• BMB Reports
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• v.51 no.2
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• pp.65-72
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• 2018

The endothelial to mesenchymal transition (EndMT) is a newly recognized, fundamental biological process involved in development and tissue regeneration, as well as pathological processes such as the complications of diabetes, fibrosis and pulmonary arterial hypertension. The EndMT process is tightly controlled by diverse signaling networks, similar to the epithelial to mesenchymal transition. Accumulating evidence suggests that microRNAs (miRNAs) are key regulators of this network, with the capacity to target multiple messenger RNAs involved in the EndMT process as well as in the regulation of disease progression. Thus, it is highly important to understand the molecular basis of miRNA control of EndMT. This review highlights the current fund of knowledge regarding the known links between miRNAs and the EndMT process, with a focus on the mechanism that regulates associated signaling pathways and discusses the potential for the EndMT as a therapeutic target to treat many diseases.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2001.04a
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• pp.887-890
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• 2001

In end milling process the underformed chip thickness and the cutting force components very periodically with phase change of the tool. In this study, up end milling process is transformed to the equivalent oblique cutting. The varying underformed chip thickness and the cutting force components in end milling process are replaced with the equivalent average ones. Then it can be possible to analyze the chip-tool friction and shear process in the shear plane of the end milling process by the equivalent oblique cutting mode. According to this analysis, when cutting Inconel 718.61% of the total energy is consumed in the shear process and the balance is consumed in the friction process.

• Proceedings of the Korean Society of Machine Tool Engineers Conference
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• 2003.04a
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• pp.167-172
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• 2003

The machining method by using end-milling tool has been applying in machining structures of various shapes because of the availability. Recently, all kinds of industries based on the parts of micro shape are developing, and the demands of mechanical micro machining technology are Increasing suddenly to produce these parts. According to such changes, the technology of the micro end-milling machining is applying as one of the most important machining means. This research is to aim at developing machining technology for various micro structures using micro end-mill. This paper introduces micro mechanical machining system with ultra precision, and demonstrates methods manufacturing all sorts of parts and moldings for industry and examples of applicable machining by using micro end-milling tool of micro sizes from hundreds to tens in diameter.

• Transactions of the Korean Society of Machine Tool Engineers
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• v.17 no.1
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• pp.113-119
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• 2008

The purpose of the present paper is to investigate the optimal shape of the brake tube-end and flare nut for automobiles using the $DEFORM^{TM}-3D$, finite element code. A flare nut is a small and important part used to join a brake tube-end in automobiles. In this instance, we studied the optimal forging processes for the tube-end and flare nut. Finite element analysis has been carried out to predict an optimal shape of the tube-end and flare nut. Also the simulation results were reflected to the forging processes design for the tube-end and flare nut. The shape of the tube-end and flare nut is in agreement with the finite element simulation and the test results.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.14 no.8
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• pp.3224-3242
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• 2020

Internet of Things (IoT) networks composed of a large number of sensors and actuators generate a huge volume of data and control commands, which should be enforced by strong data reliability. The end-to-end data reliability of IoT networks is an essential industrial enabler. Blockchain technology can provide strong data reliability and integrity within IoT networks. We designed a lightweight end-to-end blockchain network that applies to common IoT applications. Its enhanced modular architecture and lightweight consensus mechanism guarantee its practical applicability for general IoT applications. In addition, the proposed blockchain network is highly software compatible because it adopts the Hyperledger development environment. Directly embedding the proposed blockchain middleware platform in small computing devices proves its practicability.

• Animal cells and systems
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• v.3 no.4
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• pp.413-415
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• 1999

Our previous report demonstrated that the rhp51$^＋$, a recA and RAD51 homolog of the fission yeast, encodes three transcripts of 1.9, 1.6 and 1.3 kb which have at least six polyadenylation sites. The 3'-end of the gene alone can direct the formation of multiple, discrete 3'ends of the transcripts. To identify the regulatory element required for the 3'-end formation of -rhp51$^＋$ deletion mapping analysis was performed. Northern blot analysis revealed that the 254-bp DNA fragment including 4 distinct poly (A) sites downstream from the Hindlll site, is crucial for normal 3'-end formation. Deletion of the 3'-terminal AU rich region caused appearance of read-through RNA, leading to enhancement of survival rate of the rhp51 deletion mutant in response to DNA damaging agent, methylmethane sulfonate (MMS). The results imply that the rhp51$^＋$ system may be useful for molecular analysis of the 3'-end formation of RNA in the fission yeast.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2000.05a
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• pp.902-906
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• 2000

In end milling process the undeformed chip thickness and the cutting force components vary periodically with phase change of the tool. In this study, up end milling process is transformed to the equivalent oblique cutting. The varying undeformed chip thickness and the cutting force components in end milling process are replaced with the equivalent average ones. Then it can be possible to analyze the chip-tool friction and shear process in the shear plane of the end milling process by the equivalent oblique cutting model. According to this analysis, when cutting SM45C steel. 82% of the total energy is consumed in the shear process and the balance is consumed in the friction process.

• International Journal of Safety
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• v.7 no.1
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• pp.21-25
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• 2008

The occurrence of a corona is that electrical discharge due to the heterogeneity that occurs when an electrical field is concentrated in an electrode due to a cusp formed on said electrode. Wire treatment at the end of a 154kV dead end clamp for end users accelerates the occurrence of corona, which in turn leads to power loss and noise. In this study, the characteristics of the corona which occurs between porcelain insulators and support clamps of overhead lines used in l54kV power receiving facilities for end users were investigated. The corona, which cannot be identified by one common method, was measured utilizing a UV image camera. A risk assessment for fire damage and its status was suggested. The stress distribution of the electrical field by length of bare wire was suggested by means of the finite element method (FEMLAB). As a result, it was found to affect a porcelain insulators. These results can be utilized for the enhancement of clamp installation and safety in power facilities.

• Structural Engineering and Mechanics
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• v.47 no.6
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• pp.857-879
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• 2013

Numerical damage assessment of Van train station building consisting of three RC blocks due to 2011 Van Earthquakes by nonlinear dynamic analysis is presented. The structural model is created with rigid-end offsets and plastic hinges for nonlinear analysis. Rigid-end offsets are considered for connection areas and proposed for wall-supported elements. In wall-supported elements, walls take place in a limited part of the columns. Nonlinear dynamic analysis of the building with and without rigid-end offsets is performed by using real earthquake records and results are compared. The results show that rigid-end offsets have significant effects on the seismic behavior of the structures.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.24 no.9 s.180
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• pp.2191-2201
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• 2000

End effects due to sectional deformations of thin-walled beams with closed cross section are analysed by a one-dimensional theory. In particular, end effects associated with warping (out of plane m otion) and distortion (in plane motion) are investigated. The exact solutions as a vector form are newly derived to reveal slowly-decaying nature of the end effects in a thin-walled beam loaded by a couple. Several examples of thin-walled beams under various loading conditions indicate that the local end effect zone due to warping and distortion is approximately ten times the typical beam width.