• 제목/요약/키워드: E-64

Search Result 1,893, Processing Time 0.03 seconds

Age, Growth and Spawning of Enedrias nebulosus (베도라치(Enedrias nebulosus)의 연령, 성장 및 산란)

  • KANG Yong-Joo;KIM Yeong-Hye;KIM Won-Tae
    • Korean Journal of Fisheries and Aquatic Sciences
    • /
    • v.29 no.2
    • /
    • pp.191-196
    • /
    • 1996
  • Age growth and spawning period of Enedrias nebulosus were estimated based on otoliths taken from a total of 255 fish samples of E. nebulosus, which were caught in the costal waters of $Kod\v{o}kto$ near Pusan from November 1990 to October 1991. Marginal increment analysis indicates that annuli in E. nebulosus are formed in December. Spawning period was estimated to be November to January, with a peak in December. The von Bertalanffy growth equations were expressed as follows: $L_t=33.64(1-e^{-0.1357(t+2.6853)})$ and $W_t=414.11(1-e^{-0.1357(t+2.6853)})^{3.9745}$, Where $L_t$, is total length in cm, $W_t$, is total weight in g and t is age in year.

  • PDF

Korean red ginseng inhibits arginase and contributes to endothelium-dependent vasorelaxation through endothelial nitric oxide synthase coupling

  • Shin, Woosung;Yoon, Jeongyeon;Oh, Goo Taeg;Ryoo, Sungwoo
    • Journal of Ginseng Research
    • /
    • v.37 no.1
    • /
    • pp.64-73
    • /
    • 2013
  • Korean red ginseng water extract (KG-WE) has known beneficial effects on the cardiovascular system via inducting nitric oxide (NO) production in endothelium. Endothelial arginase inhibits the activity of endothelial nitric oxide synthase (eNOS) by substrate depletion, thereby reducing NO bioavailability and contributing to vascular diseases including hypertension, aging, and atherosclerosis. In the present study, we demonstrate that KG-WE inhibits arginase activity and negatively regulates NO production and reactive oxygen species generation in endothelium. This is associated with increased dimerization of eNOS without affecting the protein expression levels of either arginase or eNOS. In a vascular tension assay, when aortas isolated from wild type mice were incubated with KG-WE, NO-dependent enhanced vasorelaxation was observed. Furthermore, KG-WE administered via by drinking water to atherogenic model mice being fed high cholesterol diet improved impaired vascular function. Taken together, these results suggest that KG-WE may exert vasoprotective effects through augmentation of NO signaling by inhibiting arginase. Therefore, KG-WE may be useful in the treatment of vascular diseases derived from endothelial dysfunction, such as atherosclerosis.

A simulation of high efficiently thin film solar cell with buffer layer (버퍼층 삽입을 통한 박막 태양전지의 고효율화 시뮬레이션)

  • Kim, Heejung;Jang, Juyeon;Baek, Seungsin;Yi, Junsin
    • 한국신재생에너지학회:학술대회논문집
    • /
    • 2011.11a
    • /
    • pp.64.2-64.2
    • /
    • 2011
  • a-Si 박막 태양전지는 a-Si:H을 유리 기판 사이에 주입해 만드는 태양전지로, 뛰어난 적용성과 경제성을 지녔으나 c-Si 태양전지에 비해 낮은 변환 효율을 보이는 단점이 있다. 변환 효율을 높이기 위한 연구 방법으로는 a-Si 박막 태양전지 단일cell 제작 시 high Bandgap을 가지는 p-layer를 사용함으로 높은 Voc와 Jsc의 향상에 기여할 수 있는데, 이 때 p-layer의 defect 증가와 activation energy 증가도 동시에 일어나 변환 효율의 증가폭을 감소시킨다. 이를 보완하기 위해 본 실험에서는 p-layer에 기존의 p-a-Si:H를 사용함과 동시에 high Bandgap의 buffer layer를 p-layer와 i-layer 사이에 삽입함으로써 그 장점을 유지하고 높은 defect과 낮은 activation energy의 영향을 최소화하였다. ASA 시뮬레이션을 통해 a-Si:H보다 high Bandgap을 가지는 a-SiOx 박막을 사용하여 p-type buffer layer의 두께를 2nm, Bandgap 2.0eV, activation energy를 0.55eV로 설정하고, i-type buffer layer의 두께를 2nm, Bandgap 1.8eV로 설정하여 삽입하였을 때 박막 태양전지의 변환 효율 10.74%를 달성할 수 있었다. (Voc=904mV, Jsc=$17.48mA/cm^2$, FF=67.97).

  • PDF

Antimicrobial Resistance Profiles of eae Positive Escherichia coli (eae+ Escherichia coli의 항생제 감수성 및 내성 패턴)

  • Lee, Min-Hwa;Choi, Chang-Sun
    • Journal of Food Hygiene and Safety
    • /
    • v.22 no.2
    • /
    • pp.116-119
    • /
    • 2007
  • The antimicrobial susceptibility and antibiotic resistance patterns of 67 eae positive Escherichia coli strains isolated from pigs were investigated by disc diffusion method. Sixty-seven E. coli isolated from pigs showed susceptibility to Ceftiofur (98.5%), Lincomycin+Spectinomycin (74.6%), Danofloxacin (73.1%), Enrofloxacin (64.2%), and Neomycin (41.8%). However, the multiple resistance patterns were also seen in eae+E. coli isolates. Neomycin+Tylosin+Penicillin+Tetracycline, Tylosin+Penicillin+Tetracycline, and Neomycin+Tylosin+Danofloxacin+Penicillin+Tetracycline+Enrofloxacinwere the most prevalent patterns of multiple antibiotic resistance.

Development of power system stabilization program using optimization method (최적화 기법이 적용된 전력계통 안정화 시스템 개발)

  • Ahn, Chang-Han;Baek, Young-Sik
    • The Transactions of The Korean Institute of Electrical Engineers
    • /
    • v.64 no.3
    • /
    • pp.370-374
    • /
    • 2015
  • Various protective equiptments are used for the power system control and protection. Numerous facilities are monitored at the same time in real time and introduction of optimization method and analysis of the method are required for generation control and facility management considering the demand fluctuations. However, the existing system analysis programs are difficult to link with the other sw and there are some problems with user convenience. To solve these problems the present conditions of the system are figured out in real time and the equipment insert method was estimated by optimization method, and the system that showed the system analysis program is developed. PSS/E has been used as system anlysis program for stabilizing system development which applied the optimization. method and Python language is applied in order to link the input and output values with the DB automatically. Lastly, DLL of matlab has been made included in C++ for solving the objective function using opmization method.By linking this to DB, power flow was calculated in PSS/E and the result was represented by Intouch screen.

Proteases in Cell Lysate of Uronema marinum (Ciliata: Scuticociliatida), an Opportunistic Pathogen of Cultured Olive Flounder (Paralichthys olivaceus)

  • Kwon Se Ryun;Kim Chun Soo;Ahn Kyoung Jin;Cho Jae Bum;Chung Joon Ki;Lee Hyung Ho;Kim Ki Hong
    • Fisheries and Aquatic Sciences
    • /
    • v.5 no.3
    • /
    • pp.145-149
    • /
    • 2002
  • The effects of pH, temperature and various inhibitors on the proteolytic activity of the cell lysate of Uronema marium were investigated using colorimetric and substrate gel electro­phoretic methods. The cell lysate of U. marinum showed proteolytic activity over a wide range of pH, and pH optima ranged from pH 5 to 7. The proteolytic activity was increased according to a rise of temperature but decreased at $40^{\circ}$. The proteolytic activity of the parasite lysate was significantly inhibited by protease inhibitors including trans-epoxysuccinyl -L-leucylamido-(4-guanidino) butane (E-64), pepstatin A, phenyl-methanesulfonyl fluoride(PMSF), and ethylenediamine-tetraacetic acid (EDTA). Preincubation of the lysate with E-64 showed the maximum inhibition of the caseionolytic activity. Four protease bands (152, 97, 67 and 40 kDa) were detected by gelatin SDS-PAGE. Significant inhibition of caseinolytic activity and complete abolition of a 152 kDa band in gelatin SDS-PAGE by EDTA indicated that the cell lysate of U. marinum had a metalloprotease Another three proteolytic bands were inhibited by E64, a cysteine protease inhibitor. Preincubation of the cell lysate with pepstatin or PMSF had no effects on the protease bands.

Calpeptin Blocks Myogenic Time-dependent Loss of Cytoskeletal Proteins and Membrane Fusion of Chick Embryonic Myoblasts (계배 근원세포의 분화에 따른 세포 골격 단백질의 분해와 막 융합에 대한 Calpeptin의 억제 효과)

  • 곽규봉;김혜선;전영주;박영순;정진하;하두봉
    • The Korean Journal of Zoology
    • /
    • v.36 no.3
    • /
    • pp.342-346
    • /
    • 1993
  • The protein level of cytoskeletons in cultured myoblasts was found to gradually decrease during the course of myogenesis. This decrease, however, could be prevented by treatiag the ceils with calpeptin (benzyloxycarbonyl-Leu-nLeu-H), a cell penetrating inhibitor of calpain. In contrast, E-64, which also is a potent inhibitor of calpain but can not be transported into the cells, showed little or no effect. In addition, the treatment of calpeptin was found to stabilize a number of specific cytoskeletal proteins from degradation but without any effect on the pattern of total cells proteins. Furthermore, calpeptin, but not E-64, blocked myoblast fusion in a dose-dependent manner. These results suggest that calpain is responsible for the myogenic time-dependent loss of cytoskeletal proteins and that the degradative process is associated with myoblast fusion. These results also suggest that the differential effects of the calpain inhibitors depend on the permeabIlity of the drugs across the cell membrane.

  • PDF

Learning Behavioral Differences of e-Learning depending on Learners' Characteristics & Learning Experiences (학습자 특성 및 수강 경험에 따른 e-Learning의 학습행태 차이 분석)

  • Lee, Sookyoung;Kwon, Soung-Youn;Ko, Ki-Jung;Lim, Young-Taek
    • The Journal of Korean Association of Computer Education
    • /
    • v.10 no.2
    • /
    • pp.49-64
    • /
    • 2007
  • This research aims to investigate e-Learning behavior and its different features which may vary depending on learners' characteristics and their prior e-Learning experiences. For this purpose, a survey was conducted for adult learners who had e-Learning experiences. It included various questions including place, time and process of e-Learning. The result showed that features of e-Learning behavior varies according to learner characteristics, such as gender, educational background, and their work experiences. It also revealed that work environment and the nature of e-Learning courses are influential factors for their learning behavior.

  • PDF

Image-based Absorbed Dosimetry of Radioisotope (영상기반 방사성동위원소 흡수선량 평가)

  • Park, Yong Sung;Lee, Yong Jin;Kim, Wook;Ji, Young Hoon;Kim, Kum Bae;Kang, Joo Hyun;Lim, Sang Moo;Woo, Sang-Keun
    • Progress in Medical Physics
    • /
    • v.27 no.2
    • /
    • pp.86-92
    • /
    • 2016
  • An absorbed dose calculation method using a digital phantom is implemented in normal organs. This method cannot be employed for calculating the absorbed dose of tumor. In this study, we measure the S-value for calculating the absorbed dose of each organ and tumor. We inject a radioisotope into a torso phantom and perform Monte Carlo simulation based on the CT data. The torso phantom has lung, liver, spinal, cylinder, and tumor simulated using a spherical phantom. The radioactivity of the actual absorbed dose is measured using the injected dose of the radioisotope, which is Cu-64 73.85 MBq, and detected using a glass dosimeter in the torso phantom. To perform the Monte Carlo simulation, the information on each organ and tumor acquired using the PET/CT and CT data provides anatomical information. The anatomical information is offered above mean value and manually segmented for each organ and tumor. The residence time of the radioisotope in each organ and tumor is calculated using the time activity curve of Cu-64 radioactivity. The S-values of each organ and tumor are calculated based on the Monte Carlo simulation data using the spatial coordinate, voxel size, and density information. The absorbed dose is evaluated using that obtained through the Monte Carlo simulation and the S-value and the residence time in each organ and tumor. The absorbed dose in liver, tumor1, and tumor2 is 4.52E-02, 4.61E-02, and 5.98E-02 mGy/MBq, respectively. The difference in the absorbed dose measured using the glass dosimeter and that obtained through the Monte Carlo simulation data is within 12.3%. The result of this study is that the absorbed dose obtained using an image can evaluate each difference region and size of a region of interest.

Antimutagenic Effects of Methyl Alcohol Extracts from Auricularia auricula and Gyrophora esculenta (목이 및 석이 메틸 알콜 추출물의 항돌연변이원성)

  • Ham, Seung-Shi;Kim, Deug-Ha;Lee, Deuk-Sik
    • Korean Journal of Food Science and Technology
    • /
    • v.29 no.6
    • /
    • pp.1281-1287
    • /
    • 1997
  • This study was conducted to investigate the antimutagenic effects of methyl alcohol extracts from Auricularia auricula and Gyrophora esculenta on the SOS response induced by 4-nitroquinoline-1-oxide (4NQO), N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), mitomycin C (MMC) and 3-amino-1,4- dimethyl-5H-pyrido-[4,3-b]indol (Trp-P-1) in E. coli PQ37/plasmid pKM101. In the mutagenic test on test strain, both methyl alcohol extracts did not show mutagenic activity. In the antimutagenic test, each sample strongly inhibited the mutagenecity induced by 4NQO, MNNG, MMC and Trp-P-1. Methyl alcohol extracts from Auricularia auricula and Gyrophora esculenta showed inhibitory effects of 52% and 59% against 4NQO, 49% and 58% against MNNG, 53% and 64% against MMC, and 61% and 64% against Trp-P-1, respectively. Gyrophora esculenta extracts on the antimutagenicity showed relatively higher inhibitory effects than that of Auricularia auricula.

  • PDF