• The Journal of Internal Korean Medicine
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• v.31 no.2
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• pp.264-272
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• 2010

Objectives : This study was carried out to measure perceptions about Traditional Korean Medicine hospitals and provide data for improvement of TKM hospital management. Methods : We surveyed the general population from 1st to 17th December, 2008, and patients visiting a TKM hospital from 1st June to 9th December, 2008. Results : Result as follows. 1. The response ratio for the generally preferred medical institution was in the order of western medical clinic, pharmacy, general hospital, TKM clinic, TKM hospital. 2. The response ratio for the preferred medical institution for herbal medicine treatment was in the order of TKM clinic, herbal medicine store, TKM hospital, pharmacy. The preferred medical institution for acupuncture treatment was in the order of TKM clinic, TKM hospital, acupuncture clinic, public health center. 3. The most common response to reason for receiving traditional Korean medical care was "traditional Korean medical care is more effective than western medical care." 4. The proportion of first treatment and second treatment of patients visiting at TKM hospital was about 1:1. 5. 72.3% of patients had been to another medical institution. 6. The response ratio for the first visited medical institution for the same disease was in the order of general hospital, western medical hospital, western medical clinic, TKM clinic. 7. The response ratio for the concern about TKM treatment was in the order of expensive charge for TKM treatment, uncertainty of TKM treatment effect. Conclusions : Through this research, we can understand the perception about TKM hospital treatment of the general population and patients visiting TKM hospitals.

• Proceedings of the Korean Institute of Surface Engineering Conference
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• 2018.06a
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• pp.25-25
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• 2018

Electron beam melting (EBM) is one of powder based additive manufacturing technology used to produce parts for high geometrical complexity and directly with three-dimensional computer aided design (CAD) model. It is kind of the most promising methods with additive manufacturing for a wide range of medical applications, such as orthopedic, dental implant, and etc. This research has been investigated the microstructure and mechanical properties of as fabricated and hot iso-static pressing (HIP) processed specimens, which are made by an Arcam A1 EBM system. The Ti-6Al-4V titanium alloy powder was used as a material for the 3 dimensional printing specimens. Mechanical properties were conducted with EBM manufacturing and computer numerical control (CNC) machining specimens, respectively. Surface morphological analysis was conducted by scanning electron microscopy (SEM) for their surface, dissected plan, and fractured surface after tensile test. The mechanical properties were included tensile stress-strain and nano-indentation test as a analysis level between nano and macro. As following highlighted results, the stress-strain curves on elastic region were almost similar between as fabricated and HIP processed while the ductile (plastic deformed region) properties were higher with HIP than that of as fabricated processed.

• Herbal Formula Science
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• v.19 no.1
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• pp.183-194
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• 2011

Objectives : To estimate the shelf-life by long-term storage test of Pyungwi-san. Methods : Experiments were conducted to evaluate the stability such as the selected physicochemical, heavy metal, microbilogical experiment under an acceleration test and long-term storage test of Pyungwi-san in different storage under room temperature, refrigeration and freezing. Futhermore, HPLC analysis was performed for the determinations of glycyrrhizin in the Pyungwi-san on an Inertsil ODS-3 column(250 mm ${\times}$ 4.6 mm, 5 um) using solvent 35% acetonitrile include 0.05% phosphoric acid at 254 nm. The flow rate was 1.0 mL/min. Results : The significant change was not showed in pH, heavy metal, microbiological, identification test and quantitative analysis based on acceleration test and long-term storage test. Retention time of glycyrrhizin in HPLC chromatogram was about 16.065 min and calibration curve showed good linearity($R^2$ = 0.9999). The contents of glycyrrhizin in acceleration test and long-term storage test were 0.068~0.076 mg/mL and 0.066~0.077 mg/mL, respectively. Shelf-lifes of room temperature, refrigeration and freezing by long-term storage test were predicted 41, 24 and 34 months, respectively. Conclusions : The suggested shelf-life would be helpful on the storage and distribution of herbal medicine.

• Herbal Formula Science
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• v.18 no.2
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• pp.125-134
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• 2010

Objectives : This study was performed to compare the differences between decoctions extracted by different extraction conditions. Methods : Two different decoctions were prepared with pressured or non-pressured extraction conditions for 60, 120 and 180min. The yields of extracts, sugar contents, hydrogen ion concentrations(pH), the contents of reference compounds and individual preferences on Ssanghwa-tang(Shuanghe-tang) were investigated. Results : As extraction time increased, individual preferences for decoctions by pressured extraction tended to increase more than those by non-pressured extraction, and the yields and sugar contents of both decoctions showed the tendency of increase. The pH values of decoctions in pressured conditions were lower than those in non-pressured conditions in all extraction times and both extraction conditions showed decreasing pH values according to increase of extraction times. Of the reference compounds, paeoniflorin showed higher contents in non-pressured conditions than in pressured conditions and the contents of cinnamaldehyde were always lower in non-pressured conditions than in pressured conditions at all time. Conclusions : The decoctions of Ssanghwa-tang(Shuanghe-tang) extracted by pressured or non-pressured extraction for 60, 120, 180min exhibited different individual preferences, yields of extracts, sugar contents, pH, reference compounds contents.

• Geotechnical Engineering
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• v.13 no.4
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• pp.85-94
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• 1997

The design and construction of underground structures contain many substantial mincer dainties. A reasonable estimation of geotechnical parameters is of paramount importance and must be one of the most difficult tasks in designing and constructing underground structures. If the plastic zone exists by tunnel excavation, the ground response may also be dependent on the yield criterion mainly composed of strength parameters. In order to estimate unknown model parameters from the in-situ measurements as well as prior estimates for designing tunnels which have plastic zones, the Extended Bayesian Method(EBM) is adopted : an elasto-plastic finite element program is linked to the EBM as a mathematical model to predict the ground response. Mohr-Coulomb failure criterion is used to represent the plastic behavior. A hypothetical underground site, where the ground behaves elasto-plastically, is adopted to demonstrate the validity of the proposed feedback system.

• Microbiology and Biotechnology Letters
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• v.17 no.5
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• pp.481-488
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• 1989

A serum-free medium that could be used for the large-scale culture of mouse hybridoma to produce monoclonal antibodies was developed. The medium was based on a 1:1 mixture of Iscove's Modified Dulbecco's Medium and Ham's F-12, supplemented with insulin 10$\mu\textrm{g}$/$m\ell$, transferrin 10$\mu\textrm{g}$/$m\ell$, ethanolamine 10$\mu$M and selenium 30nM (designated EBM (enriched basal medium) with the supplements). The effect of various supplements of steroid hormones, vitamins, lipid and mineral salts was investigated and their optimal concentration was determined to replace fetal calf serum (PCS). These components were added respectively and then added by way of two or three combination to discern of which component combination was effective to the culture of hybridoma. As a result, serum-free medium KM3 (EBM with BSA 100$\mu\textrm{g}$/$m\ell$, mineral cocktail and 0.05% PEG) was deter-mined. The hybridoma Alps 25-3 cultured in this medium showed almost the same growth rate as in medium added with 2% fetal bovine serum. However, the antibody concentration from KM3 cultures was 80% of that obtained from culture with FCS. KM3 was also examined for the culture of other mouse hybridomas, KW, A4W & HCGK, and it was confirmed that it could support the growth of these hybridomas and the production of monoclonal antibodies.

• Korean Journal of Remote Sensing
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• v.20 no.2
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• pp.103-116
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• 2004

The mesoscale atmospheric models to produce surface temperature can not generally consider the effect of the sloped terrain for direct solar radiation. These have not showed the regional difference of solar radiation and as a result, have made the big error in the local surface temperature. Therefore, we wished to represent the exact locality of surface temperature by considering the geometric properties of surface as well as the vegetated properties of surface. The purpose of the study is to produce local surface ground temperature in sloped terrain diagnostically using surface Energy Balance Model (EBM) with the use of GRID model in Geographic Information Systems (GIS). In this study, surface inhomogeneity over southeastern part of Korean peninsula are considered in estimation of the absorbed surface solar radiation in terms of the illumination angle, depending on topographical aspect and slope in GRID. Also, the properties of vegetated surface which the major components for the variability of surface temperature are considered in terms of NDVI. The results of our study show the locally changes in the surface ground temperature due to local ground aspect and slope effect and local properties of vegetated surface. The more detailed distribution of local surface temperature may drive the local circulation at lower atmospheric and it may explain better the real local circulation.

• Proceedings of the International Microelectronics And Packaging Society Conference
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• 2001.07a
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• pp.63-92
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• 2001

·EC's/Japanese environmental regulation drive the Pb-free/Halogen-free application ·Most Japanese electronics companies are preparing the green products. ·All items concerning to Pb-free/halogen-free technology should be coparallely designed and developed. ·More works need to clear the unknowns on Pb-free materials ·Need of consensus on materials and standards ·EBM (Environmental Benign Manufacturing)

• Proceedings of the International Microelectronics And Packaging Society Conference
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• 2001.09a
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• pp.21-50
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• 2001

EC's/Japanese environmental regulation drive the Pb-free/Halogen-free application. Most Japanese electronics companies are preparing the green products. All items concerning to Pb-free/Halogen-ree technology should be coparallely designed and developed. More works need to clear the unknowns on Pb-free materials. Need of consensus on materials and standards. EBM (Environmental Benign Manufacturing)

• Korean Journal of Biological Psychiatry
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• v.14 no.1
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• pp.14-20
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• 2007

Objectives : The diagnosis of depression is based on a highly variable set of symptoms. Therefore, depression should not be viewed as a single disease, but a heterogenous syndrome comprised of different pathophysiologies. There are several subtypes of depression which were already incorporated in DSM-IV. This article provides a systematic review of pharmacological treatments of two recognized subtypes of depression-dysthymic disorder and atypical depression. Methods : Systematic search of relevant literatures on dysthymic disorder and atypical depression was performed by proposed search strategy of the Clinical Research Center for Depression of Korean Health 21 R&D Project. All identified literatures were carefully reviewed and classified according to SIGN grading system and summarized in a narrative manner. Results : For the treatment of dysthymic disorder and atypical depression, selective serotonin reuptake inhibitors( SSRIs) and moclobemide have more evidence than the other antidepressants. SSRIs and moclobemide showed superior tolerability than tricyclic antidepressants. Conclusions : The authors proposed treatment recommendations for dysthymic disorder and atypical depression by the methods of evidence-based medicine(EBM). However, guideline developing methods of EBM also have several inevitable limitations. Therefore, in the absence of clear and significant differences in efficacy, the choice of medication must be individualized for a particular patient based on psychiatrist's own clinical decision.