• 한국응급구조학회지
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• 제14권2호
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• pp.57-69
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• 2010

Purpose : The National Registry Exam had some problems on validity of EMT evaluation and verification. The aim of this study was to propose a New EMT National Registry Exam. Methods : Conducted using the Delphi Method(lst meeting March 29 in 2008, 2nd meeting May 31 in 2008, 3rd meeting September 20 in 2008, 4th meeting January 16 in 2009) from questionnaire data(391 from Paramedic, 317 from Basic EMT) collected between June 16-30(lst questionnaire) and October 16-30(2nd questionnaire) in 2008 and a public hearing on February 5 in 2009. Results: The subjects proposed at the request of the National Health Personnel Licensing Examination Board were Introduction, Medical+Trauma Emergencies(Paramedic & Basic) for written examination and scenarios+protocols(Paramedic), protocols(Basic) for practical examination. Conclusion : To be able to response patients' problems in various emergencies, this integrated examination was selected and proposed.

• Journal of Yeungnam Medical Science
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• 제23권1호
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• pp.10-18
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• 2006

Epithelial to mesenchymal transition (EMT) is an important etiologic factor for the development of peritoneal fibrosis in CAPD patients. Mesothelial cells are main source of trans-differentiated fibroblasts under stress from the bioincompatible peritoneal dialysate. In our study there was no difference in dialysate TGF-${\beta}$ and VEGF between the low and high GDP groups during an initial 12 months. However, after adjusting with D-CA125, the low GDPs group showed a significantly lower D-TGF-${\beta}$/D-CA125 and D-VEGF/CA125 during the initial 12 months. Among the adjusted peritoneal growth factors for CA125, VEGF/CA125 and TGF-b/CA125 were factors significantly associated with greater EMT in this study. Adjustment of the peritoneal growth factor for effluent CA125 (surrogate for mass of HPMCs) revealed significant association with EMT suggesting that the fibroblastoid transition from HPMCs could be affected by the amount of intraperitoneal growth factors (TGF-b, VEGF) per unit mass of HPMCs. There was significant improvement in both cell score and D-CA125 at the sixth and 12th months after switching from a high GDPs solution to a low GDPs solution. Use of icodextrin solution in patients who had average peritoneal transport showed not only better systemic effects such as decreased glucose absorption via dialysate but also preservation of the peritoneum, including less EMT and high mesothelial bulk mass. In conclusion, Therapy with low GDP solution including icodextrin may positively impact preservation of the peritoneal membrane integrity and prevention of peritoneal fibrosis with time on PD.

• 한국응급구조학회지
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• 제22권3호
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• pp.77-90
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• 2018

Purpose: This study aimed to assess and improve the work scope of emergency medical technicians (EMT)-paramedics in emergency medical centers. Methods: Data were collected from February 1 to 14, 2018. The questionnaire comprised a total of 56 questions: eight general questions, six questions about the recognition of EMT-paramedics in emergency medical centers, and 42 questions about their work. Data were analyzed via frequency and correlation analysis using SPSS version 18.0. Results: Regarding the work of EMTs in emergency medical centers, positive opinions were found in 23 items, negative opinions in 4 items, and both positive and negative opinions in 9 items. Regarding the questions about the necessity, work importance, professionalism, and the need for an increase4 in EMR-paramedics, depending on respondents' career, there was no statistically significant difference between the group of beginners and the group comprising beginners and that of experienced workers (p>.200). Conclusion: The expert survey revealed that the work performance of EMT-paramedics in regional emergency medical centers was trusted and showed positive results of improvement and expansion.

• 생명과학회지
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• 제29권11호
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• pp.1179-1191
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• 2019

암세포는 epithelial mesenchymal transition (EMT)를 통해 tumor invasion과 metastasis가 일어나며, 또한 정상세포와 다른 oncogenic metabolic phenotypes 획득 즉, glycolytic switch 등이 암 발생과 진행에 깊이 연관되어 있음이 잘 알려져 있다. High-mobility group box 1 (HMGB1)은 chromatin-associated nuclear protein으로 알려져 있으나, dying cells 또는 immune cells로부터 방출되기도 한다. 방출된 HMGB1은 damage-associated molecular pattern (DAMP)로서 작용하여 EMT 및 invasion, metastasis를 유도함으로서 tumor progression에 기여한다고 알려졌다. 본 연구에서 HMGB1에 의해 EMT와 glycolytic switch 유도되며, 이 과정은 Snail 의존적임을 확인하였다. 또한 HMGB1/Snail cascade는 COX subunits인 COXVIIa와 COXVIIc의 발현 억제를 통해 mitochondrial repression과 cytochrome c oxidase (COX) inhibition을 유도하였다. HMGB1은 Snail를 통해 glycolytic switch의 주요 효소인 hexokinase 2 (HK2), phosphofructokinase-2/fructose-2,6-bisphosphatase 2 (PFKFB2), phosphoglycerate mutase 1 (PGAM1)의 발현을 증가시켰다. 이들 효소는 glycolytic switch에 중요하게 관여하는 것으로 알려져 있다. 이들 해당과정의 효소들을 knockdown한 결과 HMGB1에 의한 EMT를 억제함으로써 glycolysis와 HMGB1-induced EMT가 밀접하게 연관되어 있을 제시하였다. 이상의 연구 결과들은 HMGB1/Snail cascade가 EMT 및 glycolytic switch, mitochondrial repression에 중요하게 작용할 것임을 시사한다.

• East Asian mathematical journal
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• 제39권1호
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• pp.65-73
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• 2023

In this paper, we present an optimal control strategy to prevent the EMT process by downregulating the level of overexpressed β-catenin in the cytoplasm. To do this, we propose a mathematical model that expresses relationship between the Wnt signaling pathway and TGF-β in cancer cells. We also define an optimal control problem considering the side effects that occur simultaneously with the method for controlling the concentration of β-catenin. Finally numerical simulations show that treatment effect is quantitatively changes depending on the concentration of core proteins of the Wnt signaling pathway.

• 한국화재소방학회지
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• 제1권2호
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• pp.28-41
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• 2000

Since a few years ago, great disasters have often took place in domestic and abroad, such as Sampoong Department store collapse, Sea-land disaster accident, Incheon Hof fire accidents. Whenever a lot of accidents occurred such as fire, gas explosion, traffic accident, mountain accident, various disease, people required 119 first aid service. As the result, even for the last year, average 2,608 person per day were temporary treated and carried to near hospital by 119 system. But first-aid team or first grade EMT(emergency medical technician) that should provide high quality service and save important lives, might have negatively treated or made their duty only for simple transfer, when they were imminent of emergency case in every kinds of accident spot. Because they worried about medical dispute for "task restriction for EMT" decided by medical laws or rules of first aid. So it was proposed that "task restriction for EMT" should be mitigated or released in the possible range on this occasion.

• 한국응급구조학회지
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• 제7권1호
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• pp.95-108
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• 2003

This study was conducted to identify an initial clinical experience of EMT students, so to better understand their' experience in clinical training. The subjects were 30 EMT students of C department of Emergency Medical technology in C city, who were demonstrating at the emergency room in C, T, S, W city. This study was approached by phenomenological method, collected data were analyzed by Colaizzi's method. the results were as a follows. From the protocol, significant statements were organized into 34 formulated meanings. from the formulated meanings, 21themes were identified, organized into 8 theme clusters, and then categories. EMT students got experienced 'tension resulting from new situation', 'fear in contacting with patients', 'lack of knowledge and skill', 'confidence feeling from being adapted', 'facing up to Paramedic role', 'experience of death' and 'stress'. The results of this study are to use as basic data for students attending clinical experience for the first time.

• 전기학회논문지
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• 제57권5호
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• pp.821-826
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• 2008

Recently as a progress of electric technology, modern electric systems become more and more complicated. Thus, it is difficult to use a classical method to analyze responses of the systems in complicated electromagnetic environments because there are so many coupling phenomena. The electromagnetic topology (EMT) is a helpful solution to analyze electromagnetic interference / electromagnetic compatibility (EMI/EMC) of the large complex system. In this paper, EMT is applied to analyze an active element. And then to prove the validity of this analysis, a detector circuit including Schottky barrier diode is analyzed by EMT when input power is given directly.

• 한국정보통신설비학회:학술대회논문집
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• 한국정보통신설비학회 2006년도 하계학술대회
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• pp.170-174
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• 2006

In this paper electromagnetic topology (EMT) is used to analyze the lumped components on printed circuit boards (PCBs). It is difficult to obtain desirable results about the electromagnetic coupling problems by using a numerical or an experimental method on complex systems. The EMT can be considered as a helpful method to the analysis of electromagnetic interference / electromagnetic compatibility (EMI/EMC) problems in the complex system. To verify the validity of this method, three types of the PCBs mounting a simple circuit are fabricated and experimented.

• 해양환경안전학회지
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• 제17권1호
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• pp.7-13
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• 2011

진해만을 대상으로 3차원 생태계 모델(EMT-3D)을 사용하여 PAHs 거동예측에 대한 적용성을 검토하였다. 계산치와 실측치를 비교한 결과, 모델의 재현성은 비교적 양호한 것으로 나타났다. 민감도 분석을 시행하여 영향인자를 파악한 결과, 용존 PAHs의 경우 광분해 계수의 영향이, 입자성 유기물질 내 PAHs의 경우는 입자성 유기탄소에 대한 분배계수의 영향이 중요한 요소였다. 식물플랑크톤 체내의 PAHs의 경우, 생물농축계수의 영향이 가장 큰 것으로 나타났다. 하천, 대기와 하천 및 대기의 오염부하에 대하여 저감에 따른 응답성 평가를 시행하였다.