• Title/Summary/Keyword: E.I.

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Endotoxin-induced renal tolerance against ischemia and reperfusion injury is removed by iNOS, but not eNOS, gene-deletion

  • Kim, Jee-In;Jang, Hee-Seong;Park, Kwon-Moo
    • BMB Reports
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    • v.43 no.9
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    • pp.629-634
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    • 2010
  • Endotoxin including lipopolysaccharide (LPS) confers organ tolerance against subsequent challenge by ischemia and reperfusion (I/R) insult. The mechanisms underlying this powerful adaptive defense remain to be defined. Therefore, in this study we attempted to determine whether nitric oxide (NO) and its associated enzymes, inducible NOS (iNOS) and endothelial NOS (eNOS, a constitutive NOS), are associated with LPS-induced renal tolerance against I/R injury, using iNOS (iNOS knock-out) or eNOS (eNOS knock-out) gene-deleted mice. A systemic low dose of LPS pretreatment protected kidney against I/R injury. LPS treatment increased the activity and expression of iNOS, but not eNOS, in kidney tissue. LPS pretreatment in iNOS, but not eNOS, knock-out mice did not protect kidney against I/R injury. In conclusion, the kidney tolerance to I/R injury conferred by pretreatment with LPS is mediated by increased expression and activation of iNOS.

Classroom Discourse Analysis between Teacher and Students in Science Classroom (과학 수업 시간에 발생하는 교사-학생 간 교실 담화 분석)

  • Han, Shin;Jung, Jinwoo
    • Journal of Science Education
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    • v.35 no.2
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    • pp.159-172
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    • 2011
  • The purpose of this study is to specify the quality of I-R-E pattern and question-answer affiliation between students and teacher, depending on teacher's career. This study analyzes 6 classroom discourse texts of 6th grade science class. The results of this study are as follows. First, in the case of a newly appointed teacher, I-R-E pattern is appeared repeatedly. Second, in the case of experienced teachers, expended I-R-E pattern is appeared compare with a newly appointed teacher. Third, in the case of a newly appointed teacher, independence relational structure is appeared more repeatedly than other structures. But, in the case of experienced teachers, all kinds of question-answer structures - independence, parallel, insertion, and reorganization relational structure - are appeared more evenly.

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Studies on Chemical Structure Determination of Polygonatum sibiricum Extracts(I) (황정(黃精) 추출물의 화학구조 결정에 관한 연구(I))

  • 신동수;윤중호;박주희;권기락;안철진;주우홍;강진호;문병호
    • Journal of Life Science
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    • v.9 no.2
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    • pp.207-211
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    • 1999
  • Biologically active compounds in Polygonatum sibiricum were extracted using organic solvents as hexane, CHCl$_3$, n-butanol corresponding each component. Compound I was purified from hexane layer and the chemical structure of compound I was characterized using 1H-NMR, 13C-NMR, DEPT135, COSY, HMQC, HMBC spectrum and MS-spectrum. Consequently, the chemical structure of compound I was determined as 9,12-(9E,l2E)-octade cadienoic acid.

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Studio sulla regia di Strehler -Sulla regia de I giganti della montagna- (스트렐러의 연출론 연구 - I giganti della montagna 의 시대별 연출 -)

  • Jang, Ji Yeon
    • Lettere Italiane
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    • no.27
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    • pp.155-169
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    • 2009
  • Al centro dell'interesse di Strehler ci sono sempre l'uomo e le sue azioni, e l'uomo e la posizione del teatro. Inoltre, nei suoi teatri vengono alla luce i rapporti che interessano l'uomo e la societa', l'uomo e se stesso, l'uomo e la storia, l'uomo e la politica. Strehler interpreta sempre i testi prendendo in considerazione la contemporaneita' e completa la rappresentazione strutturandola in un sistema implacabilmente coerente di segni scrulolosi. Poiche' le sue opere, anche se le stesse, sono rappresentate ogni volta con significati diversi a secondo del tempo, non si tratta soltanto di rivivere le opere, ma di metterle in scena in nuove versioni che hanno significati che interpretano i cambiamenti avvenuti. Questo e' anche il caso de I giganti della montagna. Nella prima regia di quest'opera, Strehler cerca di mettere in evidenza una concreta e generale storia umana attraverso il mito, e un messaggio che è al tempo stesso di disperazione e di fede nell'uomo. Un messaggio di perdono e di pietà. Pietà per tutti. Nella seconda regia, egli incarna, attraverso il vuoto dell'immobilita' e il silenzio, la vita della poesia. Cerca di rappresentare l'estremo degli effetti scenici attraverso la minima mobilita' in una scena immobile, e attraverso il massimo grido di dolore in una scena di silenzio. E anche i personaggi sono divisi in due diverse categorie. 'Gli scalognati', che creano 'teatro puro' non per un pubblico ma per puro giuoco, e 'la compagnia dei comici', che crea 'teatro rappresentato' che implica la possibilita' dell'interprete condizionato dai rischi, dagli errori di valutazione e d'interpretazione e che resta legato ad una realta' concreta. Attraverso questo contrasto egli vuole esprimere "il timore che nonostante tanta "rivoluzione" giovanile intorno, il cammino della societa' degli uomini verso l'abbandono di alti ideali e valori, fosse accelerato e quasi ineluttabile". Nella terza regia, i due mondi si incontrano in uno spazio dove realta' e sogno si confondono. Non sono piu' contrapposti. E' come "una tragica contestazione che i Giganti hanno vinto e che ci hanno, consapevoli o inconsapevoli, travolti, che non siamo piu gli stessi, che stiamo precipitando". Ma egli non dispera, benche' rappresenti la condizione tragica, dice al pubblico di "comunicare in silenzio la reciprocita' delle sconfitte. al di la' delle parole che non esistono".

Characteristics of the General American English exposed in Tourist Business (관광산업 현장에서 표출되는 미국 영어의 특색)

  • Hong, Kwang-Hee
    • Korean Business Review
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    • v.5
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    • pp.241-274
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    • 1992
  • General American English(=A.E.) has conservative elements as well as progressive elements. A.E. and B.E. are languages which have more similarities than differances. In this paper. I studied the process of English progress before the A.E. had come into being, and the historical background and the cahristics of A.E. coming into being. Considering the differences between A.E. and B.E. from spelling, pronunciation, vocabulary and grammar, I can give the outline as follows. A spelling 1. B.E. : au, ou $${\rightarrow}$$A.E. : a, o 2. B.E. : e $${\rightarrow}$$A.E. : i 3. B.E. : $${\ae}$$ oe $${\rightarrow}$$A.E. : e 4. B.E. : our $${\rightarrow}$$A.E. : or 5. B.E. : re $${\rightarrow}$$A.E. : er B. pronunciation 1. B.E. : [e] $${\rightarrow}$$A.E. : [i], [e], $$[\partial]$$ 2. B.E. : [a] $${\rightarrow}$$A.E. : 3. B.E. : [i(:)] $${\rightarrow}$$A.E. : [ai], $$[\partial]$$, $$[{\varepsilon}]$$ 4. B.E. : $$[{\ae}]$$ $${\rightarrow}$$A.E. : [e], [c] 5. B.E. : [ai] $${\rightarrow}$$A.E. : $$[{\ae}]$$, [e] 6. B.E. : [c] $${\rightarrow}$$A.E. : [e], [a], [o] 7. In case of "Vowel+[t]+Vowel", [t] is pronounced into [d] or [r] 8. In case of "-nt", [t] becomes a mute. 9. [t]+[j, l, m, n, r, u, or, w] $${\rightarrow}$$A.E. : [?] (=glottal stop) 10. B.E. : [w] $${\rightarrow}$$A.E. : [hw] 11. B.E. : [Voiceless consonants], [Voiced consonants] $${\leftarrow}$$A.E. : [Voiced consonants], [Voiceless consonants] C. Vocabulary The historical background and geographical conditions of those days caused lots of new compounds and neologies. D. Grammar Though we use "of" to indicate the possessive case of inanimate object, -s genitive is used in A.E. In the perfect tense, "have" is often omitted and also auxiliary verb "will" is used in any case

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Identification of Hybrid between the Tiger Grouper Epinephelus fuscoguttatus and the Giant Grouper E. lanceolatus by Analyzing COX I and RAG 2 Sequences (COX I 및 RAG 2 유전자 염기서열 분석에 의한 tiger grouper Epinephelus fuscoguttatus와 giant grouper E. lanceolatus 간 잡종의 동정)

  • Kim, Keun-Sik;Lee, Hyo-Ryeon;Sade, Ahemad;Bang, In-Chul
    • Korean Journal of Ichthyology
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    • v.26 no.1
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    • pp.70-73
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    • 2014
  • Interspecific hybrids between tiger grouper Epinephelus fuscoguttatus and giant grouper E. lanceolatus were genetically identified based on the partial sequence analysis of mitochondrial cytochrome c oxidase I (COX I) gene and nuclear recombination activating gene 2 (RAG 2) gene. Out of 585 base positions of RAG 2, a total of five nucleotide substitutions were detected between the two parental species (E. fuscoguttatus and E. lanceolatus). The hybrids had two distinct types of RAG 2 sequences corresponding to those of both parental species. Mitochondrial COX I gene sequencing showed that hybrids had sequences identical to E. fuscoguttatus. Molecular data clearly demonstrate that hybridization does occur between E. fuscoguttatus and E. lanceolatus, but with E. fuscoguttatus as the maternal parent.

UNITARY INTERPOLATION ON AX = Y IN ALG$\mathcal{L}$

  • Kang, Joo-Ho
    • Honam Mathematical Journal
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    • v.31 no.3
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    • pp.421-428
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    • 2009
  • Given operators X and Y acting on a Hilbert space $\mathcal{H}$, an interpolating operator is a bounded operator A such that AX = Y. In this paper, we showed the following : Let $\mathcal{L}$ be a subspace lattice acting on a Hilbert space $\mathcal{H}$ and let $X_i$ and $Y_i$ be operators in B($\mathcal{H}$) for i = 1, 2, ${\cdots}$. Let $P_i$ be the projection onto $\overline{rangeX_i}$ for all i = 1, 2, ${\cdots}$. If $P_kE$ = $EP_k$ for some k in $\mathbb{N}$ and all E in $\mathcal{L}$, then the following are equivalent: (1) $sup\;\{{\frac{{\parallel}E^{\perp}({\sum}^n_{i=1}Y_if_i){\parallel}}{{\parallel}E^{\perp}({\sum}^n_{i=1}Y_if_i){\parallel}}:f{\in}H,n{\in}{\mathbb{N}},E{\in}\mathcal{L}}\}$ < ${\infty}$ range $\overline{rangeY_k}\;=\;\overline{rangeX_k}\;=\;\mathcal{H}$, and < $X_kf,\;X_kg$ >=< $Y_kf,\;Y_kg$ > for some k in $\mathbb{N}$ and for all f and g in $\mathcal{H}$. (2) There exists an operator A in Alg$\mathcal{L}$ such that $AX_i$ = $Y_i$ for i = 1, 2, ${\cdots}$ and AA$^*$ = I = A$^*$A.

Genetic Polymorphism of Cytochrome P450 2E1 in Korean Population (한국인 집단에서 Cytochrome P450 2E1의 유전적 다형성)

  • 정혜광;구희경;이상섭;양규환;정태천;변부형
    • Environmental Mutagens and Carcinogens
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    • v.16 no.2
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    • pp.97-102
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    • 1996
  • In this study, we have quantified genotype frequency of the cytochrome P450 (P450) 2E1 which codes for the P450 enzyme primarily responsible for the metabolic activation of carcinogenic nitrosamines and low molecular organic solvents, in Korean population by using PCR and RFLP at two sites previously associated with some cancers; a PstI and RsaI RFLP in the transcriptional regulatory region of the human P450 2E1 gene. The genotype frequencies of homozygous wild type (PstI site-absent) and heterozygous mutant type (PstI site-present) in PstI RFLP were 0.70 and 030, respectively. The homozygous mutant type in Pstl RFLP was not observed in Korean population. The genotype frequencies of homozygous wild type (RsaI site-present), heterozygous mutant type (RsaI site-absent), and homozygous mutant type in RsaI RFLP were 0.71, 0.26, and 0.03, respectively.

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A Case Of Circadian Sleep Disorder Improved By Acupuncture On $Zh{\grave{a}}h{\grave{a}}i$(K6, 照海) And $Sh{\bar{e}}nm{\grave{a}}i$(B62) (신지.조해혈(照海穴)의 자침(刺鍼)으로 호전(好轉)된 일교차성 수면장애 치험(治驗)1례(例))

  • Lee, Kyung-Min;Kim, Tae-Hi;Kim, Sung-Uk
    • The Journal of Korea CHUNA Manual Medicine
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    • v.2 no.1
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    • pp.169-175
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    • 2001
  • Objects : The purpose of this study is find out significant (clinical) effect of applying acupuncture on $zh{\grave{a}}h{\grave{a}}i$(K6, 照海) of ${\bar{U}m-kyo-maek$(陰?脈) and $sh{\bar{e}}nm{\grave{a}}i$(B62, 申?) of Yang-kyo-maek(陽?脈) to a patient of circadian sleep disorder. Methods : We apply acupuncture on $zh{\grave{a}}h{\grave{a}}i$(K6, 照海) and $sh{\bar{e}}nm{\grave{a}}i$(B62, 申?) to a patient of circadian sleep disorder during 2 weeks. We check sleeping time day and night during 14 days. Acupuncture on $zh{\grave{a}}h{\grave{a}}i$(K6, 照海) and $sh{\bar{e}}nm{\grave{a}}i$(B62, 申?) has significant effect to circadian sleep disorder patient. Results : Acupuncture on $zh{\grave{a}}h{\grave{a}}i$(K6, 照海) and $sh{\bar{e}}nm{\grave{a}}i$(B62, 申?) has significant effect to circadian sleep disorder patient. Conclusions : 1. The physio-pathologic phenomenon of sleeping is relative to ${\bar{U}m-kyo-maek$(陰?脈) and Yang-kyo-maek(陽?脈) 2. Acupuncture therapy on $zh{\grave{a}}h{\grave{a}}i$(K6, 照海) and $sh{\bar{e}}nm{\grave{a}}i$(B62, 申?) has significant effect to circadian sleep disorder.

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