• Title/Summary/Keyword: Dynamic flow

Search Result 2,815, Processing Time 0.036 seconds

Formulation Design and Evaluation of Ursolic Acid Microemulsion Delivery System for Topical Formulation (마이크로에멀젼을 이용한 우르솔릭산 피부 적용제제의 설계 및 평가)

  • Park, Jong-Hee;Kyong, Kee-Yeol;Lee, Gye-Won;Jee, Ung-Kil
    • Journal of Pharmaceutical Investigation
    • /
    • v.35 no.4
    • /
    • pp.233-241
    • /
    • 2005
  • Ursolic acid (UA), a bioactive triterpene acid, has been known to increase collagen content in human skin in addition to other actions such as anti-inflammatory, skin-tumor prevention and anti-invasion. However, it is poorly soluble in water. Therefore, we firstly prepared microemulsion system with benzyl alcohol, ethanol and Cremophor EL, RH 40 and Brij 35 as surfactant in order to increase solubility of UA and then prepared microemulsion was dispersed in o/w cream base for the topical delivery of UA in an effort to improve anti-wrinkle effect. The pseudo-ternary phase diagrams were developed and various microemulsion formulations were prepared using benzyl alcohol as an oil, Cremophor EL, RH 40 and Brij 35 as a surfactant. The droplet size of microemulsions was characterized by dynamic light scattering. The accumulation of VA in the skin from topical cream was evaluated in vitro using hairless mouse skins. The mean droplet size was $26.8{\pm}6.6$ nm for microemulsions II with Cremophor EL. All UA creams showed pseudoplastic flow and hysterisis loop in their rheogram, depending on the type of materials added in topical creams. The in vitro accumulation data demonstrated the UA topical cream prepared with the combination of Poloxamer 407 and Xanthan gum as a copolymer showed higher accumulation percentage than those prepared with either Poloxamer 407 or Xanthan gum. These results suggest that UA topical cream using microemulsion systems may be promising for the topical delivery of UA.

An Estimation of River bed Profile of the Stream System based on the Potential Energy Concept (位置에너지 槪念에 依한 水系의 河川縱斷 推定)

  • Ahn, Sang-Jin;Kang, Kwan-Won;Kim, Chang-Su
    • Magazine of the Korean Society of Agricultural Engineers
    • /
    • v.24 no.2
    • /
    • pp.76-88
    • /
    • 1982
  • The stream morphological characteristics of a basin have important influence upon the analysis of runoff. In this study, the laws of stream morphology-the law of average stream fall and the law of least rate of potential energy expenditure-which were derived based on the analogy of entropy in thermodynamics are introduced and their validity is analysised with the data taken from the topographic maps covering the whole Geum River system. The first law is the Law of Average Stream Fall which states that under the dynamic equilibrium condition the ratio of average fall between any two different order stream in the same river basin in unity. The second law is the law of least rate of energy expenditure which states that all natural streams are intended to choose their own course of flow such that the rate of potential energy loss per unit mass of water this course is a minimum. The parameters representing the morphological characteristics of 13 tributaries in the Geum River system such as stream bifurcation ratio and stream concavity were Computed from the Horton-Strahler's laws and are used to check the law of average stream fall. The result showed that the law of average stream fall agrees reasonably well with law of Horton-Strahler. Concavity of a river basin is shown to be the determinative factor to the formation of a stream system. Concavity of a river basin is shown to be the determinative factor to the formation of a stream system. Based on Horton's Law and the law of average stream fall, longitudinal stream profiles can be calculated.

  • PDF

Development and Application of Multiple Box Water Quality Model for Estuary Reservoirs (담수호 Multiple Box 수질모형의 개발과 적용)

  • 임종환;권순국
    • Magazine of the Korean Society of Agricultural Engineers
    • /
    • v.31 no.4
    • /
    • pp.111-122
    • /
    • 1989
  • A multiple box model which is suitable for the prediction of water quality in shallow lakes with active mixing is a water quality model expected to be used widely in estuary reservoir. In this study, a multiple box water quality model for estuary reservoirs (MBQER) was developed arid the applicability of the MBQER was tested by applying data obtained from Asan-estuary reservoir. The results of this study can be summarized as follows. 1. The MBQER, dynamic water quality model, was developed to estimate 10-day water qualities of estuary reservoirs. For the proper analysis and the application of hydraulics needed to build a model, lake hydraulics was simplified by condisering only hydrological inflow and lake mixing currents. The box division in the MBQER is longitudinal one dimension for upper and middle part, and two layers for lower part of the reservoir. 2. The methods of box division for the multiple box model were ekamined and applied to Asan-estuary reservoir. For determining the number of boxes, Pe number and Pk number were used. In case of three boxes, the error by the model simplification would be estimated about 5 % Therefore, in Asan reservoir, the proper number of boxes was three. 3. The MBQER was calibrated and verified using measured data in Asan-estuary reservoir from 1986 to 1988. The Root Mean Squares(RMS) for the differences between measured data and simulated results by the MBQER were 1.10$^{\circ}$C C for water temperature, 75.8mg/1 for salinity, 0.082mg/1 for total-phosphorus showing good estimations. 4. Through the simulation of water temperature and salinity by the MBQER, the exchange flow and the mixing coefficients for the estuary lake were determined. As a result of simulation, the horizontal mixing coefficients in Asan-estuary reservoir were in the range of 1.07X 105 to 1.12X 105 cm$^2$/sec and vertical mixing coefficient was 2.90X 10-1 cm$^2$/sec.

  • PDF

Passive Control of the Vortex Shedding behind a Rectangular Cylinder Near a Wall (벽면에 근접한 사각주 후면의 와류 유동장 수동제어)

  • Lee, Bo-Sung;Kim, Tae-Yoon;Lee, Do-Hyung;Lee, Dong-Ho
    • Journal of the Korean Society for Aeronautical & Space Sciences
    • /
    • v.32 no.6
    • /
    • pp.16-22
    • /
    • 2004
  • Unsteady vortex shedding behind a rectangular cylinder near a wall influences both increasing of drag and dynamic stability of heavy vehicle, bridge or building. Incompressible Averaged Navier-Stokes equation with modified ${\varepsilon}-SST$ turbulence model is adapted for investigating the flow field between the rectangular cylinder and the wall. In case the vortex shedding happens, not only the averaged maximum velocity is higher than other cases, but the position of the maximum velocity is closer to the lower surface of rectangular cylinder. On this study, it is confirmed that the vortex shedding behind a rectangular cylinder can be suppressed by the passive control method added by horizontal and vertical fences to the lower surface of rectangular cylinder.

Air-traffic dispatching scheduling in terminal airspace (공항접근영역 항공교통 Dispatching 스케줄링 연구)

  • Jeong, Sun-Jo;Cho, Doo-Hyun;Choi, Han-Lim
    • Journal of the Korean Society for Aeronautical & Space Sciences
    • /
    • v.44 no.11
    • /
    • pp.973-980
    • /
    • 2016
  • An air traffic management (ATM) has been studied in a variety of fields to utilize an air traffic capacity efficiently and solve a congested air traffic situation due to an increment of an air traffic demand. In this paper, an air traffic management, which is related with controlling and determining the sequencing of an aircraft approaching to an airport, in terminal control area is studied. This paper focuses on scheduling algorithms with a given problem for the air traffic management with operational constraints, such as a space separation, an overtaking on the same air-route, and a route merge point (a scheduling point). For a real-time calculation, the presented algorithms focus on dispatching heuristic rules which are able to assign tasks in a fast time period with an adequate performance, which can be demonstrated as a proper and realistic scheduling algorithm. A simulation result is presented to illustrate the validity and applicability of the proposed algorithm. Each scheduling rule is analyzed on the same static and dynamic air traffic flow scenario with the ATM Monte-Carlo simulation.

The Energy Flow and Mineral Cycles in a Zoysia japonica and a Miscanthus sinensis Ecosystem on Mt. Kwanak 6. The Cycles of Ca, Mg, Na (관악산의 잔디와 억새 생태계에 있어서 에너지의 흐름과 무기물의 순환 6.Ca,Ma,Na의 순환)

  • 김정석;장남기
    • Asian Journal of Turfgrass Science
    • /
    • v.10 no.2
    • /
    • pp.105-115
    • /
    • 1996
  • To find out the mineral cycles of calcium, magnesium and sodium in dynamic grassland cosystems in a steady state condition, this investigation was conducted along the northwest side on Mt. Kwanak. The experimental results may he suromarized on the communities of a Zoysia japonica and a Miscanthus sinesis as follows. As compared with some properties of the surface soils among two semi-natural grasslands, cal- cium (Ca) was greater quantity in a Zoysia japonica, whereas, in a Miscanthus sicensis, sodium (Na)and magnesium (Mg) were greater in Mt. Kwanak. For the case of steady production and release, the ratio of annual mineral production to the amount accumulated on the top of mineral soil in a steady state provides the estimates of release constant k. The release constants of Ca, Mg and Na of the litter were 0.42, 0.25 and 0.29 in the Zoysia japonica grassland, and were 0.41, 0.54 arid 0.62 in the Miscanthus sinensis grassland, respect- ively. The half times of Ca, Mg and Na required for the release or accumulation of the litter on the grassland were 1.65, 2.77 and 2.39 in the Zoysia japonica, and were 1.69, 1.28 and 1.12 in the Miscauthus sinensis, respectively. The increasing order of the turnover parameters of the elements was Ca, Na and Mg in the Zoysia japonica grassland, and was Na, Mg and Ca in the Miscanthus Si nens is grassland. The amounts of annual cycles for Ca, Mg, Na in the grassland ecosystem under the steady-state conditions were 1.29, 0.20 and 0.12 g /m$^2$ in the Zoysia japonica grassland and 3.91, 1.04 and 0.61 g /m$^2$ in the Miscanthus sinensis grassland.

  • PDF

Centrifuge modelling of pile-soil interaction in liquefiable slopes

  • Haigh, Stuart K.;Gopal Madabhushi, S.P.
    • Geomechanics and Engineering
    • /
    • v.3 no.1
    • /
    • pp.1-16
    • /
    • 2011
  • Piles passing through sloping liquefiable deposits are prone to lateral loading if these deposits liquefy and flow during earthquakes. These lateral loads caused by the relative soil-pile movement will induce bending in the piles and may result in failure of the piles or excessive pile-head displacement. Whilst the weak nature of the flowing liquefied soil would suggest that only small loads would be exerted on the piles, it is known from case histories that piles do fail owing to the influence of laterally spreading soils. It will be shown, based on dynamic centrifuge test data, that dilatant behaviour of soil close to the pile is the major cause of these considerable transient lateral loads which are transferred to the pile. This paper reports the results of geotechnical centrifuge tests in which models of gently sloping liquefiable sand with pile foundations passing through them were subjected to earthquake excitation. The soil close to the pile was instrumented with pore-pressure transducers and contact stress cells in order to monitor the interaction between soil and pile and to track the soil stress state both upslope and downslope of the pile. The presence of instrumentation measuring pore-pressure and lateral stress close to the pile in the research described in this paper gives the opportunity to better study the soil stress state close to the pile and to compare the loads measured as being applied to the piles by the laterally spreading soils with those suggested by the JRA design code. This test data shows that lateral stresses much greater than one might expect from calculations based on the residual strength of liquefied soil may be applied to piles in flowing liquefied slopes owing to the dilative behaviour of the liquefied soil. It is shown at least for the particular geometry studied that the current JRA design code can be un-conservative by a factor of three for these dilation-affected transient lateral loads.

Nonlinear response history analysis and collapse mode study of a wind turbine tower subjected to tropical cyclonic winds

  • Dai, Kaoshan;Sheng, Chao;Zhao, Zhi;Yi, Zhengxiang;Camara, Alfredo;Bitsuamlak, Girma
    • Wind and Structures
    • /
    • v.25 no.1
    • /
    • pp.79-100
    • /
    • 2017
  • The use of wind energy resources is developing rapidly in recent decades. There is an increasing number of wind farms in high wind-velocity areas such as the Pacific Rim regions. Wind turbine towers are vulnerable to tropical cyclones and tower failures have been reported in an increasing number in these regions. Existing post-disaster failure case studies were mostly performed through forensic investigations and there are few numerical studies that address the collapse mode simulation of wind turbine towers under strong wind loads. In this paper, the wind-induced failure analysis of a conventional 65 m hub high 1.5-MW wind turbine was carried out by means of nonlinear response time-history analyses in a detailed finite element model of the structure. The wind loading was generated based on the wind field parameters adapted from the cyclone boundary layer flow. The analysis results indicate that this particular tower fails due to the formation of a full-section plastic hinge at locations that are consistent with those reported from field investigations, which suggests the validity of the proposed numerical analysis in the assessment of the performance of wind-farms under cyclonic winds. Furthermore, the numerical simulation allows to distinguish different failure stages before the dynamic collapse occurs in the proposed wind turbine tower, opening the door to future research on the control of these intermediate collapse phases.

An Experimental Study on Web Link Analysis of the Korean National Archives (국가기록원 웹사이트 링크정보 분석에 관한 실험적 연구)

  • Park, Zi-Young
    • Journal of the Korean Society for information Management
    • /
    • v.25 no.2
    • /
    • pp.167-181
    • /
    • 2008
  • In this study, web link analysis of the Korean National Archives has been Performed using LexiURL to show the dynamic web flow of the National Archives and to identify which closely related institutions the archives should seek to cooperate with for developing an institutional strategic plan. Inlink and co-inlink analysis were performed and, to identify related institutions of the Korean National Archives. a comparison was made with other countries such as Australia, England and the United Stats. Through web link analysis, several features can be detected and future directions are suggested. Most inlinks and co-inlink of the Korean National Archives were from public institutions, indicating that relationships with educational or research institutions are weak. Moreover, Korean National Archives involve fewer web links related to international activities than other countries. Proceeding from these results, educational function, research function and international activities should be fortified. Korean National Archives need to provide more materials for supporting educational and research activities and more cultural interchange among related institutions. Further research with different heritage institutions such as libraries or museums is needed.

Painterly Stroke Generation using Object Motion Analysis (객체의 움직임 해석을 이용한 회화적 스트로크 생성 방법)

  • Lee, Ho-Chang;Seo, Sang-Hyun;Ryoo, Seung-Tack;Yoon, Kyung-Hyun
    • Journal of KIISE:Computer Systems and Theory
    • /
    • v.37 no.4
    • /
    • pp.239-245
    • /
    • 2010
  • Previous painterly rendering techniques normally use image gradients for stroke generation. Although image gradients are useful for expressing object shapes, it is difficult to express the flow or movements of objects of objects. In real painting, the use of brush strokes corresponding to the actual movement of objects allows viewers to recognize objects’ motion better and express the liveliness of the objects much more. In this paper, we propose a novel painterly stroke generation algorithm to express dynamic objects based on their motion information. We first extract motion information (magnitude, direction) of a scene from a set of image sequences from the same view. Then the motion directions are used for determining stroke orientations in the regions with significant motions. Where little motion is observed, image gradients are used for determining stroke orientations. Our algorithm is useful for realistically and dynamically representing moving objects.