• Archives of Pharmacal Research
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• v.18 no.6
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• pp.415-422
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• 1995

Twenty-four flavones were synthesized with various hydroxyl and/or methoxyl groups on A and B rings. Their antimutagenic properties were evaluated against ben:w(a)pyrene (BaP) and a pool of mutagenic urine concentrate (U) using a modified liquid incubation method of Ames test. The tester strain was Salmonella typhimurium TA98+S9 Mix. The antimutagenic activities were calculated by non linear regression analysis and the doses of flavones (in nmoles) required for a 50% reduction of induced revertants with BaP and U were defined as the inhibition doses (TEX>$ID_{508}{\;}and{\;}ID_{508}$ respectively). Seventeen flavones possessed significant antimutagenic activity against BaP. $ID_{508}$ ranged from 15.1 nmoles (F22) to 1000.6 nmoles (F13). Eighteen f1avones showed significant antimutagenic activity against U. $ID_{50U}$ ranged from 23.5 nmoles (F22) to 354.6 nmoles (F3). The 2',3',4'-trihydroxyflavone (F22, $ID_{508}=15.1$ nmoles, $ID_{50U}=23.5$ nmoles) and the 2',3',4',7-tetrahydroxyflavone (F20, $ID_{508}=37.8$ nmoles; $ID_{50U}=62.3$ nmoles) had antimutagenic activities similar to those of chlorophyllin ($ID_{508}=19.6$ nmoles and $ID_{50U}=44.2$ nmoles) and were evaluated against B(alP 7,8-dihydrodiol-9,10-epoxide. Against this last mutagen, the flavones which included three OH in B ring showed the highest activity and this property seemed independent of the substituent groups on A ring.

• Advances in nano research
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• v.15 no.5
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• pp.385-399
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• 2023

Hexagonal boron nitride (h-BN), commonly referred to as Boron Nitride Nanoribbons (BNNRs), is an electrical insulator characterized by high thermal stability and a wide bandgap semiconductor property. This study delves into the electronic properties of two BNNR configurations: Armchair BNNRs (ABNNRs) and Zigzag BNNRs (ZBNNRs). Utilizing the nearest-neighbour tight-binding approach and numerical methods, the electronic properties of BNNRs were simulated. A simplifying assumption, the Hamiltonian matrix is used to compute the electronic properties by considering the self-interaction energy of a unit cell and the interaction energy between the unit cells. The edge perturbation is applied to the selected atoms of ABNNRs and ZBNNRs to simulate the electronic properties changes. This simulation work is done by generating a custom script using numerical computational methods in MATLAB software. When benchmarked against a reference study, our results aligned closely in terms of band structure and bandgap energy for ABNNRs. However, variations were observed in the peak values of the continuous curves for the local density of states. This discrepancy can be attributed to the use of numerical methods in our study, in contrast to the semi-analytical approach adopted in the reference work.

• The Korean Journal of Pharmacology
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• v.18 no.1
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• pp.65-72
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• 1982

It has been known that retinoids are intrinsically of critical importance for control of premalignant epithelial cell differentiation. In the absence of retinoids, normal cellular differentiation and growth does not occur in epithelia such as those of trachea and bronchi. Furthermore, it was also reported that retinoid deficiency enhanced susceptibility to chemical carcinogenesis in the respiratory system, in the bladder, and in the colon of the experimental animal. In 1974, Bollag examined the effects of synthetic retinoids in prevention of development of cancer and demonstrated synthetic retinoids to have more favorable therapeutic index than retinoic acid for causing regression of skin papilloma in mice. Therefore, it was assumed that this anticarcinogenic effect of vitamin A derivatives could be due to modification of the metabolism of the carcinogenic polycyclic hydrocarbon, which must first be activated to exert their effect. Hill and Shih reported that vitamin A compounds and analogs had inhibitory effect on drug metabolizing enzyme from liver and lung tissue of mouse and hamster. Lucy suggested that the chemoprevention effect of vitamin A derivatives is due to reaction with molecular oxygen, and it is possible that inhibition of hydroxybenzpyrene formation is a result of this property. On the other hand, butylated hydroxytoluene which is a potent antioxidant strongly inhibited the formation of mammary tumor induced by dimethylbenranthracene. Also, it was observed that this antioxidant inhibited cancer induction in rats by N-2-fluo-renylacetamide. The purpose of this experiment was to investigate the effect of vitamin A derivatives such as retinoic acid and retinoid on drug-metabolizing enzyme and to determine whether riboflavin tetrabutylate or vitamin E could prevent of modify any changes induced by vitamin A delivatives in the rats. The results obtained were as followings. 1) Body weight was significantly reduced by retinoic acid, but not by retinoid. 2) Retinoic acid markedly increased liver weight while retincid showed no effect on liver weight. Treatment of riboflavin tetrabutylate did not affect retinoic acid-induced change in both body weight and liver weight. 3) Both retinoic acid and retinoid remarkably decreased the activity of aminopyrine demethylase. Pretreatment of riboflavin tetrabutylate, however, prevented inhibitory effect of retinoic acid on the enzyme activity. 4) No significant effect of vitamin E on aminopyrine demethylase was observed in both groups treated with retinoic acid and retinoid.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.7
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• pp.3140-3145
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• 2012

In this paper, a design method for a compact slot antenna fed by a coplanar waveguide (CPW) is studied. A T-shaped tuning stub is inserted inside a narrow rectangular slot and the slot is impedance matched to the CPW feedline by adjusting the width, length, and position of the stub. The resonance frequency is adjustable by the slot length and the antenna size can be reduced by bending the slot. The resonance frequency and impedance matching property of the compact slot antenna are similar to those of the half-wavelength slot antenna, which enables one to design compact antenna of this type with ease. A compact slot antenna for 2.45-GHz ISM band is designed, fabricated on an FR4 substrate (dielectric constant of 4.4 and thickness of 0.8 mm), and experimentally tested. The measured results agree well with the simulations, which confirms the validity of this study. The fabricated compact slot antenna shows an impedance bandwidth of 200 MHz(2.32-2.52 GHz) for a VSWR < 2, which is suitable for 2.45-GHz ISM band (2.4-2.48 GHz). The measured radiation patterns show ${\infty}$-shaped directional pattern in the E-plane and nearly omni-directional pattern in the H-plane with a peak gain of 2.0 dBi, which are similar to those of a monopole antenna. The proposed antenna is expected to be suitable for the applications as antennas for WLAN, RFID, and mobile handset.

• Journal of Animal Science and Technology
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• v.45 no.2
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• pp.297-308
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• 2003

Subjective pork quality was determined on the six groups of the following treatments. Meat samples were obtained from pigs which had been fed with finishing pig diets containing 5% beef tallow(C), 3% beef tallow and 2% perillar seed oil(T1), 250ppm vitamin E($\alpha$-tocopheryl acetate) in T1(T2), 3% beef tallow and 2% squid viscera oil(T3), 250ppm vitamin E in T3(T4), 3% beef tallow and 2% CLA(Conjugated linoleic acid, T5). In the fatty acid composition, SFA(Saturated fatty acid) and EFA(Essential fatty acid) were higher in T5 than in the rest of three treatments such as C, T1, T3 groups, while UFA(Unsaturated fatty acid), MUFA(Monounsaturated fatty acid), UFA/SFA, MUFA/SFA were low. The total content of amino acid in the T3 were higher those for the rest of rest of C, T1, T5 the content for vitamin added treatment(T2, T4) groups higher than non treated one. T3 and T5 showed higher TBARS(Thiobarbituric acid reactive substance) values than the C and T1 groups VBN(Volatile basic nitrogen) values were higher in the order of T5>T3>T1>C. There was no difference in total plate counts, number of lactic acid bacteria and number of E. coli. In sensory property, the C and T1 showed a higher acceptance than the T3 and T5. In cooked meats, the T3 showed a lower hardness than that of control(C), T1 and, with a higher acceptance. In TBARS, VBN, total counts, lactic counts, and E. coli counts, sensory test of cooked meat and raw meat, there was no significant difference between vitamin supplement groups within each oil treatment.

• Corrosion Science and Technology
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• v.8 no.2
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• pp.74-80
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• 2009

The high alkaline property in the concrete pore solution protects the embedded steel in concrete from corrosion due to aggressive ions attack. However, a continuous supply of those ions, in particular, chlorides altogether with a pH fall in electrochemical reaction on the steel surface eventually depassivate the steel to corrode. To mitigate chloride-induced corrosion in concrete structures, finely grained mineral admixtures, for example, pulverized fuel ash (PFA), ground granulated blast furnace slag (GGBS) and silica fume (SF) have been often advised to replace ordinary Portland cement (OPC) partially as binder. A consistent assessment of those partial replacements has been rarely performed with respect to the resistance of each binder to corrosion, although the studies for each binder were extensively looked into in a way of measuring the corrosion rate, influence of microstructure or chemistry of chlorides ions with cement hydrations. The paper studies the behavior of steel corrosion, chloride transport, pore structure and buffering capacity of those cementitious binders. The corrosion rate of steel in mortars of OPC, 30% PFA, 60% GGBS and 10% SF respectively, with chloride in cast ranging from 0.0 to 3.0% by weight of binder was measured at 7, 28 and 150 days to determine the chloride threshold level and the rate of corrosion propagation, using the anodic polarization technique. Mercury intrusion porosimetry was also applied to cement pastes of each binder at 7 and 28 days to ensure the development of pore structure. Finally, the release rate of bound chlorides (i.e. buffering capacity) was measured at 150 days. The chloride threshold level was determined assuming that the corrosion rate is beyond 1-2 mA/$m^3$ at corrosion and the order of the level was OPC > 10% SF > 60% GGBS > 30% PFA. Mercury intrusion porosimetry showed that 10% SF paste produced the most dense pore structure, followed by 60% GGBS, 30% PFA and OPC pastes, respectively. It was found that OPC itself is beneficial in resisting to corrosion initiation, but use of pozzolanic materials as binders shows more resistance to chloride transport into concrete, thus delay the onset of corrosion.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.11 no.1
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• pp.9-16
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• 1991

The concept of damage is all-pervasive in structural engineering. It can be considered a state variable and defined to vary from 0(no damage) to 1(failure). Thus, the factor of safety against failure, the most important aspect of a structure, cannot be assessed without evaluating the damageability of a structure under load. It is the objective of the research reported herein to study the behavior of concrete under repeated load applications. Concrete is known to deteriorate under such loading, i.e., it suffers damage of increasing degree. Its response to future loading is a function of the amount of damage sustained during previous load exposures. The same can be said about reinforced concrete members and entire structures, but here we wish to consider only plain concrete and express some of its material properties as functions of the degree of sustained damage. The work described herein is based on the stipulation that the energy dissipation capacity of plain concrete is a material property and the damage accumulates in direct proportion to the degree to which the energy dissipation capacity is being exhausted, in some analogy to both high- and low-cycle failure behavior of materials.

• Earthquakes and Structures
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• v.12 no.3
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• pp.321-332
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• 2017

The reverse fault is a dangerous geological hazard faced by buried steel pipelines. Permanent ground deformation along the fault trace will induce large compressive strain leading to buckling failure of the pipe. A hybrid pipe-shell element based numerical model programed by INP code supported by ABAQUS solver was proposed in this study to explore the strain performance of buried X80 steel pipeline under reverse fault displacement. Accuracy of the numerical model was validated by previous full scale experimental results. Based on this model, parametric analysis was conducted to study the effects of four main kinds of parameters, e.g., pipe parameters, fault parameters, load parameter and soil property parameters, on the strain demand. Based on 2340 peak strain results of various combinations of design parameters, a semi-empirical model for strain demand prediction of X80 pipeline at reverse fault crossings was proposed. In general, reverse faults encountered by pipelines are involved in 3D oblique reverse faults, which can be considered as a combination of reverse fault and strike-slip fault. So a compressive strain demand estimation procedure for X80 pipeline crossing oblique-reverse faults was proposed by combining the presented semi-empirical model and the previous one for compression strike-slip fault (Liu 2016). Accuracy and efficiency of this proposed method was validated by fifteen design cases faced by the Second West to East Gas pipeline. The proposed method can be directly applied to the strain based design of X80 steel pipeline crossing oblique-reverse faults, with much higher efficiency than common numerical models.

• Journal of Pharmaceutical Investigation
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• v.33 no.3
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• pp.179-185
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• 2003

Melatonin (MT) is an indole amide pineal hormone. It has not only very short half-life but also pH-sensitive property. The sustained release dosage form which delivers MT in a circadian fashion over 8 h is clinical value. The purpose of this study is to prepare sugar beads using multiple coating methods and enteric-coated in a sustained release to evaluate in vitro release characteristics in simulated gastric and intestinal fluids. The $Eudragit^{\circledR}$ as a polymer, sustained release membrane, and triethylcitrate (TEC) as a plasticzer were used. Multi-coated melatonin delivery system was composed of sugar, various excipients, $Eudragit^{\circledR}$ and enteric materials (e.g. hydroxy propyl methyl cellulose phthalate, HPMCP), and prepared by fluid bed coater. The dissolution test was carried out using the basket method at a stirring speed of 100 rpm at $37^{\circ}C$ in simulated gastric (pH 1.2) and intestinal fluid (pH 7.4). The released amount of MT was determined by High performance liquid chromatography method. The morhologies of surface and cross section of multi-coated beads were observed by scanning electron microscope. Size of multi-coated sugar beads was ranged over $1000{\sim}1300\;{\mu}m$. The release rate of MT from coated beads was limited in simulated gastric fluid (pH 1.2), but it was sustained in intestinal fluid (pH 7.4) during $3{\sim}8$ hours. The MT beads may provide small-intestine-targeted device for oral delivery. Studies on animal and relative experiment are in process.

• International Journal of Highway Engineering
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• v.14 no.4
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• pp.63-72
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• 2012

PURPOSES : Hot-mix asphalt(HMA) concretes show a trend of strength increase at low temperature due to binder stiffness increase, but strength decrease below a ceratin low temperature. This is due to the differential thermal contraction(DTC) which is induced by a significant difference in coefficients of thermal contraction between aggregate and asphalt which is coated around the aggregate. This DTC damage is well known to occur in HMA concrete, but is not yet investigated in warm-mix asphalt(WMA) concretes. METHODS : To evaluate DTC damage on WMA in this study, the flexural strength($S_f$) of WMA concretes, which were produced at $30{\sim}40^{\circ}C$ lower temperature, was evaluated in comparison with that of HMA at -5, -15 and $-25^{\circ}C$. RESULTS : Most of WMA and HMA mixtures showed flexural strength increase down to $-15^{\circ}C$ and decrease below $-15^{\circ}C$. this type of strength reduction below $-15^{\circ}C$ can e explained as the effect of differential thermal contraction that is a consequence of the large difference in coefficients of thermal contraction between aggregate and asphalt. the property reduction of WMA is similar the result of previous works dealt with HMA mixtures. CONCLUSIONS : Even though there is some differences by materials used, the WMA concretes showed a significantly lower DTC damage than HMA concrete at low temperature at ${\alpha}$=0.05 level.