF across gender. However, there were six DIF items across Canada and Taiwan, ten across Canada and Iran, and six across Taiwan and Iran. Conclusions: The BM22 has satisfactory psychometric properties, and could assess the QoL of patients with bone metastases specifically focusing on their symptoms. Clinicians may want to use it to capture the underlying QoL for patients with bone metastases. However, the score of item 17 should be interpreted with caution when comparing male and female patients. In addition, researchers should note that variation in DIF items may occur when conducting an international study.

• Journal of Gastric Cancer
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• 제7권4호
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• pp.213-218
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• 2007

목적: 조기위암 수술에 복강경 적용의 용이성 및 종양학적 안정성에 대해서는 많은 연구가 아루어지고 있으나, 복 강경 적용의 또 다른 목적인 '삶와 질' 향상에 대한 연구 는 아직 미흡한 현실이다. 이에 저자들은 위암 수술에 복강경 적용이 '삶의 질' 향상에 미치는 장기적 영향을 평가 하고자 본 연구를 고안하였다. 대상 및 방법: 2003년 1월부터 2004년 12월까지만 2년간 순천향대학병원 외과에서 위 절제 수술 후 위암 1기로 진단된 154명의 환자들을 대상으로 수술 후 1년 이상 경과한 시점에서 설문조사를 시행하였다. EORTC OLQ-C30(3판)과 EORTC QLQ-ST022 한글판을 이용하여 한 명의 전문 간호사에 의해 외래 방문 시 직접 면담 혹은 전화 상담을 통해 설문조사를 시행했으며, 통계처리는 SPSS 12.0 for Windows를 이용하였다. 결과: 전체 대상 환자 154명 중 86명에서 설문 조사가 이루어져 58%의 응답률을 보였으며, 86명(개복군: 57명, 복강경군: 29명)의 평균 연령은 55세였고, 남자가 60명 여자가 26명으로 남녀 비는 2.3 : 1 이었다. 개복 군의 종양 크기는 평균 2.42 cm로 복강경군의 평균 종양 크기 1.8 cm에 비해 유의하게 크기가 컸으며(P=0.003), 평균 획득 림프절 수도 개복 군에서 36개로 유의하게 더 많았다(P=0.000). 그 외 종양관련 인자인 원발암와 침윤도, 림프절 전이 및 TNM 병기에 있어서 양 군 간에 차이는 없었다. 전반적인 건강 상태와 관련된 2 항목의 평균 점수는 개복 군이 57 (${\pm}20.6$), 복강경 군이 60.3 (${\pm}20.4$)으로 양 군 간에 유의한 차이는 없었으며, 기능과 관련된 15 항목과 증상과 관련된 13항목에 있어서도 양군 간에 유의한 차이는 없었다. EORTC QLQ-STO22를 이용한 '삶의 질' 비교 결과 개복군의 평균 점수는 94.5 (${\pm}97.3$), 복강경군은 68.9 (${\pm}64.9$)로 개복군에서 전반적으로 불편한 증상을 많이 호소하였으나 통계학적인 차이는 없었다. 결론: EORTC QLQ-C30 (3판)과 EORTC QLQ-STO22 한글판을 이용한 설문조사 결과 장기적인 측면에서 위 절제술에 복 강경 적용이 환자의 '삶의 질' 향상에 영향을 미치지 못했다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권23호
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• pp.10121-10128
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• 2015

Background: Cancers impose an increasing burden on health of the populations and individuals, but little is known about cancer patient satisfaction with care. The aim of this study was to assess the psychometric properties of the Persian version of European Organisation for Research and Treatment of Cancer (EORTC) In-Patsat32, as a recently developed questionnaire to assess cancer patient satisfaction with care and information provided during hospital admission. Materials and Methods: Complying with EORTC protocols, the Persian version of Inpatsat32 was translated and piloted in a small group of patients, then applied to 380 cancer patients admitted to different oncology wards in Tehran. Validity (convergent, discriminant, and divergent) and reliability of the tool was assessed through using multitrait analysis, factor analysis, intraclass correlations, Chronbach's alpha and test-retest (on a sample of 70 patients). Results: Good acceptance and high sensitivity of the questionnaire with low floor and ceiling effects were recognized, indicating power of the instrument to detect differences between groups with heterogeneous levels of satisfaction. Multitrait scaling analyses supported the convergent validity of the majority of scales (correlation coefficient >0.4) and favorable discriminant validity (item own scale correlation >0.8). There was no correlation between In-patsat32 scales and the EORTC-C30, which measures different concepts, confirming divergent validity of the tool. Internal consistency for all domains was high (${\alpha}$ >0.70) except for the hospital access score and the test-retest reliability was excellent (r=0.86-0.96). There was a weak responsiveness to change except for nurses technical skills. Principle component analysis confirmed five domains with much improved internal consistency (${\alpha}$ >0.9). Conclusions: The Persian version of the EORTC-in-patsat32 module is a reliable and valid instrument to measure cancer patient satisfaction with care received during their hospitalization period and can be utilized in clinical cancer research.

• Journal of Gastric Cancer
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• 제10권1호
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• pp.34-39
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• 2010

목적: 위암 환자에 있어서 근치적 위절제술 후, 위 절제 범위에 따라 삶의 질의 차이가 있다고 한다. 본 연구에서는 수술 후 장시간 경과 후 절제 범위에 따른 삶의 질의 차이를 확인했다. 대상 및 방법: 위암으로 근치적 위절제술을 받은 환자 중, 수술 후 5년이 지나 정기검진을 위해 외래를 방문한 166명을 대상으로 하여, EORTC QLQ-C30 3판과 EORTC QLQSTO22의 한국어판을 이용하여 삶의 질을 평가하였다. 결과: EORTC QLQ-C30으로 수술 후 5년에 평가한 삶의 질은, 육체적, 역할, 정서적, 인지, 사회적 기능 척도 및 피로감, 통증, 호흡곤란, 설사, 경제적 부담감의 척도에서 위아전절제술을 받은 후에 나은 삶의 질을 보이는 경향이 있었으나 통계학적으로 유의한 수준은 아니었다. 전체적인 건강 및 삶의 질, 오심과 구토, 수면장애, 식욕감퇴, 변비의 척도에서는 위전절제술을 받은 후에 더 나은 삶의 질을 보이는 경향이 있었으나 통계학적으로 유의한 수준은 아니었다. EORTC QLQ-STO22로 수술 후 5년에 평가한 삶의 질은, 모든 척도에서 위아전절제술을 받은 후에 더 나은삶의 질을 보이는 경향이 있었으나 통계학적으로 유의한 수준은 아니었다. 결론: 수술 후 단기적인 삶의 질의 차이는 있지만, 위암 완치 후에도 장기적으로 지속되는 삶의 질의 악화를 염려하여, 근치적 위절제술의 절제 범위를 축소할 필요는 없겠으며, 종양학적 원칙에 입각한 수술이 필요하겠다.

• 대한한방내과학회지
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• 제37권5호
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• pp.776-785
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• 2016

The purpose of this study is to report and demonstrate the effect of Korean medical treatment on a wedge resection of a lung patient with mucinous adenocarcinoma. The patient was an 84-year-old female who was diagnosed with mucinous adenocarcinoma and underwent wedge resection. The patient was treated with acupuncture and herbal medicine (Banhahubak-tang and Gamiondam-tang). The EORTC Quality of Life Questionnaire, Core 30 (EORTC QLQ-C30), EORTC Quality of Life Questionnaire, Lung Cancer 13 (EORTC QLQ-LC13), numeric rating scale (NRS), and the Global Assessment (G/A) were used to assess the changes in symptoms, including operation site pain and dyspnea. After treatment, the patient showed improvement in operation site pain and dyspnea, based on the NRS and G/A. However, dyspnea and pain were aggravated based on the EORTC QLQ-C30 and EORTC QLQ-LC13. Therefore, Korean medicine may have a substantial benefit for patients with mucinous adenocarcinoma after wedge resection of the lung.

• 한국전문물리치료학회지
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• 제20권1호
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• pp.36-46
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• 2013

This study examined the effects of a physical therapy program on quality of life (QOL), and neck and shoulder disability in head and neck cancer patients. The program included neck and shoulder range of motion (ROM) exercises, massage, progressive strengthening exercises, and stretching exercises. Sixteen patients who were assigned to an experimental group performed physical therapy for 40 minutes three times a week for eight weeks. Fifteen other patients were assigned to a control group who did not performed the physical therapy program. The European organization for research and treatment of cancer (EORTC QLQ-C30) and head and neck (EORTC QLQ-H&N) instruments, and the Neck Disability Index (NDI) were assessed before and after the rehabilitation program. The 40-minute program consisted of a 10-minute ROM exercise for the neck and shoulder, a 10-minute massage and 15-minute of progressive resistance exercises, followed by a five-minute stretching exercises. Statistically significant differences were noted for changes in global health, physical function in the EORTC QLQ-C30 and cancer related symptoms in the EORTC QLQ-H&N35 (p<.05). The NDI also showed significant differences (p<.05). Physical therapy may therefore benefit the physical aspects and QOL and improve neck and shoulder disability in patients with head and neck cancer.

• 한국전문물리치료학회지
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• 제19권1호
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• pp.56-65
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• 2012

This study examines the effects of a rehabilitation program on quality of life (QOL), cardiopulmonary function and fatigue during radiotherapy for breast cancer patients. The program includes aerobic exercise, stretching and strengthening exercises. Sixty-five women participated in this study and they were asked to perform supervised exercises that last for 60 minutes five times a week for six weeks. The European organization for research and treatment of cancer-cancer (EORTC QLQ-C30) and the breast (EORTC QLQ-BR23), predicted maximal volume of oxygen consumption ($VO_{2max}$) and fatigue severity scale (FSS) were assessed before and after the rehabilitation program. The 60-minute program consisted of a 10-minute warm-up, 30-minute of aerobic exercises, and 15-minute of strengthening exercises, followed by a five-minute cool-down. Heart rates were monitored throughout the exercise class to ensure that patients were exercising at the target heart rate of 40~75% of the age-adjusted heart rate maximum. There were statistically significant differences in the changes of physical function and cancer related symptoms in the EORTC QLQ-C30 and EORTC QLQ-BR23 (p<.05). There was a statistically significant improvement in the predicted $VO_{2max}$ (p<.05), although there were no significant differences in the FSS (p>.05). The results of our study suggest that a supervised rehabilitation program may benefit the physical aspects and QOL of patients receiving radiotherapy for breast cancer.

• Asian Pacific Journal of Cancer Prevention
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• 제17권1호
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• pp.255-259
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• 2016

Background: Reliable and validated instruments are needed in order to study the quality of life in myeloma patients. This study aimed to translate and explore the psychometric properties of the European Organisation for Research and Treatment of Cancer (EORTC) myeloma module (QLQ-MY20) in Iranian patients. Materials and Methods: Two hundred and fifteen patients with multiple myeloma (MM) were recruited from Imam Khomeini Hospital, Tehran. A standard forward-backward translation procedure was implemented. Participating patients were asked to complete the EORTC QLQ-C30 and the QLQ-MY20 three times, at study entry, after two weeks, and again after three months. Data were tested for the range of measurement, internal consistency, test-retest reliability, known group comparison, responsiveness and factor structure. Results: Mean age of the patients was 60.7 years. No floor and ceiling effects were seen for the QLQ-MY20. Cronbach's ${\alpha}$ was greater than 0.80 for all three multi-item scales (ranging from 0.82 to 0.93). All four scales had test-retest reliability of 0.85 or greater. Results of the confirmatory factor analysis that the hypothesized 3-scale measurement model of the QLQ-MY20. Moreover, the Persian version for the QLQ-MY20 differentiated between subgroups of the patients in terms of beta-2 microglobulin, fracture and performance status. The responsiveness of the QLQ-MY20 to change over time was confirmed within 3 months. Conclusions: the results of our study indicate that our Iranian version of the QLQ-MY20 is a feasible, reliable and valid questionnaire for assessing the condition-specific quality of life of patients with MM.