• Asian Pacific Journal of Cancer Prevention
• /
• 제16권14호
• /
• pp.5913-5916
• /
• 2015

Gestational trophoblastic neoplasia (GTN) is the malignant form of gestational trophoblastic disease. In non-metastatic GTN, the outcomes of treatment are impressive with methotrexate (MTX) or actinomycin D. We retrospectively reviewed the outcomes of non-metastatic GTN treated at our center from January, 1999 to December, 2013. One hundred and nine patients were recruited to the study. The median age was 33.1 years and over 90% were referral cases. Abnormal vaginal symptoms developed in 37.6% while 56.4% were asymptomatic. The most common antecedent pregnancy was a complete mole (92.7%) with the median interval time from antecedent pregnancy to GTN development being 2.0 months. The median pretreatment B-hCG was 5,624 mIu/ml. The most common first line treatment was methotrexate (MTX) and folinic acid (91.7%) followed by weekly MTX (4.6%), etoposide+ MTX+actinomycin D (EMA) (2.8%), and actinomycin D (0.9%), with the median number of cycles at 5.0. The positive response to first line chemotherapy was 73.8%. The patients were given subsequent chemotherapeutic regimens after resistance to the first line therapy and showed a final remission rate of 89.9%.The significant factor that was frequently found in patients who were non-responders to the first line treatment was a hysterectomy procedure. Two patients developed lung metastasis and brain metastasis at one and four years after the first treatment, respectively. In conclusion, the outcomes of non-metastatic GTN were excellent. However, the patients need long term follow up due to the possibility of developing multiple organ metastases.

• Asian-Australasian Journal of Animal Sciences
• /
• 제26권10호
• /
• pp.1388-1398
• /
• 2013

The present study investigated the contribution of carcass traits on carcass prices of Holstein steers in Korea. Phenotypic data consisted of 76,814 slaughtered Holsteins (1 to 6 yrs) from all over Korea. The means for live body weight at slaughter (BWT), chilled carcass weight (CWT), dressing percentage (DP), quantity grade index (QGI), eye muscle area (EMA), backfat thickness (BF) and marbling score (MS), carcass unit price (CUP), and carcass sell prices (CSP) were 729.0 kg, 414.2 kg, 56.79%, 64.42, $75.26cm^2$, 5.77 mm, 1.98, 8,952.80 Korean won/kg and 3,722.80 Thousand Korean won/head. Least squares means were significantly different by various age groups, season of slaughter, marbling scores and yield grades. Pearson's correlation coefficients of CUP with carcass traits ranged from 0.12 to 0.62. Besides, the relationships of carcass traits with CSP were relatively stronger than those with CUP. The multiple regression models for CUP and CSP with carcass traits accounted 39 to 63% of the total variation, respectively. Marbling score had maximum economic effects (partial coefficients) on both prices. In addition, the highest standardized partial coefficients (relative economic weights) for CUP and CSP were calculated to be on MS and CWT by 0.608 and 0.520, respectively. Path analyses showed that MS (0.376) and CWT (0.336) had maximum total effects on CUP and CSP, respectively; whereas BF contributed negatively. Further sub-group (age and season of slaughter) analyses also confirmed the overall outcomes. However, the relative economic weights and total path contributions also varied among the animal sub-groups. This study suggested the significant influences of carcass traits on carcass prices; especially MS and CWT were found to govern the carcass prices of Holstein steers in Korea.

• Journal of Animal Science and Technology
• /
• 제53권6호
• /
• pp.511-516
• /
• 2011

Fas gene known to associate with intramuscular fat content in Korean cattle was selected for DNA marker development. Fas (APO-1, CD95), a member of the tumor necrosis factor (TNF) receptor superfamily, is a cell membrane protein that mediates apoptosis (programmed cell death). We discovered single nucleotide polymorphisms (SNPs) within Fas gene in order to develop novel DNA markers at genomic level. Of this gene to search for SNP, sequences of whole exon and 1kb range of both front and back of the gene using 24 cattle were determined by direct-sequencing methods. As a result, 16 SNPs in exon, 37 SNPs in intron and 2 SNPs in promoter region, a total of 55 SNPs were discovered. In these SNPs, thirty-one common polymorphic sites were selected considering their allele frequencies, haplotype-tagging status and Linkage Disequilibrium (LD) for genotyping in larger-scale subjects. Selected SNPs were confirmed genotype through SNaPshot method (n=274) and were examined for possible genetic association of Fas polymorphisms with carcass weight (CWT), eye muscle area (EMA), and backfat thickness (BF). So, the SNP have been identified significant g.-12T>G, g.1112T>G and g.32548T>C. These results suggest that polymorphism of Fas gene was associated with meat quality traits in Hanwoo.

• Archives of Plastic Surgery
• /
• 제35권1호
• /
• pp.100-103
• /
• 2008

Purpose: Eccrine porocarcinoma is a very rare, potentially fatal tumor which arises from the intraepidermal portion of the eccrine sweat ductal apparatus. It does not have a characteristic clinical feature but does have a high incidence of metastasis. It may be developed de novo or in a preexisting benign eccrine poroma. It usually affects older people and is located most commonly on lower extremities. We report a rare case of eccrine porocarcinoma which developed on the back without metastasis. Methods: The patient was a 94-year-old woman who showed a painful, ulcerated, dark brown colored polypoid $3.5{\times}3.0cm$ sized mass on the back for 3 years. We totally excised the lesion including normal tissue. Results: After wide excision of the lesion, pathologist reported an eccrine porocarcinoma. Histopathologic findings reveal that the classic type of eccrine gland carcinoma, eccrine porocarcinoma. Immunocytochemical studies showed a positive reactivity to anti-EMA antibody and anti-CEA antibody. Conclusion: Authors experienced a rare case of primary eccrine porocarcinoma on the back. Because of the propensity to develop local recurrence, wide excision of the primary tumor with histologic confirmation of negative margins represents the only curative treatment regimen for eccrine porocarcinoma.

• 대한세포병리학회지
• /
• 제17권1호
• /
• pp.51-55
• /
• 2006

The plasmacytoid variant is an extremely rare form of urothelial carcinoma in which the malignant cells resemble those of plasmacytoma. We report the cytologic features of 3 cases of this disorder. All 3 patients were male and presented with painless macroscopic hematuria. The voided urine cytology revealed a few scattered clusters of tumor cells in a bloody background. Each tumor cell had an abundant amount of cytoplasm that was clear or densely stained and characterized by eccentrically located nuclei. A histological examination of tissue obtained from a radical cystectomy confirmed the cytologic diagnosis in each 3 case, revealing a diffusely infiltrating tumor composed of round, noncohesive tumor cells demonstrating a high nuclear grade. These cells had infiltrated the tunica propria in 2 cases, but were limited to the submucosa in 1 case. The tumor cells were plasmacytoid in appearance, each demonstrating an eccentric nucleus and dense cytoplasm, as seen in the cytologic findings. All of the tumors were immunoreactive for pancytokeratin, CK7, CK20; negative for epithelial membrane antigen (EMA), leukocyte common antigen (LCA), kappa, lambda, and CD79a. Thus, it is important to consider the plasmacytoid variant of urothelial carcinoma in addition to plasmacytoma or lymphoma as a diagnosis when encountering plasmacytoid tumor cells in a voided urine sample.

• 한국축산식품학회지
• /
• 제36권2호
• /
• pp.223-229
• /
• 2016

The carcass size performances and the meat quality of Gannan and Sibu yak were determined using M. supraspinatus (SU), M. longissimus thoracis (LT) and M.quadriceps femoris (QF). It is found that Sibu yak had significantly higher carcass weight (CW) than Gannan yak with difference of nearly 40 kg, as well as significantly higher eye muscle area (EMA), carcass thorax depth (CTD), round perimeter (RP), etc. The carcass performances of steer yak were significantly higher than heifer yak except meat thickness at round (MTR) (p<0.05). The results show that both yak breed and gender had significant effects on carcass performances. It could be seen that the variation of carcass size performances from breeds is as large as from gender (50.22% and 46.25% of total variation, respectively) through principal component analysis (PCA). Sibu yak had significantly higher L*, b*, WBSF, cooking loss and Fat content, while Gannan yak had significantly higher a*, press loss, protein content and moisture (p<0.05). Yak gender and muscle had insignificant effects on meat colour and water holding capacity (p>0.05). The variation of meat quality of yak from breed is up to 59.46% of total variation according to PCA. It is shown that the difference between breeds, for Gannan yak and Sibu yak, plays an important role in carcass size performance and meat quality.

• 환경정책연구
• /
• 제8권3호
• /
• pp.81-113
• /
• 2009

본 논문은 기업의 환경경영활동과 지속가능한 발전과의 상관관계를 분석하는 것을 목적으로 하였다. 이를 위해 기업의 환경경영활동을 지속가능성 측면에서 평가할 수 있도록 경제, 환경, 그리고 사회적 지표를 선정하여 평가모형(SDEM)을 구축하였다. 평가모형은 델-파이, 계층적 분석방법(AHP)을 활용하여 자료의 선정과 가중치를 결정하였다. 그리고 우리나라 기업 58개사를 대상으로 실증분석을 수행하였다. 분석결과에 따르면 환경경영 도입 단계가 높을수록, 기업규모가 클수록, 환경경영을 실천한지 오래될수록, 그리고 공기업일수록 지속가능한 발전에 미친 성과가 높은 것으로 분석되었다. 또한 경제적 성과와 환경적 성과와의 상관관계가 높은 것으로 나타났다. 또한 공기업이 민간기업에 비해 보다 높은 성과를 보이는 것으로 분석되었다.

• Structural Engineering and Mechanics
• /
• 제52권5호
• /
• pp.1019-1032
• /
• 2014

Rails are key elements in railway superstructure since these elements receive directly the train load transmitted by the wheels. Simultaneously, rails must provide effective stress transference to the rest of the track elements. This track element often deteriorates as a consequence of the vehicle passing or manufacturing imperfections that cause in rail several defects. Among these rail defects, transverse cracks highlights and are considered a severe pathology because they can suddenly trigger the rail failure. This study is focused on UIC-60 rails with transverse cracks. A 3-D FEM model is developed in ANSYS for the flawless rail in which conditions simulating the crack presence are implemented. To account for the inertia loss of the rail as a consequence of the cracking, a reduction of the bending stiffness of the rail is considered. The numerical models have been calibrated using the first four bending vibration modes in terms of frequencies. These vibration frequencies have been obtained using the Experimental Modal Analysis technique, studying the changes in the modal parameters of the rails induced by the crack and comparing the results obtained by the model with experimental results. Finally, the calibrated and validated models for the single rail have been implemented in a complete railway ballasted track FEM model in order to study the static influence of the cracks on the rail deflection caused by a load passing.

• 한국컴퓨터정보학회논문지
• /
• 제8권3호
• /
• pp.113-123
• /
• 2003

본 논문에서는 주식의 종가, 거래량 기술적 지표인 MACD(Moving Average Convergence Divergence) 값과 투자 심리선값을 입력 패턴으로 사용하여 개별 금융지표지수에 대한 매도, 중립 및 매수 시점 예측을 수행하는 신경망 모델이 제안된다. 이 모델은 역전파 알고리즘을 이용한 시계열 예측 기능과 균등다층연산 기능을 갖는다. 학습 데이터의 수가 각 범주들(매도, 중립, 매수)에 균일하게 분포되어 있지 않을 경우 기존의 신경망은 가장 우세한 범주의 예측 정확성만을 향상시키는 문제점을 가지고 있다. 따라서, 본 논문에서는 신경망의 구조, 동작, 학습 알고리즘에 대해 표현한 후 다른 범주의 예측 정확성도 향상시키기 위해 각 범주의 중요성을 이용하여 학습 데이터의 수를 조절하는 균등다층연산 방법을 제안한다. 실험 결과, 균등다층연산 신경망을 이용한 금융지표지수 예측 방법이 기존의 신경망을 이용한 금융지표지수 예측 방법 보다 각 범주에 대해 높은 정확성 비율을 보임을 확인할 수 있었다.

• Restorative Dentistry and Endodontics
• /
• 제21권2호
• /
• pp.642-651
• /
• 1996

The purpose of this study was to evaluate the relationship between monomer compositions and the changes in the degree of conversion in the various layers of composites after additional heat curing. Four types of composites and 3 types of inlay ovens were used in this study. Composite was placed in a 4-mm thick teflon mold, and light cured from the top for 60 seconds. Ten samples were prepared for each composite ; 5 of these were additionally heat cured in an inlay oven as the manufacturer recommended. After light curing or light and heat curing, the samples were sectioned into four parts and assigned to groups A, B, C, or D according to their distance from the light source. These sections were then thinned to 50-$70{\mu}m$, and these wafers were analyzed with a Fourier Transform Infrared Spectrometer(FI-IR) to determine the degree of conversion. A standard baseline technique was used to calculate the degree of conversion. $^{13}C$ NMR spectra of bis-GMA, TEGDMA and bis-EMA, were acquired using a Varian Gemini spectrometer operated at 200 MHz. $CDCl_3$ solvent was used for qualitative analysis. The degree of conversion was affected by bis-GMA : TEGDMA ratio but it seemed to be also affected by other factors. When the composites were heat cured, significant increases in the degree of conversion were noted throughout the samples, but the amount of increase differed between materials. Thus, clinical performance of a heat-treated composite inlay may be different depending on materials.