• Asian Pacific Journal of Cancer Prevention
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• 제16권4호
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• pp.1495-1499
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• 2015

Background: c-Kit is a proto-oncogene that encodes a tyrosine kinase receptor (CD117). Mean platelet volume (MPV) is a useful marker for demonstrating thrombocyte function. We aimed to investigate whether c-kit is expressed in benign, preneoplastic and neoplastic endometrial tissues and whether MPV has a relation with c-kit expression and its intensity. Materials and Methods: c-Kit expression was investigated immunohistochemically in 10 samples of normal endometrium (n=10), simple endometrial hyperplasia (5 cases with atypia and 10 cases without atypia), complex endometrial hyperplasia (10 cases with atypia and 10 cases without atypia) and endometrial cancer (EC) (10 cases grade I and 10 cases grade II) and MPV of all cases was checked. Results: c-Kit expression was observed at very low rates in cases with normal endometrial tissues (NE) and in hyperplasia without atypia. c-Kit expression and immunostaining were strong in endometrial atypia and EC. MPV levels of complex atypical endometrial hyperplasia (CAEH) (p:0.002), EC grade I (ECG I) (p<0.001) and EC grade II (ECG II) (p<0.001) were significantly elevated when compared with the NE group. Both c-kit expression and intensity of immunostaining had a positive correlation with MPV level. Conclusions: While c-kit expression and intensity of immunostaining were mildly positive in NE and hyperplasia without atypia, they were clearly observed in EC and hyperplasia with atypia. As c-kit expression is related to the mutagenesis a long-term followup may be needed in these cases. A high MPV level may be a good test for demonstrating c-kit expression and intensity of immunostaining.

• 전기화학회지
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• 제6권3호
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• pp.183-186
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• 2003

In a PEM fuel cell electrode, backing layer has tremendous impact on electrode performance. The backing layer provides structural support for the porous electrode, distributes the reactants to the other layers and acts as a current collector. It has major influence on the water management in a PEM fuel cell. Selection of suitable backing layer material for the fabrication of electrode is thus very important to achieve high performance. In this paper we have compared the performance of PEM fuel cell electrodes fabricated using carbon paper EC-TPI-060T, carbon cloth EC-CCI-060T, (ElectroChem Inc.USA) and Carbon cloth from Textron, USA (CPW 003 grade). Mass transport problem was observed under non-pressurized condition, at high current densities, in the caie of EC-CC1-060T carbon cloth electrode (at $50^{\circ}C$), due to its higher thickness. The performance of carbon paper electrode was higher than EC-CCI-060T carbon cloth electrode. The performance of Textron carbon cloth was comparable to EC-TPI -060T carbon paper.

• Tuberculosis and Respiratory Diseases
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• 제54권4호
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• pp.415-428
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• 2003

연구배경 : 소세포폐암에 대한 항암화학치료에 etoposide와 cisplatin(EP) 또는 etoposide와 carboplatin(EC)이 가장 흔히 사용되는 병합요법인데, 전반적인 관해율은 75-85%(제한기 65-90%), 완전관해율은 20-30%(제한기 45-75%)로 보고되고 있다. 치료후 재발되는 소세포폐암환자에 대하여 구제(salvage)화학요법제로 topotecan을 사용하였을 때 90일 이내에 재발되는 불응성 재발(refractory relapse, RR)인 경우 관해율이 6.4%인 반면에, 90일 이후에 재발되는 감수성 재발(sensitive relapse, SR)에서는 37.8%의 관해율이 보고되고 있다. 저자는 EC요법과 2차 구제화학요법으로 topotecan요법의 치료효과와 부작용을 조사하여 기존의 성적들과 비교하고자 하였다. 대상 및 방법 : 1996년부터 2002년 6월까지 전남대병원 내과에서 소세포 폐암으로 치료를 받았던 환자들 중에서 EC요법과 재발되어 topotecan구제 화학요법을 받은 환자를 대상으로 임상경과를 후향적으로 조사하였다. 일차치료로서 etoposide 100 $mg/m^2$ (day 1-3), carboplatin 300 $mg/m^2$(day 1)을 3주 이상의 간격을 두고 투여하여, 3주기 이상 화학요법을 받은 경우들을 대상으로 하였고, 이차치료로 topotecan을 투여한 경우에는 1.5 $mg/m^2$을 제 1일에서 제 5일까지 3주 간격으로 2주기 이상 받은 환자들을 대상으로 하였다. 치료에 대한 반응의 평가는 완전관해(complete remission, CR), 부분관해(partial remission, PR), 불변(stable disease, SD), 진행(progressive disease, PD)으로 구분하였고 생존기간은 치료시작일로부터 중앙생존기간(median survival time, MST)으로 표기하였다. 결 과 : 총 101예에서 1차 선택 약제로 EC요법 후 관해율은 57.4%(58예)로 CR은 15.8%(16예), PR은 41.6%(42예)이었다. 제한기(69명)에서의 관해율은 69.6%(48예)로 CR은 23.2%(16예), PR은 46.4%(32예)였으며, 확장기(32명)에서의 관해율은 31.3%(10예)로 모두 PR반응을 보였다. 수행 능력(performance status score, PS)과 동통, 호흡곤란, 기침 등 임상 증상의 변화를 평가하였는데 58예(57.4%)에서 전신상태와 증상의 호전을 보였다. 전체 관해군의 관해 유지기간(중앙값)은 10.3개월(5.8개월~57.7개월)이었고 치료에 따른 호중구 감소증(G4)은 24예(23.8%), 혈소판감소증(Grade 4)은 2예(2%)에서 관찰되었다. 1차 화학치료에 불응하여 바로 다른 약제로 바꾸어 치료한 9예와 1차 치료 후 2차구제화학요법을 받지 않았던 71예를 제외한, 21예의 환자들은 EC요법으로 SD이상 반응을 보였으나 재발하여 topotecan을 투여 받은 군이었다. 총 21예 중 관해율은 SR군(8예)의 경우 PR 25%(2예), SD 25%(2예), PD 50%(4예)를 보였고, RR군(13예)에서는 PR 15.4%(2예), SD 15.4%(2예), PD 69.2%(9예)를 나타냈으나 유의한 차이는 아니었다. 생존 기간의 비교에서도 SR군은 MST 8개월로 RR군의 MST 7개월과 비교하여 유의한 차이는 없었다. 치료에 따른 독성으로 호중구감소증(Grade 4)은 6예 (28.3%), 혈소판감소증(Grade 4)은 3예(14.3%)에서 관찰되었다. 결 론 : EC와 topotecan 치료 모두 기존의 보고들과 비슷한 관해율을 보였으며 수용 가능한 정도의 부작용이 관찰되었다.

• Steel and Composite Structures
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• 제5권1호
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• pp.35-47
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• 2005

This paper presents the results of a series of tests carried out on hollow and concrete-filled coldformed steel sections subjected to axial and bending forces. The effects of eccentricity ratio and strength of in-fill on the behaviour of these sections were studied. A total of forty-eight medium sized columns and six beams were tested to failure. Extensive measurements of material properties, strains, axial shortening and lateral deflection were carried out. Interaction of local and overall buckling was observed in the tests. Failure mode observations were local buckling coupled with overall buckling. A description of the specially fabricated end fixtures for applying eccentric loading to the columns and to simulate pinned end condition is also presented. The experimental results of hollow columns are compared with the existing Indian, British and American codes of practice and the results of concrete-filled columns are compared with EC4 recommendations. It is seen that in the case of hollow columns predictions based on British and American codes of practice and in the case of concrete-filled columns predictions based on EC4 recommendations agree reasonably well with the experimental results. From the experiments it is seen that the provision of in-fill substantially increases the ultimate load carrying capacity of the order of one and a half to two times and the increase in strength of the in-filled concrete from a low grade concrete of compressive strength 24.94 MPa to a high grade concrete of compressive strength 33.26 MPa increases the ultimate load carrying capacity by one and a half times irrespective of the eccentricity of loading.

• Asian Pacific Journal of Cancer Prevention
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• 제15권15호
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• pp.6353-6356
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• 2014

Background: The purpose of this study was to investigate and evaluate risk factors for lymph node metastases (LNM) in cases of endometrial cancer (EC). Materials and Methods: A retrospective single institution analysis of patients surgically staged for EC at Ankara Oncology Education and Research Hospital from 1996 to 2010 was performed. Roles of prognostic factors, such as age, histological type, grade, depth of myometrial invasion, cervical involvement, peritoneal cytology, and tumor size, in the prediction of LNM were evaluated. Fisher's exact test and logistic regression analysis were used to assess the effects of various factors on LNM. Results: LNM was observed in 22 out of 247 patients (8.9%) and was significantly more common in the presence of tumors of higher grade, deep myometrial invasion (DMI), cervical involvement, size >2cm, and with positive peritoneal cytology. Logistic regression analysis revealed that DMI remained the only independent risk factor for LNM. NPV, PPV, sensitivity, and specificity for satisfying LNM risk were 98.0, 19.5, 86.3, and 65.3%, respectively for DMI. Conclusions: The incidence of LNM is influenced independently by DMI. If data support a conclusion of DMI, LND should be seriously considered.

• 한국전기전자재료학회논문지
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• 제20권12호
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• pp.1099-1104
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• 2007

In order to develop non-heated STAl(super thermal resistant Aluminum alloy) for ampacity gain conductor, the systematic research was carried out. Especailly, the effect of a very small amount of Zr, Sc element in EC grade Al ingot on mechanical and electrical properties was our priority. As a result, it was found that the strength and recrystallization temperature of designed alloy was gradually increased with Zr, Sc addition up to 0.3 wt.%. However, the electric conductivity showed no drastic change. The tensile strength and recrystalliztion temperature, $17.75{\sim}20.05\;kgf/mm^2$ and $420{\sim}520\;^{\circ}C$, was obtained at 0.3 wt.% Zr, Sc addition, respectively. Particles of the $Al_3Zr$ and $Al_3Sc$ phase affected the ambient and elevated-temperature strength of the alloys.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2007년도 하계학술대회 논문집 Vol.8
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• pp.519-520
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• 2007

In order to develop non-heated STAl(super thermal resistant Aluminum alloy) for ampacity gain conductor, the systematic research was carried out. Especially, the effect of a very small amount of Zr element in EC grade Al ingot on mechanical and electrical properties was our priority. As a result, it was found that the strength and recrystallization temperature of designed alloy was gradually increased with Zr addition up to 0.3wt.%. However, the electric conductivity showed no drastic change. The tensile strength and recrystalliztion temperature, $17.75\;kgf/mm^2$ and $420^{\circ}C$, was obtained at 0.3 wt.% Zr addition, respectively.

• Asian Pacific Journal of Cancer Prevention
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• 제14권4호
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• pp.2429-2432
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• 2013

Background and Objectives: Yanting in Sichuan Province is one of the highest risk areas of esophageal cancer (EC) in the world. We here summarize the epidemiology of EC in Yanting using data from the national screening programme during 2006-2011. Methods: Random cluster sampling was used to select a proportion of natural villages from six towns in Yanting, and residents aged 40-69 years old were invited for screening. Participants were screened using endoscopy with iodine staining and then confirmed by histological examinations. Results: The overall detection rates of low-grade hyperplasia (LH), moderate hyperplasia (MH), high-grade hyperplasia (HH), carcinoma in situ (CIS), intramucosal carcinoma (IC) and invasive carcinoma (INC) were 5.33%, 1.28%, 0.68%, 0.15%, 0.06% and 0.29%, respectively. The detection rates of LH, MH, HH and INC increased with age, reaching the peak among those aged 60-65 years, and the prevalences of LH and MH were higher among men than among women. In addition, the detection rates of hyperplasia were much higher in mountainous than in hilly areas. Conclusions: Among the high risk population, there are a great number of people with early-stage EC or precancerous conditions who do not have presenting symptoms. In particular, the elderly, men, or those living in mountainous areas are the most vulnerable population. It is therefore important to reinforce health education and screening services among such high risk populations.

• Asian Pacific Journal of Cancer Prevention
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• 제13권1호
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• pp.169-173
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• 2012

Objective: This study aimed to explore the differences in the curative and side effects of chemoradiotherapy on esophageal cancer (EC) among Xinjiang Han, Uigur and Kazakh patients. Methods: 170 patients with IIA stage-IV of esophageal squamous cell carcinoma were analyzed retrospectively. Based on different nationalities, they were divided into the Han, Uigur and Kazakh groups. The 1-, 2- and 3-year survival rates, incidence of the side effects (including hematological toxicities, radioactive esophagitis and percutaneous reactions) and application of antibiotics and harmonics were compared among the groups. There was no significant difference in the short-term curative effects among the Han, Uigur and Kazakh groups. The 1- 2- and 3-year survival rates of the three groups were 84%, 40%, 26%; 78%, 27%, 18%; and 60%, 21%, 12% ($x^2$=14.497, P<0.05). The incidence rate of hamatological toxicity ${\geq}$Grade 2 in the Kazakh group was significantly lower than that in the Han or Uigur group. Results: The incidence rates of radioactive esophagitis and percutaneous reactions Grade 2 in the Han group were significantly higher than those in the Uigur or Kazakh group. There was no significant difference in the types of applied antibiotics among the groups, but there were significant differences in the days of antibiotic application and proportion of patients receiving harmonics between the Hans and either of other groups. Conclusion: Chemoradiotherapy shows a better effect in the long-term survival rate among Han EC patients compared with Uigur or Kazakh EC patients. Uigur and Kazakh patients show a better tolerance to the side effects of chemoradiotherapy compared with Hans.

• 생물환경조절학회지
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• 제26권1호
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• pp.35-42
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• 2017

토마토를 저면관비 방법으로 육묘할 때 유묘 생장과 상토 무기원소 농도 변화에 적합한 추비의 종류 및 농도를 구명하기 위해 본 실험을 수행하였다. 육묘용 2종류의 동절기 혼합상토 피트모스 0-6mm(PM06)+perlite 1-2mm(PE2)(7:3, v/v)와 피트모스 5-15mm(PM515)+PE2(7:3, v/v)를 72공 플러그 트레이에 각각 충전하고 토마토 '도태랑다이아' 종자를 파종하여 발아시킨 후 생장상에서 35일간 육묘하였다. 자엽형성기에 추비를 시작하였고 13-2-13, 15-0-15, 20-9-20($N-P_2O_5-K_2O$) 복합비료를 순서대로 처리하였다. 추비시 생육 단계별로 $25mg{\cdot}L^{-1}$의 농도차(N 기준)를 둔 3종류의 Program을 두어 시비하였으며, 플러그 트레이의 수분이 포화 기준으로 40-50%로 감소하였을 때 저면관비하였다. 파종 후 1, 2, 4 및 5주째 혼합상토를 상부, 중간, 하부로 3등분하여 포화추출한 후 추출용액의 pH, EC 및 무기이온 농도를 분석하고, 5주 후에 유묘생장을 조사하였다. 육묘 기간 중 상토의 pH는 PM06+PE2가 PM515+PE2 보다 높았으며, 하부와 중간이상부보다 높은 경향이었다. EC는 PM06+PE2가 PM515+PE2보다 높았으며 평균적으로 상부가 하부보다 2배 이상 높았다. $NH_4-N$과 $K^+$ 농도는 2종류 혼합상토의 모든 시비 Program에서 육묘 후 5주까지 높아졌으며, PM06+PE2의 추비 프로그램 3에서 가장 높았다. $NO_3-N$ 농도는 PM06+PE2에서 육묘기간 동안 높아졌고 추비농도가 높을수록 그러한 경향이 뚜렷하였다. 지상부 생체중을 비롯한 유묘의 생장은 PM06+PE2의 추비 Program 2에서 가장 우수하였다. 따라서 2종류 혼합상토를 이용한 공정육묘시 13-2-13, 15-0-15 및 20-9-20을 순서대로, 질소 기준 $25mg{\cdot}L^{-1}$에서 $125mg{\cdot}L^{-1}$까지 육묘기에 따라 점차적으로 높여 추비하는 방법이 적합하다고 판단하였다.