• 미생물학회지
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• 제29권1호
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• pp.25-33
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• 1991

Antiviral activities of papaverine and nucleoside analogs, 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine (DHPG) and acyclovir, against human cytomegalovirus (HCMV) infection were compared in vitro. Papaverine and DHPG were effective in reducing infectious HCMV yields with $ED_{50}{\s}$ (effective dose 50: the concentraion at which 50% of virus yields was obtained) of approximately 1.02 and $0.45{\mu}{\M}$, respectively; while acyclovir was less effective with an $ED_{50}$ of about $10.4{\mu}{\M}$The relative cytotoxicity of these drugs was evaluated under the same conditions used to measure infectious HCMV yields. Papaverine and DHPG demonstrated little cellular toxicity as measured by their effect on the viability of confluent cells at concentrations in the range of those demonstrating potent inhibition of HCMV replication. Similarly, protein synthesis was largely unaffected by these drugs in stationary mock-infected cells as measured by the incorporation of isotopically labelled amino acids. In contrast, cellular DNA synthesis was invariably reduced in the presence of either drug. HCMV-specific DNA synthesis was also strongly inhibited by papaverine and DHPG.

• 미생물학회지
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• 제25권1호
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• pp.28-33
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• 1987

Celluloytic bacteria, -Gram positive, Gram negative and actionmycetes-were used to study their catabolic pathways of carbohydrate. It was found that Embden-Meyerhof-Parnas(EMP) pathway and hexose monophosphate(MHP) shunt were operated in Cellulomonase sp. CS1-1, C. flavigena, and Pseudomonas fluorescens subsp. cellulosa when they were cultured in a glucose containing medium, whilst gluconate was catabolised mainly via Entner-Doudoroff(ED) pathway, and to some extend through HMP shunt. Enzymes of ED pathway in the orgamisms were induced by gluconate. On the other hand Nocardia cellulans catabolised glucose and gluconate via EMP pathway and HMP shunt. The growth rate of N. Cellulans on gluconate were much slower than that on glucose.

• Toxicological Research
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• 제21권2호
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• pp.141-150
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• 2005

1,3-Dichloro-2-propanol (1,3-DCP) is known as chloride chemicals and causes severe hepatotoxic agent. The Ito cells and Kupffer's cells of the liver in the 5 old F344 Rats were exposed to 1,3-DCP gas chamber for 6 hours/ a day, 5 days/ a week, and 13 weeks, in the 0, 5, 20, 80 ppm, respectively. After then the body weights, liver weights, and relative liver weight to body weight were measured, and the hepatic tissues were prepared by the routine and Immunostain method, and observed by the LM, and EM. In the results, there were severe body weight decrease (p<0.05) in the 80 ppm of the male and female rats. The relative liver weights to the body weight were increased relate with exposed 1,3-DCP concentration (P<0.001). Inflammatory cells, infiltration was observed at the perivascular area in the 20 ppm exposed group, and bilirubin pigment infiltration, bile duct hyperplasia, inflammation hepatocytic necrosis, fibrosis were observed in the 80 ppm exposure group. In the 80 ppm exposure group, disarrangement of the endothelial cells, erythrocytes and hepatic cell fragment in the Disse space and numerous migration macrophages were observed in the necrotic area by EM observation. In the immunostained hepatic tissues positive stained ED1 cells were extremely increased (P<0.05) in central vein area, but ED2 was weakly positive immunostained in the 80 ppm exposed group. Immunostained desmin was observed in the Ito cell. It was no difference in the low and medium exposed group but it was typical increase in the necrotic area. In conclusion, These results suggest that NOAEL of 1,3-DCP may be 5 ppm in rats and the Immunostained of desmin, ED1 and ED2 positive cells activated in the inflammatory liver were related to the exposure volume and density. The increase of the Ito cells were related to the severe phagocytosis of the Kupffer's cells.

• 환경영향평가
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• 제22권1호
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• pp.89-97
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• 2013

RADCONS Ver. 1.0 (RADiological CONSequence Assessment Program) was developed for radiological risk assessment in this study. A Gaussian plume model was used to analyze the fate and transport of radionuclides released into the air in case of accidents. Both single meterological data and time series meterological data can be used in RADCONS. To assess the radiological risk of the early phase after an accident, ED (Effective Dose) estimated by both deterministic and probabilistic approaches are presented. These EDs by deterministic and probabilistic will be helpful to efficient decision making for decision makers. External doses from deposited materials by time are presented for quantifying the effects of mid and late phases of an accident. A radiological risk assessment was conducted using RADCONS for an accident scenario of 1 Ci of Cs-137. The maximum of ED for radii of 1,000 meters from the accident point was 8.51E-4 mSv. After Monte-Carlo simulation, considering the uncertainty of the breathing rate and dispersion parameters, the average ED was 8.49E-4, and the 95 percentile was 1.10E-3. A data base of the dose coefficients and a sampling module of the meteorological data will be modified to improve the user's convenience in the next version.

• 한국의학물리학회지:의학물리
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• 제32권3호
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• pp.59-69
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• 2021

Purpose: The relationship between computed tomography (CT) number and electron density (ED) has been investigated in previous studies. However, the role of these measures for guiding cancer treatment remains unclear. Methods: The CT number was plotted against ED for different imaging protocols. The CT number was imported into ED tables for the Pinnacle treatment planning system (TPS) and was used to determine the effect on dose calculations. Conversion tables for radiation dose calculations were generated and subsequently monitored using a dosimeter to determine the effect of different CT scanning protocols and treatment sites. These tables were used to retrospectively recalculate the radiation therapy plans for 41 patients after an incorrect scanning protocol was inadvertently used. The gamma index was further used to assess the dose distribution, percentage dose difference (DD), and distance-to-agreement (DTA). Results: For densities <1.1 g/cm³, the standard deviation of the CT number was ±0.6% and the greatest variation was noted for brain protocol conditions. For densities >1.1 g/cm³, the standard deviation of the CT number was ±21.2% and the greatest variation occurred for the tube voltage and head and neck (H&N) protocol conditions. These findings suggest that the factors most affecting the CT number are the tube voltage and treatment site (brain and H&N). Gamma index analyses for the 41 retrospective clinical cases, as well as brain metastases and H&N tumors, showed gamma passing rates >90% and <90% for the passing criterion of 2%/2 and 1%/1 mm, respectively. Conclusions: The CT protocol should be carefully decided for TPS. The correct protocol should be used for the corresponding TPS based on the treatment site because this especially affects the dose distribution for brain metastases and H&N tumor recognition. Such steps could help reduce systematic errors.

• Clinical and Experimental Pediatrics
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• 제58권12호
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• pp.466-471
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• 2015

Purpose: This study attempted to examine parental satisfaction with pediatric emergency care (PEC) in Korea and investigate the features influencing overall satisfaction. Methods: A nationwide, cross-sectional survey was conducted among parents who had taken their children to an Emergency Department (ED) in the three years prior to the study. A 21-item, structured questionnaire was administered to the parents through a web-based system. Participants' satisfaction levels and the strength of the association between PEC components and overall satisfaction were rated using a 7-point Likert scale. Results: In total, 1,000 parents participated in the survey, of which 402 (40.2%) stated that they were generally satisfied with the delivered PEC. Female participants, mothers, and parents with low-acuity patients were more likely to be dissatisfied with the delivered PEC. Although the ED environment was the lowest level of satisfaction, it did not significantly influence the respondents' overall levels of satisfaction. The most influential factors in terms of overall satisfaction were "nurses' professionalism" and "doctors' attitude and proper explanation". Conclusion: Parents' overall level of satisfaction with PEC is relatively low and is closely related to factors associated with ED personnel.

• 중환자간호학회지
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• 제9권1호
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• pp.15-26
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• 2016

Purpose: The aim of this study was to identify thinking strategies in the complicated decision-making process based on real patient-based data of triage nurses in the emergency department (ED). Methods: This study used the 'think aloud' method to collect data from 8 triage nurses from one general hospital ED in South Korea. The data were analyzed with protocol analysis using thinking strategies. Results: The triage process was divided into three stages. The first stage consisted of 8 thinking strategies, including searching for information. They used intuition based on directly observed concepts for identifying a crisis. The second stage consisted of 17 thinking strategies related to the decision-making process. They assessed patients and generated a hypothesis to try to understand their health problems through analytic thinking. The third stage consisted of 10 thinking strategies, including qualifying. They considered the situation of the ED and properly triaged the patients. During the triage process, they frequently used judging the value and searching for information on 17 thinking strategies. Conclusions: Triage nurses demonstrated various connected thinking strategies for each stage. Based on our results, further studies should be done to develop a triage education program.

• 전기학회논문지
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• 제66권7호
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• pp.1017-1024
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• 2017

The International Electrotechnical Commission(IEC) 61000-4-15 is a standard proposing techniques for a flicker meter test and measurement method. The IEC61000-4-15 ed1 announced in 1997 was not include tests for accurate verification. Also it was not explained flicker meter algorithm that can be directly applied to the other power systems. But the new edition of IEC61000-4-15 ed2 prescribes a variety of tests for verify flicker meter algorithm and it explains 'correction factor' used for measuring flicker in other power systems. It can measure flicker severity in 220V system by multiplying correction factor to the measured values with the 230V algorithm. This paper compared the method of measuring flicker severity in korea power system using the correction factor and the modified weighting filter, after verifying of digital flicker meter algorithm created by using matlab based on IEC61000-4-15 ed2.

• International Journal of Contents
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• 제14권2호
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• pp.1-6
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• 2018

In a wireless mobile communication system, a pilot signal has been considered to be a necessary signal for estimating a changing channel between a base station and a terminal. All mobile communication systems developed so far have a specification for transmitting pilot signals. However, although the pilot signal transmission is easy to estimate the channel,(Ed: unclear wording: it is easy to use the pilot signal transmission to estimate the channel?) it should be minimized because it uses radio resources for data transmission. In this paper, we propose a pilotless channel estimation scheme (PCE) by introducing the clustering method of unsupervised learning used in our deep learning into channel estimation.(Ed: highlight- unclear) The PCE estimates the channel using only the data symbols without using the pilot signal at all. Also, to apply PCE to a real system, we evaluated the performance of PCE based on the resource block (RB), which is a resource allocation unit used in LTE. According to the results of this study, the PCE always provides a better mean square error (MSE) performance than the least square estimator using pilots, although it does not use the pilot signal at all. The MSE performance of the PCE is affected by the number of data symbols used and the frequency selectivity of the channel. In this paper, we provide simulation results considering various effects(Ed: unclear, clarify).

• Korean Membrane Journal
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• 제3권1호
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• pp.39-50
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• 2001

The counter-diffusion of two gaseous substances permeating a polymeric membrane has been investigated both experimentally and theoretically. The aim of the study was to find mutual effects, if any, that could influence the permeability and diffusivity data. The experimental data were obtained with an isostatic permeameter operating at ambient pressure and 303 K: helium, nitrogen, carbon dioxide methane were used as permeating gas at different partial pressure; helium or nitrogen as equilibrating or carrier gas. No evident mutual effect of the counter-diffusing gas was observed. The theoretical analysis gave some insight into the phenomena and it was concluded that at near-atmospheric pressures, and in the absence of swelling phenomena no mutual interaction exists. On a theoretical basis any mutual interaction between diffusing and counter-diffusing gases could only occur: i) at high pressures , when the free movement of permeating gas molecules within the polymer is hindered by the counter-diffusing gas; ii) when a large part of the free volume fraction is occupied by the counter--diffusing gas; iii) swelling phenomena modify the structure and free volume fraction of the polymer.